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Targeting epicardial adipose tissue:A potential therapeutic strategy for heart failure with preserved ejection fraction with type 2 diabetes mellitus

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World Journal of Diabetes 2023年第6期14卷 724-740页

作者： yu-jiao shi Guo-Ju Dong Ming Guo Department of Cardiovascular Medicine Xiyuan HospitalChinese Academy of Traditional Chinese MedicineBeijing 100091China

Heart failure with preserved ejection fraction(HFpEF)is a heterogeneous syndrome with various comorbidities,multiple cardiac and extracardiac pathophysiologic abnormalities,and diverse phenotypic *** HFpEF is a heterogeneous disease with different phenotypes,individualized treatment is *** with type 2 diabetes mellitus(T2DM)represents a specific phenotype of HFpEF,with about 45%-50% of HFpEF patients suffering from *** inflammation associated with dysregulated glucose metabolism is a critical pathological mechanism of HFpEF with T2DM,which is intimately related to the expansion and dysfunction(inflammation and hypermetabolic activity)of epicardial adipose tissue(EAT).EAT is well established as a very active endocrine organ that can regulate the pathophysiological processes of HFpEF with T2DM through the paracrine and endocrine ***,suppressing abnormal EAT expansion may be a promising therapeutic strategy for HFpEF with *** there is no treatment specifically for EAT,lifestyle management,bariatric surgery,and some pharmaceutical interventions(anti-cytokine drugs,statins,proprotein convertase subtilisin/kexin type 9 inhibitors,metformin,glucagon-like peptide-1 receptor agonists,and especially sodium-glucose cotransporter-2 inhibitors)have been shown to attenuate the inflammatory response or expansion of ***,these treatments may be beneficial in improving the clinical symptoms or prognosis of patients with ***,well-designed randomized controlled trials are needed to validate the efficacy of current *** addition,more novel and effective therapies targeting EAT are needed in the future.

关键词： Epicardial adipose tissue Heart failure with preserved ejection fraction Type 2 diabetes mellitus Inflammation Anti-hyperglycemic drugs Sodium-glucose cotransporter-2 inhibitors

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VX-765 reduces neuroinflammation after spinal cord injury in mice

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Neural Regeneration Research 2021年第9期16卷 1836-1847页

作者： Jing Chen yu-Qing Chen yu-jiao shi Shu-Qin Ding Lin Shen Rui Wang Qi-Yi Wang Cheng Zha Hai Ding Jian-Guo Hu He-Zuo Lü Clinical Laboratory the First Affiliated Hospital of Bengbu Medical CollegeBengbuAnhui ProvinceChina Anhui Key Laboratory of Tissue Transplantation the First Affiliated Hospital of Bengbu Medical CollegeBengbuAnhui ProvinceChina Department of Immunology Bengbu Medical Collegeand Anhui Key Laboratory of Infection and Immunity at Bengbu Medical CollegeBengbuAnhui ProvinceChina

Inflammation is a major cause of neuronal injury after spinal cord injury. We hypothesized that inhibiting caspase-1 activation may reduce neuroinflammation after spinal cord injury, thus producing a protective effect in the injured spinal cord. A mouse model of T9 contusive spinal cord injury was established using an Infinite Horizon Impactor, and VX-765, a selective inhibitor of caspase-1, was administered for 7 successive days after spinal cord injury. The results showed that:(1) VX-765 inhibited spinal cord injury-induced caspase-1 activation and interleukin-1β and interleukin-18 secretion.(2) After spinal cord injury, an increase in M1 cells mainly came from local microglia rather than infiltrating macrophages.(3) Pro-inflammatory Th1 Th17 cells were predominant in the Th subsets. VX-765 suppressed total macrophage infiltration, M1 macrophages/microglia, Th1 and Th1 Th17 subset differentiation, and cytotoxic T cells activation;increased M2 microglia;and promoted Th2 and Treg differentiation.(4) VX-765 reduced the fibrotic area, promoted white matter myelination, alleviated motor neuron injury, and improved functional recovery. These findings suggest that VX-765 can reduce neuroinflammation and improve nerve function recovery after spinal cord injury by inhibiting caspase-1/interleukin-1β/interleukin-18. This may be a potential strategy for treating spinal cord injury. This study was approved by the Animal Care Ethics Committee of Bengbu Medical College(approval No. 2017-037) on February 23, 2017.

关键词： immune cell subsets immune function inflammasomes leukocyte infiltration macrophages microglia pathways spinal cord injury

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High-energy-density lithium manganese iron phosphate for lithium-ion batteries: Progresses, challenges, and prospects

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Journal of Energy Chemistry 2025年第1期100卷 1-17页

作者： Bokun Zhang Xiaoyun Wang Shuai Wang Yan Li Libo Chen Handong jiao Zhijing yu Jiguo Tu State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing Research Institute for Intelligent Wearable Systems The Hong Kong Polytechnic University Institute of Advanced Structure Technology Beijing Institute of Technology

The soaring demand for smart portable electronics and electric vehicles is propelling the advancements in high-energy–density lithium-ion *** manganese iron phosphate (LiMnxFe1-xPO4) has garnered significant attention as a promising positive electrode material for lithium-ion batteries due to its advantages of low cost,high safety,long cycle life,high voltage,good high-temperature performance,and high energy *** LiMnxFe1-xPO4has made significant breakthroughs in the past few decades,there are still facing great challenges in poor electronic conductivity and Li-ion diffusion,manganese dissolution affecting battery cycling performance,as well as low tap *** review systematically summarizes the reaction mechanisms,various synthesis methods,and electrochemical properties of LiMnxFe1-xPO4to analyze reaction processes accurately and guide material ***,the main challenges currently faced are concluded,and the corresponding various modification strategies are discussed to enhance the reaction kinetics and electrochemical performance of LiMnxFe1-xPO4,including multi-scale particle regulation,heteroatom doping,surface coating,as well as microscopic morphology ***,in view of the current research challenges faced by intrinsic reaction processes,kinetics,and energy storage applications,the promising research directions are *** importantly,it is expected to provide key insights into the development of high-performance and stable LiMnxFe1-xPO4materials,to achieve practical energy storage requirements.

关键词： Lithium manganese iron phosphate High energy density Lithium-ion batteries Reaction mechanism Tap density

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Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

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Nano-Micro Letters 2025年第2期17卷 548-565页

作者： Ming‑yuan yu Jing Wu Guang Yin Fan‑Zhen jiao Zhong‑Zhen yu Jin Qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods

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“有料、有趣、有责任”——浅谈成人教学的新质量标准

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天津职业院校联合学报 2013年第10期15卷 91-93页

作者：焦雨石天津市新华职工大学天津300040

成人教育的衰退其根源在于教学质量的低下,而教学教学质量的低下又缘起于质量标准的落后,导致无法满足当今学员的新要求。如何与时俱进?文章对成人教学质量的新标准加以阐述。

关键词：成人教学教学质量教学标准

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建国后毛泽东平等外交思想探析

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安康师专学报 2005年第2期17卷 8-10页

作者：焦玉石郭华武汉大学政治与公共管理学院湖北武汉430072

本文就建国后毛泽东平等外交思想产生的时代背景、丰富内涵、实现途径进行了探讨。

关键词：平等外交毛泽东时代背景

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光照对细鳞裂腹鱼受精卵孵化率及仔鱼生长、摄食的影响

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水生态学杂志 2017年第5期38卷 97-102页

作者：秦希获刘国勇邬玉娇石小涛王小玲三峡大学生物与制药学院宜昌443002 三峡库区生态环境教育部工程研究中心三峡大学宜昌443002 武汉市农业综合执法监督总队武汉430023

研究光照对细鳞裂腹鱼胚胎孵化及20日龄内仔鱼生长、摄食的影响,探讨了细鳞裂腹鱼胚胎及仔鱼所需的适宜光照条件,为该鱼的基础生物学研究积累资料,也为人工繁殖和养殖生产提供参考。仔鱼为人工育苗池中随机抽取的初孵仔鱼,仔鱼饵料为小... 详细信息

研究光照对细鳞裂腹鱼胚胎孵化及20日龄内仔鱼生长、摄食的影响,探讨了细鳞裂腹鱼胚胎及仔鱼所需的适宜光照条件,为该鱼的基础生物学研究积累资料,也为人工繁殖和养殖生产提供参考。仔鱼为人工育苗池中随机抽取的初孵仔鱼,仔鱼饵料为小球藻和鲜酵母混合培育的褶皱臂尾轮虫。水源为天然河水,试验期间水温16.0~18.0℃、溶解氧6.8~8.5 mg/L、pH 6.5~6.8,采用三基色节能荧光灯为暗室内光源。结果表明,在10~360 lx范围内,随着光照强度的增加,孵化率逐渐升高,300~360 lx时达到最高的孵化率88.1%,此后孵化率随着光照强度的增大又有所下降,细鳞裂腹鱼受精卵孵化适宜的光照强度为300~720 lx。光照对细鳞裂腹鱼仔鱼的生长及摄食有显著影响。12日龄后的仔鱼在40~60 lx光照强度下生长最好、摄食强度最大,400~600 lx次之;此后随着光照强度的增大,摄食强度又显著下降。在40~6 000 lx范围内随光照强度的增强,摄食强度下降,生长则变差。黑暗条件下的仔鱼摄食强度和摄食率最低,生长接近停滞,在15日龄时全部死亡。细鳞裂腹鱼仔鱼在20日龄以内的适宜光照强度为40~600 lx。

关键词：细鳞裂腹鱼光照强度孵化率生长摄食

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VEGF、nm23在胆囊癌中的表达及与淋巴结转移相互关系的研究

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天津医药 2003年第2期31卷 80-81页

作者：郝继辉俞鸣焦振山史玉荣天津医科大学附属肿瘤医院腹部外科 300060

目的 :研究VEGF与nm23基因在胆囊癌中的表达及其在淋巴结转移中的作用 ,并探讨两者的相互关系。方法 :采用免疫组化法 ,检测VEGF蛋白及nm23蛋白在胆囊癌中的表达。结果 :VEGF在胆囊癌中的阳性表达率为86 7 % ,明显高于正常组织 ;而nm23... 详细信息

目的 :研究VEGF与nm23基因在胆囊癌中的表达及其在淋巴结转移中的作用 ,并探讨两者的相互关系。方法 :采用免疫组化法 ,检测VEGF蛋白及nm23蛋白在胆囊癌中的表达。结果 :VEGF在胆囊癌中的阳性表达率为86 7 % ,明显高于正常组织 ;而nm23阳性表达率则为40 % ,显著低于正常组织 ;两者在胆囊癌组织中的表达呈负相关趋势。结论 :VEGF与nm23基因协同促进胆囊癌的淋巴结转移。

关键词： VEGF nm23 胆囊癌内皮生长因子肿瘤转移免疫组织化学

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石油污染物在滨海潜水层中的迁移预测

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人民黄河 2011年第8期33卷 86-87,90页

作者：胡红亮刘国东余世娇李龙国四川大学水利水电学院四川成都610065 四川大学水力学与山区河流开发保护国家重点实验室四川成都610065

以山东滨海某人工填海区的原油储备库为例,选定石油污染组分溶解度为源强浓度,运用单向随流输移和一维扩散模型研究了地下水中石油污染物的运移规律。结果表明:①在单个油罐连续泄漏的情况下,石油污染组分在进入地下水后10 d、1个月、3... 详细信息

以山东滨海某人工填海区的原油储备库为例,选定石油污染组分溶解度为源强浓度,运用单向随流输移和一维扩散模型研究了地下水中石油污染物的运移规律。结果表明:①在单个油罐连续泄漏的情况下,石油污染组分在进入地下水后10 d、1个月、3个月、6个月、1 a、2 a和3 a后的运移距离分别为2.2、4.8、11.2、19.9、36.0、66.7 m和96.6 m;②石油一旦发生泄漏,在可能的条件下可采取包气带土层换填等措施来切断污染源;③在人工填海区,可以通过增加填埋黏土、加强场地碾压等措施人为改变水文地质条件,避免可能的污染。

关键词：石油污染物地下水污染潜水层滨海地区

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Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss

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Neural Regeneration Research 2025年第10期20卷 3025-3039页

作者： Jia Fang Zhuangzhuang Li Pengjun Wang Xiaoxu Zhang Song Mao Yini Li Dongzhen yu Xiaoyan Li Yazhi Xing Haibo shi Shankai Yin Department of Otolaryngology Head and Neck Surgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineOtolaryngology Institute of Shanghai Jiao Tong UniversityShanghai Key Laboratory of Sleep Disordered BreathingShanghaiChina Department of Otorhinolaryngology-Head and Neck Surgery Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial ***,their use leads to irreversible hearing damage by causing apoptosis of hair cells as their direct *** addition,the hearing damage caused by aminoglycosides involves damage of spiral ganglion neurons upon *** investigate the mechanisms underlying spiral ganglion neuron degeneration induced by aminoglycosides,we used a C57BL/6J mouse model treated with *** found that the mice exhibited auditory deficits following the acute loss of outer hair *** ganglion neurons displayed hallmarks of pyroptosis and exhibited progressive degeneration over *** profiling of these neurons showed significant upregulation of genes associated with inflammation and immune response,particularly those related to the NLRP3 *** of the canonical pyroptotic pathway in spiral ganglion neurons was observed,accompanied by infiltration of macrophages and the release of proinflammatory *** intervention targeting NLRP3 using Mcc950 and genetic intervention using NLRP3 knockout ameliorated spiral ganglion neuron degeneration in the injury *** findings suggest that NLRP3 inflammasome-mediated pyroptosis plays a role in aminoglycoside-induced spiral ganglion neuron *** of this pathway may offer a potential therapeutic strategy for treating sensorineural hearing loss by reducing spiral ganglion neuron degeneration.

关键词： degeneration hearing loss macrophages Mcc950 neuroinflammation NLRP3 inflammasome ototoxicity pyroptosis sensorineural hearing loss spiral ganglion neuron

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