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Ginzburg-Landau Vortex and Mean Curvature Flow with External Force Field

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Acta Mathematica Sinica,English Series 2006年第6期22卷 1831-1842页

作者： Huai yu jian Yan Nan liu Department of Mathematical Sciences Tsinghua University Beijing 100084 P. R. China

This paper is devoted to the study of the vortex dynamics of the Cauchy problem for a parabolic Ginzburg Landau system which simulates inhomogeneous type II superconducting materials and three-dimensional superconducting thin films having variable thickness. We will prove that the vortex of the problem is moved by a codimension k mean curvature flow with external force field. Besides, we will show that the mean curvature flow depends strongly on the external force, having completely different phenomena from the usual mean curvature flow.

关键词： system of parabolic equations Ginzburg-Landau vortex mean curvature flow

Cyanidation of gold clay ore containing arsenic and manganese

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International Journal of Minerals,Metallurgy and Materials 2010年第2期17卷 132-136页

作者： yu-liang Li jian liu Wei-sheng Guan School of Environmental Science and Engineering Chang＇an University Xi＇an 710054 China

The extraction process of gold and silver from the gold clay ore containing arsenic and manganese was *** the conventional technique,the leaching rates of gold and silver are 78.23%and 49.02%,*** eliminate the negative effects of arsenic and manganese on cyanidation and increase the gold and silver leaching rates,a novel catalyst was *** content of the catalyst used in the process was 8 g per 500 g org sample,the sample size was 60μm and the pH value was kept between 10 and *** with the catalyst for 3-5 h under certain conditions,the gold leaching rate increased to over 90%and the silver leaching rate increased to 80%-90%.The catalyst can effectively liberate gold and silver from the enclosure of arsenic and manganese and the industrial experiment has great significance to the development and utilization of the gold clay ore containing arsenic and manganese.

关键词： gold ore cyanidation catalyst gold silver leaching rate

Stereoselective　Syntheses　of　Some　β-D-1-Thioglycopyranosides　and　Bis(β-D-glycopyranosyl)　Sulfides　by　Phase　Transition　Catalysis

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Chemical Research in Chinese Universities 1997年第1期13卷 23-28页

作者： yu jian xin, liu Fang min, SUN Wan fu and liu yu ting (Department of Chemistry, Xinjiang University, Ulumuqi, 830046) XINjianG UNIV DEPT CHEMULUMUQI 830046PEOPLES R CHINA

The present paper covers the stereoselective syntheses of four 1 thiogalactopyranosides 1—4 and three thio disaccharides 5—7 through the PTC methods and their structures confirmed by means of elementary analysis, ... 详细信息

关键词： Synthesis Phase transition catalysis Thiogalactopyranoside Thio disaccharide Stereospecificity

Impact of uterine artery embolization on ovarian function and pregnancy outcome after uterine-fibroids treatment:A prospective study

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World Journal of Clinical Cases 2024年第15期12卷 2551-2559页

作者： Jing-Lei liu Zhi-Hui Liang Bao Cui jian-yu liu Li Sun Department of Interventional Treatment 980(Bethune International Peace)Hospital of PLA Joint Logistics Support ForcesShijiazhuang 050082Hebei ProvinceChina Department of Obstetrics and Gynecology 980(Bethune International Peace)Hospital of PLA Joint Logistics Support ForcesShijiazhuang 050082Hebei ProvinceChina

Uterine fibroids are benign tumors that originate from smooth muscle cells of the *** is the most common gynecological disorder,affecting up to 80%of women of reproductive *** fibroids can cause various symptoms such as abnormal uterine bleeding,pelvic pain,infertility,and pregnancy *** treatment options for uterine fibroids include medical therapy,surgical intervention,and minimally invasive *** To compare ovarian function of women with uterine fibroids who did or did not undergo uterine artery embolization(UAE).METHODS This prospective cohort study enrolled 87 women with symptomatic uterine fibroids who underwent UAE,and 87 women with the same symptoms who did not undergo UAE but received conservative management or other *** two groups were matched for age,body mass index,parity,and baseline characteristics of uterine *** primary outcome was ovarian function that was evaluated by serum levels of follicle-stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2),and anti-Müllerian hormone(AMH),as well as ovarian reserve tests,such as antral follicle count(AFC)and ovarian volume(OV).The secondary outcome was fertility that was evaluated based on the menstrual cycle,ovulation,conception,pregnancy,and *** participants were followed-up for 36 months and assessed at 1,3,6,12,24,and 36 months after *** The study found that the most common minor complication of UAE was postembolization syndrome in 73.6% of women,resolving within a *** significant differences were observed between the UAE group and the control group in serum levels of reproductive hormones(FSH,LH,E2,AMH)and ovarian reserve indicators(AFC,OV)at any point up to 36 months ***,there were no significant differences in conception,pregnancy,or delivery rates,with the average time to conception and gestational age at delivery being similar between the two *** weights were also ***

关键词： Uterine fibroids Uterine artery embolization Ovarian function Fertility Pregnancy outcome Embolic agent

Calibration and data restoration of light field modulated imaging spectrometer

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Chinese Physics B 2018年第8期27卷 179-186页

作者： Li-Juan Su Qiang-Qiang Yan Yan yuan Shi-Feng Wang yu-jian liu Key Laboratory of Precision Opto-mechatronics Technology of Ministry of Education Beihang UniversityBeijing 100191China Key Laboratory of Spectral Imaging Technology of Chinese Academy of Sciences Xi＇an Institute of Optics and Precision MechanicsChinese Academy of SciencesXi ＇ an 710119China

A light field modulated imaging spectrometer （LFMIS） can acquire the spatial-spectral datacube of targets of interest or a scene in a single shot. The spectral information of a point target is imaged on the pixels covered by a microlens. The pixels receive spectral information from different spectral filters to the diffraction and misalignments of the optical components. In this paper, we present a linear spectral multiplexing model of the acquired target spectrum. A calibration method is proposed for calibrating the center wavelengths and bandwidths of channels of an LFMIS system based on the liner-variable filter （LVF） and for determining the spectral multiplexing matrix. In order to improve the accuracy of the restored spectral data, we introduce a reconstruction algorithm based on the total least square （TLS） approach. Simulation and experimental results confirm the performance of the spectrum reconstruction algorithm and validate the feasibility of the proposed calibrating scheme.

关键词： light field modulated imaging spectrometer linear-variable filter spectral calibration spectral re-construction

Discovery of a natural small‑molecule AMP‑activated kinase activator that alleviates nonalcoholic steatohepatitis

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Marine Life Science & Technology 2023年第2期5卷 196-210页

作者： Jin Chen Li Xu Xue-Qing Zhang Xue liu Zi-Xuan Zhang Qiu-Mei Zhu jian-yu liu Muhammad Omer Iqbal Ning Ding Chang-Lun Shao Mei-Yan Wei yu-Chao Gu Key Laboratory of Marine Drugs the Ministry of EducationSchool of Medicine and PharmacyOcean University of ChinaQingdao 266003China Laboratory for Marine Drugs and Bioproducts Laoshan LaboratoryQingdao 266237China College of Food Science and Engineering Ocean University of ChinaQingdao 266003China Key Laboratory of Glycoscience and Glycotechnology of Shandong Province Qingdao 266003China The Massachusetts General Hospital Cancer Center Harvard Medical SchoolBostonMA 02114USA

Non-alcoholic steatohepatitis(NASH)is a primary cause of cirrhosis and hepatocellular ***,there is no approved drug treatment for ***-activated kinase(AMPK)is an important metabolic sensor and whole-body *** has been proposed that AMPK activators could be used for treating metabolic diseases such as obesity,type 2 diabetes and *** this study,we screened a marine natural compound library by monitoring AMPK activity and found a potent AMPK activator,candidusin A(CHNQD-0803).Further studies showed that CHNQD-0803 directly binds recombinant AMPK with a K_(D) value of 4.728×10^(-8) M and activates AMPK at both molecular and intracellular *** then investigated the roles and mechanisms of CHNQD-0803 in PA-induced fat deposition,LPS-stimulated infammation,TGF-β-induced fbrosis cell models and the MCD-induced mouse model of *** results showed that CHNQD-0803 inhibited the expression of adipogenesis genes and reduced fat deposition,negatively regulated the NF-κB-TNFαinfammatory axis to suppress infammation,and ameliorated liver injury and *** data indicate that CHNQD-0803 as an AMPK activator is a novel potential therapeutic candidate for NASH treatment.

关键词： NASH AMPK Infammation Lipid metabolism Fibrosis Marine drug

Synthesis of 1,2:4,5-di-O-Isopropylidene-3-C-Cyano-β-D-ribo-hex-2-ulo Pyranose by Phase Transition Catalysis

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Chemical Research in Chinese Universities 1992年第2期8卷 169-172页

作者： yu jian-xin and liu yu-ting (Chemistry Department of Xinjiang University, Wulumuqi, 830046)

Introduction The cyano branched carbohydrates are useful, versatil intermediaries for the synthesis of branched sugars having biological activity in nature. Owing to the good yield, mild reaction conditions and high s... 详细信息

关键词： Phase transition catalysis Synthesis Stereospecificity 1,2:4,5-di-O-Iso-propylidene-3-C-Cyano-β-D-ribo-hex-2-ulo pyranose

Discovery of a potential bladder cancer inhibitor CHNQD-01281 by regulating EGFR and promoting infiltration of cytotoxic T cells

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Marine Life Science & Technology 2024年第3期6卷 502-514页

作者： jian-yu liu Yao-Yao jiang Peng-Jie Li Bo Yao Yi-Jing Song Ji-Xiu Gao Gulab Said Yang Gao Jun-yu Lai Chang-Lun Shao Key Laboratory of Marine Drugs the Ministry of Education of ChinaSchool of Medicine and PharmacyOcean University of ChinaQingdao 266003China Department of Critical Care Medicine the Affiliated Hospital of Qingdao UniversityQingdao 266003China Department of Chemistry Women University SwabiSwabi 23430Pakistan Laoshan Laboratory Qingdao 266237China Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education College of Chemistry and Chemical EngineeringHainan Normal UniversityHaikou 571158China

As one of the common malignancies that threaten human life,bladder cancer occurs frequently with a high mortality rate in the world,due to its invasion,recurrence and drug *** products from marine microorganisms are becoming the hotspots in discovery of new candidate drug entities,especially in the area of *** A(BFA)is a natural Arf-GEFs inhibitor,but due to the low aqueous solubility,strong toxicity,and poor bioavailability,it is urgent to conduct structural optimization ***,a new BFA pyridine acrylate derivative CHNQD-01281 with improved solubility was prepared and found to exert moderate to strong antiproliferative activity on a variety of human cancer cell *** was noteworthy that CHNQD-01281 was most sensitive to two bladder cancer cell lines T24 and J82(IC50=0.079 and 0.081μmol/L)with high selectivity index(SI=14.68 and 14.32),suggesting a superior safety to *** vivo studies revealed that CHNQD-01281 remarkably suppressed tumor growth in a T24 nude mice xenograft model(TGI=52.63%)and prolonged the survival time(ILS=68.16%)in an MB49 allogeneic mouse model via inducing infiltration of cytotoxic T *** mechanism exploration indicated that CHNQD-01281 regulated both EGFR/PI3K/AKT and EGFR/ERK pathways and mediated the chemotactic effect of chemokines on immune effector ***,CHNQD-01281 may serve as a potential therapeutic agent for bladder cancer through multiple mechanisms.

关键词： Bladder cancer Marine natural products Brefeldin A EGFR/PI3K/AKT EGFR/ERK T-cell infiltration

Effects of confining pressure and pore pressure on multipole borehole acoustic field in fluid-saturated porous media

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Chinese Physics B 2024年第1期33卷 468-476页

作者：赵志强刘金霞刘建宇崔志文 College of Physics Jilin UniversityChangchun 130012China

In-situ stress is a common stress in the exploration and development of oil reservoirs. Therefore, it is of great significance to study the propagation characteristics of borehole acoustic waves in fluid-saturated porous media under *** on the acoustoelastic theory of fluid-saturated porous media, the field equation of fluid-saturated porous media under the conditions of confining pressure and pore pressure and the acoustic field formula of multipole source excitation in open hole are given. The influences of pore pressure and confining pressure on guided waves of multipole borehole acoustic field in fluid-saturated porous media are investigated. The numerical results show that the phase velocity and excitation intensity of guided wave increase significantly under the confining pressure. For a given confining pressure, the phase velocity of the guided wave decreases with pore pressure increasing. The excitation intensity of guided wave increases at low frequency and then decreases at high frequency with pore pressure increasing, except for that of Stoneley wave which decreases in the whole frequency range. These results will help us get an insight into the influences of confining pressure and pore pressure on the acoustic field of multipole source in borehole around fluid-saturated porous media.

关键词： confining pressure pore pressure fluid-saturated porous media multipole borehole acoustic field