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Chemical inequivalence behavior of the protons attached to the same carbon in ethylene-propylene copolymer(EPC)

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Chinese Chemical Letters 2008年第4期19卷 469-474页

作者： Peng yu Bi hui Ru dong Nan Nan Wang College of Science Beijing University of Chemical TechnologyBeijing 100029PR China

Six ethylene-propylene copolymer samples with different structural parameters were analyzed by ^1H NMR,^13C NMR and ^1H-^13C COSY in this *** the aid of the ^1H-^13C COSY spectra of ethylene-propylene copolymer,the chemical inequivalence behavior of the protons attached to the same carbon in the ethylene-propylene copolymer could be observed. Four basic types of chemical bonds were divided,and two kinds of main conformations were proposed to explain this phenomenon. Based on the calculation of conformation distribution,it can be proved that the explanation of this phenomenon was reasonable.

关键词： Chemical inequivalence Ethylene-propylcne copolymer NMR

Critical bubble radius in solvent sublation

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Chinese Chemical Letters 2007年第10期18卷 1293-1296页

作者： Peng yu Bi hui Ru dong Nan Nan Wang College of Science Beijing University of Chemical Technology Beijing 100029 People＇s Republic of China

The complex compound of dithizone-Co（Ⅱ） was separated and concentrated from the aqueous phase to n-octanol by solvent sublation. From the analysis of the coalescence behavior of bubbles on water-organic interface, the conception of critical bubble radius was proposed, and the value of the critical bubble radius in the water-octanol system was obtained： 1.196 × 10^-3 m. The simulation of the mathematical model using CBR and experimental data is completed with perfect results, and the simulation of the mathematical model using CBR is very different with the classic one. The analytical results proved that the critical bubble radius should be adequately considered in mathematical model of solvent sublation.

关键词： Solvent sublation Coalescence behavior Bubble Critical bubble radius

Effect of water droplet in solvent sublation

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Chinese Chemical Letters 2008年第5期19卷 623-626页

作者： Peng yu Bi hui Ru dong Nan Nan Wang College of Science Beijing University of Chemical Technology Beijing 100029 China

Aqueous phase layer around bubble and water droplet are two additional processes in solvent sublation. In the dynamic process of mass transfer, they are always neglected, but they are very important in the investigation of thermodynamic equilibrium. In this paper, the effect of water droplet in solvent sublation was discussed in detail, and the previous mathematical model of solvent subaltion was improved. Matlab 6.5 was used to simulate the process of water droplets, and the comparison between the previous hypothesis and the improvement in this paper showed the superiority, especially in the investigation of thermodynamic equilibrium. Moreover, the separation and concentration of the complex compound dithizone-Co（Ⅱ） from aqueous phase to n-octanol by solvent sublation also proved the improved mathematical model was reasonable.

关键词： Solvent sublation Water droplet Mathematical model

Towards adaptable synchrotron image restoration pipeline

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Nuclear Science and Techniques 2024年第10期35卷 4-16页

作者： Chun Li Xiao-Xue Bi yu-Jun Zhang Zhen Zhang Li-Wen Wang Jian Zhuang dong-Liang Chen yu-hui dong Yi Zhang Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230029China

Synchrotron microscopic data commonly suffer from poor image quality with degraded resolution incurred by instrumentation defects or experimental *** restoration methods are often applied to recover the reduced resolution,providing improved image details that can greatly facilitate scientific *** these methods,deconvolution techniques are straightforward,yet either require known prior information or struggle to tackle large experimental *** learning(DL)-based super-resolution(SR)methods handle large data well,however data scarcity and model generalizability are *** addition,current image restoration methods are mostly offline and inefficient for many beamlines where high data volumes and data complexity issues are *** overcome these limitations,an online image-restoration pipeline that adaptably selects suitable algorithms and models from a method repertoire is *** this study,using both deconvolution and pretrained DL-based SR models,we show that different restoration efficacies can be achieved on different types of synchrotron experimental *** describe the necessity,feasibility,and significance of constructing such an image-restoration pipeline for future synchrotron experiments.

关键词： Synchrotron Deconvolution Deep learning Super-resolution Pipeline

FOXA1 in prostate cancer

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Asian Journal of Andrology 2023年第3期25卷 287-295页

作者： hui-yu dong Lei Ding Tian-Ren Zhou Tao Yan Jie Li Chao Liang Department of Urology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of Clinical Medicine Suzhou Vocational Health CollegeSuzhou 215009China

Most prostate cancers initially respond to androgen deprivation therapy(ADT).With the long-term application of ADT,localized prostate cancer will progress to castration-resistant prostate cancer(CRPC),metastatic CRPC(mCRPC),and neuroendocrine prostate cancer(NEPC),and the transcriptional network *** box protein A1(FOXA1)may play a key role in this process through multiple *** better understand the role of FOXA1 in prostate cancer,we review the interplay among FOXA1-targeted genes,modulators of FOXA1,and FOXA1 with a particular emphasis on androgen receptor(AR)***,we discuss the distinct role of FOXA1 mutations in prostate cancer and clinical significance of *** summarize possible regulation pathways of FOXA1 in different stages of prostate *** focus on links between FOXA1 and AR,which may play different roles in various types of prostate ***,we discuss FOXA1 mutation and its clinical significance in prostate ***1 regulates the development of prostate cancer through various pathways,and it could be a biomarker for mCRPC and *** efforts need to focus on mechanisms underlying mutation of FOXA1 in advanced prostate *** believe that FOXA1 would be a prognostic marker and therapeutic target in prostate cancer.

关键词： androgen receptor forkhead box protein A1 mutation prostate cancer

Enzalutamide and olaparib synergistically suppress castration-resistant prostate cancer progression by promoting apoptosis through inhibiting nonhomologous end joining pathway

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Asian Journal of Andrology 2023年第6期25卷 687-694页

作者： hui-yu dong Pan Zang Mei-Ling Bao Tian-Ren Zhou Chen-Bo Ni Lei Ding Xu-Song Zhao Jie Li Chao Liang Department of Urology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of Pathology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China

Recent studies revealed the relationship among homologous recombination repair(HRR),androgen receptor(AR),and poly(adenosine diphosphate-ribose)polymerase(PARP);however,the synergy between anti-androgen enzalutamide(ENZ)and PARP inhibitor olaparib(OLA)remains ***,we showed that the synergistic effect of ENZ and OLA significantly reduced proliferation and induced apoptosis in AR-positive prostate cancer cell ***-generation sequencing followed by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses revealed the significant effects of ENZ plus OLA on nonhomologous end joining(NHEJ)and apoptosis *** combined with OLA synergistically inhibited the NHEJ pathway by repressing DNA-dependent protein kinase catalytic subunit(DNA-PKcs)and X-ray repair cross complementing 4(XRCC4).Moreover,our data showed that ENZ could enhance the response of prostate cancer cells to the combination therapy by reversing the anti-apoptotic effect of OLA through the downregulation of anti-apoptotic gene insulin-like growth factor 1 receptor(IGF1R)and the upregulation of pro-apoptotic gene death-associated protein kinase 1(DAPK1).Collectively,our results suggested that ENZ combined with OLA can promote prostate cancer cell apoptosis by multiple pathways other than inducing HRR defects,providing evidence for the combined use of ENZ and OLA in prostate cancer regardless of HRR gene mutation status.

关键词： apoptosis enzalutamide nonhomologous end joining olaparib prostate cancer

Morinda officinalis oligosaccharides increase serotonin in the brain and ameliorate depression via promoting 5-hydroxytryptophan production in the gut microbiota

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Acta Pharmaceutica Sinica B 2022年第8期12卷 3298-3312页

作者： Zheng-Wei Zhang Chun-Sheng Gao Heng Zhang Jian Yang Ya-Ping Wang Li-Bin Pan Hang yu Chi-yu He Hai-Bin Luo Zhen-Xiong Zhao Xin-Bo Zhou yu-Li Wang Jie Fu Pei Han yu-hui dong Gang Wang Song Li Yan Wang Jian-dong Jiang Wu Zhong State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences/Peking Union Medical CollegeBeijing 100050China Beijing Institute of Pharmacology and Toxicology Beijing 100000China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China The National Clinical Research Center for Mental Disorders&Beijing Key Laboratory of Mental Disorders Beijing Anding HospitalCapital Medical UniversityBeijing 100088China Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijing 100069China School of Pharmaceutical Sciences Hainan UniversityHainan 570228China National Engineering Research Center for the Emergence Drugs Beijing 100000China

Morinda officinalis oligosaccharides(MOO) are an oral drug approved in China for the treatment of depression in China. However, MOO is hardly absorbed so that their anti-depressant mechanism has not been elucidated. Here, we show that oral MOO acted on tryptophan → 5-hydroxytryptophan(5-HTP) → serotonin(5-HT) metabolic pathway in the gut microbiota. MOO could increase tryptophan hydroxylase levels in the gut microbiota which accelerated 5-HTP production from tryptophan;meanwhile, MOO inhibited 5-hydroxytryptophan decarboxylase activity, thus reduced 5-HT generation,and accumulated 5-HTP. The raised 5-HTP from the gut microbiota was absorbed to the blood, and then passed across the blood-brain barrier to improve 5-HT levels in the brain. Additionally, pentasaccharide,as one of the main components in MOO, exerted the significant anti-depressant effect through a mechanism identical to that of MOO. This study reveals for the first time that MOO can alleviate depression via increasing 5-HTP in the gut microbiota.

关键词： Depression Morinda oficinalis oligosaccharides Gut microbiota Tryptophan hydroxylase 5-Hydroxytryptophan decarboxylase 5-Hydroxytryptophan Serotonin Drug metabolism

Quantitative Detection of Screening for Cervical Lesions with ThinPrep Cytology Test

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Clinical oncology and cancer researeh 2010年第5期7卷 299-302页

作者： Hong-xin ZHANG Yi-min SONG Su-hong LI yu-hui YIN dong-ling GAO Kui-sheng CHEN Department of Pathology the First Affiliated Hospital Zhengzhou University Henan Key Laboratory for Tumor Pathology Zhengzhou 450052. Henan Province. China.

OBJECTIVE To investigate the available parameters in gynecological screening for cervical lesions by liquid-based cytology technology （ThinPrep Cytology Test, TCT） and The Bethesda System （TBS）, also with computer image analysis. METHODS With application of the image analysis system, all grades of cervical lesion cells were detected quantitatively and sorted in atypical squamous cells of undetermined significance （ASCUS）, atypical squamous cells-cannot exclude HSIL （ASC-H）, low-grade squamous intraepithelial lesion （LSIL）, high-grade squamous intraepithelial lesion （HSIL） and cervical squamous cell carcinoma （SCC） with the mean optical density （MOD）, average grey （AG）, positive units （PU）, and nucleus to cytoplasmic ratio （N： C）. Differences between each group of cells were compared and analyzed statistically. RESULTS Apart from four stereologic parameters in LSIL and HSIL groups there were no differences among them, in the other groups, there was statistically significant in differences between MOD, AG and PU values. Differences between them in the ratio of nucleus to cytoplasm were highly statistically significant. CONCLUSION Stereological indexes may serve as a screening tool for cervical lesions. The image analysis system is expected to become a new means of cytological assisted diagnosis.

关键词： cell biology uterine cervical neoplasms TBS image analysis computer-assisted.

Fabrication and property analysis of AlGaInP red light LED with high bright

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Optoelectronics Letters 2007年第6期3卷 417-419页

作者： HAN Jun LI Jian-jun DENG Jun XING Yan-hui yu Xiao-dong LIN Wei-zhi LIU Ying SHEN Guang-di Beijing Optoelectronic Technology Lab Beijing University of Technology Beijing 100022 China

The LED with DBR and enhancing transmission film was grown by MOCVD. At 20 mA DC injection current, the LED peak wavelength was 623 nm, the light intensity was 200 mcd, and the output light power was 2.14 mW. The ligh... 详细信息

关键词：高亮度灯发光二极管技术性能产品制造