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Exploring the interaction between the gut microbiota and cyclic adenosine monophosphate-protein kinase A signaling pathway:a potential therapeutic approach for neurodegenerative diseases

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Neural Regeneration Research 2025年第11期20卷 3095-3112页

作者： Fengcheng Deng Dan Yang Lingxi Qing Yifei Chen Jilian zou Meiling Jia Qian Wang Runda Jiang Lihua Huang College of Pharmacy Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina

The interaction between the gut microbiota and cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)signaling pathway in the host's central nervous system plays a crucial role in neurological diseases and enhances communication along the gut–brain *** gut microbiota influences the cAMP-PKA signaling pathway through its metabolites,which activates the vagus nerve and modulates the immune and neuroendocrine ***,alterations in the cAMP-PKA signaling pathway can affect the composition of the gut microbiota,creating a dynamic network of microbial-host *** reciprocal regulation affects neurodevelopment,neurotransmitter control,and behavioral traits,thus playing a role in the modulation of neurological *** coordinated activity of the gut microbiota and the cAMP-PKA signaling pathway regulates processes such as amyloid-β protein aggregation,mitochondrial dysfunction,abnormal energy metabolism,microglial activation,oxidative stress,and neurotransmitter release,which collectively influence the onset and progression of neurological *** study explores the complex interplay between the gut microbiota and cAMP-PKA signaling pathway,along with its implications for potential therapeutic interventions in neurological *** pharmacological research has shown that restoring the balance between gut flora and cAMP-PKA signaling pathway may improve outcomes in neurodegenerative diseases and emotional *** can be achieved through various methods such as dietary modifications,probiotic supplements,Chinese herbal extracts,combinations of Chinese herbs,and innovative dosage *** findings suggest that regulating the gut microbiota and cAMP-PKA signaling pathway may provide valuable evidence for developing novel therapeutic approaches for neurodegenerative diseases.

关键词： cyclic adenosine monophosphate emotional disorders gut microbiota neurodegenerative diseases neurological diseases protein kinase A reciprocal regulation signaling pathway strategy therapies

FORCE REDUCTION OF FLOW AROUND A SINUSOIDAL WAVY CYLINDER

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Journal of Hydrodynamics 2009年第3期21卷 308-315页

作者： zou Lin LIN yu-feng School of Mechanical and Electronic Engineering Wuhan University of Technology Wuhan 430070 China Department of Mechanical Engineering The Hong Kong Polytechnic University Hong Kong China

A large eddy simulation of cross-flow around a sinusoidal wavy cylinder at Re = 3000 was performed and the load cell measurement was introduced for the validation test. The mean flow field and the near wake flow structures were presented and compared with those for a circular cylinder at the same Reynolds number. The mean drag coefficient for the wavy cylinder is smaller than that for a corresponding circular cylinder due to the formation of a longer wake vortex generated by the wavy cylinder. The fluctuating lift coefficient of the wavy cylinder is also greatly reduced. This kind of wavy surface leads to the formation of 3-D free shear layers which are more stable than purely 2-D free shear layers. Such free shear layers only roll up into mature vortices at further downstream position and significantly modify the near wake structures and the pressure distributions around the wavy cylinder. Moreover, the simulations in laminar flow condition were also performed to investigate the effect of Reynolds number on force reduction control.

关键词： wavy cylinder force reduction Large Eddy Simulation (LES) Reynolds number effect

A Note on Supersaturated Design

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Acta Mathematicae Applicatae Sinica 2022年第3期38卷 729-739页

作者： Na zou hong QIN School of Statistics and Mathematics Zhongnan University of Economics and LawWuhan 430073China Faculty of Mathematics and Statistics Central China Normal UniversityWuhan 430079China

Supersaturated designs are common choice for screening *** paper studies the properties of supersaturated *** give new lower bounds of E(s^(2))-criterion and E(f_(NOD))-*** linkages between the combined/double design and its original design are firstly provided,and the lower bounds of E(s^(2)) and E(f_(NOD)) for the combined/double design are also ***,the close relationship between the minimum Lee-moment aberration criterion and the criteria for optimal supersaturated designs is *** theoretical results can be used to construct or search for optimal supersaturated designs in *** results are also provided,which lend further support to our theoretical findings.

关键词： supersaturated design E(s^(2))-criterion E(f_(NOD))-criterion minimum Lee-moment aberration criterion foldover double

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高效液相色谱法测定疮灵液中9种成分的含量

中南药学 2016年第12期14卷 1354-1358页

作者：束晓玉陈慧周慧娟姜誉弘邹静刘志辉南京中医药大学附属医院南京210029 南京中医药大学南京210046

目的建立HPLC法同时测定疮灵液中没食子酸、金丝桃苷、异槲皮苷、杨梅素、槲皮素、大黄酸、大黄素、大黄酚、大黄素甲醚的含量。方法采用Hedera C18 ODS-2色谱柱(4.6 mm×250 mm,5μm);以乙腈-0.1%磷酸水溶液为流动相进行梯度洗脱,流速1... 详细信息

目的建立HPLC法同时测定疮灵液中没食子酸、金丝桃苷、异槲皮苷、杨梅素、槲皮素、大黄酸、大黄素、大黄酚、大黄素甲醚的含量。方法采用Hedera C18 ODS-2色谱柱(4.6 mm×250 mm,5μm);以乙腈-0.1%磷酸水溶液为流动相进行梯度洗脱,流速1.0 m L·min-1,检测波长254 nm,柱温30℃。结果没食子酸、金丝桃苷、异槲皮苷、杨梅素、槲皮素、大黄酸、大黄素、大黄酚、大黄素甲醚线性范围分别为0.0073~0.2323 mg·m L^(-1)(r=0.9999),0.0069~0.2198 mg·m L^(-1)(r=0.9999),0.0030~0.0949 mg·m L^(-1)(r=0.9999),0.0027~0.0870 mg·m L^(-1)(r=0.9999),0.0006~0.0195mg·m L^(-1)(r=0.9999),0.0003~0.0110 mg·m L^(-1)(r=0.9999),0.0003~0.0092 mg·m L^(-1)(r=0.9999),0.0003~0.0110 mg·m L^(-1)(r=0.9999),0.000 094~0.0030 mg·m L^(-1)(r=0.9999)。平均回收率分别为100.0%(RSD=0.1%),100.4%(RSD=1.7%),100.5%(RSD=1.4%),100.3%(RSD=2.0%),99.6%(RSD=1.9%),101.6%(RSD=1.7%),100.9%(RSD=1.9%),100.4%(RSD=1.8%),98.2%(RSD=4.6%)。结论本试验建立的疮灵液含量测定方法,简便可靠,重复性好,可用于疮灵液的质量控制。

关键词：疮灵液高效液相色谱法大黄黄蜀葵花诃子

FLOW PATTERNS AND FORCE CHARACTERISTICS OF LAMINAR FLOW PAST FOUR CYLINDERS IN DIAMOND ARRANGEMENT

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Journal of Hydrodynamics 2011年第1期23卷 55-64页

作者： zou Lin LIN yu-feng LU hong School of Mechanical and Electronic Engineering Wuhan University of Technology Wuhan 430070 China Department of Mechanical Engineering The Hong Kong Polytechnic University Hong Kong China

A three-dimensional numerical investigation of cross-flow past four circular cylinders in a diamond arrangement at Reynolds number of 200 is carried *** the spacing ratios（L /D）ranging from 1.2 to 5.0,the flow patterns can be classified into three basic *** critical spacing ratio for the transition from narrow gap flow pattern to vortex impingement flow pattern around the cylinders is found to beL /D=3.0,while a single bluff-body flow pattern is observed atL /D=*** relationship between the three-dimensional flow patterns and force characteristics around the four cylinders shows that the variation of forces and Strouhal numbers againstL /D are generally governed by these three kinds of flow *** is concluded that the spacing ratio has important effects on the development of the free shear layers about the cylinders and hence has significant effects on the force and pressure characteristics of the four cylinders with different spacing ratios.

关键词： four cylinders spacing ratio flow pattern force characteristics

Language Adaptation for Entity Relation Classification via Adversarial Neural Networks

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Journal of Computer Science & Technology 2021年第1期36卷 207-220页

作者： Bo-Wei zou Rong-Tao Huang Zeng-Zhuang Xu yu hong Guo-Dong Zhou School of Computer Science and Technology Soochow UniversitySuzhou 215006China Institute for Infocomm Research Agency for ScienceTechnology and ResearchSingapore 138635Singapore

Entity relation classification aims to classify the semantic relationship between two marked entities in a given sentence,and plays a vital role in various natural language processing ***,existing studies focus on exploiting mono-lingual data in English,due to the lack of labeled data in other *** to effectively benefit from a richly-labeled language to help a poorly-labeled language is still an open *** this paper,we come up with a language adaptation framework for cross-lingual entity relation *** basic idea is to employ adversarial neural networks(AdvNN)to transfer feature representations from one language to ***,such a language adaptation framework enables feature imitation via the competition between a sentence encoder and a rival language discriminator to generate effective *** verify the effectiveness of AdvNN,we introduce two kinds of adversarial structures,dual-channel AdvNN and single-channel *** results on the ACE 2005 multilingual training corpus show that our single-channel AdvNN achieves the best performance on both unsupervised and semi-supervised scenarios,yielding an improvement of 6.61%and 2.98%over the state-of-the-art,*** with baselines which directly adopt a machine translation module,we find that both dual-channel and single-channel AdvNN significantly improve the performances(F1)of cross-lingual entity relation ***,extensive analysis and discussion demonstrate the appropriateness and effectiveness of different parameter settings in our language adaptation framework.

关键词： adversarial neural network entity relation classification language adaptation

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交联型吸水膨胀弹性体的研究

特种橡胶制品 2004年第4期25卷 5-7,23页

作者：张玉红邹其超何本桥何培新湖北大学化学与材料科学学院武汉430062

采用氯化聚乙烯(CPE)和聚乙二醇(PEG)的钠盐发生偶联反应合成了交联型吸水膨胀弹性体,讨论了反应条件对共聚物中PEG含量的影响,并且讨论了其溶胀性能。结果表明,交联型吸水膨胀弹性体中PEG含量随反应时间的延长、反应温度的升高而增大... 详细信息

采用氯化聚乙烯(CPE)和聚乙二醇(PEG)的钠盐发生偶联反应合成了交联型吸水膨胀弹性体,讨论了反应条件对共聚物中PEG含量的影响,并且讨论了其溶胀性能。结果表明,交联型吸水膨胀弹性体中PEG含量随反应时间的延长、反应温度的升高而增大。随环境温度的升高,该材料的平衡吸水率增大。交联聚合物随吸水时间的延长而增大,吸水5d就达到平衡,最大吸水率为208 2%,该聚合物的保水能力随时间的延长而降低,吸收的水分越多,失去的水分也越多。

关键词：交联吸水吸水膨胀弹性体

Simulations of electron zebra stripes in the inner radiation belt using a composite empirical electric field model

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Science China Earth Sciences 2025年第1期 27-38页

作者： Ziyang WANG Ying LIU Qiugang ZONG hong zou yuguang YE Xuzhi ZHOU Chao yuE Shan WANG Institute of Space Physics and Applied Technology Peking University State Key Laboratory of Lunar and Planetary Science Macau University of Science and Technology

The phenomenon termed “zebra stripes” manifests as regular patterns in the energy-space(L shell) spectrum of energetic electrons(ranging from tens to hundreds ke V) within the inner radiation belt. These structures exhibit drift-periodic behavior and commonly arise from large-scale electric field perturbations near the substorm onsets. In this study, we introduce a composite electric field model and replicate the formation, structure, and evolution of zebra stripes using a bounce-averaged test particle code under this electric field model. High-resolution measurements of energetic electrons obtained from the Van Allen Probes and the recently launched Macao Science Satellites-1 are used as initial conditions and served to validate our test particle simulations. Comparative analyses between observed data and simulations demonstrate our test particle method's efficacy in capturing zebra stripes' general behavior. Moreover, the composite model proves capable of reproducing realistic variations in the electric field within the inner radiation belt to a certain extent. Nevertheless, subtle differences emerge in the flux strength and the positions of stripes. These disparities primarily stem from limitations inherent in the electric field model and the initial conditions of the simulation. Acknowledging that the model represents an average case, it is conceivable that real-world scenarios may deviate from the average, thereby introducing variations in the observed phenomena.

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Solidification segregation behavior of Nb-containing 310S steel

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Journal of Iron and Steel Research International 2023年第1期30卷 82-87页

作者： yu-tuo Zhang Hao zou School of Materials Science and Engineering Shenyang Ligong UniversityShenyang 110159LiaoningChina Institute of Metal Research Chinese Academy of SciencesShenyang 110016LiaoningChina

The solidification characteristics and segregation behavior of solute elements Nb,Ni,Mn,Si,Cr and C in 0.3 wt.%Nb-310S steel were investigated using the isothermal solidification quenching experiment and Thermo-Calc *** phase transformation for 0.3%Nb-310S steel under equilibrium condition can be summarized as follows:liquid(L)→L+γ(1406℃)→γ(1334℃)→γ+NbC(1322℃)→γ+NbC+M_(23)C_(6)(1006℃)→γ+NbC+M_(23)C_(6)→σ(755℃).The results showed that the solidification began with the formation of primary austenite *** volume fraction of the liquid phase decreased rapidly as the temperature decreased in the initial solidification stage,and then,the liquid phase fraction decreased *** austenite formed,Mn and Ni were enriched in the solid phase,while Nb and C were rejected into the *** was present the highest segregation coefficient in 0.3%Nb-310S austenitic stainless *** segregation of Nb was the most serious,followed by Mn,Ni and *** and Si exhibited slight segregation during the *** solidification was terminated by the formation of NbC phase.

关键词： 310S steel Nb Solidification Segregation Thermo-Calc calculation