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Synthesis of 5-Aryl-1, 2-dihydro-1-pyrrolizinones

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Chinese Chemical Letters 2003年第6期14卷 565-568页

作者： hong yu*, Fei wang, Shou Fang ZHANG Shenyang Pharmaceutical University, Shenyang 110015 Shenyang Pharmaceutical University

In order to search for new potent anti-inflammatory and analgesic agents in pyrrolizinones, the title compounds were designed and synthesized. A series of the compounds were prepared with two different synthetic sche... 详细信息

关键词： 5-Aryl-1 2-dihydro-1-pyrrolizinone anti-inflammation analgesic synthesis.

Hippocampal insulin resistance and the Sirtuin 1 signaling pathway in diabetes-induced cognitive dysfunction

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Neural Regeneration Research 2021年第12期16卷 2465-2474页

作者： Hui Yang Lin Tang Zhan Qu Shi-Hui Lei Wei Li yu-hong wang The First Hospital of Hunan University of Chinese Medicine ChangshaHunan ProvinceChina Science and Technology Innovation Center Hunan University of Chinese MedicineChangshaHunan ProvinceChina School of Nursing Health Science CenterXi’an Jiaotong UniversityXi’anShaanxi ProvinceChina

In the peripheral nervous system,the activation of Sirtuin 1 can improve insulin resistance;however,the role played by Sirtuin 1 in the central nervous system remains *** this study,rat models of diabetes mellitus were generated by a single injection of *** 8 weeks after streptozotocin injection,the Morris water maze test and western blot assays confirmed that the diabetic model rats had learning and memory deficits,insulin resistance,and Sirtuin 1 expression could be detected in the *** and the insulin receptor inhibitor S961 were intranasally administered to investigate the regulatory effects of insulin signaling on Sirtuin *** results showed that insulin administration improved the impaired cognitive function of diabetic model rats and increased the expression levels of phosphorylated insulin receptor,phosphorylated insulin receptor substrate 1,and Sirtuin 1 in the ***,S961 administration resulted in more severe cognitive dysfunction and reduced the expression levels of phosphorylated insulin receptor,phosphorylated insulin receptor substrate 1,and Sirtuin *** Sirtuin 1 activator SRT2104 and the inhibitor Sirtinol were injected into the lateral ventricle,which revealed that the activation of Sirtuin 1 increased the expression levels of target of rapamycin complex 1,phosphorylated cAMP-response elementbinding protein,and brain-derived neurotrophic *** dendritic length and spine density also increased in response to Sirtuin 1 *** contrast,Sirtinol decreased the expression levels of target of rapamycin complex 1,phosphorylated cAMP-response elementbinding protein,and brain-derived neurotrophic factor and damaged the dendritic *** findings suggest that the Sirtuin 1 signaling pathway plays an important role in the development of insulin resistance-related cognitive deficits in diabetic *** study was approved by the Animal Ethics Welfare Committee of the First Affili

关键词： brain-derived neurotrophic factor cognitive function dendritic structure diabetes hippocampus insulin resistance Sirtuin 1 target of rapamycin complex 1

Abnormal Glu/mGluR2/3/PI3K pathway in the hippocampal neurovascular unit leads to diabetesrelated depression

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Neural Regeneration Research 2021年第4期16卷 727-733页

作者： Jian Liu yuan-Shan Han Lin Liu Lin Tang Hui Yang Pan Meng hong-Qing Zhao yu-hong wang The First Hospital Hunan University of Chinese MedicineChangshaHunan ProvinceChina Institute of Innovation and Applied Research Hunan University of Chinese MedicineChangshaHunan ProvinceChina Key Laboratory of Chinese Material Medical Power and Innovation Drugs Established by Human Provincial Government and Ministry Hunan University of Chinese MedicineChangshaHunan ProvinceChina The Domestic First Class Construction Discipline of Chinese Medicine in Hunan University of Chinese Medicine ChangshaHunan ProvinceChina

Our previous studies have shown that glutamate and hippocampal neuron apoptosis are key signals and direct factors associated with diabetes-related depression,and structural and functional damage to the hippocampal neurovascular unit has been associated with diabetesrelated ***,the underlying mechanism remains *** hypothesized that diabetes-related depression might be associated with the glutamate(Glu)/metabotropic glutamate receptor2/3(mGluR2/3)/phosphoinositide 3-kinase(PI3K)pathway,activated by glucocorticoid receptors in the hippocampal neurovascular *** test this hypothesis,rat hippocampal neurovascular unit models,containing hippocampal neurons,astrocytes,and brain microvascular endothelial cells,were treated with 150 mM glucose and 200μM corticosterone,to induce diabetes-related *** results showed that under conditions of diabetes complicated by depression,hippocampal neurovascular units were damaged,leading to decreased barrier function;elevated Glu levels;upregulated glucocorticoid receptor,vesicular glutamate transporter 3(VGLUT-3),and metabotropic glutamate receptor 2/3(mGluR2/3)expression;downregulated excitatory amino acid transporter 1(EAAT-1)expression;and alteration of the balance of key proteins associated with the extracellular signal-regulated kinase(ERK)/glial cell-derived neurotrophic factor(GDNF)/PI3K signaling ***,the viability of neurons was dramatically reduced in the model of diabetes-related depression,and neuronal apoptosis,and caspase-3 and caspase-9 expression levels,were *** results suggest that the Glu/mGluR2/3/PI3K pathway,induced by glucocorticoid receptor activation in the hippocampal neurovascular unit,may be associated with diabetes-related *** study was approved by the Laboratory Animal Ethics Committee of The First Hospital of Hunan University of Chinese Medicine,China(approval ***-ZYFY-2019-11-12)on November 12,2019.

关键词： diabetes-related depression factor hippocampus in vitro neurovascular unit pathways protein

Aerodynamic actuation characteristics of radio-frequency discharge plasma and control of supersonic flow

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Chinese Physics B 2019年第2期28卷 321-330页

作者： Zhen Yang Hui-Min Song hong-yu wang Shan-Guang Guo Min Jia Kang wang Science and Technology on Plasma Dynamics Laboratory Air Force Engineering University

In this paper, aerodynamic actuation characteristics of radio-frequency(RF) discharge plasma are studied and a method is proposed for shock wave control based on RF discharge. Under the static condition, a RF diffuse glow discharge can be observed; under the supersonic inflow, the plasma is blown downstream but remains continuous and ***-resolved schlieren is used for flow field visualization. It is found that RF discharge not only leads to continuous energy deposition on the electrode surface but also induces a compression wave. Under the supersonic inflow condition, a weak oblique shock wave is induced by discharge. Experimental results of the shock wave control indicate that the applied actuation can disperse the bottom structure of the ramp-induced oblique shock wave, which is also observed in the extracted shock wave structure after image processing. More importantly, this control effect can be maintained steadily due to the continuous high-frequency(MHz) discharge. Finally, correlations for schlieren images and numerical simulations are employed to further explore the flow control mechanism. It is observed that the vortex in the boundary layer increases after the application of actuation, meaning that the boundary layer in the downstream of the actuation position is thickened. This is equivalent to covering a layer of low-density smooth wall around the compression corner and on the ramp surface, thereby weakening the compressibility at the compression corner. Our results demonstrate the ability of RF plasma aerodynamic actuation to control the supersonic airflow.

关键词： radio-frequency(RF) discharge plasma surface discharge flow control aerodynamic actuation

Inhibitory effect of compound NS5806 on cardiac transient outward potassium channel dependents on interaction between auxiliary subunits

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中国药理学与毒理学杂志 2017年第10期31卷 1027-1028页

作者： hong-xue ZHANG Hua ZHANG yu-hong wang Yan-fang XU Department of Pharmacology Hebei Medical University the Key Laboratory of New Drug Pharmacology and Toxicolog Hebei Province the Key Laboratory of Neural and Vascular Biology Ministry of Education Institute of Masteria Medica Chinese Academy of Medical Sciences & Peking Union Medical College

OBJECTIVE Transient outward potassium current(I_(to)) plays a crucial role in cardiac phase 1 repolarization and the channels are assembled by pore-forming α-subunits(K_v4.2 or K_v4.3) and auxiliary subunits(KCh IP2 and DPP6).Previous studies have found that the compound NS5806 increases I_(to) in canine ventricular cardiomyocytes through slowing current ***,we reported that NS5806 produced an acute inhibitory action on I_(to) in mouse ventricular cardiomyocytes and human induced pluripotent stem cell-derived cardiomyocytes(hi PS-CM).METHODS Whole-cell patch-clamp was used to record I_(to) in native myocytes and in HEK cells expressing cloned K_v4.x/KCh IP2/DPP6 channels;Western-blot detected the channel protein *** In isolated mouse ventricular cardiomyocytes,NS5806(0.1-30 μmol·L^(-1)) inhibited I_(to) in a concentration-dependent manner with IC50 of 6.6±1.9 μmol·L^(-1).The current decay was significantly accelerated with a time constant from 53.8±5.5 to 41.8±3.0 ms at +60 m V(P<0.01).Similarly,NS5806 concentration-dependently reduced the I_(to) peak current amplitude with an acceleration of current *** addition,NS5806 increased I Kv4.2/KCh IP2 and delayed current decay,but decreased I Kv4.2/KCh IP2/DPP6 with the acceleration of current *** inhibitory action on the current was more potent if DPP6 expression level was increased from K_v4.2/KCh IP2/DPP6 1∶1∶1 to 1∶1∶***-blot showed a higher expression of DPP6 protein in mouse heart and in hi PS-CM compared to canine ***,specific knock-down DPP6 expression by si RNA antagonized the inhibitory action of NS5806 in hi *** results pointed to an important role of DPP6 subunit in the regulation of NS5806 on the *** using molecular docking simulation,five interaction sites with high possibility between KCh IP2 and DPP6 were *** of those sites changed the inhibitory action of NS58056 into excitatory effect on the current with the delay of current

关键词： NS5806 Ito hiPS-CM molecular docking

Electrospinning-derived functional carbon-based materials for energy conversion and storage

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Chinese Chemical Letters 2024年第6期35卷 3-13页

作者： Xinyu Ren hong Liu Jingang wang Jiayuan yu Institute for Advanced Interdisciplinary Research(iAIR) School of Chemistry and Chemical EngineeringUniversity of JinanJi’nan 250022China State Key Laboratory of Crystal Materials Shandong UniversityJi’nan 250100China

The over-exploitation of fossil fuel energy has brought about serious environmental *** would be of great significance to construct efficient energy conversion and storage system to maximize utilize renewable energy,which contributes to reducing environmental *** the past few years,in terms of electrocatalysis and energy storage,carbon fiber materials show great advantages due to its outstanding electrical conductivity,good flexibility and mechanical *** a simple and low-cost technique,electrospinning can be employed to prepare various *** is noted that the functional fiber materials with different special structure and composition can be obtained for energy conversion and storage by combining electrospinning with other *** this paper,the structural design,controllable synthesis and multifunctional applications of electrospinning-derived functional carbon-based materials(EFCMs)is ***,we briefly introduce the history,basic principle and typical equipment of *** we discuss the strategies for preparing EFCMs with different structures and composition in *** addition,we show recently the application of advanced EFCMs in energy conversion and storage,such as nitrogen species reduction reaction,CO_(2) reduction reaction,oxygen reduction reaction,water-splitting,supercapacitors and ion *** the end,we propose some perspectives on the future development direction of EFCMs.

关键词： Electrospinning Carbon materials Functional fiber Energy conversion Energy storage Electrocatalysis

Track-Pattern-Based Characteristics of Extratropical Transitioning Tropical Cyclones in the Western North Pacific

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Advances in Atmospheric Sciences 2024年第6期41卷 1251-1263页

作者： hong HUANG Dan WU yuan wang Zhen wang yu LIU College of Meteorology and Oceanography National University of Defense TechnologyChangsha 410000China No.31631 Army of PLA Huizhou 516000China School of Atmospheric Sciences and Key Laboratory of Mesoscale Severe Weather/Ministry of Education Nanjing 210023China No.93721 Army of PLA Shuozhou 038300China

Based on the Regional Specialized Meteorological Center(RSMC)Tokyo-Typhoon Center best-track data and the NCEP-NCAR reanalysis dataset,extratropical transitioning(ET)tropical cyclones(ETCs)over the western North Pacific(WNP)during 1951–2021 are classified into six clusters using the fuzzy c-means clustering method(FCM)according to their track *** characteristics of the six hard-clustered ETCs with the highest membership coefficient are *** tropical cyclones(TCs)that were assigned to clusters C2,C5,and C6 made landfall over eastern Asian countries,which severely threatened these *** landfalling TCs,93.2%completed their ET after landfall,whereas 39.8%of ETCs completed their transition within one *** frequency of ETCs over the WNP has decreased in the past four decades,wherein cluster C5 demonstrated a significant decrease on both interannual and interdecadal timescales with the expansion and intensification of the western Pacific subtropical high(WPSH).This large-scale circulation pattern is favorable for C2 and causes it to become the dominant track pattern,owning to it containing the largest number of intensifying ETCs among the six clusters,a number that has increased insignificantly over the past four *** surface roughness variation and three-dimensional background circulation led to C5 containing the maximum number of landfalling TCs and a minimum number of intensifying *** results will facilitate a better understanding of the spatiotemporal distributions of ET events and associated environment background fields,which will benefit the effective monitoring of these events over the WNP.

关键词： Western North Pacific tropical cyclone extratropical transition fuzzy c-means clustering method

Decoration of Electrospun Nanofibers with Magnetic Nanoparticles via Electrospinning and Sol-gel Process

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Chemical Research in Chinese Universities 2010年第5期26卷 847-850页

作者： YANG Fan ZHENG Wei HUANG Hui-min LI Zhen-yu ZHANG hong-nan wang Wei wang Ce Alan G. MacDiarmid Institute Jilin University Changchun 130012 P. R. China

Polyacrylonitrile（PAN）/Fe3O4 composite nanofibers were successfully obtained through electrospinning and sol-gel technology. The resulting magnetic Fe3O4 nanoparticles were homogeneously distributed on the surface of PAN nanofibers and the diameters of polyacrylonitrile nanofibers and nanoparticles were easily controlled, respectively. The distribution of Fe3O4 nanoparticles inside the nanofibrous composite was investigated by field emission scanning electron microscopy and transmission electron microscopy. X-ray diffraction reveals the presence of Fe3O4 nanoparticles in the composite nanofiber. The resulting sample shows a super paramagnetic behavior.

关键词： Electrospinning Magnetic Fe3O4 Nanoparticle Sol-gel

Reliability analysis of carbon fiber rod-reinforced umbilical cable under tension using an improved sampling method

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Petroleum Science 2024年第4期21卷 2769-2778页

作者： yu Zhang hong-yu Zhang Ran Xia Si-Ao Jiang Fang wang College of Safety and Ocean Engineering China University of Petroleum China Academy of Aerospace Aerodynamics China Aerospace Science and Technology Group College of Engineering Science and Technology Shanghai Ocean University

The umbilical cable is a vital component of subsea production systems that provide power, chemical agents, control signals et al., and its requirement for reliability is exceedingly high. However, as the umbilical cable is a composite structure comprising multiple functional units, the reliability analysis of such cables involves numerous parameters that can impact calculation efficiency. In this paper, the reliability analysis of a new kind of umbilical cable with carbon fiber rod under tension is analyzed. The global dynamic analytical model is first established to determine the maximum tension load, then the local analytical model of umbilical cable including each unit are constructed by finite element method(FEM). Based on the mechanical analytical model, the reliability of umbilical cable under tension load is studied using response surface method(RSM) and Monte Carlo method. During the calculation process, a new tangent plane sampling method to calculate the response surface function(RSF) is proposed in this paper, which could make sampling points faster come close to the RSF curve, and it is proved that the calculation efficiency increases about 33% comparing with traditional method.

关键词： Umbilical cable Carbon fiber rod Failure analysis Response surface method Reliability