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Oxaliplatin and 5-fluorouracil hepatic infusion with lipiodolized chemoembolization in large hepatocellular carcinoma

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World Journal of Gastroenterology 2015年第13期21卷 3970-3977页

作者： Jing-Huan Li Xiao-Ying Xie Lan Zhang Fan Le Ning-Ling Ge Li-Xin Li yu-hong gan Yi Chen Ju-Bo Zhang Tong-Chun Xue Rong-Xin Chen Jing-Lin Xia Bo-Heng Zhang Sheng-Long Ye Yan-hong Wang Zheng-gang Ren Key Laboratory of Carcinogenesis and Cancer Invasion Liver Cancer InstituteZhongshan HospitalFudan UniversityMinistry of Education

AIM: To investigate transarterial chemoembolization(TACE) with hepatic infusion of oxaliplatin and 5-fluorouracil and Lipiodol chemoembolization in large hepatocellular carcinoma(HCC).METHODS: In this retrospective study, 132 patients with unresectable HCCs larger than 10 cm were treated with hepatic infusion of oxaliplatin and 5-fluorouracil followed by Lipiodol chemoembolization. The primary endpoint was overall survival(OS). Sixteen-week disease-control rate, time to progression(TTP), and major complications were also studied. Univariate and multivariate analyses were performed to identify prognostic factors affecting OS and ***: A total of 319 procedures were performed in the 132 patients. Eleven(8.3%) patients received radical resection following TACE treatment(median time to initial TACE 4.3 ± 2.3 mo). The median OS and TTP were 10.3 and 3.0 mo respectively, with a 50.0% 16-wk disease-control rate. Major complications were encountered in 6.0%(8/132) of patients following TACE and included serious jaundice in 1.5%(2/132) patients, aleukia in 1.5%(2/132), and hepatic failure in 3.0%(4/132). One patient died within one month due to serious hepatic failure and severe sepsis after receiving the second TACE. The risk factor associated with TTP was baseline alpha-fetoprotein level, and vascular invasion was an independent factor related to ***: Hepatic infusion of oxaliplatin and 5-fluorouracil followed by lipiodolized-chemoembolization is a safe and promising treatment for patients with HCCs larger than 10 cm in diameter.

关键词： Hepatic infusion Large hepatocellular carcinoma Ox

随机载荷下船海结构疲劳裂纹扩展寿命数值计算方法研究

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船舶力学 2020年第7期24卷 942-950页

作者：张永矿黄小平余宏淦上海交通大学海洋工程国家重点实验室上海200240

采用有限元方法计算裂纹应力强度因子来预报船海结构的疲劳裂纹扩展是一种普遍认可的方法。由于需要根据裂纹尺寸不断更新有限元模型进行大量的计算,相当耗时,在某种程度上阻碍了该方法的广泛应用。本文针对变幅随机载荷,结合单一曲线... 详细信息

采用有限元方法计算裂纹应力强度因子来预报船海结构的疲劳裂纹扩展是一种普遍认可的方法。由于需要根据裂纹尺寸不断更新有限元模型进行大量的计算,相当耗时,在某种程度上阻碍了该方法的广泛应用。本文针对变幅随机载荷,结合单一曲线模型提出了Cycle-by-Cycle(CBC)和数值计算方法(欧拉法、改进欧拉法、3阶龙格库塔法)相结合的计算格式。并分别应用在表面裂纹的疲劳裂纹扩展计算中,通过和常规CBC计算结果对比发现:随着步数增加,三种数值计算方法都可以达到较高精度;相比欧拉法,高阶计算方法的步长可以取得更大,而计算精度还可以更高。将该方法应用在一些需要有限元程序计算应力强度因子的复杂结构疲劳裂纹扩展中,可以有效减少裂纹更新次数,进而减少计算时间,提高计算效率。

关键词：裂纹扩展高阶数值积分快速计算随机载荷风暴模型

基于PSO-SVR的土压平衡盾构施工进度优化

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浙江大学学报（工学版） 2022年第8期56卷 1523-1532页

作者：秦元余宏淦陶建峰孙浩刘成良上海隧道工程有限公司上海200232 上海交通大学机械与动力工程学院上海200240

针对隧道掘进机(TBM)利用率预测研究匮乏的问题,建立数据驱动的利用率预测模型并进一步对施工进度展开优化.结合新加坡某地铁隧道项目数据,研究地质类型、司机操作与载荷对TBM利用率的影响,提出基于支持向量回归(SVR)的利用率预测方法,... 详细信息

针对隧道掘进机(TBM)利用率预测研究匮乏的问题,建立数据驱动的利用率预测模型并进一步对施工进度展开优化.结合新加坡某地铁隧道项目数据,研究地质类型、司机操作与载荷对TBM利用率的影响,提出基于支持向量回归(SVR)的利用率预测方法,并以施工进度最大为目标展开操作参数优化.利用SVR建立掘进环利用率与地质类型、载荷、操作参数的映射模型;建立以施工进度最大为目标,以地质类型、载荷、操作参数为约束边界的优化方程;利用粒子群优化(PSO)寻找特定地质类型下最优的操作参数.结果表明:SVR模型在验证集和测试集上的R2分别为0.729和0.625,均优于多元线性回归、决策树、k最近邻、随机森林、AdaBoost和XGBoost模型;PSO能准确地找出最优的操作参数.

关键词：土压平衡盾构施工进度优化利用率预测 PSO-SVR 操作参数

Determination of 23 organophosphorous pesticides in surface water using solid-phase microextraction followed by gas chromatography with mass spectrometry detection

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Determination of 23 organophosphorous pesticides in surface ...

基于高斯过程的阀控非对称液压缸模型预测控制

2010广东省预防医学会学术年会

作者： Xiaojing Li,Rongfei Peng~*,Cong Huang,hong yu,Pingsheng gan Guangzhou Center for Disease Control and Prevention,510080 Guangdong,People’s Republic of China

Determination of 23 organophosphorous pesticides(sulfotep,phorate,demeton,diazinon,disulfoton, kitazin.P,chlorpyrifos-methyl,methyl-parathion,ronnel,fenitrothion,malathion,chlorpyrifos,fenthion, parathion,bromophos,isofenphos-methyl,phenthoate,quinalphos,ethion,triazophos,carbophenothion, pirimiphos-methyl,pirimiphos-ethyl) in water using solid-phase microextraction(SPME) with gas chromatography-mass spectrometry detection(GC-MS) was *** influence of various parameters on pesticides extraction efficiency by SPME was thoroughly *** quantitation in the selective ion monitoring(SIM) mode,the linear range of most compounds was found to be between 0.05 and 10μg L and the detection limits were between 0.7 and 50 ng *** validate matrix effects for drinking and surface water,the recoveries were calculated between 72%and 119%.SPME in combination with GC-MS is a sensitive and effective method for the determination of organophosphorous pesticides (OPPs) in water samples.

关键词： Solid-phase microextraction Gas chromatogaraphy-mass spectrometry Organophosphorous pesticides Waters

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液压与气动 2021年第8期45卷 26-33页

作者：孙浩陶建峰余宏淦刘成良上海交通大学机械与动力工程学院上海200240

针对阀控非对称液压缸系统在采用PID控制器进行位置闭环控制时,存在液压缸活塞位置超调和由伺服阀阀芯切换导致控制效果差的问题,设计了基于高斯过程的非线性模型预测控制器。采用高斯过程回归训练得到阀控非对称缸系统的离散数学模型,... 详细信息

针对阀控非对称液压缸系统在采用PID控制器进行位置闭环控制时,存在液压缸活塞位置超调和由伺服阀阀芯切换导致控制效果差的问题,设计了基于高斯过程的非线性模型预测控制器。采用高斯过程回归训练得到阀控非对称缸系统的离散数学模型,通过求解二次规划问题,控制器输出最优序列。仿真结果表明,该机器学习方法有效估计了位置增量中噪声的标准差,预测输出更接近真实值;在多约束条件下能有效提高系统响应时间,保证活塞位置无超调,位置控制精度满足0.1 mm。

关键词：阀控非对称液压缸位置控制模型预测控制高斯过程回归

LargeVis降维与马氏距离结合的谐波减速器健康评估方法

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机械设计与制造 2023年第9期391卷 1-5页

作者：丁浩伦陶建峰余宏淦赵言正上海交通大学机械与动力工程学院上海200240

谐波减速器作为工业机器人核心部件,其性能是影响工业机器人加工精度的重要因素之一。由于其结构复杂且性能衰退具有强非线性,难以直接通过传统失效物理模型等理论计算方法对健康性能进行分析。为此,提出一种基于流形学习的降维方法,实... 详细信息

谐波减速器作为工业机器人核心部件,其性能是影响工业机器人加工精度的重要因素之一。由于其结构复杂且性能衰退具有强非线性,难以直接通过传统失效物理模型等理论计算方法对健康性能进行分析。为此,提出一种基于流形学习的降维方法,实现对谐波减速器健康状态的量化评估:该方法提取不同状态下的原始信号时域特征作为高维输入向量,利用LargeVis流形学习方法将高维数据的内蕴流形在低维空间中得到表征,并构造马氏距离度量,建立状态数据与健康值之间的非线性映射关系,最终得到健康评估结果。通过加速寿命试验进行验证并与其他常见方法对比,该方法状态识别准确率高,鲁棒性更好,可快速实现数据可视化,能有效应用于机器人用谐波减速器的健康评估。

关键词：谐波减速器健康评估 LargeVis算法马氏距离

160例肺通气功能正常患者的弥散功能结果分析

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黑龙江医学 2016年第12期40卷 1099-1101页

作者：李玉红甘春燕冯银合德阳市人民医院四川德阳618000

目的研究肺通气功能正常患者的肺弥散功能变化情况。方法选取160例通气指标无明显差异的患者进行弥散功能检测,根据临床病史资料将患者分为实验组(82例)与对照组(78例),分别对两组患者在通气功能正常情况下进行弥散功能检测,比较两组患... 详细信息

目的研究肺通气功能正常患者的肺弥散功能变化情况。方法选取160例通气指标无明显差异的患者进行弥散功能检测,根据临床病史资料将患者分为实验组(82例)与对照组(78例),分别对两组患者在通气功能正常情况下进行弥散功能检测,比较两组患者肺弥散功能指标变化情况。结果通气功能正常的两组患者均存在有弥散功能的异常降低,以实验组最明显(异常降低率63.4%),差异有统计学意义(P<0.05)。结论应重视弥散功能检测在临床中的应用,尤其是有肺基础疾病及有呼吸系统症状者,伴有呼吸困难明显者,在检测肺通气功能的同时最好覆盖弥散功能检测以全面评估肺功能受损情况,以免延迟患者的诊断与治疗。

关键词：肺功能检测弥散功能临床应用

Understanding the battery safety improvement enabled by a quasi-solid-state battery design

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Chinese Physics B 2022年第11期31卷 36-41页

作者： Luyu gan Rusong Chen Xiqian yu hong Li Beijing Advanced Innovation Center for Materials Genome Engineering Institute of PhysicsChinese Academy of SciencesBeijing 100190China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Beijing Frontier Research Center on Clean Energy Huairou DivisionInstitute of PhysicsChinese Academy of SciencesBeijing 101400China

The rapid development of lithium-ion batteries(LIBs)is faced with challenge of its safety bottleneck,calling for design and chemistry *** the proposed strategies,the development of solid-state batteries(SSBs)seems the most promising solution,but to date no practical SSB has been in large-scale *** safety performance of SSBs is also *** this article,a brief review on LIB safety issue is made and the safety short boards of LIBs are emphasized.A systematic safety design in quasi-SSB chemistry is proposed to conquer the intrinsic safety weak points of LIBs and the effects are accessed based on existing *** is believed that a systematic and targeted solution in SSB chemistry design can effectively improve the battery safety,promoting larger-scale application of LIBs.

关键词： battery safety thermodynamics kinetics solid-state batteries

Partial Dynamic Dimension Reduction for Conditional Mean in Regression

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Journal of Systems Science & Complexity 2020年第5期33卷 1585-1601页

作者： gan Shengjin yu Zhou School of Electronical and Information Engineering Fuqing Brunch of Fujian Normal UniuversityFuqing350300China School of Statistics East China Normal UniversityShanghai 200062China

In many regression analysis,the authors are interested in regression mean of response variate given predictors,not its the conditional *** paper is concerned with dimension reduction of predictors in sense of mean function of response conditioning on *** authors introduce the notion of partial dynamic central mean dimension reduction subspace,different from central mean dimension reduction subspace,it has varying subspace in the domain of predictors,and its structural dimensionality may not be the same point by *** authors study the property of partial dynamic central mean dimension reduction subspace,and develop estimated methods called dynamic ordinary least squares and dynamic principal Hessian directions,which are extension of ordinary least squares and principal Hessian directions based on central mean dimension reduction *** kernel estimate methods for dynamic ordinary least squares and dynamic Principal Hessian Directions are employed,and large sample properties of estimators are given under the regular *** and real data analysis demonstrate that they are effective.

关键词： Dynamic ordinary least square estimate dynamic principal Hessian directions kernel estimate partial dimension reduction