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Heteroplasmy Level of the Mitochondrial tRNA^(Leu(UUR)) A3243G Mutation in a Chinese Family Is Positively Associated with Earlier Age-of-onset and Increasing Severity of Diabetes

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Chinese Medical Sciences Journal 2009年第1期24卷 20-25页

作者： Shi Zhang An-li Tong yun Zhang Min Nie yu-xiu li heng Wang Department of Endocrinology Key Laboratory of Endocrinology of Ministry of HealthPeking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 China

Objective To investigate the mutations of mitochondrial genome in a pedigree with suspected maternally inherited diabetes and deafness and to explore the correlations between the mutations and clinical features. Methods Genomic DNA was isolated from blood leucocytes of each member of the pedigree. The mitochondrial genome was amplified with 24-pair primers that could cover the entire mitochondrial DNA. Direct sequencing of PCR products was used to identify any mitochondrial DNA mutations. Results Family members on the maternal side all harbored the tRNA^Lcu（UUR） A3243G mutation. The paternal side family members did not have the mutation. The age-of-onset of diabetes of the 4 maternal side family members was 15, 41, 44, and 65 years old, and their corresponding heteroplasmy level of the mutation was 34.5%, 14.9%, 14.6%, and 5.9%, respectively. The age-of-onset of diabetes and heteroplasmy level of A3243G mutation were negatively correlated with a correlation coefficient of -0.980（P=0.02）. Meanwhile, patient with high heteroplasmy level of A3243G mutation had relatively low severity of disease. Moreover, 6 reported polymorphisms and 2 new variants were found. Conclusions The main cause of diabetes in this pedigree is the tRNA^Lcu（UUR） A3243G mutation. However, other gene variants may contribute to its pathogenicity. The heteroplasmy level of the tRNA^Lcu（UUR） A3243G mutation is positively associated with earlier age-of-onset and increasing severity of diabetes.

关键词： maternally inherited diabetes and deafness tRNA^Lcu(UUR) A3243G mutation beteroplasmy

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恐怖犯罪活动组织和人员之情报信息搜集研究

情报杂志 2017年第2期36卷 32-39页

作者：贾宇李恒西北政法大学反恐怖主义法学院西安710122

[目的/意义]恐怖主义犯罪是全人类的公敌,打击恐怖主义犯罪是世界各国义不容辞的责任。反恐情报信息工作是反恐怖斗争的第一道防线,情报信息能否准确搜集是反恐怖工作成功与否的关键。[方法/过程]分析当前国内外恐怖犯罪斗争特点,对国... 详细信息

[目的/意义]恐怖主义犯罪是全人类的公敌,打击恐怖主义犯罪是世界各国义不容辞的责任。反恐情报信息工作是反恐怖斗争的第一道防线,情报信息能否准确搜集是反恐怖工作成功与否的关键。[方法/过程]分析当前国内外恐怖犯罪斗争特点,对国内外恐怖活动形势进行评估,明确恐怖活动组织和人员情报信息搜集重点。[结果/结论]提出完善恐怖活动组织和人员之情报信息搜集的具体策略。

关键词：恐怖活动恐怖组织反恐情报情报信息情报搜集

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恶性胸腔积液的治疗现状与进展

肿瘤防治研究 2007年第12期34卷 973-976页

作者：于立恒安徽阜阳市人民医院 236000

恶性胸腔积液是晚期恶性肿瘤尤其是晚期肺癌的常见并发症之一,往往积液量多,发生迅速,造成患者呼吸困难,严重影响患者的生存质量,甚至危及生命。积极有效地控制恶性胸腔积液能减轻病人的痛苦、提高生活质量、延长生命。有关恶性胸腔积... 详细信息

恶性胸腔积液是晚期恶性肿瘤尤其是晚期肺癌的常见并发症之一,往往积液量多,发生迅速,造成患者呼吸困难,严重影响患者的生存质量,甚至危及生命。积极有效地控制恶性胸腔积液能减轻病人的痛苦、提高生活质量、延长生命。有关恶性胸腔积液治疗的文献报道颇多,方法涉及到内、外及放射科,各种治疗手段都有一定的疗效、适应征和副作用。本文就恶性胸腔积液的治疗现状及进展作一简要介绍:[第一段]

关键词：恶性胸腔积液肿瘤治疗

THE STICK-SliP MOTION OF THE SMOOTH IMPACT DRIVE MECHANISM BASED ON TRAPEZOID DRIVE SIGNAL

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THE STICK-SLIP MOTION OF THE SMOOTH IMPACT DRIVE MECHANISM B...

Surgical treatment of 82 patients with diabetic lower limb ischemia by distal arterial bypass

2016年全国压电和声波理论及器件应用研讨会

作者： Dong CHEN Xiao-hui LU Ting-hai Cheng heng-yu li School of Mechatronic Engineering Chang Chun University of Technology

ISBN: (纸本)9781509011902

Background, Motivation and Objective Smooth impact drive mechanism(SIDM) is a kind of piezoelectric inertial mechanism. The key part of the SIDM is piezoelectric stack. The SIDM is excited by the asymmetry drive signal, such as ramp drive signal. The SIDM has a character of nano-positioning accuracy and can be used in the fields such as micro-assemble and nanometer technology. The SIDM is driven by the asymmetry drive signal and the motion of "stick" and "slip" are produced at the driving part of friction rod. Germany researcher Matthias hunstig drives a SIDM utilizing a triangle signal. The SIDM motion process is analyzed utilizing friction force and get a conclusion that the stick–slip operation can get the maximum output velocity principally. The Korea researcher Jonghyun Lee drives a SIDM utilizing a trapezoid drive signal, which has a dual-slider and successfully is used for a compact zoom lens system. The stick-slip motion is introduced. But the stick-slip motion should be analyzed utilizing a kinematics more explicitly. Statement of Contribution/Methods In order to research the stick–slip motion utilizing kinematics in the drive process, the trapezoid signal is used for driving the SIDM. The motion of "stick" and "slip" are produced at the driving part of friction rod. The two motions can influent the slider displacement. The two motions are helpful to analysis qualitatively and quantitatively the slider displacement including forward, backward and valid step. The smooth impact diving mechanism motion process which utilizes the friction and impact force is analyzed and the motion function is obtained. The stick-slip critical time is got. The stick-slip critical time is used for judging the slider motion station. Results For test the theoretical stick-slip critical time, the experiment system is built, which is composed of personal computer, signal generator, power amplifier and laser displacement sensor. A series trapezoid drive signal which has different ris

关键词： Smooth impact drive mechanism Stick-slip motion Trapezoid drive signal Stick-slip critical time

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Chinese Medical Journal 2007年第2期120卷 106-109页

作者： GU Yong-quan ZHANG Jian QI li-xing yu heng-xi li Jian-xin li Xue-feng GUO lian-rui LUO Tao CUI Shi-jun WANG Zhong-gao Department of Vascular Surgery Xuan Wu Hospital and Institute of Vascular Surgery Capital Medical University Beijing 100053 China

Background Diabetic lower limb ischemia is a serious complication of diabetes mellitus. This study was conducted to investigate the effectiveness of distal arterial bypass treatment in diabetic patients with lower limb ischemia. Methods From July 2000 to July 2004, 96 lower limbs of 82 diabetic patients （type 2） with severe lower limb ischemia were treated in Xuan Wu Hospital. Arterial bypass with femoro-popliteal polytetrafluoroethylene （PTFE） and graft-tibial autologous grafts was performed on 31 limbs （32.3%）. Popliteal-tibial artery bypass alone was performed on 22 limbs （22.9%）. Combined lilac artery stenting, femoro-popliteal artery PTFE graft bypass, and graft-tibial artery autologous graft bypass was performed on 12 limbs （12.5%）, and femoro-tibial artery graft bypass was performed on 10 limbs （10.4%）. Popliteal-tibial-pedal artery graft bypass was performed on 7 limbs （7.3%）. Results Arterial grafts in 92 limbs of 79 patients were patent on discharge. Three patients with 4 ischemic limbs （3.7%） died of respiratory failure 12 hours, 3 days and 7 days after operation respectively. Early operation success rate was 96.3% （79/82）. Graft patency rate of patients on discharge was 95.8% （92/96）. The short-term total effectiveness rate was 83.3% （80/96）. Foot ulcer healing rate was 35.7% （10/28）. 97.4% （75/77） patients were followed up for a mean of 13.5 months. The long-term total effective rate was 80.7% （71/88）. The total amputation rate was 4.5% （4/88）. Mortality was 4.5%. The total graft patency rate was 90.9% （80/88）.Conclusion In the treatment of diabetic foot, distal lower limb arterial bypass can help to avoid amputation or lower the amputation level, and may promote foot ulcer healing and improve patient＇s quality of life.

关键词： diabetic angiopathies diabetes complications lower extremity distal arterial bypass

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一种异构组网雷达系统抗欺骗式假目标方法

电子科技大学学报 2019年第5期48卷 706-710页

作者：于恒力张林让刘洁怡李强西安电子科技大学雷达信号处理国家重点实验室

同构体系下组网雷达配置方式简单,抗欺骗式假目标算法单一。该文提出一种异构组网雷达系统抗欺骗式假目标方法,对于既包含两坐标雷达又包含三坐标雷达的异构组网雷达系统,首先利用三坐标雷达对目标进行定位,计算目标相对于两坐标雷达的... 详细信息

同构体系下组网雷达配置方式简单,抗欺骗式假目标算法单一。该文提出一种异构组网雷达系统抗欺骗式假目标方法,对于既包含两坐标雷达又包含三坐标雷达的异构组网雷达系统,首先利用三坐标雷达对目标进行定位,计算目标相对于两坐标雷达的距离、方位角信息。然后,将该计算值与两坐标雷达对目标的量测值进行比较,通过构造卡方检验对真假目标进行有效鉴别。仿真结果表明,该算法可以有效地鉴别欺骗式假目标,并分析了欺骗距离、目标量测个数和雷达测角精度对算法鉴别概率的影响。

关键词：卡方检验欺骗式假目标鉴别概率异构组网雷达量测值

反全球化与金砖国家合作——一种跨层次理论分析

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厦门大学学报（哲学社会科学版） 2017年第4期67卷 51-63页

作者：付宇珩李一平厦门大学南洋研究院福建厦门361005

反全球化浪潮源于国家之间与国家内部的利益博弈和权力斗争,因而其后果也是跨层次的。目前学界对金砖国家合作的研究大多只停留在体系层次,缺乏跨层次的理论分析。现有的跨层次分析大多未能很好地把握国家与社会的关系及其对外交政策的... 详细信息

反全球化浪潮源于国家之间与国家内部的利益博弈和权力斗争,因而其后果也是跨层次的。目前学界对金砖国家合作的研究大多只停留在体系层次,缺乏跨层次的理论分析。现有的跨层次分析大多未能很好地把握国家与社会的关系及其对外交政策的影响。体系层次的国际竞争压力与经济相互依赖,以及国内层次的国家自主性与政治合法性共同塑造了国家在国际合作中的行为。金砖国家一方面有共同反对西方国家的既得利益与霸权,并继续支持经济全球化的合作动机,另一方面却难以产生团结一致的合作行动。这是由它们与西方国家之间、它们相互之间的实力差距与竞争压力,以及各自国家自主性与政治合法性对外交决策的影响共同决定的。金砖国家应当致力于凝聚经济全球化共识,在合作中坚持稳中求进的原则。各成员国应当保持战略定力,巩固经贸关系,强调互帮互助,用好现有的合作成果来解决国内发展问题。

关键词：反全球化金砖国家合作跨层次分析国家自主性政治合法性

Boosting hydrocarbon conversion via Cu-doping induced oxygen vacancies on CeO2 in CO2 electroreduction

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Journal of Energy Chemistry 2025年第1期100卷 66-76页

作者： Lei Xue Tong Shi Chenhui Han heng Zhang Fenrong liu Haorun li Yan Wang Xiaojun Gu Shanghong Zeng Inner Mongolia Key Laboratory of Chemistry and Physics of Rare Earth Materials School of Chemistry and Chemical Engineering Inner Mongolia University State Key Laboratory of Coal Conversion Institute of Coal Chemistry Chinese Academy of Sciences Institute of Catalysis Department of Chemistry Zhejiang University National Key Laboratory of Baiyunobo Rare Earth Resource Research and Comprehensive Utilization Baotou Research Institute of Rare Earths

Conversion of CO2back to hydrocarbons is the most direct way of closing the“carbon cycle”,and its significance is further enlarged if this process is driven by renewable energies such as ***,precisely controlling the product selectivity towards hydrocarbons against the competitive hydrogen evolution remains challenging,especially for Cu-based ***,we report a novel defect engineering strategy,by which Cu-doping-induced oxygen vacancies on CeO2nanorods were effectively created,with adjustable vacancy/Cu *** resulting optimum catalyst shows up to 79% catalytic current density to hydrocarbons （excluding CO）,with 49% faradaic efficiency to *** and density functional theory unveil that the ratio between oxygen vacancy and Cu affects significantly the formation of*CHO and activation of H2O,which leads to the following deep hydrogenation to *** findings may spur new insights for designing and developing more controllable chemical process relevant to CO2utilization.

关键词： Oxygen vacancy Hydrocarbon production Reaction mechanism

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安全计算机通信管理机制的形式化验证与实现

通信学报 2016年第11期37卷 196-202页

作者：梁靓曹源马连川张玉琢李恒奎北京交通大学电子信息工程学院北京100044 北京交通大学轨道交通运行控制系统国家工程研究中心北京100044 中车青岛四方机车车辆股份有限公司山东青岛266111

为提高下一代列车运行控制(简称列控)系统安全计算机的系统兼容性,首先对其结构进行简要分析,并对管理机制进行设计,建立了管理单元状态转移模型,同时以形式化验证工具对模型的正确性进行了验证。在此基础上对基于微控制单元(MCU,micro ... 详细信息

为提高下一代列车运行控制(简称列控)系统安全计算机的系统兼容性,首先对其结构进行简要分析,并对管理机制进行设计,建立了管理单元状态转移模型,同时以形式化验证工具对模型的正确性进行了验证。在此基础上对基于微控制单元(MCU,micro controller unit)的管理单元进行了软硬件的设计实现与测试。验证和测试结果表明,所设计的管理机制符合设计规范的要求,管理单元能够实现预期的状态转移功能。

关键词：列控系统安全计算机通信管理机制形式化验证