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Fatty acid binding protein 5 is a novel therapeutic target for hepatocellular carcinoma

World Journal of Clinical Oncology 2024年第1期15卷 130-144页

作者： Yan Li William Lee Zhen-Gang Zhao Yi Liu hao Cui hao-yu wang Department of Gastroenterology Tianjin Third Central HospitalTianjin 300170China Biomedical Engineering Texas A&M UniversityCollege StationTX 77843United States

BACKGROUND Hepatocellular carcinoma(HCC)is an aggressive subtype of liver cancer and is one of the most common cancers with high mortality worldwide.Reprogrammed lipid metabolism plays crucial roles in HCC cancer cell survival,growth,and evolution.Emerging evidence suggests the importance of fatty acid binding proteins(FABPs)in contribution to cancer progression and metastasis;however,how these FABPs are dysregulated in cancer cells,especially in HCC,and the roles of FABPs in cancer progression have not been well defined.AIM To understand the genetic alterations and expression of FABPs and their associated cancer hallmarks and oncogenes in contributing to cancer malignancies.METHODS We used The Cancer Genome Atlas datasets of pan cancer and liver hepatocellular carcinoma(LIHC)as well as patient cohorts with other cancer types in this study.We investigated genetic alterations of FABPs in various cancer types.mRNA expression was used to determine if FABPs are abnormally expressed in tumor tissues compared to non-tumor controls and to investigate whether their expression correlates with patient clinical outcome,enriched cancer hallmarks and oncogenes previously reported for patients with HCC.We determined the protein levels of FABP5 and its correlated genes in two HCC cell lines and assessed the potential of FABP5 inhibition in treating HCC cells.RESULTS We discovered that a gene cluster including five FABP family members(FABP4,FABP5,FABP8,FABP9 and FABP12)is frequently co-amplified in cancer.Amplification,in fact,is the most common genetic alteration for FABPs,leading to overexpression of FABPs.FABP5 showed the greatest differential mRNA expression comparing tumor with non-tumor tissues.High FABP5 expression correlates well with worse patient outcomes(P<0.05).FABP5 expression highly correlates with enrichment of G2M checkpoint(r=0.33,P=1.1e-10),TP53 signaling pathway(r=0.22,P=1.7e-5)and many genes in the gene sets such as CDK1(r=0.56,P=0),CDK4(r=0.49,P=0),and TP53(r=0.22,P=1.6e-5).Furthermore,FABP5 also correlates

关键词： Hepatocellular carcinoma Fatty acid binding protein Novel target Amplification Correlated expression

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MiR-214-3p Prevents the Development of Perioperative Neurocognitive Disorders in Elderly Rats

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Current Medical Science 2022年第4期42卷 871-884页

作者： yu-hao wang Yong-wang CHEN Wan-li XIAO Xue-lian LI Lan FENG yu-lin LIU Xiao-xia DUAN Department of Anesthesiology the Affiliated Hospital of Southwest Medical UniversityLuzhou 646000China Laboratory of Anesthesiology Southwest Medical UniversityLuzhou 646000China Department of Anesthesiology Southwest Medical UniversityLuzhou 646000China

Objective:This study aimed to identify microRNAs(miRNAs)involved in the development of perioperative neurocognitive disorders(PND).Methods:Plasma exosomal miRNA expression was examined in patients before and after cardiopulmonary bypass(CPB)using microarray and qRT-PCR and these patients were diagnosed as PND later.Elderly rats were subjected to CPB,and the cognitive functions were examined.Bioinformatics analysis was conducted to predict the targets of miR-214-3p.Rats were administered rno-miR-214-3p agomir before or after CPB to investigate the role of miR-214-3p in PND development.Results:We identified 76 differentially expressed plasma exosomal miRNAs in PND patients after surgery(P0.58),including the upregulated hsa-miR-214-3p(P=0.002399392).Prostaglandin-endoperoxide synthase 2(PTGS2)was predicted as a miR-214-3p target.In rats,CPB reduced the platform crossing numbers and target quadrant stay time,accompanied with hippocampal neuronal necrosis.The rno-miR-214-3p level was significantly increased in plasma exosomes but decreased in rat hippocampus after surgery,exhibiting a negative correlation(P<0.001,r=-0.762).A negative correlation between miR-214-3p and PTGS2 protein expression was also observed in the hippocampus after surgery.Importantly,rno-miR-214-3p agomir treatment,before or after surgery,significantly increased the platform crossing numbers(P=0.035)and target quadrant stay time(P=0.029)compared with negative control.Hippocampal PTGS2 protein level was increased in the untreated surgery group and decreased in response to rno-miR-214-3p agomir treatment before or after surgery(both P<0.05 vs.negative control).Conclusion:These data suggest that miR-214-3p/PTGS2 signaling contributes to the development of PND,serving as a potential therapeutic target for PND.

关键词： perioperative neurocognitive disorder sexosome hippocampus miR-214-3p prostaglandin-endoperoxide synthase 2

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Improving the understanding of PI-RADS in practice: characters of PI-RADS 4 and 5 lesions with negative biopsy

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Asian Journal of Andrology 2023年第2期25卷 217-222页

作者： yu-hao wang Chao Liang Fei-Peng Zhu Tian-Ren Zhou Jie Li Zeng-Jun wang Bian-Jiang Liu Department of Urology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of Radiology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China

The Prostate Imaging Reporting and Data System(PI-RADS)has good ability to identify the nature of lesions on prostate magnetic resonance imaging(MRI).However,some lesions are still reported as PI-RADS 4 and 5 but are biopsy-proven benign.Herein,we aimed to summarize the reasons for the negative prostate biopsy of patients who were assessed as PI-RADS 4 and 5 by biparameter MRI.We retrospectively sorted out the prostate MRI,treatment,and follow-up results of patients who underwent a biparameter MRI examination of the prostate in The First Affiliated Hospital of Nanjing Medical University(Nanjing,China)from August 2019 to June 2021 with PI-RADS 4 and 5 but a negative biopsy.We focused on reviewing the MRI characteristics.A total of 467 patients underwent transperineal prostate biopsy.Among them,biopsy pathology of 93 cases were negative.After follow-up,90 patients were ruled out of prostate cancer.Among the 90 cases,40 were considered to be overestimated PI-RADS after review.A total of 22 cases were transition zone(TZ)lesions with regular appearance and clear boundaries,and 3 cases were symmetrical lesions.Among 15 cases,the TZ nodules penetrated the peripheral zone(PZ)and were mistaken for the origin of PZ.A total of 17 cases of lesions were difficult to distinguish from prostate cancer.Among them,5 cases were granulomatous inflammation(1 case of prostate tuberculosis).A total of 33 cases were ambiguous lesions,whose performance was between PI-RADS 3 and 4.In summary,the reasons for“false-positive MRI diagnosis”included PI-RADS overestimation,ambiguous images giving higher PI-RADS,diseases that were really difficult to distinguish,and missed lesion in the initial biopsy;and the first two accounted for the most.

关键词： biopsy negative PI-RADS 4 and 5 prostate cancer

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Microstructure,Mechanical Properties,and Corrosion Behavior of Mg-Al-Ca Alloy Prepared by Friction Stir Processing

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Acta Metallurgica Sinica(English Letters) 2022年第5期35卷 703-713页

作者： Wen wang Shan-Yong Chen Ke Qiao Pai Peng Peng Han Bing Wu Chen-Xi wang Jia wang yu-hao wang Kuai-She wang School of Metallurgical Engineering National and Local Joint Engineering Research Center for Functional Materials ProcessingXi’an University of Architecture and TechnologyXi’an710055China

Friction stir processing(FSP)was used to modify the microstructure and improve the mechanical properties and corrosion resistance of an Mg-Al-Ca alloy.The results demonstrated that,after FSP,the grain size of the Mg-Al-Ca alloy was decreased from 13.3 to 6.7μm.Meanwhile,the Al_(8)Mn_(5) phase was broken and dispersed,and its amount was increased.The yield strength and ultimate tensile strength of the Mg-Al-Ca alloy were increased by 17.0%and 10.1%,respectively,due to the combination of fine grain,second phase,and orientation strengthening,while the elongation was slightly decreased.The immersion and electrochemical corrosion rates in 3.5 wt%NaCl solution decreased by 18.4%and 37.5%,respectively,which contributed to grain refinement.However,the stress corrosion cracking(SCC)resistance of the modified Mg-Al-Ca alloy decreased significantly,which was mainly due to the filiform corrosion induced by the Al_(8)Mn_(5) phase.SCC was mainly controlled by anodic dissolution,while the cathodic hydrogen evolution accelerated the SCC process.

关键词： Friction stir processing Mg-Al-Ca alloy Second phase Mechanical properties Stress corrosion cracking

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Redox Memristors with Volatile Threshold Switching Behavior for Neuromorphic Computing

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Journal of Electronic Science and Technology 2022年第4期20卷 356-374页

作者： yu-hao wang Tian-Cheng Gong Ya-Xin Ding Yang Li Wei wang Zi-Ang Chen Nan Du Erika Covi Matteo Farronato Dniele Ielmini Xu-Meng Zhang Qing Luo Key Laboratory of Microelectronic Devices and Integrated Technology Institute of Microelectronics of the Chinese Academy of SciencesBeijing 100029 University of Chinese Academy of Sciences Beijing 100049 Peng Cheng Laboratory Shenzhen 518055 Institute for Solid State Physics University of JenaJena 07743 Department of Quantum Detection Leibniz Institute of Photonic TechnologyJena 07743 Nanoelectronic Materials Laboratory Dresden 01187 Department of Electronics Information and BioengineeringPolitecnico di MilanoMilan 20133 Frontier Institute of Chip and System Fudan UniversityShanghai 200433

The spiking neural network(SNN),closely inspired by the human brain,is one of the most powerful platforms to enable highly efficient,low cost,and robust neuromorphic computations in hardware using traditional or emerging electron devices within an integrated system.In the hardware implementation,the building of artificial spiking neurons is fundamental for constructing the whole system.However,with the slowing down of Moore’s Law,the traditional complementary metal-oxide-semiconductor(CMOS)technology is gradually fading and is unable to meet the growing needs of neuromorphic computing.Besides,the existing artificial neuron circuits are complex owing to the limited bio-plausibility of CMOS devices.Memristors with volatile threshold switching(TS)behaviors and rich dynamics are promising candidates to emulate the biological spiking neurons beyond the CMOS technology and build high-efficient neuromorphic systems.Herein,the state-of-the-art about the fundamental knowledge of SNNs is reviewed.Moreover,we review the implementation of TS memristor-based neurons and their systems,and point out the challenges that should be further considered from devices to circuits in the system demonstrations.We hope that this review could provide clues and be helpful for the future development of neuromorphic computing with memristors.

关键词： Memristors neuromorphic computing threshold switching

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A cross-sectional study into the correlation of common household risk factors and allergic rhinitis in Taiwan's tropical environment

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亚太热带医药杂志：英文版 2017年第2期10卷 127-133页

作者： yu-hao wang yu-Chieh wang Pi-Hsiung Wu Lan Hsu Chung-Yang wang Chung-Ren Jan Hsing-hao Su Department of Microbiology and Immunology University of Rochester Department of Biology Wake Forest University Department of Otorhinolaryngology Head and Neck SurgeryKaohsiung Veterans General Hospital Department of Dermatology Kaohsiung Veterans General Hospital Anshing Clinic Department of Medical Education and Research Kaohsiung Veterans General Hospital

Objective:To discuss the effect of lesser-known potential risk factors,such as bedroom showers,on the prevalence of allergic rhinitis.Methods:A cross-sectional,population-based study was performed using both survey and fungal culturing in southern Taiwan.There were 998 participants enrolled in the survey,and 513 sets of fungal culture obtained.With score for allergic rhinitis(SFAR) more than 7,the patient was defined to have allergic rhinitis.Risks of allergic rhinitis were calculated as odds ratios for various predicted risk factors by logistic regression.Correlation between predicted risk factors and fungal level were examined with linear regression.Results:The adjusted odds ratio of frequently using bedroom shower to having allergic rhinitis was 1.572(95% confidence interval:1.090-2.265),and 0.962 for people with older age to have AR(95% confidence interval:0.949-0.976).As to the 24-hour fungal level,the standardized coefficient was 0.254 for frequent use of bedroom shower,and 0.106 for window open hours.Conclusions:Use of bedroom shower is a potential risk factor for allergic rhinitis development.

关键词： Allergic rhinitis Allergens Environment Fungi Indoor air quality

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Neurotrophic effects of dental pulp stem cells in repair of peripheral nerve after crush injury

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World Journal of Stem Cells 2020年第10期12卷 1196-1213页

作者： Dian-Ri wang yu-hao wang Jian Pan Wei-Dong Tian State Key Laboratory of Oral Disease West China Hospital of StomatologySichuan UniversityChengdu 610041Sichuan ProvinceChina National Clinical Research Center for Oral Diseases&Department of Oral and Maxillofacial Surgery West China Hospital of StomatologySichuan UniversityChengdu 610041Sichuan ProvinceChina National Engineering Laboratory for Oral Regenerative Medicine West China Hospital of StomatologySichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Nerve diseases and injuries,which are usually accompanied by motor or sensory dysfunction and disorder,impose a heavy burden upon patients and greatly reduce their quality of life.Dental pulp stem cells(DPSCs),derived from the neural crest,have many characteristics that are similar to those of neural cells,indicating that they can be an ideal source for neural repair.AIM To explore the potential roles and molecular mechanisms of DPSCs in crushed nerve recovery.METHODS DPSCs were isolated,cultured,and identified by multilineage differentiation and flow cytometry.Western blot and immunofluorescent staining were applied to analyze the expression levels of neurotrophic proteins in DPSCs after neural induction.Then,we collected the secretions of DPSCs.We analyzed their effects on RSC96 cell proliferation and migration by CCK8 and transwell assays.Finally,we generated a sciatic nerve crush injury model in vivo and used the sciatic function index,walking track analysis,muscle weight,and hematoxylin&eosin(H&E)staining to further evaluate the nerve repair ability of DPSCs.RESULTS DPSCs highly expressed several specific neural markers,including GFAP,S100,Nestin,P75,and NF200,and were inclined toward neural differentiation.Furthermore,neural-induced DPSCs(N-DPSCs)could express neurotrophic factors,including NGF,BDNF,and GDNF.The secretions of N-DPSCs could enhance the proliferation and migration of Schwann cells.In vivo,both DPSC and N-DPSC implants alleviated gastrocnemius muscle atrophy.However,in terms of anatomy and motor function,as shown by H&E staining,immunofluorescent staining,and walking track analyses,the repair effects of N-DPSCs were more sustained,potent,and effective than those of DPSCs and the controls.CONCLUSION In summary,this study demonstrated that DPSCs are inclined to differentiate into neural cells.N-DPSCs express neurotrophic proteins that could enhance the proliferation and migration of SCs.Furthermore,our results suggested that NDPSCs could help crushed nerves with functional recovery an

关键词： Dental pulp stem cells Nerve repair Nerve regeneration Neurotrophic effects

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Area Efficient Pattern Representation of Binary Neural Networks on RRAM

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Journal of Computer Science & Technology 2021年第5期36卷 1155-1166页

作者： Feng wang Guo-Jie Luo Guang-yu Sun yu-hao wang Di-Min Niu Hong-Zhong Zheng Center for Energy-Efficient Computing and Applications Peking UniversityBeijing 100871China Pingtouge Alibaba GroupHangzhou 310052China

Resistive random access memory(RRAM)has been demonstrated to implement multiply-and-accumulate(MAC)operations using a highly parallel analog fashion,which dramatically accelerates the convolutional neural networks(CNNs).Since CNNs require considerable converters between analog crossbars and digital peripheral circuits,recent studies map the binary neural networks(BNNs)onto RRAM and binarize the weights to{+1,-1}.However,two mainstream representations for BNN weights introduce patterns of redundant 0s and 1s when dealing with negative weights.In this work,we reduce the area of redundant 0s and 1s by proposing a BNN weight representation framework based on the novel pattern representation and a corresponding architecture.First,we spilt the weight matrix into several small matrices by clustering adjacent columns together.Second,we extract 1s'patterns,i.e.,the submatrices only containing 1s,from the small weight matrix,such that each final output can be represented by the sum of several patterns.Third,we map these patterns onto RRAM crossbars,including pattern computation crossbars(PCCs)and pattern accumulation crossbars(PACs).Finally,we compare the pattern representation with two mainstream representations and adopt the more area efficient one.The evaluation results demonstrate that our framework can save over 20%of crossbar area effectively,compared with two mainstream representations.

关键词： binary neural network(BNN) pattern resistive random access memory(RRAM)

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A two-stage parametric subspace model for efficient contrast-preserving decolorization

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Frontiers of Information Technology & Electronic Engineering 2017年第11期18卷 1874-1882页

作者： Hong-yang LU Qie-gen LIU yu-hao wang Xiao-hua DENG Department of Electronic Information Engineering Nanchang University Nanchang 330031 China Institute of Space Science and Technology Nanchang University Nanchang 330031 China

rgb2gray转换模型是目前最为经典和流行的彩色图像灰度化方法。最新的研究表明,对一阶线性模型的三个加权参数进行自适应离散搜索具有良好的潜力。在本文中,我们提出一种两步法方式,将参数搜索策略扩充到二阶多变量多项式模型。该模型... 详细信息

rgb2gray转换模型是目前最为经典和流行的彩色图像灰度化方法。最新的研究表明,对一阶线性模型的三个加权参数进行自适应离散搜索具有良好的潜力。在本文中,我们提出一种两步法方式,将参数搜索策略扩充到二阶多变量多项式模型。该模型划分为三个子空间的和,本文论证了第一个子空间是最为重要的,并且第二和三个子空间可以看作为对其进行加细的部分。在模型的第一步,将梯度相似性测度(gradient correlation similarity,Gcs)用于第一个子空间,得到一个初步的灰度化图像。然后,再次使用Gcs对初步灰度图像和第二、三子空间所引出形成的候选图像进行最优解搜索。通过数值实验,在定量评价、定性视觉评价和算法复杂度方面表明了本方法的有效性。

关键词：彩色图像灰度化子空间建模二阶多项式模型梯度相关相似离散搜索

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Morphology and activity relationships of macroporous CuO-ZnO-ZrO_2 catalysts for methanol synthesis from CO_2 hydrogenation

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Rare Metals 2016年第10期35卷 790-796页

作者： yu-hao wang Wen-Gui Gao Hua wang Yan-E Zheng Kong-Zhai Li Ru-Gui Ma State Key Laboratory of Complex Nonferrous Metal Resources Clean Utilization Engineering Faculty of Metallurgy and Energy EngineeringKunming University of Science and Technology

A series of macroporous CuO-ZnO-ZrO2 （CZZ） catalysts with different Zn/Zr ratios were successfully prepared by template method and characterized by X-ray diffraction （XRD）, N2 adsorption, reactive N2O adsorption, scanning electron microscopy （SEM）, H2 temperature-pro- grammed reduction （H2-TPR）, and transmission electron microscopy （TEM）. The activity of the catalysts was tested for methanol synthesis from CO2 hydrogenation. It is found that the increase in the Zn/Zr ratio could lead to the sintering of the catalysts, destroying the macroporous structure integrity. The macroporous CZZ catalysts own lower Zn/Zr ratio, exhibiting a better morphology and activity. For comparison, the conventional nonporous CZZ catalysts were also investigated. The results show that the CZZ catalysts with macroporous structure own smaller particles, higher CO2 conversion, and CH3OH yield. It reveals that the macroporous structure could inhibit the growth of the par- ticle size, and the special porous structure is favorable for diffusion and penetration of CO2, which could improve the catalytic activities.

关键词： Macroporous structure CuO-ZnO-ZrO2 catalysts CO2 hydrogenation Methanol Activity

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