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Small molecules for mesenchymal stem cell fate determination

World Journal of Stem Cells 2019年第12期11卷 1084-1103页

作者： yu-hao cheng Jing-cheng Dong Qin Bian Institute for Cell Engineering Johns Hopkins University School of MedicineBaltimoreMD 21205United States Department of Integrative Medicine Huashan HospitalFudan UniversityShanghai 200040China

Mesenchymal stem cells(MSCs)are adult stem cells harboring self-renewal and multilineage differentiation potential that are capable of differentiating into osteoblasts,adipocytes,or chondrocytes in vitro,and regulating the bone marrow microenvironment and adipose tissue remodeling in *** process of fate determination is initiated by signaling molecules that drive MSCs into a specific *** of MSC fate determination leads to different bone and adipose tissue-related diseases,including aging,osteoporosis,and insulin *** progress has been made in recent years in discovering small molecules and their underlying mechanisms control the cell fate of MSCs both in vitro and in *** this review,we summarize recent findings in applying small molecules to the trilineage commitment of MSCs,for instance,genistein,medicarpin,and icariin for the osteogenic cell fate commitment;isorhamnetin,risedronate,and arctigenin for pro-adipogenesis;and atractylenolides and dihydroartemisinin for chondrogenic fate *** highlight the underlying mechanisms,including direct regulation,epigenetic modification,and post-translational modification of signaling molecules in the AMPK,MAPK,Notch,PI3K/AKT,Hedgehog signaling pathways *** discuss the small molecules that are currently being studied in clinical *** target-based manipulation of lineage-specific commitment by small molecules offers substantial insights into bone marrow microenvironment regulation,adipose tissue homeostasis,and therapeutic strategies for MSC-related diseases.

关键词： Mesenchymal stem cell Mesenchymal stromal cell Cell fate determination Small molecules Natural compounds Signaling pathways

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Seismic dynamic stability of double-slider rock slopes containing tension cracks

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Journal of Mountain Science 2023年第7期20卷 2093-2106页

作者： ZHU Chen-hao Zhao Lian-heng HU Shi-hong ZUO Shi yu cheng-hao School of Civil Engineering Central South UniversityChangsha 410075China Key Laboratory of Heavy-haul Railway Engineering Structure Ministry of EducationCentral South UniversityChangsha 410075China

Earthquakes have significant impact on rock slopes,thus studying the seismic stability of double-slider rock slopes containing tension cracks is *** proposed an analysis method on the seismic dynamic slope *** method utilizes discrete Fourier transform to decompose real earthquake waves into a combination of harmonic *** waves are then used in conjunction with the pseudo-dynamic method and safety factor calculation formula to compute the safety *** approach accurately captures the influence of seismic time history characteristics on the dynamic stability of double-slider rock slopes containing tension *** minimum safety factor in the obtained time history curves of the safety factor reflects the most unfavorable state of the slopes under seismic *** analysis is conducted using six sets of actual earthquake ground motion data obtained from the Pacific Earthquake Engineering Research Center’s NGAWest2 ground-shaking record *** conclusions are as follows:(1)There is an inverse correlation between the average seismic acceleration amplitude and the minimum safety ***,the seismic acceleration amplitude standard deviation shows a positive correlation with the minimum safety *** global sensitivity of geometric parameters in the slope model is higher than other influencing factors.(2)The proposed dynamic stability analysis method can capture the dynamic characteristics of earthquakes,emphasizing the minimum safety factor of the slope in the seismic time history as a stability *** contrast,the pseudo-static method may yield unsafe results.(3)A safety factor expression considering hydrostatic pressure is proposed.A negative correlation was observed between the height of the water level line and the minimum safety factor.

关键词： Earthquake Rock slope Tension crack Modified Pseudo-Dynamic Method Discrete Fourier transform

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Transcriptomic alterations underline aging of osteogenic bone marrow stromal cells

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World Journal of Stem Cells 2021年第1期13卷 128-138页

作者： yu-hao cheng Shu-Fen Liu Jing-cheng Dong Qin Bian Institute for Cell Engineering Johns Hopkins University School of MedicineBaltimoreMD 21205United States Institute of Spine Shanghai University of Traditional Chinese MedicineShanghai 200030China Department of Integrative Medicine Huashan HospitalFudan UniversityShanghai 200040China

BACKGROUND Multipotent bone marrow stromal cells(BMSCs)are adult stem cells that form functional osteoblasts and play a critical role in bone *** aging,an increase in bone loss and reduction in structural integrity lead to osteoporosis and result in an increased risk of *** examined age-dependent histological changes in murine vertebrae and uncovered that bone loss begins as early as the age of 1 *** To identify the functional alterations and transcriptomic dynamics of BMSCs during early bone *** We collected BMSCs from mice at early to middle ages and compared their selfrenewal and differentiation ***,we obtained the transcriptomic profiles of BMSCs at 1 mo,3 mo,and 7 *** The colony-forming and osteogenic commitment capacity showed a comparable finding that decreased at the age of 1 *** transcriptomic analysis showed the enrichment of osteoblastic regulation genes at 1 mo and loss of osteogenic features at 3 *** BMSCs at 7 mo showed enrichment of adipogenic and DNA repair ***,we demonstrated that the WNT and MAPK signaling pathways were upregulated at 1 mo,followed by increased pro-inflammatory and apoptotic *** Our study uncovered the cellular and molecular dynamics of bone aging in mice and demonstrated the contribution of BMSCs to the early stage of age-related bone loss.

关键词： Bone marrow stromal cell Mesenchymal stem cell Mesenchymal stromal cell Aging Bone modeling and remodeling Transcriptome

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Gradient‑Layered MXene/Hollow Lignin Nanospheres Architecture Design for Flexible and Stretchable Supercapacitors

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Nano-Micro Letters 2025年第2期17卷 447-462页

作者： haonan Zhang cheng hao Tongtong Fu Dian yu Jane Howe Kaiwen Chen Ning Yan hao Ren Huamin Zhai Jiangsu Provincial Key Lab of Sustainable Pulp and Paper Technology and Biomass Materials NanJing Forestry UniversityNanjing 210037People’s Republic of China Department of Chemical Engineering and Applied Chemistry University of Toronto200 College StreetTorontoON M5S 3E5Canada Department of Materials Science and Engineering University of Toronto184 College StreetTorontoON M5S 3E4Canada College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037People’s Republic of China

With the rapid development of flexible wearable electronics,the demand for stretchable energy storage devices has *** this work,a novel gradient-layered architecture was design based on single-pore hollow lignin nanospheres(HLNPs)-intercalated two-dimensional transition metal carbide(Ti_(3)C_(2)T_(x) MXene)for fabricating highly stretchable and durable *** depositing and inserting HLNPs in the MXene layers with a bottom-up decreasing gradient,a multilayered porous MXene structure with smooth ion channels was constructed by reducing the overstacking of MXene ***,the micro-chamber architecture of thin-walled lignin nanospheres effectively extended the contact area between lignin and MXene to improve ion and electron accessibility,thus better utilizing the pseudocapacitive property of *** these strategies effectively enhanced the capacitive performance of the *** addition,HLNPs,which acted as a protective phase for MXene layer,enhanced mechanical properties of the wrinkled stretchable electrodes by releasing stress through slip and deformation during the stretch-release cycling and greatly improved the structural integrity and capacitive stability of the *** electrodes and symmetric flexible all-solid-state supercapacitors capable of enduring 600%uniaxial tensile strain were developed with high specific capacitances of 1273 mF cm^(−2)(241 F g^(−1))and 514 mF cm^(−2)(95 F g^(−1)),***,their capacitances were well preserved after 1000 times of 600%stretch-release *** study showcased new possibilities of incorporating biobased lignin nanospheres in energy storage devices to fabricate stretchable devices leveraging synergies among various two-dimensional nanomaterials.

关键词： Hollow lignin nanospheres MXene Gradient-layered architecture Wrinkled electrodes Stretchable supercapacitors

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纳秒脉冲激光斜入射辐照铝靶等离子体羽流及微冲量特性研究

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光谱学与光谱分析 2023年第3期43卷 933-939页

作者：于程浩叶继飞周伟静常浩郭威航天工程大学宇航科学与技术系激光推进及其应用国家重点实验室北京101416

为研究脉冲激光斜入射烧蚀铝靶冲量耦合机理,直接测量其宏观冲量耦合特性是其中一种手段,但激光烧蚀包含多种物理过程,仅仅研究其宏观力学性能难以深入分析冲量形成机理,脉冲激光烧蚀形成的等离子体羽流喷射是诱发力学效应的重要过程,因... 详细信息

为研究脉冲激光斜入射烧蚀铝靶冲量耦合机理,直接测量其宏观冲量耦合特性是其中一种手段,但激光烧蚀包含多种物理过程,仅仅研究其宏观力学性能难以深入分析冲量形成机理,脉冲激光烧蚀形成的等离子体羽流喷射是诱发力学效应的重要过程,因此,在研究宏观力学性能的基础上,通过开展脉冲激光斜入射烧蚀铝靶等离子体羽流及发射光谱特性测量研究,深入分析脉冲激光烧蚀冲量耦合机理。围绕单脉冲1064nm激光斜入射烧蚀铝靶开展研究,首先通过构建高速摄影测量系统和发射光谱测量系统,获得了典型激光能量密度斜入射烧蚀铝靶产生的等离子体羽流图像、等离子体光谱图像和等离子体发射光谱,基于等离子体发射光谱,利用Boltzmann作图法和Stark展宽法,分别研究了脉冲激光多种斜入射角度下等离子体温度、电子数密度随能量密度的变化关系;通过搭建扭摆微冲量测量系统,研究了脉冲激光多种斜入射角度下,沿着激光入射方向的冲量耦合系数随能量密度的变化。研究中遵循从羽流微尺度演化过程到冲量宏观力学性能测量分析的研究思路。实验结果表明,随着能量密度的增加,等离子体羽流发光强度增强,羽流离化程度增加,等离子体温度、电子数密度均先迅速增加,冲量耦合系数也迅速增加;当能量密度大于15 J·cm^(-2)时,由于等离子体屏蔽效应,等离子体温度、电子数密度均逐渐趋于饱和,最终导致冲量耦合系数随着能量密度的增加而减小;此外,随着入射角度的增加,等离子体温度、电子数密度均逐渐减小,导致冲量耦合系数也随之减小。研究结果表明,利用高速摄影和发射光谱可较好地分析脉冲激光烧蚀冲量耦合机理,研究结果可为激光空间碎片清除、空间微推力器、空间非合作目标消旋等空间应用的关键参数优化提供参考。

关键词：激光烧蚀斜入射等离子体羽流高速摄影发射光谱等离子体屏蔽冲量耦合

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Fanlian Huazhuo formula:A promising therapeutic approach for metabolic associated steatotic liver disease

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World Journal of Gastroenterology 2025年第1期31卷 167-171页

作者： Chun-Han cheng Wen-Rui hao Tzu-Hurng cheng Department of Medical Education Linkou Chang Gung Memorial HospitalTaoyuan 33305Taiwan Division of Cardiology Department of Internal MedicineShuang Ho HospitalMinistry of Health and WelfareTaipei Medical UniversityNew Taipei 23561Taiwan Division of Cardiology Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11002Taiwan Department of Biochemistry School of MedicineCollege of MedicineChina Medical UniversityTaichung 404328Taiwan

This article reviews the study,“Fanlian huazhuo formula alleviates high-fat-dietinduced nonalcoholic fatty liver disease by modulating autophagy and lipid synthesis signaling pathway”published in the World Journal of *** study explores the therapeutic potential of Fanlian Huazhuo formula(FLHZF)in treating metabolic-associated steatotic liver disease(MASLD),demonstrating that FLHZF reduces lipid accumulation,oxidative stress,and liver injury in MASLD models by modulating key signaling pathways involved in lipid metabolism and *** editorial emphasizes the potential of FLHZF as a treatment for MASLD and calls for further research to verify its clinical efficacy.

关键词： Fanlian Huazhuo formula Metabolic associated steatotic liver disease Autophagy Lipid metabolism Oxidative stress

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连续激光辐照对三结砷化镓电池散射光谱的特性影响

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光谱学与光谱分析 2023年第12期43卷 3674-3681页

作者：郭威常浩徐灿周伟静于程浩姬刚航天工程大学研究生院北京101416 航天工程大学宇航科学与技术系北京101416 航天工程大学航天指挥学院北京101416

太阳能电池作为一种高效的光电转化器,被广泛地应用于光伏发电系统中。激光作为一种高亮度光源辐照电池时,会导致其出现损伤,可利用电池的表面散射光谱特性,对其损伤程度进行判别。通过目标表面散射光谱测量系统,对激光辐照后的三结砷... 详细信息

太阳能电池作为一种高效的光电转化器,被广泛地应用于光伏发电系统中。激光作为一种高亮度光源辐照电池时,会导致其出现损伤,可利用电池的表面散射光谱特性,对其损伤程度进行判别。通过目标表面散射光谱测量系统,对激光辐照后的三结砷化镓电池散射光谱进行测量,并计算双向反射分布函数(BRDF)。其中测量系统主要由FX 2000和NIR 17型光纤光谱仪组成,针对电池表面的强镜反射特性,在实验中采用了入射角和反射角为30°的测量几何模型。原始三结砷化镓太阳能电池的结构主要包括减反射膜DAR层、顶电池GaInP层、中电池GaAs层和底电池Ge层,其散射光谱特征包括可见光谱段(500~900 nm)的吸收特性及近红外谱段(900~1 200 nm)的类周期振荡特性,在对连续激光辐照损伤后电池的光谱特性进行实验测量后,得到了损伤电池光谱BRDF的变化,并结合基于薄膜干涉理论的电池散射光谱模型,对各膜层损伤后的特征进行了分析。结果表明:DAR层的主要作用是降低光谱反射能量,对光谱曲线的特性影响较小;Ge层对光谱曲线形状基本无影响;电池散射光谱吸收和干涉等特征主要由GaInP层和GaAs层所引起,其中,GaInP层主要影响可见光谱段的吸收特性,并对近红外谱段内的干涉特性起到调制作用,而GaAs层主要影响近红外谱段的干涉特性,当其损伤到一定程度后,会导致可见光谱段内出现干涉特性。最后,在实验结果分析的基础上,通过模型研究了电池各层对散射光谱特性的影响,并讨论了基于散射光谱特性的电池损伤程度判别,研究结果可为电池激光损伤判别提供参考。

关键词：激光辐照三结砷化镓电池散射光谱表面形貌损伤特性

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草乌煎煮时间、给药剂量与抗炎镇痛功效的相关性研究

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中药材 2006年第12期29卷 1318-1322页

作者：张宏余成浩彭成上海第二军医大学药学院生药教研室上海200433 成都中医药大学四川成都610075

目的:研究草乌煎煮时间、给药剂量与抗炎镇痛功效的相关性,确定药物发挥功效的最佳煎煮时间和给药剂量。方法:根据草乌祛风除湿止痛的功效,选择热板痛证模型、扭体痛证模型、急性炎证模型、亚急性炎症模型等,运用均匀设计和回归分析方法... 详细信息

目的:研究草乌煎煮时间、给药剂量与抗炎镇痛功效的相关性,确定药物发挥功效的最佳煎煮时间和给药剂量。方法:根据草乌祛风除湿止痛的功效,选择热板痛证模型、扭体痛证模型、急性炎证模型、亚急性炎症模型等,运用均匀设计和回归分析方法,确定药物不同功效的最佳煎煮时间和最佳给药剂量。结果:草乌能明显抑制二甲苯所致小鼠耳廓肿胀;显著对抗鸡蛋清所致大鼠足跖肿胀;抑制巴豆油所致大鼠炎性肉芽肿的增生,减少炎性渗出液。显著减少醋酸所致小鼠扭体次数,延长小鼠扭体潜伏期;明显延长热板刺激小鼠添足潜伏期,提高热板小鼠痛阀值。草乌发挥抗炎功效的最佳煎煮时间为6 h,最佳给药剂量为2.4 g/kg;镇痛功效的最佳煎煮时间为6 h,最佳给药剂量为2.4 g/kg。结论:草乌具有明显的抗炎作用和中枢镇痛作用;煎煮时间、给药剂量与抗炎镇痛功效显著相关。发挥抗炎镇痛功效的最佳煎煮时间和剂量为6 h和2.4 g/kg。

关键词：草乌抗炎镇痛煎煮时间给药剂量均匀设计相关性

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