检索结果-南通市图书馆

Metabolic reprogramming: a new option for the treatment of spinal cord injury

Neural Regeneration Research 2025年第4期20卷 1042-1057页

作者： Jiangjie Chen Jinyang Chen Chao yu Kaishun Xia Biao Yang Ronghao Wang Yi Li Kesi Shi yuang Zhang haibin xu xuesong Zhang Jingkai Wang Qixin Chen Chengzhen Liang Department of Orthopedics The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang ProvinceChina Orthopedics Research Institute of Zhejiang University Zhejiang UniversityHangzhouZhejiang ProvinceChina Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province HangzhouZhejiang ProvinceChina Clinical Research Center of Motor System Disease of Zhejiang Province HangzhouZhejiang ProvinceChina Qiandongnan Prefecture People’s Hospital KailiGuizhou ProvinceChina Department of Orthopedics Fourth Medical CenterChinese PLA General HospitalBeijingChina

Spinal cord injuries impose a notably economic burden on society,mainly because of the severe after-effects they *** the ongoing development of various therapies for spinal cord injuries,their effectiveness remains ***,a deeper understanding of metabolism has opened up a new therapeutic opportunity in the form of metabolic *** this review,we explore the metabolic changes that occur during spinal cord injuries,their consequences,and the therapeutic tools available for metabolic *** spinal cord metabolism is characterized by independent cellular metabolism and intercellular metabolic ***,spinal cord injury results in metabolic disorders that include disturbances in glucose metabolism,lipid metabolism,and mitochondrial *** metabolic disturbances lead to corresponding pathological changes,including the failure of axonal regeneration,the accumulation of scarring,and the activation of *** rescue spinal cord injury at the metabolic level,potential metabolic reprogramming approaches have emerged,including replenishing metabolic substrates,reconstituting metabolic couplings,and targeting mitochondrial therapies to alter cell *** available evidence suggests that metabolic reprogramming holds great promise as a next-generation approach for the treatment of spinal cord *** further advance the metabolic treatment of the spinal cord injury,future efforts should focus on a deeper understanding of neurometabolism,the development of more advanced metabolomics technologies,and the design of highly effective metabolic interventions.

关键词： axons glycolysis metabolic reprogramming metabolism mitochondria neural regeneration neuroprotection oxidative phosphorylation spinal cord injury therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Flow variability along a vegetated natural stream under various sediment transport rates

引用

Journal of Mountain Science 2018年第11期15卷 2347-2364页

作者： WANG hai-zhou xu Ze-xing yu hai-ti WANG Xie-kang State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan University

The influence of vegetation and sediment on flow characteristics in open channels cannot be neglected. To study the flow variability under the effects of the instream natural vegetation and sediment supply, experiments were conducted with varied water and sediment supply in a movable bed of a river prototype. The instantaneous threedimensional velocities near two types of vegetation patches(the shrub and the weed) and along the centerline of the main channel with vegetation belts were measured using a 3-D side-looking acoustic Doppler velocimetry. The experimental results show that both the instream vegetation and sediment supply strongly affect the flow and turbulence characteristics. In the case of vegetation patches, both the shrub and weed have a considerable influence on the distribution of the streamwise velocity and turbulence intensity of their surrounding water. The streamwise velocity distribution followed as J-shape and linear shape around the weed and shrub under different experimental conditions. The turbulence intensity was large at the top of the weed and shrub;the shrub had its greatest influence on the downstream water flow. In the case of vegetation belts,the streamwise velocity along the centerline of the main channel exhibited an S-shape, J-shape and linear shape at different locations under varied water,vegetation structures and riverbed *** turbulence intensity along the centerline of the main channel ranged from 0.0 to 0.1. The upstream turbulence intensity was affected considerably by a sediment supply, while the downstream turbulence intensity changed with the varied vegetation characteristics and riverbed topography. The second flow coefficient M-value increased longitudinally and was almost positive along the centerline of the main channel, implying that the rotational direction of the secondary current cell was clockwise.

关键词： Natural vegetation Sediment supply Velocity profile Turbulence intensity Secondary flow Movable bed

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Recent developments in aqueous ammonia-based post-combustion CO2 capture technologies

引用

Chinese Journal of Chemical Engineering 2018年第11期26卷 2255-2265页

作者： hai yu CSIRO Energy 10 Murray Dwyer Circuit Mayfield West NSW 2304 Australia

Aqueous ammonia(NH3) is a promising alternative solvent for the capture of industrial CO_2 emissions, given its high chemical stability and CO_2 removal capacity, and low material costs and regeneration energy. NH3 also has potential for capturing multiple flue gas components, including NOx, SOxand CO_2, and producing value-added chemicals. However, its high volatility and low reactivity towards CO_2 limit its economic viability. Considerable efforts have been made to advance aqueous NH3-based post-combustion capture technologies in the last few years: in particular, General Electric's chilled NH3 process, CSIRO's mild-temperature aqueous NH3 process and SRI International's mixed-salts(NH3 and potassium carbonate) technology. Here, we review these research activities and other developments in the field, and outline future research needed to further improve aqueous NH3-based CO_2 capture technologies.

关键词： Aqueous ammonia NH3 Post-combustion capture Ammonia loss Regeneration energy Amines

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Prediction of microvascular invasion in hepatocellular carcinoma with preoperative imaging radiomic analysis: Is it ready for prime time?

引用

Hepatobiliary & Pancreatic Diseases International 2019年第3期18卷 289-290页

作者： Gang xu Hua-yu Yang hai-Feng xu Department of Liver Surgery Peking Union Medical College (PUMC) Hospital PUMC & Chinese Academy of Medical Sciences

Microvascular invasion (MVI), also known as microvascular tumor embolism, refers to the cancer cell nest in vessels lined with endothelial cells. MVI may be found in the small branches of the portal vein and hepatic v... 详细信息

关键词： MVI branches vessels

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Seismic damage of mountain tunnels during the 5.12 Wenchuan earthquake

引用

Journal of Mountain Science 2016年第11期13卷 1958-1972页

作者： yu hai-tao CHEN Jun-tao yuAN Yong ZHAO xu Key Laboratory of Urban Security and Disaster Engineering of Ministry of Education Beijing University of Technology Beijing 100124 China

A number of mountain tunnels suffered significant damage to various extent during the 2008 Wenchuan earthquake in *** ranging from small to heavy cracking was observed both at the portal and inside the tunnels,while some sections close to the faults completely collapsed.A summary of qualitative data collected from reports and papers is presented regarding the behavior of the 55 mountain tunnels near the epicenter during the *** on the seismic investigation and data collection of mountain tunnels,the tunnel damage is classified into six most common damage models involving cracking,spalling,shear failure,dislocation,pavement uplift and *** study and discussion are then carried out on the damage *** order to examine the influencing factors of the damage magnitude of the mountain tunnels,the correlations between epicentral distance,earthquake intensity,overburden depth,geological condition and damage levels are *** relationships between earthquake parameters and different damagemodels are developed and ***,suggestions are provided to improve the seismic resistance of mountain tunnels.

关键词： Wenchuan earthquake Mountain tunnels Damage model Influencing factors Seismic capacity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Role of short-wavelength filtering lenses in delaying myopia progression and amelioration of asthenopia in juveniles

引用

International Journal of Ophthalmology(English edition) 2017年第8期10卷 1261-1267页

作者： hai-Lan Zhao Jin Jiang Jie yu hai-Ming xu Department of Ophthalmology Zhejiang Provincial People's Hospital Hangzhou 310014 Zhejiang Province China

AIM： To evaluate the positive effects of blue-violet light filtering lenses in delaying myopia and relieving asthenopia in juveniles. METHODS： Sixty ametropia juveniles （aged range, 11-15y） were randomized into two groups： the test group （30 children, 60 eyes）, wearing blue-violet light filtering lenses; and the control group （30 children, 60 eyes）, wearing ordinary aspherical lenses. Baseline refractive power of the affected eyes and axial length of the two groups was recorded. After 1-year, the patients underwent contrast sensitivity （glare and non-glare under bright and dark conditions）, accommodation-related testing, asthenopia questionnaire assessment, and adverse reaction questionnaire assessment. RESULTS： After ly of wearing the filtering lenses, changes in refractive power and axial length were not significantly different between the two groups （P〉0.05）. Under bright conditions, the contrast sensitivities at low and medium- frequency grating （vision angles of 6.3, 4.0, and 2.5） with glare in the test group were significantly higher than in the control group （P〈0.05）, while the contrast sensitivity at low-frequency grating （vision angles of 6.3 and 4.0） in the absence of glare in the test group was higher than in the control group （P〈0.05）. Under glare and non-glare dark conditions, the contrast sensitivities of various frequencies in the test group did not show significant differences compared with those in the control group （P〉0.05）. In the test group, the amplitude of accommodation, accommodative lag, and accommodative sensitivity of patients wearing glasses for 6 and 12mo were significantly elevated （P〈0.05）, while the asthenopia gratings were significantly decreased （P〈0.05）. Nevertheless, in the control group,the amplitude of accommodation, accommodative lag, and accommodative sensitivity after 12mo were not significantly altered compared with baseline （P〉0.05）, and the asthenopia grating was not significantly decreased （P〉0.05）. In addition, after we

关键词： short-wavelength filtering lenses asthenopia juvenile myopia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Controlling Chaos in Hénon Map by the Constant Feedback Method

引用

Communications in Theoretical Physics 2007年第2X期48卷 279-287页

作者： HAO Jian-Hong xu hai-Bo yu Jin-Jiang Department of Information Engineering North China Electric Power University. Beijing 102206 China Institute of Applied Physics and Computational Mathematics Beijing 100088 China Department of Physics Shijiazhuang College Shijiazhuang 050801 China

We demonstrate the constant feedback and the modified constant feedback method to the Hénon map. Using the convergence of the chaotic orbit in finite time, we can control the system from chaos to the stable fixed point, and even to the stable period-2 orbit or higher periodic orbit by the action of a proper feedback strength and pulse interval. We also find that the multi-steady solutions appear with the same control strength and different initial conditions. The aim of this control method is explicit and the feedback strength is easy to determine. The method is robust under the presence of weak external noise.

关键词： constant feedback modified constant feedback finite time convergence zone Hénon map multisteady solutions

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

柔嫩艾美耳球虫顶膜抗原-1潜在子孢子互作蛋白的筛选

引用

中国动物传染病学报 2017年第3期25卷 61-67页

作者：崔晓霞黄兵赵其平韩红玉朱顺海徐帅兵谢雨翔唐敏杨志远董辉中国农业科学院上海兽医研究所农业部动物寄生虫学重点开放实验室上海200241 江苏省动物重要疫病与人兽共患病防控协同创新中心扬州225009 上海师范大学生命与环境科学学院上海200234

为了筛选与柔嫩艾美耳球虫顶膜抗原-1(Eimeria tenella apical membrance antigen 1,EtAMA1)存在互作的子孢子蛋白,以柔嫩艾美耳球虫子孢子c DNA为模板,PCR扩增EtAMA1基因胞外区,将扩增产物与p GEX-6P-1连接,构建原核表达质粒p GEX-6P-1... 详细信息

为了筛选与柔嫩艾美耳球虫顶膜抗原-1(Eimeria tenella apical membrance antigen 1,EtAMA1)存在互作的子孢子蛋白,以柔嫩艾美耳球虫子孢子c DNA为模板,PCR扩增EtAMA1基因胞外区,将扩增产物与p GEX-6P-1连接,构建原核表达质粒p GEX-6P-1-EtAMA1,表达、纯化重组蛋白EtAMA1-GST。纯化的重组蛋白经Western blot验证,结果显示在75 k Da处有单一的目的条带,证实了所获得的蛋白为EtAMA1-GST融合蛋白。将EtAMA1-GST蛋白、GST蛋白和PBS分别与谷胱甘肽琼脂糖珠孵育后,再分别与子孢子裂解物共孵育,洗脱液经SDS-PAGE分析后,结果显示三者之间的条带明显不同。将差异条带切下进行质谱分析,对获得的蛋白质肽段与Uniprot中鸡球虫蛋白质数据库进行Blast比对,初步获得了10个与EtAMA1存在潜在互作的柔嫩艾美耳球虫子孢子蛋白,包括微线体蛋白、糖酵解酶类、肌动蛋白相关因子以及一些保守蛋白等,他们广泛参与了虫体的入侵、发育、能量代谢等生物学过程。研究结果为进一步阐明EtAMA1在球虫入侵宿主细胞中发挥重要作用的分子机制奠定了基础。

关键词：柔嫩艾美耳球虫顶膜抗原-1 GST pull-down 相互作用蛋白

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Preface for the Special Issue on“Safety and Intelligent Maintenance of Offshore Structures”

引用

China Ocean Engineering 2024年第2期38卷 181-182页

作者： xu Wan-hai State Key Laboratory of Hydraulic Engineering Intelligent Construction and Operation Tianjin UniversityTianjin 300072China

The ocean serves as a vital carrier for human resource development and economic growth and contains rich mineral resources such as oil,natural gas,polymetallic nodules,cobalt-rich ferromanganese crusts,polymetallic sulfides,and rare earth ***,the ocean has wealthy reserves of wind,wave,tidal,and solar energy,making it an essential strategic space for sustainable future ***,offshore structures are complex.

关键词： ocean offshore tidal

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Novel Wake Oscillator Model for Vortex-Induced Vibrations Prediction of A Cylinder Considering the Influence of Reynolds Number

引用

China Ocean Engineering 2018年第2期32卷 132-143页

作者： GAO Xi-feng XIE Wu-de xu Wan-hai BAI yu-chuan ZHU hai-tao State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin UniversityTianjin 300072China Collaborative Innovation Centre for Advanced Ship and Deep-Sea Exploration Shanghai 200240China

It is well known that the Reynolds number has a significant effect on the vortex-induced vibrations(VIV) of cylinders. In this paper, a novel in-line(IL) and cross-flow(CF) coupling VIV prediction model for circular cylinders has been proposed, in which the influence of the Reynolds number was comprehensively considered. The Strouhal number linked with the vortex shedding frequency was calculated through a function of the Reynolds number. The coefficient of the mean drag force was fitted as a new piecewise function of the Reynolds number, and its amplification resulted from the CF VIV was also taken into account. The oscillating drag and lift forces were modelled with classical van der Pol wake oscillators and their empirical parameters were determined based on the lock-in boundaries and the peak-amplitude formulas. A new peak-amplitude formula for the IL VIV was developed under the resonance condition with respect to the mass-damping ratio and the Reynolds number. When compared with the results from the experiments and some other prediction models, the present model could give good estimations on the vibration amplitudes and frequencies of the VIV both for elastically-mounted rigid and long flexible cylinders. The present model considering the influence of the Reynolds number could generally provide better results than that neglecting the effect of the Reynolds number.

关键词： vortex-induced vibrations Reynolds number wake oscillator model cylinder

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：