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Antithetical impacts of deleterious LRP1B mutations in non-squamous and squamous NSCLCs on predicting benefits from immune checkpoint inhibitor alone or with chemotherapy over chemotherapy alone: retrospective analyses of the POPLAR/OAK and CHOICE-01 trial

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Science China Life Sciences 2025年第1期 249-262页

作者： Jinliang Wang Wenyong Zhou yu xu Jianchun Duan Qiaoxia Zhou Guoqiang Wang Leo Li Chunwei xu Wenxian Wang Shangli Cai Zhijie Wang Jie Wang Department of Oncology The Fifth Medical Center of Chinese PLA General Hospital Department of Thoracic Surgery Shanghai Chest HospitalSchool of MedicineShanghai Jiao Tong University Burning Rock Biotech CAMS Key Laboratory of Translational Research on Lung Cancer State Key Laboratory of Molecular OncologyDepartment of Medical OncologyNational Cancer Center/National Clinical Research Center for ancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Institute of Basic Medicine and Cancer (IBMC) Chinese Academy of Sciences Department of Clinical Trial The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)

In non-small cell lung cancers,the non-squamous and squamous subtypes（nsqNSCLC and sqNSCLC） exhibit disparities in pathophysiology,tumor immunology,and potential genomic correlates affecting responses to immune checkpoint inhibitor（ICI）-based *** our inhouse training cohort（n=85）,the presence of the LRP1B deleterious mutation（LRP1B-del） was associated with longer and shorter progression-free survival（PFS） on ICIs alone in nsqNSCLCs and sqNSCLCs,respectively(Pinteraction=0.008).These results were validated using a larger public ICI cohort(n=208,Pinteraction<0.001).Multiplex immunofluorescence staining revealed an association between LRP1B-del and increased and decreased numbers of tumor-infiltrating CD8+T cells in nsqNSCLCs（P=0.040） and sqNSCLCs（P=0.014）,*** the POPLAR/OAK cohort,nsqNSCLCs with LRP1B-del demonstrated improved PFS benefits from atezolizumab over docetaxel(hazard ratio（HR）=0.70,P=0.046),whereas this benefit was negligible in those without LRP1B-del（HR=1.05,P=0.64）.Conversely,sqNSCLCs without LRP1B-del benefited more from atezolizumab（HR=0.60,P=0.002） than those with LRP1B-del（HR=1.30,P=0.31）.Consistent results were observed in the in-house CHOICE-01 cohort,in which nsqNSCLCs with LRP1B-del and sqNSCLCs without LRP1B-del benefited more from toripalimab plus chemotherapy than from chemotherapy alone(Pinteraction=0.008).This multi-cohort study delineates the antithetical impacts of LRP1B-del in nsqNSCLCs and sqNSCLCs on predicting the benefits from ICI alone or with chemotherapy over chemotherapy *** findings highlight the distinct clinical utility of LRP1B-del in guiding treatment choices for nsqNSCLCs and sqNSCLCs,emphasizing the necessity for a detailed analysis based on pathological subtypes when investigating biomarkers for cancer therapeutics.

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Advances in the Development of Gradient Scaffolds Made of Nano-Micromaterials for Musculoskeletal Tissue Regeneration

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NANO-MICRO LETTERS 2025年第1期17卷 1-46页

作者： Fang, Lei Lin, Xiaoqi xu, Ruian Liu, Lu Zhang, yu Tian, Feng Li, Jiao Jiao xue, Jiajia Beijing Univ Chem Technol Beijing Lab Biomed Mat Beijing 100029 Peoples R China Beijing Univ Chem Technol State Key Lab Organ Inorgan Composites Beijing 100029 Peoples R China Univ Technol Sydney Fac Engn & IT Sch Biomed Engn Sydney NSW 2007 Australia

This review highlights the gradient variations in the structural composition of musculoskeletal tissues and comprehensively examines recent progress in the fabrication and application of biomimetic gradient scaffolds for musculoskeletal *** challenges and prospects of gradient scaffolds for clinical application are discussed. The intricate hierarchical structure of musculoskeletal tissues, including bone and interface tissues, necessitates the use of complex scaffold designs and material structures to serve as tissue-engineered substitutes. This has led to growing interest in the development of gradient bone scaffolds with hierarchical structures mimicking the extracellular matrix of native tissues to achieve improved therapeutic outcomes. Building on the anatomical characteristics of bone and interfacial tissues, this review provides a summary of current strategies used to design and fabricate biomimetic gradient scaffolds for repairing musculoskeletal tissues, specifically focusing on methods used to construct compositional and structural gradients within the scaffolds. The latest applications of gradient scaffolds for the regeneration of bone, osteochondral, and tendon-to-bone interfaces are presented. Furthermore, the current progress of testing gradient scaffolds in physiologically relevant animal models of skeletal repair is discussed, as well as the challenges and prospects of moving these scaffolds into clinical application for treating musculoskeletal injuries.

关键词： Gradient scaffolds Musculoskeletal tissues Advanced manufacturing Biomaterials Tissue regeneration

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Preparation of Co/S co-doped carbon catalysts for excellent methylene blue degradation

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 169-181页

作者： haixu Li Haobo He Tiannan Jiang yunfei Du Zhichen Wu Liang xu Xinjie Wang Xiaoguang Liu Wanhua yu Wendong xue School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Beijing Jinyu Tongda Refractory Technologies Co. Ltd.Beijing 100085China

S and Co co-doped carbon catalysts were prepared via pyrolysis of MOF-71 and thiourea mixtures at 800℃at a mass ratio of MOF-71 to thiourea of 1:0.1 to effectively activate peroxymonosulfate(PMS)for methylene blue(MB)*** effects of two different mixing routes were identified on the MB degradation ***,the catalyst obtained by the alcohol solvent evaporation(MOF-AEP)mixing route could degrade 95.60%MB(50 mg/L)within 4 min(degradation rate:K=0.78 min^(-1)),which was faster than that derived from the direct grinding method(MOF-DGP,80.97%,K=0.39 min^(-1)).X-ray photoelectron spectroscopy revealed that the Co-S content of MOF-AEP(43.39at%)was less than that of MOF-DGP(54.73at%),and the proportion of C-S-C in MOF-AEP(13.56at%)was higher than that of MOF-DGP(10.67at%).Density functional theory calculations revealed that the adsorption energy of Co for PMS was -2.94 eV when sulfur was doped as C-S-C on the carbon skeleton,which was higher than that when sulfur was doped next to cobalt in the form of Co-S bond(-2.86 eV).Thus,the C-S-C sites might provide more contributions to activate PMS compared with ***,the degradation parameters,including pH and MOF-AEP dosage,were ***,radical quenching experiments and electron paramagnetic resonance(EPR)measurements revealed that ^(1)O_(2)might be the primary catalytic species,whereas·O~(2-)might be the secondary one in degrading MB.

关键词： advanced oxidation process alcohol solvent evaporation hydrogen bond S and Co co-doped carbon catalysts wastewater remediation

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Lipomatous ependymoma with ZFTA:RELA fusion-positive:A case report

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World Journal of Clinical Cases 2025年第1期13卷 48-55页

作者： Xiao-yu Zhao Juan-Han yu Yi-Hua Wang Yi-Xin Liu Lu xu Lin Fu Ning Yi China Medical University The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Pathology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Anshan Cancer Hospital Anshan 114000Liaoning ProvinceChina

BACKGROUND Ependymoma with lipomatous differentiation is a rare type of *** ZFTA fusion-positive supratentorial ependymoma is a novel tumor type in the 2021 World Health Organization classification of central nervous system *** fusion-positive lipomatous ependymoma has not been reported to *** SUMMARY We reported a case of a 15-year-old Chinese male who had a sudden convulsion lasting approximately six *** resonance imaging showed a round cystic shadow of approximately 1.9 cm×1.5 cm×1.9 cm under the right parieto-occipital *** examination showed characteristic perivascular pseudorosettes and adipose differentiation in the ***-chemical staining showed that the tumor cells were negative for cytokeratin,NeuN,Syn and p53,but positive for GFAP,vimentin and S-100 ***-ficant punctate intracytoplasmic EMA immunoreactivity was *** level of Ki-67 was about 5%.Genetic analysis revealed ZFTA:RELA fusion.A cranio-tomy with total excision of the tumor was *** follow-up time was 36 months,no evidence of disease recurrence was found in magnetic resonance *** Based on these findings,the patient was diagnosed as a ependymoma with ZFTA fusion and lipomatous *** case report provides information on the microscopic morphological features of ependymoma with ZFTA fusion and lipomatous differentiation,which can help pathologists to make a definitive diagnosis of this tumor.

关键词： Ependymoma Lipomatous Molecular classification Supratentorial ZFTA:RELA fusion Case report

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一种对流层散射信号快速高精度无源定位算法

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舰船电子对抗 2017年第4期50卷 50-54页

作者：高轶王玉梅徐海洋海军装备部信息系统局北京100841 中国船舶重工集团公司第七二三研究所江苏扬州225001

为提高利用对流层散射信号超视距侦察定位响应速度,进一步降低计算误差,研究并提出了一种改进的测向方位面定位算法,分析了计算误差。仿真分析结论表明,该算法简单,具有计算误差小、反应速度快等特点,适合于工程应用。

关键词：超视距无源定位对流层散射

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Fluorogen-activating proteins: beyond classical fluorescent proteins

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Acta Pharmaceutica Sinica B 2018年第3期8卷 339-348页

作者： Shengnan xu hai-yu Hu State Key Laboratory of Bioactive Substances and Function of Natural Medicine Institute of Materia Medica Peking Union Medical College and Chinese Academy of Medical Sciences Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation Institute of Materia Medica Peking Union Medical College and Chinese Academy of Medical Sciences

Fluorescence imaging is a powerful technique for the real-time noninvasive monitoring of protein dynamics. Recently, fluorogen activating proteins(FAPs)/fluorogen probes for protein imaging were developed. Unlike the traditional fluorescent proteins(FPs), FAPs do not fluoresce unless bound to their specific small-molecule fluorogens. When using FAPs/fluorogen probes, a washing step is not required for the removal of free probes from the cells, thus allowing rapid and specific detection of proteins in living cells with high signal-to-noise ratio. Furthermore, with different fluorogens, living cell multi-color proteins labeling system was developed. In this review, we describe about the discovery of FAPs, the design strategy of FAP fluorogens, the application of the FAP technology and the advances of FAP technology in protein labeling systems.

关键词： Fluorogen activating proteins Fluorogens Genetically encoded sensors Fluorescence imaging Molecular imaging

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LED自动注胶机胶水气泡去除系统的设计

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机电工程技术 2006年第9期35卷 35-37页

作者：罗小林伍瑞华余海旭广东技术师范学院广东广州510635 广东江门职业技术学院广东江门529030 广东广播电视大学广东广州510091

本文从LED自动注胶机总体开发方案出发,详细探究了LED自动注胶机生产过程中胶水气泡去除机理,制定了相应方案和进行了部件的结构设计。

关键词：注胶机气泡去除

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把字句的生成及相关问题

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信阳师范学院学报（哲学社会科学版） 2010年第2期30卷 86-91页

作者：刘培玉许海命长沙理工大学文学院湖南长沙410004

文章探讨了由一个扩展的动核结构和两个动核结构生成把字句的情况,并考察了特殊类型把字句的生成情况,探究了动结式组配过程中论元的位置选择原则,提出了动结式论元的计算公式,指出"把"的宾语的原始位置有三个:一是VP后的位置,一是V和P... 详细信息

文章探讨了由一个扩展的动核结构和两个动核结构生成把字句的情况,并考察了特殊类型把字句的生成情况,探究了动结式组配过程中论元的位置选择原则,提出了动结式论元的计算公式,指出"把"的宾语的原始位置有三个:一是VP后的位置,一是V和P之间的位置,一是VP后名词短语定语的位置。

关键词：动核结构把字句生成相关问题

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大豆蛋白纤维与苎麻混纺织物的研究与开发

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染整技术 2004年第2期26卷 12-16页

作者：黄荣连许海育东华大学化学化工学院上海200051

介绍大豆纤维/苎麻混纺织物开发的背景、意义,产品开发的难点和研究方向。强调双活性基活性染料的应用以及纤维改性的作用。

关键词：大豆蛋白纤维苎麻纤维双活性基活性染料纤维改性混纺织物产品开发

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Estimation of velocity potential of water waves using a Luenberger-like observer

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Science China(Information Sciences) 2020年第12期63卷 139-152页

作者： Yang yu hai-Long PEI Cheng-Zhong xu Key Laboratory of Autonomous Systems and Networked Control Ministry of EducationSouth China University of Technology Unmanned Aerial Vehicle Systems Engineering Technology Research Center of Guangzhou South China University of Technology LAGEPP University Claude Bernard-Lyon 1

We propose a Luenberger-like observer for a water wave system. The water wave dynamics are assumed to be governed by the linearized water wave equation(LWWE). Our proposed observer estimates the velocity potential of water waves by measuring only the surface wave elevation. The information of the water-wave velocity field is then extracted from the gradient of the velocity potential. It is shown that the estimation error of the observer converges exponentially to zero as time tends to infinity. Furthermore,we numerically solve the LWWE and observer equation by the finite difference method. The efficiency of our proposed numerical scheme and the performance of the observer are validated by numerical simulation results.

关键词： linearized water wave equation LWWE Luenberger-like observer numerical simulations

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