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Using preoperative N-terminal pro-B-type natriuretic peptide levels for predicting major adverse cardiovascular events and myocardial injury after noncardiac surgery in Chinese advanced-age patients

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Journal of Geriatric Cardiology 2022年第10期19卷 768-779页

作者： Kai ZHANG Chang LIU Jian TAN yu-hai xu Jiang-Bei CAO Yan-Hong LIU Qiang FU Jing-Sheng LOU Wei-Dong MI Hao LI Department of Anesthesiology the First Medical CentreChinese PLA General HospitalBeijingChina Medical School of Chinese PLA BeijingChina Department of Thoracic Surgery the Seventh Medical CentreChinese PLA General HospitalBeijingChina Department of Anesthesiology Air Force Medical CenterBeijingChina

BACKGROUND N-terminal pro-B-type natriuretic peptide(NT-proBNP)is often viewed as an indicator for heart ***,the prognostic association and the predictive utility of NT-proBNP for postoperative major adverse cardiovascular events(MACEs)and myocardial injury after noncardiac surgery(MINS)among older patients are *** In this study,we included 5033 patients aged 65 years or older who underwent noncardiac surgery with preoperative NT-proBNP *** regression was adopted to model the associations between preoperative NT-proBNP and the risk of MACEs and *** receiver operating characteristic curve was used to determine the predictive value of *** A total of 5033 patients were enrolled,63 patients(1.25%)and 525 patients(10.43%)had incident postoperative MACEs and MINS,*** of the receiver operating characteristic curve indicated that the cutoff values of ln(NT-proBNP)for MACEs and MINS were 5.16(174 pg/mL)and 5.30(200 pg/mL),*** preoperative ln(NT-proBNP)to the Revised Cardiac Risk Index score and the Cardiac and Stroke Risk Model boosted the area under the receiver operating characteristic curves from 0.682 to 0.726 and 0.787 to 0.804,*** inclusion of preoperative NT-proBNP in the prediction models significantly increased the reclassification and *** Increased preoperative NT-proBNP was associated with a higher risk of postoperative MACEs and *** inclusion of NT-proBNP enhances the predictive ability of the preexisting models.

关键词： patients preoperative surgery

Genetical and Physiological Basis of Plant Type Model of Erect and Large Panicle Japonica Super Rice in Northern China

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Agricultural Sciences in China 2010年第4期9卷 457-462页

作者： xu Zheng-jin, CHEN Wen-fu, HUANG Rui-dong, ZHANG Wen-zhong, MA Dian-rong, WANG Jia-yu, xu hai and ZHAO Ming-hui Key Lab of Northern Japonica Rice Breeding of Liaoning Province, Shenyang Agricultural University, Shenyang 110161, P.R.China [a] Key Lab of Northern Japonica Rice Breeding of Liaoning Province Shenyang Agricultural University Shenyang 110161 P.R. China

The historical changes in rice yields across China were explored. The physiological mechanisms and genetic basis of the erect and large panicle super-high-yield plant type model for breeding japonica super rice were analyzed mainly on the panicle type, number of large vascular bundles （LVB） in the panicle neck, and the panicle type index （PTI）. In the production point of view, we suggested that, for the breeding of super-high-yield japonica rice, the erect panicle types with more LVB numbers in the panicle neck and superior upper grains in the secondary branches would be the key factors. The information has potential significance in the rice breeding and productivity not only in China but also throughout the rice production areas of the world.

关键词： super rice plant type panicle type erect panicle

Systems Biology Application in Research on Sustainable Utilization of Chinese Materia Medica Resources

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Chinese Herbal Medicines 2015年第3期7卷 196-203页

作者： Sheng Wang hai-yu xu Lan-ping Guo Lu-qi Huang Chang-xiao Liu State Key Laboratory Breeding Base of Dao-di Herbs National Resource Center for Chinese Materia Medica China Academy of Chinese Medical Sciences Tianjin Binhai Research Center for Food and Drug Regulatory Science Tianjin Center for New Drug Evaluation ResearchTianjin Institute of Pharmaceutical Research

This paper reviews the progress of systems biology applied to researching on sustainable utilization of Chinese materia medica （CMM） resources in the following aspects： identification and evaluation of CMM resources, analysis of biosynthesis and their regulation of active ingredients in medicinal plants, metabolic engineering and synthetic biology research of medicinal plants, and molecular breeding of medicinal plants. Development of systems biology is currently leading to extremely broad applications in the field of CMM resources, and systems biology wiil become a significant approach for the sustainable utilization of CMM resources.

关键词： biosynthesis breeding design Chinese materia medica evaluation identification metabolic engineering synthetic biology systems biology

A New Concept on Quality Marker for Quality Assessment and Process Control of Chinese Medicines

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Chinese Herbal Medicines 2017年第1期9卷 3-13页

作者： Chang-xiao Liu Yi-yu Cheng De-an Guo Tie-jun Zhang Ya-zhuo Li Wen-bin Hou Lu-qi Huang hai-yu xu Research Center for New Drug Evaluation Tianjin Institute of Pharmaceutical Research Tianjin 300193 China Institute of Pharmaceutical Information Zhejiang University Hangzhou 310058 China Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China Research Center for Modern Chinese Medicines Tianjin Institute of Pharmaceutical Research Tianjin 300193 China Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing 100700 China

Chinese medicine （CM） is the most typical conventional therapy compared with any other traditional or alternative medicine systems. The active components of CMs are either primary or secondary metabolites generated by metabolic and biosynthetic enzymes in plants, protecting the plants from environmental stress. The characteristics of these metabolites are diverse, complicated and unique. In this paper, current approaches for quality assessment were extensively reviewed, a new concept of quality marker （Q-marker） was then proposed for CM quality assessment. Additionally, definition of the Q-marker, as well as the relevant methods, were discussed, on the basis of the biosynthetic pathways of secondary metabolites and source of biological active components. Study design of Q-marker is complex system for quality assessment and production process control of CM products with transitivity and traceability. Therefore, the system with characteristics of transmission and traceability is expected to be established for regulation of quality. Upon the concept which the transitivity and traceability in the quality assessment and production process control covered the entire process, such as raw materials, decoction slices, processing, extraction and production can be further enhanced. The transitivity and traceability will inevitably require close attention to ＂who, what, where, when, and why＂ details at each stage of Q-markers of CM production form raw materials to patent product. The establishing quality standards are enablers of many and various transitivity and traceability solutions, not a solution in them. It means that the transitivity and traceability system is readily link between products and across borders in quality. According to the thinking mode and methods of investigation on quality assessment of CM product, we focus on the entire process, in terms of safety and effectiveness and quality control. The standard preparation of CM or CM decoction is not only the basis

关键词： Chinese medicine formulation medicinal resource quality administration quality marker quality standard quantitative analysis secondary metabolites

Network Pharmacology Evaluation Method Guidance-Draft

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World Journal of Traditional Chinese Medicine 2021年第1期7卷 146-154页

作者： Shao Li Yi-Tao Chen Qing-Yang Ding Jian-Ye Dai Xian-Chun Duan yuan-Jia Hu Xin-Xing Lai Qing-Fei Liu Ming Niu Rong-Wu Xiang Zheng Xiang hai-yu xu Xin Wang Hong-Jun Yang Kuo Yang Ming Yang hai-Yang yu Bo Zhang Peng Zhang Qian-Ru Zhang Hui-Hui Zhao Jing Zhao Institute for TCM-X MOE Key Laboratory of Bioinformatics/Bioinformatics DivisionBNRISTDepartment of AutomationTsinghua UniversityBeijing 100084P.R.China 不详

Foreword Note:Some of the document contents may involve certain patents,the identification of which is not the responsibility of the institution that releases the *** drafting organizations:Tsinghua University,Special... 详细信息

关键词： document draft institution

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin Yin Yalan xu Jie Mu yu Leng Lei Ma yu Zheng Ruizhi Li Yin Wang Peifeng Li hai Zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

Network Pharmacology Bridges Traditional Application and Modern Development of Traditional Chinese Medicine

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Chinese Herbal Medicines 2015年第1期7卷 3-17页

作者： Chang-xiao Liu Rui Liu Hui-rong Fan xue-feng Xiao Xiao-peng Chen hai-yu xu Yan-ping Lin Center for Drug Evaluation Research Tianjin Institute of Pharmaceutical Research School of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine Department of Molecular Biosciences School of Veterinary MedicineUniversity of California Tasly Academy Tasly Holding Group Institute of Chinese Materia Medica Chinese Academy of Traditional Chinese Medicine

Traditional Chinese medicine （TCM） has developed over thousands of years and has accumulated abundant clinical experience, forming a comprehensive and unique medical system. Emerging evidence has begun to illustrate TCM as an area of important medical rediscoveries. This review article briefly introduced the concept, significance, and technology of network pharmacology based on network biology and systems biology. It focused on the theoretical system and potential prospect of TCM network applied in TCM research and development including predicting new drug targets, action mechanism, new drug discovery; evaluating pharmacodynamics, pharmacokinetics, safety, toxicology, quality control, and bioinformatics of drugs. We also discussed the opportunities and challenges in the development and application of network pharmacology in the modernization of TCM research.

关键词： network biology network pharmacology systems biology traditional Chinese medicine

Inspires effective alternatives to backpropagation:predictive coding helps understand and build learning

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Neural Regeneration Research 2025年第11期20卷 3215-3216页

作者： Zhenghua xu Miao yu yuhang Song School of Health Sciences and Biomedical Engineering Hebei University of TechnologyTianjinChina Department of Computer Science University of OxfordOxfordUK

Artificial neural networks are capable of machine learning by simulating the hiera rchical structure of the human *** enable learning by brain and machine,it is essential to accurately identify and correct the prediction errors,referred to as credit assignment(Lillicrap et al.,2020).It is critical to develop artificial intelligence by understanding how the brain deals with credit assignment in neuroscience.

关键词： assignment learning enable

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齿轮疲劳失效分析与工艺参数优化

失效分析与预防 2018年第3期13卷 189-195页

作者：于海旭神华宝日希勒能源有限公司设备维修中心内蒙古呼伦贝尔021000

齿轮传动在航空、机械、冶金、交通运输等领域中得到了广泛的应用,齿轮构件的疲劳失效会导致整个传动系统的失效。为了确保齿轮运行的平稳性和可靠性,对20Cr Mn Ti渗碳齿轮的工艺参数进行优化。先对齿轮常见的齿根弯曲疲劳和齿面接触疲... 详细信息

齿轮传动在航空、机械、冶金、交通运输等领域中得到了广泛的应用,齿轮构件的疲劳失效会导致整个传动系统的失效。为了确保齿轮运行的平稳性和可靠性,对20Cr Mn Ti渗碳齿轮的工艺参数进行优化。先对齿轮常见的齿根弯曲疲劳和齿面接触疲劳进行详细的失效机理分析,并基于此利用田口方法设计齿轮疲劳正交试验,然后根据设计参数进行齿轮疲劳试验,利用Minitab软件对试验数据进行分析。结果表明:影响齿轮疲劳性能的因素等级排序分别是渗碳层深度、心部硬度和表面粗糙度,且渗碳层深度的影响程度远大于后两者。

关键词：齿轮疲劳失效机理分析田口方法工艺参数优化