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Science Bulletin 2024年第10期69卷 1458-1471页

作者：马远林高凯孙晓璇王金鑫杨扬武建荧柴安平姚立刘楠郁昊苏怡卢天兰王力芳岳伟华章晓辉徐林张岱李俊 Peking university Sixth Hospital Peking University Institute of Mental HealthNHC Key Laboratory of Mental Health(Peking University)National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital)Key Laboratory of Mental HealthChinese Academy of Medical SciencesBeijing 100191China The First Affiliated Hospital Chongqing Medical UniversityChongqing Key Laboratory of NeurologyChongqing 400016China Changping Laboratory Beijing 102206China d Chinese Institute for Brain Research Beijing 102206China Laboratory of learning and Memory Kunming Institute of ZoologyChinese Academy of SciencesKunming 650201China Shenzhen key Laboratory of Translational Research for Brain Diseases The Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsShenzhen 518055China state key Laboratory of {2. neuroscience and learning IDG/McGovern Institute for Brain ResearchBeijing Normal UniversityBeijing 100875China PKU-IDG/McGovern Institute for Brain Research Peking UniversityBeijing 100871China

Synaptic dysfunction is a core component of the pathophysiology of ***,the genetic risk factors and molecular mechanisms related to synaptic dysfunction are still not fully *** Stonin 2.STON2.gene encodes a major adaptor for clathrin-mediated endocytosis(CME)of synaptic *** this study,we showed that the C-C(307Pro-851Ala)haplotype of STON2.increases the susceptibility to schizophrenia and examined whether STON2.variations cause schizophrenia-like behaviors through the regulation of *** found that schizophrenia-related STON2.variations led to protein dephosphorylation,which affected its interaction with synaptotagmin 1(Syt1),a calcium sensor protein located in the presynaptic membrane that is critical for ***2.07Pro851Ala knockin mice exhibited deficits in synaptic transmission,short-term plasticity,and schizophrenia-like ***,among seven antipsychotic drugs,patients with the C-C(307Pro-851Ala)haplotype responded better to haloperidol than did the T-A(307Ser-851Ser)*** recovery of deficits in Syt1 sorting and synaptic transmission by acute administration of haloperidol effectively improved schizophrenia-like behaviors in STON2.07Pro851Ala knockin *** findings demonstrated the effect of schizophreniarelated STON2.variations on synaptic dysfunction through the regulation of CME,which might be attractive therapeutic targets for treating schizophrenia-like phenotypes.

关键词： STON2.variations Schizophrenia Synaptic dysfunction Syt1 Haloperidol

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Local synchronization and amplitude of the fluctuation of spontaneous brain activity in attention-deficit/hyperactivity disorder:a resting-state fMRI study

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neuroscience Bulletin 2013年第5期29卷 603-613页

作者： Li An Qing-Jiu Cao Man-Qiu Sui Li Sun Qi-Hong Zou yu-Feng Zang yu-Feng Wang Institute of Mental Health Peking University key Laboratory of Mental Health Ministry of Health Peking University MRI Research Center and beijing key Lab of Medical Physics and Engineering Peking University Center for Cognition and Brain Disorders and The Affiliated Hospital Hangzhou Normal University Zhejiang key Laboratory for Research in Assessment of cognitive Impairments state key Laboratory of {2. neuroscience and learning Beijing Normal University

Regional homogeneity（ReHo）and the amplitude of low-frequency fluctuation（ALFF）are two approaches to depicting different regional characteristics of resting-state functional magnetic resonance imaging（RS-fMRI）*** they can complementarily reveal brain regional functional abnormalities in attention-deficit/hyperactivity disorder（ADHD）remains *** this study,we applied ReHo and ALFF to 2. medication-na ve boys diagnosed with ADHD and 2. age-matched healthy male controls using whole-brain voxel-wise *** analyses were conducted in the ADHD group to investigate the relationship between the regional spontaneous brain activity measured by the two approaches and the clinical symptoms of *** found that the ReHo method showed widely-distributed differences between the two groups in the fronto-cingulo-occipitocerebellar circuitry,while the ALFF method showed a difference only in the right occipital *** a larger smoothing kernel and a more lenient threshold were used for ALFF,more overlapped regions were found between ALFF and ReHo,and ALFF even found some new regions with group *** ADHD symptom scores were correlated with the ReHo values in the right cerebellum,dorsal anterior cingulate cortex and left lingual gyrus in the ADHD group,while no correlation was detected between ALFF and ADHD *** conclusion,ReHo may be more sensitive to regional abnormalities,at least in boys with ADHD,than *** ALFF may be complementary to ReHo in measuring local spontaneous *** of the two may yield a more comprehensive pathophy-siological framework for ADHD.

关键词： resting state functional magnetic resonance imaging regional homogeneity amplitude of low-frequency fluctuation attention-deficit/hyperactivity disorder

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A Virtual Reality Platform for Context-Dependent cognitive Research in

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neuroscience Bulletin 2023年第5期39卷 717-730页

作者： Xue-Tong Qu Jin-Ni Wu yunqing Wen Long Che Shi-Lei Lv Li Liu Li-Jie Zhan Tian-Yi Liu Hua He yu Liu Chun Xu Institute of neuroscience State Key Laboratory of NeuroscienceCenter for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China university of the Chinese Academy of Sciences Beijing 100049China Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology Shanghai 201210China Institute of Automation Chinese Academy of SciencesBeijing 100190China Department of Neurosurgery Third Affiliated Hospital of Navy Military Medical UniversityShanghai 200438China

Animal survival necessitates adaptive behav-iors in volatile environmental *** reality(VR)technology is instrumental to study the neural mechanisms underlying behaviors modulated by environmental con-text by simulating the real world with maximized control of contextual *** current VR tools for rodents have limited flexibility and performance(e.g.,frame rate)for context-dependent cognitive ***,we describe a high-performance VR platform with which to study con-textual behaviors immersed in editable virtual *** platform was assembled from modular hardware and custom-written software with flexibility and *** this platform,we trained mice to perform context-dependent cognitive tasks with rules ranging from discrim-ination to delayed-sample-to-match while recording from thousands of hippocampal place *** precise manipula-tions of context elements,we found that the context recogni-tion was intact with partial context elements,but impaired by exchanges of context ***,our work establishes a configurable VR platform with which to investigate context-dependent cognition with large-scale neural recording.

关键词： Virtual reality Spatial context Contextual behavior Hippocampus Place cell-learning and memory Ca^(2.)imaging

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Frequency-dependent alterations in regional homogeneity in young carriers of the apolipoprotein E genotype

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Science Bulletin 2017年第9期62卷 654-655页

作者： Xi-Ze Jia Yi-Wen Zhang yu-Feng Zang Hui-Jie Li CAS key Laboratory of Behavioral Science Institute of Psychology Beijing 100101 China university of Chinese Academy of Sciences Beijing 100049 China Zhejiang key Laboratory for Research in Assessment of cognitive Impairments Center for Cognition and Brain Disorders Hangzhou Normal University Hangzhou 311121 China Institutes of Psychological Sciences Hangzhou Normal University Hangzhou 311121 China

Using resting-state functional magnetic resonance imaging(rf MRI),previous studies showed that the APOE e4 allele might affect the functional connectivity between remote brain regions[1,2..However,the local functional... 详细信息

关键词： test MRI data SPM Re Frequency-dependent alterations in regional homogeneity in young carriers of the apolipoprotein E genotype MTL FWHM FOV

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Decreased regional homogeneity in major depression as revealed by resting-state functional magnetic resonance imaging

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Chinese Medical Journal 2011年第3期124卷 369-373页

作者： PENG Dai-hui JIANG Kai-da FANG Yi-ru XU Yi-feng SHEN Ting LONG Xiang-yu LIU Jun ZANG yu-feng Division of Mood Disorder Shanghai Mental Health Center Medical School of ColleagueShanghai Jiao Tong University Shanghai 200030 China Medical Center of Clinic Department Shanghai Mental Health Center Medical School of ColleagueShanghai Jiao Tong University Shanghai 200030 China state key Laboratory of {2. neuroscience and learning Beijing Normal University Beijing 100875 China Department of Medical Imaging Shanghai Pu Tuo People's Hospital Shanghai 200060 China

Backgroud Functional imaging studies indicate abnormal activities in cortico-limbic network in depression during either task or resting state. The present work was to explore the abnormal spontaneous activity shown with regional homogeneity （ReHo） in depression by resting-state functional magnetic resonance imaging （fMRI）.Methods Using fMRI, the differences of regional brain activity were measured in resting state in depressed vs. healthy participants. Sixteen participants firstly diagnosed with major depressive disorder and 16 controls were scanned during resting state. A novel method based on ReHo was used to detect spontaneous hemodynamic responses across the whole *** ReHo in the left thalamus, left temporal lobe, left cerebellar posterior lobe, and the bilateral occipital lobe was found to be significantly decreased in depression compared to healthy controls in resting state of *** Abnormal spontaneous activity exists in the left thalamus, left temporal lobe, left cerebellar posterior lobe,and the bilateral occipital lobe. And the ReHo may be a potential reference in understanding the distinct brain activity in resting state of depression.

关键词： depression first episode functional magnetic resonance imaging resting state regional homogeneity

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Role of the Hippocampus in Distinct Memory Traces: Timing of Match and Mismatch Enhancement Revealed by Intracranial Recording

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neuroscience Bulletin 2017年第6期33卷 664-674页

作者： Bing Ni Ruijie Wu Tao yu Hongwei Zhu Yongjie Li Zuxiang Liu beijing Institute of Functional Neurosurgery Xuanwu Hospital Capital Medical University state key Laboratory of Brain and {2. Science Institute of Biophysics The Innovation Center of Excellence on Brain Science Chinese Academy of Sciences

A previous functional magnetic resonance imaging study reported evidence for parallel memory traces in the hippocampus： a controlled match signal detecting matches to internally-generated goal states and an automatic mismatch signal identifying unpredicted perceptual novelty. However, the timing information in this process is unknown. In the current study, facilitated by the high spatial and temporal resolution of intracranial recording from human patients, we confirmed that the left posterior hippocampus played an important role in the goal match enhancement effect, in which combinations of object identity and location were involved. We also found that this effect happened within 52. ms to 735 ms after the probe onset, ＊150 ms later than the perceptual mismatch enhancement found bilaterally in both the anterior and posterior hippocampus. More specifically, the latency of the perceptual mismatch enhancement effect of the right hippocampus was positively correlated with the performance accuracy. These results suggested that the hippocampus is crucial in working memory if features binding with location are involved in the task and the goal match enhancement effect happens after perceptual mismatch enhancement, implying the dissociation of different components of working memory at the hippocampus. Moreover, single trial decoding results suggested that theintracranial field potential response in the right hippocampus can classify the match or switch task. This is consistent with the findings that the right hippocampal activity observed during the simulation of the future events may reflect the encoding of the simulation into memory.

关键词： Working memory ECoG Hippocampus

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Neural correlates of audio-visual modal interference inhibition investigated in children by ERP

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Science China(Life Sciences) 2011年第2期54卷 194-200页

作者： WANG YiWen LIN ChongDe LIANG Jing WANG yu ZHANG WenXin Academy of Psychology and Behavior Tianjin Normal University Tianjin 300074 China School of Psychology Shandong normal university Jinan 250014 China state key Laboratory of {2. neuroscience and learning Beijing Normal University Beijing 100875 China

In order to detect cross-sectional age characteristics of cognitive neural mechanisms in audio-visual modal interference inhibition,event-related potentials(ERP) of 14 10-year-old children were recorded while performing the words interference *** incongruent conditions,the participants were required to inhibit the audio interference words of the same *** present findings provided the preliminary evidence of brain mechanism for the children's inhibition development in the specific childhood stage.

关键词：干扰抑制神经机制 ERP 视听小儿事件相关电位横断面参与者

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Single-nucleus transcriptomic profiling of multiple organs in a rhesus macaque model of SARS-CoV-2.infection

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Zoological Research 2022年第6期43卷 1041-1062页

作者： Qiang Ma Wenji Ma Tian-Zhang Song Zhaobo Wu Zeyuan Liu Zhenxiang Hu Jian-Bao Han Ling Xu Bo Zeng Bosong Wang Yinuo Sun Dan-Dan yu Qian Wu Yong-Gang Yao Yong-Tang Zheng Xiaoqun Wang state key Laboratory of Brain and {2. Science Institute of BiophysicsChinese Academy of SciencesBeijing 100101China university of Chinese Academy of Sciences Beijing 100049China key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Kunming National High-Level Biosafety Research Center for Non-Human Primates Center for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China National Resource Center for Non-Human Primates National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China LivzonBio Inc.ZhuhaiGuangdong 519045China state key Laboratory of {2. neuroscience and learning Beijing Normal UniversityBeijing 100875China IDG/McGovern Institute for Brain Research Beijing Normal UniversityBeijing 100875China Advanced Innovation Center for Human Brain Protection Beijing Institute for Brain DisordersCapital Medical UniversityBeijing 100069China

Infection with severe acute respiratory syndrome coronavirus 2.SARS-CoV-2. causes diverse clinical manifestations and tissue injuries in multiple ***, cellular and molecular understanding of SARS-CoV-2.infection-associated pathology and immune defense features in different organs remains incomplete. Here, we profiled approximately 77 000single-nucleus transcriptomes of the lung, liver,kidney, and cerebral cortex in rhesus macaques(Macaca mulatta) infected with SARS-CoV-2.and healthy controls. Integrated analysis of the multiorgan dataset suggested that the liver harbored the strongest global transcriptional alterations. We observed prominent impairment in lung epithelial cells, especially in AT2.and ciliated cells, and evident signs of fibrosis in fibroblasts. These lung injury characteristics are similar to those reported in patients with coronavirus disease 2.19(COVID-19).Furthermore, we found suppressed MHC class I/II molecular activity in the lung, inflammatory response in the liver, and activation of the kynurenine pathway,which induced the development of an immunosuppressive microenvironment. Analysis of the kidney dataset highlighted tropism of tubule cells to SARS-CoV-2. and we found membranous nephropathy(an autoimmune disease) caused by podocyte dysregulation. In addition, we identified the pathological states of astrocytes and oligodendrocytes in the cerebral cortex, providing molecular insights into COVID-19-related neurological implications. Overall, our multi-organ single-nucleus transcriptomic survey of SARS-CoV-2.infected rhesus macaques broadens our understanding of disease features and antiviral immune defects caused by SARS-CoV-2.infection,which may facilitate the development of therapeutic interventions for COVID-19.

关键词： SARS-CoV-2 Rhesus macaque Animal model Single-nucleus RNA sequencing Antiviral immune defects Multiple organs

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Alteration of functional connectivity in patients with Alzheimer’s disease revealed by resting-state functional magnetic resonance imaging

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Neural Regeneration Research 2020年第2期15卷 285-292页

作者： Jie Zhao yu-Hang Du Xue-Tong Ding Xue-Hu Wang Guo-Zun Men School of Electronic and Information Engineering Hebei UniversityBaodingHebei ProvinceChina Research Center of Machine Vision Engineering & Technology of Hebei Province BaodingHebei ProvinceChina key Laboratory of Digital Medical Engineering of Hebei Province BaodingHebei ProvinceChina School of Economics Hebei UniversityBaodingHebei ProvinceChina

The main symptom of patients with Alzheimer’s disease is cognitive dysfunction. Alzheimer’s disease is mainly diagnosed based on changes in brain structure. Functional connectivity reflects the synchrony of functional activities between non-adjacent brain regions, and changes in functional connectivity appear earlier than those in brain structure. In this study, we detected resting-state functional connectivity changes in patients with Alzheimer’s disease to provide reference evidence for disease prediction. Functional magnetic resonance imaging data from patients with Alzheimer’s disease were used to show whether particular white and gray matter areas had certain functional connectivity patterns and if these patterns changed with disease severity. In nine white and corresponding gray matter regions, correlations of {2. cognition, early mild cognitive impairment, and late mild cognitive impairment with blood oxygen level-dependent signal time series were detected. Average correlation coefficient analysis indicated functional connectivity patterns between white and gray matter in the resting state of patients with Alzheimer’s disease. Functional connectivity pattern variation correlated with disease severity, with some regions having relatively strong or weak correlations. We found that the correlation coefficients of five regions were 0.3–0.5 in patients with {2. cognition and 0–0.2.in those developing Alzheimer’s disease. Moreover, in the other four regions, the range increased to 0.45–0.7 with increasing cognitive impairment. In some white and gray matter areas, there were specific connectivity patterns. Changes in regional white and gray matter connectivity patterns may be used to predict Alzheimer’s disease;however, detailed information on specific connectivity patterns is needed. All study data were obtained from the Alzheimer’s Disease Neuroimaging Initiative Library of the Image and Data Archive Database.

关键词： Alzheimer's disease blood oxygen level-dependent signal correlation coefficient functional connectivity pattern functional magnetic resonance imaging gray matter resting state white matter

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Shanghai Autism Early Development:An Integrative Chinese ASD Cohort

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neuroscience Bulletin 2022年第12期38卷 1603-1607页

作者： yuan Dai yuqi Liu Lingli Zhang Tai Ren Hui Wang Juehua yu Xin Liu Zilin Chen Lin Deng Minyi Tao Hangyu Tan Chu‑Chung Huang Jiaying Zhang Qiang Luo Jianfeng Feng Miao Cao Fei Li Department of Developmental and Behavioral Pediatric and Child Primary Care Brain and Behavioral Research Unit of Shanghai Institute for Pediatric Research and Ministry of Education-Shanghai Key Laboratory for Children’s Environmental HealthXinhua HospitalShanghai Jiao Tong University School of MedicineShanghai 200092China Center for Experimental Studies and Research The First Afliated Hospital of Kunming Medical UniversityKunming 650032China key Laboratory of Brain Functional Genomics(Ministry of Education) Afliated Mental Health CenterSchool of Psychology and Cognitive ScienceEast China Normal UniversityShanghai 200062China Shanghai Changning Mental Health Center Shanghai 200335China state key Laboratory of {2. neuroscience and learning Beijing Normal UniversityBeijing 100875China beijing key Laboratory of Brain Imaging and Connectomics Beijing Normal UniversityBeijing 100875China IDG/McGovern Institute for Brain Research Beijing Normal UniversityBeijing 100875China National Clinical Research Center for Aging and Medicine at Huashan Hospital Fudan UniversityShanghai 200433China Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghai 200433China state key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain Science Institutes of Brain Science and Human Phenome InstituteFudan UniversityShanghai 200032China key Laboratory of Computational neuroscience and Brain-Inspired Intelligence Ministry of EducationFudan UniversityShanghai 200433China

Why Was the Cohort Set Up?Autism spectrum disorder(ASD)is a child neurodevelopmental disorder,the onset of which is generally within 3 years of age,and often leads to lifelong impaired social and cognitive functions,w... 详细信息

关键词： impaired Cohort ASD

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