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Risk of Developing Non-Alcoholic Fatty Liver Disease Over Time in a Cohort of the Elderly in Qingdao,China

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生物医学与环境科学:英文版 2023年第8期36卷 760-767页

作者： LIU Li shao yu Han feng En Qiang shao Zhu Gang XING Dong Ming Cancer Institute The Affiliated Hospital of Qingdao UniversityQingdao UniversityQingdao 266071ShandongChina Qingdao Cancer Institute Qingdao 266071ShandongChina Qingdao Municipal Center for Disease Control and Prevention Qingdao 266033ShandongChina Qingdao Institute of Preventive Medicine Qingdao 266033ShandongChina Shandong Muhua Medical Technology Co. LtdQingdao 266109ShandongChina School of Life Sciences Tsinghua UniversityBeijing 100084China

Nonalcoholic fatty liver disease(NAFLD)is characterized by fat accumulation in the liver in the absence of alcohol consumption and comprises a variety of conditions such as simple steatosis,nonalcoholic steatohepatitis,fibrosis,and cirrhosis^([1]).More than one-quarter of the world’s population experience NAFLD^([2]).The prevalence of NAFLD in China increased from 23.8%in 2001 to 32.9%in 2018,indicating that hepatitis B virus is the primary cause of chronic liver disease^([3]).

关键词： NAFLD liver Liver

Potential Mechanisms and Effects of Chinese Medicines in Treatment of Diabetic Atherosclerosis by Modulating NLRP3 Inflammasome:A Narrative Review

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Chinese Journal of Integrative Medicine 2022年第8期28卷 753-761页

作者： yuAN Jia-yao FU yu feng Zhi-hai SANG feng shao Ming-yi LI Lei-lei School of First Clinical Henan University of Chinese MedicineZhengzhou450000China Department of Endocrinology The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Department of Key Laboratory of Viral Diseases Prevention and Treatment of Traditional Chinese Medicine of Henan Province The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Department of Gastroenterology The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China

Nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3(NLRP3)is an intracellular sensor that detects endogenous danger signals and environmental irritants to assemble into the NLRP3 inflammasome.Activation of the NLRP3 inflammasome leads to the secretion of the proinflammatory cytokines interleutkin(IL)-1β and IL-18 and induces pyroptosis.Recent studies have shown that the NLRP3 inflammasome participates in the initiation and progression of diabetic atherosclerosis through pathological mechanisms such as β-cell dysfunction,insulin resistance,endothelial cell dysfunction,monocyte adhesion and infiltration,and smooth muscle cell proliferation and migration.In diabetic atherosclerosis,Chinese medicine has been proven effective for the inflammatory response mediated by the NLRP3 inflammasome.This review summarizes the latest progress on the NLRP3 inflammasome in the pathogenesis and potential Chinese medicine treatment of diabetic atherosclerosis.

关键词： Chinese medicine diabetic atherosclerosis NLRP3 inflammasome interleukin-1β TXNIP pyroptosis

Enhanced electromagnetic wave absorption properties of ZIF-67 modified polymer-derived SiCN ceramics by in situ construction of multiple heterointerfaces

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Rare Metals 2023年第5期42卷 1635-1644页

作者： Tao-Bo Geng Gao-yuan yu Gao-feng shao Xiao-Gu Huang School of Chemistry and Materials Science Nanjing University of Information Science&TechnologyNanjing210044China

Multiphase polymer-derived ceramics have the advantages of thermal stability and adjustable dielectric properties,which exhibit significant potential for use in high-temperature microwave absorbing materials.Herein,Co-containing polymer-derived SiCN(Co-SiCN)ceramics were successfully synthesized by the physical mixing of zeolitic imidazolate framework(ZIF)-67 and polysilazane precursors and subsequent pyrolysis.The phase and chemical compositions,microstructures,dielectric properties,electromagnetic wave absorption(EWA)performance,and mechanism of the ceramics were investigated.The results showed that the introduction of ZIF-67 promoted the in situ formation of dielectric loss phases,including SiC nanocrystals,CoSi nanocrystals,and free carbon.The phase composition can be regulated by controlling the pyrolysis temperature to achieve ideal EWA properties.The Co-SiCN ceramic pyrolyzed at 1500℃demonstrated excellent EWA performance,with a maximum effective absorption band(EAB_(max))of 3.0 GHz at an ultralow thickness of 1.05 mm and minimum reflection loss(RL_(min))of-46.4 dB at a low frequency of 6 GHz.Compared with other reported SiCN-based ceramics containing magnetic metals,the ceramics prepared in this study stand out because of their low RL and high EAB at low thicknesses.The superior microwave absorption performance of the Co-SiCN ceramics is attributed to the heterointerface polarization,and impedance matching induced by the synergistic effects of their co-existing electromagnetic transparent/absorption phases.This study provides new insights into the development of high-performance SiCNbased microwave absorbers.

关键词： Polymer-derived SiCN ceramic Multiple heterointerfaces Zeolitic imidazolate framework(ZIF-67) Electromagnetic wave absorption(EWA)

Abscisic acid-dependent PMT1 expression regulates salt tolerance by alleviating abscisic acid-mediated reactive oxygen species production in Arabidopsis

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Journal of Integrative Plant Biology 2022年第9期64卷 1803-1820页

作者： Qi yu He Jian feng Jin He Qiang Lou feng feng Dang Ji Ming Xu shao Jian Zheng Jian Li Yang State Key Laboratory of Plant Physiology and Biochemistry College of Life SciencesZhejiang UniversityHangzhou310058 China State Key Laboratory of Subtropical Silviculture Zhejiang A&F UniversityHangzhou311300 China State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources South China Agricultural UniversityGuangzhou510642 China

Phosphocholine(PCho)is an intermediate metabolite of nonplastid plant membranes that is essential for salt tolerance.However,how PCho metabolism modulates response to salt stress remains unknown.Here,we characterize the role of phosphoethanolamine N-methyltransferase 1(PMT1)in salt stress tolerance in Arabidopsis thaliana using a T-DNA insertional mutant,geneediting alleles,and complemented lines.The pmt1 mutants showed a severe inhibition of root elongation when exposed to salt stress,but exogenous ChoCl or lecithin rescued this defect.pmt1 also displayed altered glycerolipid metabolism under salt stress,suggesting that glycerolipids contribute to salt tolerance.Moreover,pmt1 mutants exhibited altered reactive oxygen species(ROS)accumulation and distribution,reduced cell division activity,and disturbed auxin distribution in the primary root compared with wild-type seedlings.We show that PMT1 expression is induced by salt stress and relies on the abscisic acid(ABA)signaling pathway,as this induction was abolished in the aba2-1 and pyl112458 mutants.However,ABA aggravated the salt sensitivity of the pmt1 mutants by perturbing ROS distribution in the root tip.Taken together,we propose that PMT1 is an important phosphoethanolamine N-methyltransferase participating in root development of primary root elongation under salt stress conditions by balancing ROS production and distribution through ABA signaling.

关键词： abscisic acid(ABA) oxidative stress plasma membrane phosphoethanolamine N-methyltransferase phospholipid metabolism salt stress

Instance selection method for improving graph-based semi-supervised learning

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Frontiers of Computer Science 2018年第4期12卷 725-735页

作者： Hai WANG shao-Bo WANG yu-feng LI 1 National Key Laboratory for Novel Software Technology Nanjing University Nanjing 210023 China Collaborative Innovation Center of Novel Software Technology and Industrialization Nanjing 210023 China

Graph-based semi-supervised learning is an important semi-supervised learning paradigm. Although graphbased semi-supervised learning methods have been shown to be helpful in various situations, they may adversely affect performance when using unlabeled data. In this paper, we propose a new graph-based semi-supervised learning method based on instance selection in order to reduce the chances of performance degeneration. Our basic idea is that given a set of unlabeled instances, it is not the best approach to exploit all the unlabeled instances; instead, we should exploit the unlabeled instances that are highly likely to help improve the performance, while not taking into account the ones with high risk. We develop both transductive and inductive variants of our method. Experiments on a broad range of data sets show that the chances of performance degeneration of our proposed method are much smaller than those of many state-of-the-art graph-based semi-supervised learning methods.

关键词： graph-based semi-supervised learning performance degeneration instance selection

Heterostructured Co_(3)O_(4)-SnO_(2)composites containing oxygen vacancy with high activity and recyclability toward NH_(3)BH_(3)dehydrogenation

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Rare Metals 2023年第9期42卷 3013-3023页

作者： Hui-Ze Wang You-Xiang shao yu-Fa feng yu-Jie Tan Qing-yu Liao Xiao-Dong Chen Xue-feng Zhang Zhao-Hui Guo Hao Li School of Chemistry and Materials Engineering Huizhou UniversityHuizhou516007China Guangdong Provincial Key Laboratory for Electronic Functional Materials and Devices Huizhou UniversityHuizhou516007China

Ammonia borane(NH_(3)BH_(3),AB)has been regarded as a promising chemical hydrogen storage material owing to its high hydrogen density and superior stability.Thus,the development of low-cost and high-efficient heterogeneous catalysts for the dehydrogenation of AB has attracted considerable scholarly attention.In this study,heterostructured Co_(3)O_(4)-SnO_(2)catalysts containing oxygen vacancy(V_(o))with different Co/Sn atomic ratios(designated as V_(o)-Co-Sn_(5:x))were synthesized via a simple coprecipitation-calcination method under mild reaction conditions.The catalyst containing an optimized Co/Sn atomic ratio of 5:2(V_(o)-Co-Sn_(5:2))exhibited robust catalytic performance with a turnover frequency value of 17.6mol_(H2)·mol^(-1)_(metal)·min^(-1).Moreover,82.6%of the original activity of the catalyst was retained after 14 catalytic cycles,indicating the high stability of the catalyst.Diversified characterization combined with the density functional theory(DFT)calculation confirmed the transfer of electrons from Co_(3)O_(4)to Sn O_(2)and the distribution of the separated charges on SnO_(2)-Co_(3)O_(4)interface.The transfer of electrons and the distribution of charges facilitated the adsorption and activation of water on the catalyst,thus accelerating the dissociation of H_(2)O molecule(the ratedetermining step of AB hydrolysis).It was found that the V_(o)adjusted the electron structure of the catalysts rather than acted as active sites.These findings will provide researchers with useful information for designing cheap and highly efficient catalysts for catalytic AB hydrolysis.

关键词： Ammonia borane(AB) Cobalt-tin composite oxide Heterocatalysis Hydrogen production Oxygen vacancy

Ru Nanoparticles Supported on Co-Embedded N-Doped Carbon Nanotubes as Efficient Electrocatalysts for Hydrogen Evolution in Basic Media

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Chemical Research in Chinese Universities 2020年第3期36卷 425-430页

作者： YAN Baolin LIU Dapeng feng Xilan shao Mingzhe ZHANG yu Key Laboratory of Bio-inspired SniaH Interfacial Science and Techiology of Ministry of EducationSchool of ChemistryBeihang UniversityBeijing 100191P.R.China Inteniational Research Institute for Multidisciplinary Science Beihang UniversityBeijing 100191P.R.China Beijing Advanced Innovation Center for Biomedical Engineering Beihang UniversityBeijing 100191P.R.China

A challenging but urgent task is to construct efficient and robust hydrogen evolution reaction(HER)electrocatalysts for practically feasible and sustainable hydrogen production through alkaline water electrolysis.Herein we report a simple and mild pyrolysis method to synthesize the efficient Ru nanoparticles(NPs) supported on Co-embedded N-doped carbon nanotubes(Ru/Co-NCNTs)catalyst for HER in basic media.The Ru/Co-NCNTs display remarkable performance with a low overpotential of only 35mV at 10mA/cm^2,a small Tafel slope(36mV/dec),and a high mass activity in 1mol/L KOH,which is superior to commercial 20% Pt/C catalyst.This excellent performance is benefited from the enhanced conductivity of N-doped carbon nanotubes(NCNTs)and high intrinsic activity triggered by synergistic coupling between Ru NPs and Co-embedded N-doped carbon nanotubes(Co-NCNTs).

关键词： Carbon nanotube Ru nanoparticle Hydrogen evolution reaction(HER) Electrocatalyst

Clarifying effect of welding conditions on microstructure and mechanical properties of friction stir spot-welded DH590 automotive high-strength steel plates

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Journal of Iron and Steel Research(International) 2021年第2期28卷 232-243页

作者： Ya-peng Zhao Lian-feng Chen Shi-jie Zhu yu-feng Sun shao-kang Guan School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001HenanChina Henan Key Laboratory of Advanced Magnesium Alloys Zhengzhou UniversityZhengzhou 450001HenanChina Beijing Shougang Co. Ltd.Beijing 100041China

Friction stir spot welding was successfully applied to the 1.2-mm-thick DH590 dual-phase steel plates by using a polycrystalline cubic boron nitride rotating tool.During welding,the rotation speed ranged from 600 to 1000 r/min and the penetration depth ranged from 0.1 to 0.3 mm.In the spot joints,the size of the stir zone increased with the increase in rotation speed as well as the penetration depth of the tool.Comparing with the banded ferrite and martensite structure of the base metal,a mixed microstructure of ferrite and tempered martensite,refined bainite structure and coarse martensite structure were found in the heat-affected zone,thermomechanically affected zone and stir zone of the joints,respectively.Two kinds of interfacial shapes were formed between the upper and lower steel plates,and the formation of the bonded interface was dominated mainly by the penetration depth of the rotating tool rather than the rotation speed.It was revealed that the joints with straight interfaces showed higher shear tensile loads comparing with those with hook-like interfaces.Shear tensile tests showed that the maximum shear tensile load reached about 15.56 kN when the rotation speed and penetration depth were set as 800 r/min and 0.3 mm,respectively.The specimen was fractured through plug failure mode with a total elongation of about 5.6 mm.

关键词： Friction stir spot welding DH590 dual-phase steel Microstructure Joint strength Microhardness

Target detection for multi-UAVs via digital pheromones and navigation algorithm in unknown environments

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Frontiers of Information Technology & Electronic Engineering 2020年第5期21卷 796-808页

作者： Yan shao Zhi-feng ZHAO Rong-peng LI yu-geng ZHOU College of Information Science and Electronic Engineering Zhejiang UniversityHangzhou 310027China Zhejiang Lab Hangzhou 311121China Institute of Wanfeng Jinyuan Holding Group Co. Ltd.Shaoxing 312000China

Coordinating multiple unmanned aerial vehicles(multi-UAVs)is a challenging technique in highly dynamic and sophisticated environments.Based on digital pheromones as well as current mainstream unmanned system controlling algorithms,we propose a strategy for multi-UAVs to acquire targets with limited prior knowledge.In particular,we put forward a more reasonable and effective pheromone update mechanism,by improving digital pheromone fusion algorithms for different semantic pheromones and planning individuals’probabilistic behavioral decision-making schemes.Also,inspired by the flocking model in nature,considering the limitations of some individuals in perception and communication,we design a navigation algorithm model on top of Olfati-Saber’s algorithm for flocking control,by further replacing the pheromone scalar to a vector.Simulation results show that the proposed algorithm can yield superior performance in terms of coverage,detection and revisit efficiency,and the capability of obstacle avoidance.

关键词： Collective intelligence Digital pheromones Artificial potential field Navigation algorithm