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Journal of Analysis and Testing 2024年第2期8卷 237-244页

作者： fei yu yue Wang Caiyuan yu Wei Zhang Xuefeng Bai State Key Laboratory of Quality Research in Chinese Medicines Macao Institute for Applied Research in Medicine and HealthMacao University of Science and TechnologyTaipaMacao999078China Baotou Cancer Hospital Baotou014040Inner MongoliaChina

miR-18a has been identified as a significantly expressed microRNA(miRNA)in non-small cell lung cancer(NSCLC)and plays a vital role in cancer cell transformation,metastasis,and ***,a pair of binary probes from numerous probe pairs based on single nucleotide polymorphism analyses of miR-18a and miR-18b was first designed and screened to develop a Y-shaped ratio biosensor for accurate detection of serum miR-18a in *** special structure of the binary probes combined with the hairpin showed strong specificity for miR-18a,which was confirmed by polyacrylamide gel electrophoresis assay and square wave voltammetry ***,it is beneficial to immobilize single-stranded DNA(ssDNA)probes due to the large specific surface area of nanoporous gold,thereby improving the sensitivity of the *** Y-shaped ratio biosensor exhibited a wide detection range and can quantify the concentration of miR-18a in the range of 10 fmol/L–100 pmol/L,with a limit of detection of 0.211 fmol/L(S/N=3).Moreover,it exhibits excellent detection capabilities in serum samples since the biosensor showed a high selectivity toward the coexistence of miR-18a and ***,the prepared Y-shaped ratio biosensor is a highly sensitive and specific miR-18a detection tool,capable of identifying microscopic amounts of miR-18a in serum samples,providing great potential for early screening of NSCLC.

关键词： Nanoporous gold Y-shaped biosensor miR-18a NSCLC

Stigmasterol protects human brain microvessel endothelial cells against ischemia-reperfusion injury through suppressing EPHA2 phosphorylation

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Chinese Journal of Natural Medicines 2023年第2期21卷 127-135页

作者： LI Suping XU fei yu Liang yu Qian yu Nengwei FU Jing Department of Neurology Sichuan Academy of Medical Sciences&Sichuan Provincial People’s HospitalChengdu 610072China Department of Rehabilitation Sichuan Academy of Medical Sciences&Sichuan Provincial People’s HospitalChengdu 610072China

Stigmasterol is a plant sterol with anti-apoptotic,anti-oxidative and anti-inflammatory effect through multiple *** this study,we further assessed whether it exerts protective effect on human brain microvessel endothelial cells(HBMECs)against ischemia-reperfusion injury and explored the underlying *** were used to establish an in vitro oxygen and glucose deprivation/reperfusion(OGD/R)model,while a middle cerebral artery occlusion(MCAO)model of rats were *** interaction between stigmasterol and EPHA2 was detected by surface plasmon resonance(SPR)and cellular thermal shift assay(CETSA).The results showed that 10μmol·L−1 stigmasterol significantly protected cell viability,alleviated the loss of tight junction proteins and attenuated the blood-brain barrier(BBB)damage induced by OGD/R in the in vitro *** molecular docking showed that stigmasterol might interact with EPHA2 at multiple sites,including T692,a critical gatekeep residue of this *** ephrin-A1(an EPHA2 ligand)exacerbated OGD/R-induced EPHA2 phosphorylation at S897,facilitated ZO-1/claudin-5 loss,and promoted BBB leakage in vitro,which were significantly attenuated after stigmasterol *** rat MCAO model confirmed these protective effects in *** summary,these findings suggest that stigmasterol protects HBMECs against ischemia-reperfusion injury by maintaining cell viability,reducing the loss of tight junction proteins,and attenuating the BBB *** protective effects are at least meditated by its interaction with EPHA2 and inhibitory effect on EPHA2 phosphorylation.

关键词： Stigmasterol Oxygen and glucose deprivation/reperfusion EPHA2 Blood-brain barrier

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On l-th NMDS Codes

Chinese Journal of Electronics 2014年第3期23卷 454-457页

作者： TONG Hongxi CHEN Wenhai yu fei Department of Mathematics Shanghai University Science and Technology on Communication Security Laboratory

Linear codes with Singleton defects equivalent to 0, 1, 2 are studied, and they have good properties. They are called MDS codes, NMDS codes, NNMDS cdoes, respectively. In this paper, we study linear codes with large Singleton defects and these codes have same good properties with MDS codes, NMDS codes, NNMDS codes. We call them l-th NMDS codes. A series of iff conditions of l-th NMDS codes is presented. And we give an upper bound on length of l-th NMDS codes. In the last,some examples of l-th NMDS codes are given.

关键词： Linear codes Maximum distance separated(MDS) codes Singleton defects Near maximum distance separated(NMDS) codes Generalized Ham

Fatigue behaviors of Z2CND18.12N stainless steel under thermal-mechanical cycling

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Acta Metallurgica Sinica(English Letters) 2011年第2期24卷 101-108页

作者： Liubing WANG Dunji yu fei XUE Weiwei yu Jian CHEN Xu CHEN School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China Suzhou Nuclear Power Institute Suzhou 2400511 China Key Laboratory of Efficient & Clean Energy Utilization College of Hunan Province ChangshaUniversity of Science and Technology Changsha 410114 China

Tests under mechanical strain control were performed to investigate the TMF behavior of Z2CND18.12N within the temperature range between 150–550 ？ C. Different strain amplitudes and phase-angles were applied. Total strain controlled low cycle fatigue test was also performed at the peak temperature of TMF cycling. The results show that the cyclic stress response of the material displayed an initial hardening regime followed by a saturation period and then cyclic softening till failure. The TMF cycling leads to the development of significant amounts of mean stress. Some life prediction models were employed to predict the TMF life of Z2CND18.12N, and the results indicate that the energy-based models provide good prediction on the thermal-mechanical fatigue behaviors of this material. An optical microscopic observation shows that the surface crack initiations and crack propagations are typically transgranular mode.

关键词： Thermomechanical fatigue Z2CND18.12N Life prediction Microstructural behavior

日粮中添加枯草芽孢杆菌对高氧气调包装猪肉蛋白质和脂质氧化的影响

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食品科学 2025年第1期46卷 142-148页

作者：张悦于江刘飞张玉玉张一敏毛衍伟山东农业大学食品科学与工程学院山东泰安271018 山东省农业科学院畜牧兽医研究所农业农村部畜禽生物组学重点实验室山东济南250100

为探究日粮添加枯草芽孢杆菌对猪肉抗氧化能力以及高氧气调包装贮藏期间猪肉肉色、蛋白质氧化、脂质氧化和感官品质的影响,选取对照组(只饲喂基础日粮)和处理组(基础日粮添加枯草芽孢杆菌)的三元杂交(杜洛克×长白×大约克)猪各6只,屠... 详细信息

为探究日粮添加枯草芽孢杆菌对猪肉抗氧化能力以及高氧气调包装贮藏期间猪肉肉色、蛋白质氧化、脂质氧化和感官品质的影响,选取对照组(只饲喂基础日粮)和处理组(基础日粮添加枯草芽孢杆菌)的三元杂交(杜洛克×长白×大约克)猪各6只,屠宰后取背最长肌测定抗氧化酶活性,其余背最长肌样品进行高氧气调包装,4℃冷库贮藏,分别在0、5、10、15、20?d测定肉色、丙二醛(malondialdehyde,MDA)、羰基和巯基含量,并进行感官评价。结果表明:与对照组相比,处理组能够显著提高超氧化物歧化酶、谷胱甘肽过氧化物酶和过氧化氢酶活性(P<0.05),增强猪肉的抗氧化能力;日粮中添加枯草芽孢杆菌可以显著改善高氧气调包装猪肉的肉色(P<0.05);在低温贮藏期间,处理组能够显著降低MDA含量(P<0.05),抑制高氧气调包装猪肉的脂肪氧化;日粮中添加枯草芽孢杆菌能够显著抑制高氧气调包装猪肉的蛋白质氧化、羰基的生成和巯基损失(P<0.05),同时显著提高猪肉打开包装前的颜色和打开包装后的总体喜爱度评分(P<0.05)。综上,在日粮中添加枯草芽孢杆菌可提高猪肉的抗氧化能力、改善猪肉在高氧气调包装中的肉色、抑制蛋白质和脂质氧化,提高猪肉的食用品质。

关键词：枯草芽孢杆菌猪肉抗氧化能力脂质氧化蛋白质氧化

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T-cell immunity:a barrier to Omicron immune evasion

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Signal Transduction and Targeted Therapy 2022年第9期7卷 3184-3186页

作者： fei yu Wanbo Tai Gong Cheng College of Life Sciences Hebei Agricultural University071001 BaodingChina Tsinghua Peking Joint Center for Life Sciences School of MedicineTsinghua University100084 BejingChina Institute of Infectious Diseases Shenzhen Bay Laboratory518132 ShenzhenChina

A recent study published in Cell by Naranbhai et *** that although the extent may vary,T-cell responses induced by infection by or vaccination against the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)are cross-reactive toward the Omicron variant in most individuals,highlighting the role T-cell immunity plays in preventing immune evasion by the Omicron and even future variants.

关键词： immunity acute

Droplet Bridging Effect in Polymer/Polymer/Filler Ternary Composites

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Chinese Journal of Polymer Science 2024年第12期42卷 1966-1975,I0010页

作者： Feng-Yi Hou Li Peng fei yu Xian-Bo Huang Wei yu Advanced Rheology Institute Department of Polymer Science and EngineeringShanghai Jiao Tong UniversityShanghai200240China National Certified Enterprise Technology Center Kingfa Science and Technology Co.Ltd.Guangzhou510663China DPI P.O.Box 9025600 AXEindhovenThe Netherlands

In particle-filled polymer composites with selective distributions of fillers in one phase,much attention has been focused on the“volume exclusion effect”in reducing the percolation threshold of filler,while the role of dispersed polymer phase acting as bridges of fillers in the particle network has largely been ***,we studied industrially important ternary composites,polypropylene(PP)/ethylene-octene copolymer(a polyolefin elastomer,POE)/talc systems,and adopted rheology to reveal the bridging behavior of POE droplets in the network of talc *** is found that talc fillers concentrate in the PP phase using the“blend first”protocol,while more talc particles are located at the interface of PP and POE phases using the“filler first”*** the POE viscosity and talc size can affect the migration of talc from the POE phase to the PP phase in the“filler first”*** linear rheology behavior indicates that besides the“volume exclusion effect”,the talc-POE hybrid network can further contribute to the reinforcement ***,the POE droplet bridging structure can facilitate the rebuilding of the hybrid network after large amplitude oscillatory shear,in contrast to the un-recoverable structures in the PP/talc binary *** correlation between rheology and selective distribution of fillers in ternary composites may provide practical guidance for processing and designing advanced polymer composites with controlled selective location of fillers.

关键词： Polypropylene Filler selective localization Rheology Bridging

Synthesis, and Investigation of the Reactive Oxygen Species of a Novel Cyclicpeptide-2,6-dimethoxyhydroquinone-3- mercaptoacetic Acid Conjugate

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Chinese Chemical Letters 2001年第12期12卷 1075-1078页

作者： yu fei SONG Hui Min ZHEN Institute of Molecular Science Shanxi University Taiyuan Teacher's College

In this paper, we report the synthesis of a potential anti-cancer agent: Cyclo[Val-Lys(DMQ-MA)-Gaba]. The cytotoxic agent conjugated to the N-terminal and the xi -amino group of lysine of the tripeptide is 2,6-dimethoxyhydroquinone-3-mercaptoacetic acid (DMQ-MA). By employing the rhodamine B degradation method and ESR spectra, we testify the reactive oxygen species - hydroxyl radicals produced by the drug.

关键词： 2,6-dimethoxyhydroquinone-3-mercaptoacetic acid cyclicpeptide

Magnetoelastic Instability in Ring-Shaped Molecule Magnets with Next-Nearest Neighbor Coupling

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Communications in Theoretical Physics 2009年第12期52卷 1125-1128页

作者： LI Peng-fei CHEN yu-Guang Department of Mathematics and Physics Shanghai University of Electric Power Shanghai 200090 China pohl Institute of Solid State Physics Tongji University Shanghai 200092 China

In considering next-nearest neighbor （NNN） coupling, we numerically investigate the magnetoelastic instability in ring-shaped mesoscopic antiferromagnetic Heisenberg spin 1/2 systems with spin-phonon interaction. The results indicate that, for antiferromagnetic NNN coupling J2, there may be a critical value J2^c, at which the ground state is dimerized for arbitrary lattice spring constant and beyond and below which the magnetoelastic instability behavior is different from each other. The values of J2^c are irrelevant to the system size. For ferromagnetic NNN coupling, only continuous transition is present from dimerized phase to uniform phase as lattice spring constant is increased.

关键词： single molecule magnets magnetoelastic instability spin-phonon interaction

RXTE /ASM and Swift /BAT observations of spectral transitions in bright X-ray binaries in 2005-2010

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Research in Astronomy and Astrophysics 2011年第4期11卷 434-444页

作者： Jing Tang Wen-fei yu Zhen Yan Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical Observatory Shanghai 200030 China

We have studied X-ray spectral state transitions that can be seen in the long- term monitoring light curves of bright X-ray binaries from the All-Sky Monitor （ASM） onboard the Rossi X-ray Timing Explorer （RXTE） and the Burst Alert Telescope （BAT） onboard Swift during a period of five years from 2005 to 2010. We have applied a program to automatically identify the hard-to-soft （H-S） spectral state transitions in the bright X-ray binaries monitored by the ASM and the BAT. In total, we identified 128 hard-to-soft transitions, of which 59 occurred after 2008. We also determined the transition fluxes and the peak fluxes of the following soft states, updated the measurements of the luminosity corresponding to the H-S transition and the peak luminosity of the following soft state in about 30 bright persistent and transient black hole and neutron star binaries following yu ＆Yan, and found the luminosity correlation and the luminosity range of spectral transitions in data between 2008-2010 are about the same as those derived from data before 2008. This further strengthens the idea that the luminosity at which the H-S spectral transition occurs in the Galactic X-ray binaries is determined by non-stationary accretion parameters such as the rate-of-change of the mass accretion rate rather than the mass accretion rate itself. The correlation is also found to hold in data of individual sources 4U 1608-52 and 4U 1636-53.

关键词： X-rays binaries -- stars neutron -- black hole physics