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Precise gradient separation of nanoparticles using reduced graphene oxide-polyoxomolybdate membranes

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Science China Chemistry 2025年第01期 209-216页

作者： Yixin Yang Wanlei Zhao Ruoxuan Zheng Hongqiang Li Wei Chen yu-fei Song State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Quzhou Institute for Innovation in Resource Chemical Engineering

The purification and size sieving of nanoparticles （NPs） represents a significant scientific ***,the r GO-polyoxometalates (POMs=PMo12,Mo132and Mo368) membranes were fabricated successfully via a simple and scalable POMsassisted in-situ photoreduction *** the mass ratio of r GO to PMo12was 1:30,the resultant r GO-PMo12membranes with highly ordered and uniform nanochannels of 1.0 nm can be obtained,which showed an accurate carbon quantum dots（CQDs） separation with a cut-off size approximately 1.0 *** increase of the size of the interlayered POMs from PMo12（1.0 nm）,{Mo132}（2.9 nm） to{Mo368}（3.8 nm）,the resultant r GO-PMo12,r GO-Mo132and r GO-Mo368exhibited precise gradient separation of CQDs and Au nanoparticles by size exclusion *** results pave a promising way to construct new twodimensional （2D） membranes for highly efficient size-selective separation.

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High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai yuan Zhuang Shenghua Lu Qianqian Ge Hao Li yu Deng Hongbin Wu Xiaojian Xu fei Niu Xinlong Dong Bin Zhang Baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu Xiao-Jia Yang Qian-Ru He fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong Wu Dan-Dan Xu Kang He Chang-Qing Liu Li-fei Song Zheng-Zhi Wu Qian-Qian Jiang Shao-yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

法压式冲泡对海南罗布斯塔咖啡感官品质的影响

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食品科学 2025年第1期46卷 108-120页

作者：刘迪劳菲董文江于鑫欣中国农业大学食品科学与营养工程学院国家果蔬加工工程技术研究中心农业农村部果蔬加工重点实验室北京市食品非热加工重点实验室北京100083 中国热带农业科学院香料饮料研究所海南万宁571533 海南省特色热带作物适宜性加工与品质控制重点实验室国家重要热带作物工程技术研究中心海南万宁571533

以中度烘焙海南罗布斯塔咖啡为研究对象,制备可溶性固形物质量分数为2%的法压式咖啡,采用喜好度评价对4种冲泡参数进行单因素和响应面试验优化,通过感官定量描述分析结合气相色谱-质谱联用法、超高效液相色谱法挖掘咖啡喜好度与其感官... 详细信息

以中度烘焙海南罗布斯塔咖啡为研究对象,制备可溶性固形物质量分数为2%的法压式咖啡,采用喜好度评价对4种冲泡参数进行单因素和响应面试验优化,通过感官定量描述分析结合气相色谱-质谱联用法、超高效液相色谱法挖掘咖啡喜好度与其感官特性及风味物质之间的相关性信息。结果表明,咖啡萃取质量浓度会随着咖啡粒径减小、粉水比增加、冲泡水温升高或冲泡时间延长而显著增大(P<0.05)。咖啡喜好度(0~6分,七点法)在粉水比1∶5(m/m)、研磨度8、冲泡水温92℃、冲泡6min时达到最高(3.3±1.6)。咖啡中共检测出78种挥发性成分,通过气味活性值分析得大马士酮、3-乙基-2,5-甲基吡嗪等关键香气化合物10种。Pearson相关性分析表明,喜好度与咖啡的圆润感、巧克力香属性呈正相关,与咖啡因、具有丁香味和酚味的4-乙基愈创木酚、4-乙烯基愈创木酚及具有粪臭味的3-甲基吲哚呈负相关。本研究能为挖掘海南罗布斯塔咖啡的风味喜好及其物质基础提供一定理论依据。

关键词：罗布斯塔咖啡冲泡参数感官定量描述分析气相色谱-质谱联用 Pearson相关性

分期取穴针刺法结合表面肌电生物反馈对脑卒中后吞咽障碍患者吞咽功能的影响

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临床研究 2025年第1期33卷 103-106页

作者：禹恒孙飞郑州市第十五人民医院康复科河南郑州450000 河南中医药大学第三附属医院疼痛科河南郑州450000

目的探讨分期取穴针刺法结合表面肌电生物反馈(sEMGBF)对脑卒中后吞咽障碍患者吞咽功能的影响。方法选择郑州市第十五人民医院在2021年1月至2023年1月收治的80例脑卒中后吞咽障碍患者作为研究对象,将其随机划分为观察组和对照组,各40名... 详细信息

目的探讨分期取穴针刺法结合表面肌电生物反馈(sEMGBF)对脑卒中后吞咽障碍患者吞咽功能的影响。方法选择郑州市第十五人民医院在2021年1月至2023年1月收治的80例脑卒中后吞咽障碍患者作为研究对象,将其随机划分为观察组和对照组,各40名。对照组给予sEMGBF法治疗,观察组在对照组基础上给予分期取穴针刺法治疗。比较两组洼田饮水试验(WST)、表面肌电图(sEMG)检测结果、吞咽疗效、吞咽功能、生活质量。结果治疗后,两组患者WST分级均明显改善,且观察组优于对照组,差异有统计学意义(P<0.05);与治疗前比较,两组患者sEMG平均波幅升高,且观察组高于对照组,差异有统计学意义;两组患者吞咽时限降低,且观察组低于对照组,差异有统计学意义(P<0.05);观察组疗后有效率显著高于对照组,差异有统计学意义(P<0.05);与治疗前比较,两组患者SSA评分均降低,且观察组降低幅度更大,差异有统计学意义(P<0.05);两组患者较治疗前SWAL-QOL评分均升高,且观察组上升幅度更大,差异有统计学意义(P<0.05)。结论对脑卒中后吞咽障碍患者给予分期取穴针刺法结合表面肌电生物反馈治疗,可明显改善患者吞咽功能,提高生活质量,获得良好恢复效果,值得应用。

关键词：脑卒中分期取穴针刺法表面肌电生物反馈吞咽障碍

Breakthrough in Li-mediated continuous electrosynthesis of ammonia

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Science China Chemistry 2024年第10期67卷 3191-3192页

作者： fei Zhan Chang yu State Key Laboratory of Chemical Resource Engineering College of Chemical EngineeringBeijing University of Chemical TechnologyBeijing 100029China State Key Laboratory of Fine Chemicals Liaoning Key Lab for Energy Materials and Chemical EngineeringSchool of Chemical EngineeringDalian University of TechnologyDalian 116024China

Ammonia(NH3)ranks among the manufactured chemicals,with an annual production surpassing 182 million tons[1],which is an indispensable raw material for fertilizer industry and has been recognized as a promising carbon-... 详细信息

关键词： ammonia Ammonia suppl

The existence of Zeno behavior and its application to finite-time event-triggered control

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Science China(Information Sciences) 2020年第3期63卷 293-299页

作者： Hao yu fei HAO The Seventh Research Division School of Automation Science and Electrical EngineeringBeihang University

Dear editor,Event-triggered control is a control strategy that is not necessarily periodic and takes resource constraints into consideration, such as limited communication bandwidth and restricted energy resources [1]. In event-triggered control, the execution of control tasks is decided by an event, instead of a fixed period of time(known as time-triggered control). The event is generated by a

关键词： origin The existence of Zeno behavior and its application to finite-time event-triggered control

CONSTRUCTIONS OF THREE-TRANSMIT-ANTENNA SPACE-TIME CODES

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Journal of Systems Science & Complexity 2007年第3期20卷 381-385页

作者： Hongxi TONG .fei yu Department of Mathematics University of Science and Technology of China Hefei 230026 China.

In this paper, we give design methods for three-transmit-antenna space-time codes which have reasonable parameters. A few examples are given to show that some unitary space-time codes constructed with our methods are ... 详细信息

关键词： Differential space-time modulation diversity products unitary space-time codes.