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Hardware-in-the-Loop Simulation System for Space Manipulator Docking: Model,Stability and Experimental Evaluation

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Journal of Beijing Institute of Technology 2020年第1期29卷 89-102页

作者： Simiao yu Shutao Zheng yu Yang Zhiyong qu Junwei Han School of Mechatronics Engineering Harbin Institute of TechnologyHarbin 150001China

A manipulator-type docking hardware-in-the-loop(HIL)simulation system is proposed in this paper,with further development of the space docking technology and corresponding requirements of the engineering ***,the structure of the manipulator-type HIL simulation system is *** mass and the flexibility of the manipulator has an important influence on the stability of the HIL system,which is the premise of accurately simulating actual space ***,the docking HIL simulation models of rigid,flexible and flexible-light space manipulators are *** characteristics of the three HIL systems are studied from three important aspects:the system parameter configuration relation,the system stability condition and the dynamics frequency simulation *** key conclusions obtained were that the system satisfies stability or reproduction ***,the influence of different manipulators on the system stability is further *** accuracy of the calculated results is verified experimentally.

关键词： manipulator docking hardware-in-the-loop(HIL)simulation parameter configuration stability condition dynamics frequency simulation capability

Hemoglobin integrated red blood cell membrane-coated metalorganic framework nano-platform for improving the self-adaptive blood glucose management

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Nano Research 2025年第1期18卷 618-627页

作者： Shuai Wu Li Zhu Sheng Ni Xiong Zhao Meng Yan yuan Zhong Karissa Kusuma Yi Liang Kaiwen Bao Kai qu Xian Qin Kun Zhang Wuquan Deng Da Sun Wei Wu Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing 400044China Chongqing University Three Gorges Hospital Chongqing Municipality Clinical Research Center for Endocrinology and Metabolic DiseasesChongqing 404000China Institute of Life Sciences&Biomedical Collaborative Innovation Center of Zhejiang Province Wenzhou UniversityWenzhou 325035China Department of Endocrinology School of MedicineChongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400014China

Diabetes,a prevalent chronic metabolic disorder,often leads to severe ***,existing treatment methods may pose life-threatening risks due to poor patient compliance and inaccurate dosing of subcutaneous insulin ***,a biomimetic red blood cell(RBC)membrane-coated glucose-responsive nanoplatform is developed for controlling insulin *** nanoplatforms with RBC membrane can prolong the half-life of nano-formulation in vivo mediated by the biomimetic immune ***,the cascade catalytic effect of glucose oxidase(GOx)encapsulated in metal-organic frameworks(MOFs)and hemoglobin(Hb)in the RBC membrane are able to not only facilitate glucose-responsive insulin release,but also eliminate the detrimental by-product hydrogen peroxide(H_(2)O_(2))resulting from the Hb mediated H_(2)O_(2)*** in vitro and in vivo studies have demonstrated the favorable glucose-responsive performances of this advanced nano-platform with a single intravenous injection maintaining blood glucose balance in Type 1 Diabetes(T1D)mice for an extended duration without the hypoglycemia ***,this biomimetic insulin delivery system is poised to function as a strategy for the intravenous insulin administration,offering a promising drug candidate for the self-adaptive long-term T1D treatment.

关键词： glucose-responsive metal-organic frameworks red blood cell membrane insulin delivery glucose oxidase hemoglobin

Vascular endothelial growth factor: an attractive target in the treatment of hypoxic/ischemic brain injury

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Neural Regeneration Research 2016年第1期11卷 174-179页

作者： Hui Guo Hui Zhou Jie Lu Yi qu Dan yu yu Tong Department of Pediatrics West China Second University Hospital Sichuan University Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education West China Second University Hospital Sichuan University Department of Medical Cosmetology Chengdu Second People’s Hospital

Cerebral hypoxia or ischemia results in cell death and cerebral edema, as well as other cellular reactions such as angiogenesis and the reestablishment of functional microvasculature to promote recovery from brain injury. Vascular endothelial growth factor is expressed in the central nervous system after hypoxic/ischemic brain injury, and is involved in the process of brain repair via the regulation of angiogenesis, neurogenesis, neurite outgrowth, and cerebral edema, which all require vascular endothelial growth factor signaling. In this review, we focus on the role of the vascular endothelial growth factor signaling pathway in the response to hypoxic/ischemic brain injury, and discuss potential therapeutic interventions.

关键词： nerve regeneration VEGF VEGFR HIF1 PI3K/Akt pathway Akt/e NOS pathway JAK/STAT Src-SSe CKS pathway hypoxic/ischemic brain injury neural regeneration

Flexible three-band motion-compensated temporal filtering for scalable video coding

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The Journal of China Universities of Posts and Telecommunications 2009年第1期16卷 116-120页

作者： WANG Yong-yu SUN qu yuAN Chao-wei Century College Beijing University of Posts and Telecommunications Beijing 100876 China School of Information Engineering University of Science and Technology Beijing Beijing 100083 China School of Telecommunication and Network Technology Beijing University of Posts and Telecommunications Beijing 100876 China

A novel scheme for scalable video coding using three-band lifting-based motion-compensated transform is presented in this article. A series of flexible three-band motion-compensated lifting steps are used to implement the temporal wavelet transform, which provide improved compression performance by selecting specific motion model according to real video sequences, and offer higher temporal scalability flexibility by using three-band lifting steps. The experimental results compared with motion picture expert group （MPEG）-4 codec concerning standard video sequences demonstrate the effectiveness of the method.

关键词： wavelet transform lifting scalable video coding three-band temporal decomposition motion-compensated temporal filtering (MCTF)

Research Progress and Development Tendency of Nitrogen-alloyed Austenitic Stainless Steels

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Journal of Iron and Steel Research International 2015年第2期22卷 91-98页

作者： yu-ping LANG Hua-peng qu Hai-tao CHEN yu-qing WENG Central Iron and Steel Research Institute

Research progress on nitrogen alloyed austenitic stainless steels was expounded through the development of steel grades. In addition, hot topics in the research of nitrogen-alloyed austenitic stainless steels were discussed, in cluding the solubility of nitrogen, brittle ductile transition, and welding. On this basis, it was proposed that the fu- ture development tendency of nitrogen alloyed austenitic stainless steels lied in the three fields of high-performance steels, resource saving steels, and biologically friendly steels. The problems encountered during the research of ni- trogen-alloyed austenitic stainless steels were discussed.

关键词： nitrogen-alloyed austenitic stainless steel nitrogen solubility brittle-ductile transition welding

Changes in corneal endothelial cell density in patients with primary open-angle glaucoma

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World Journal of Clinical Cases 2019年第15期7卷 1978-1985页

作者： Zi-Yan yu Ling Wu Bo qu Department of Ophthalmology 4th Affiliated Hospital of China Medical UniversityEye hospital of China Medical UniversityKey Laboratory of Lens Research of Liaoning ProvinceShenyang 110005Liaoning ProvinceChina Department of Ophthalmology the 4th people’s Hospital of ShenyangShenyang 110005Liaoning ProvinceChina

BACKGROUND Glaucoma is a group of diseases characterized by a specific pattern of optic nerve neuropathy and *** evidence demonstrates glaucoma associated corneal endothelium ***-compression mechanism due to elevated intraocular pressure(IOP),cell toxicity after long term exposure to preservatives and glaucoma surgery have been reported to be the possible ***,we compare the specular endothelial microscopy in primary open-angle glaucoma(POAG)patients and healthy controls of the same age group to observe the corneal endothelium changes and the correlations to the mean IOP in a Chinese case control *** To investigate corneal endothelial cell density in Chinese patients with *** A case control study was performed on 60 eyes of 60 patients with *** criteria included history of corneal diseases,intraocular diseases,contact lens use,ocular trauma or surgery(including intraocular surgery and laser treatment),congenital abnormalities or systemic diseases such as *** pressure was measured using Goldmann *** specular microscopy(TOPCON SP-2000P)was performed on central corneas and endothelial images were *** cell density,area and cell counts were *** Endothelial cell density was 2959±236 cells/mm2 in healthy controls and 2757±262 cells/mm2 in patients with *** POAG eyes had significantly lower endothelial cell density compared to healthy control eyes(P<0.001).In the POAG group,endothelial cell density was 2686±233 cells/mm2 in the patients receiving medication and 2856±272 cells/mm2 in the untreated *** eyes receiving medication had significantly lower endothelial cell density compared to untreated *** was a negative correlation between cell density and mean IOP(r=-0.286,P=0.004),positive correlation between the average cell area and mean IOP(r=0.228,P=0.022),maximum cell area and mean IOP(r=0.218,P=0.029)and minimum cell area and

关键词： Corneal endothelium Primary open angle glaucoma Intraocular pressure

Influence of Integral Instability of Kramers-Kronig Transformation on Photoabsorption Cross Sections

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Communications in Theoretical Physics 2009年第8期52卷 369-376页

作者： MA Xiao-Guang GONG yu-Bing qu Zhao-Jun Department of Physics Ludong University Yantai 264025 China

The photoabsorption cross sections of condensed atoms and molecules have proven to be dependent not only on the imaginary parts but also on the real parts of the polarizabilities due to the strong interatomie interactions in condensed environment. The real parts of the polarizabilities calculated usually by using the famous Kramers-Kronig transformation （KKT） from the photoabsorption cross sections of the isolated atoms are very sensitive to the accuracy of the implementation method of the infinite integral in the KKT. The influence of the integral instability of the KKT and the real part of the polarizability on the variation of the photoabsorption cross sections with the number density and the structure of the condensed matter has been studied in the present work for the first time. The conclusion is that the integration method with interpolation has given more reasonable results than the direct truncation method if some appropriate interpolation functions have been used. Some notes and conclusions have also been given for the applications of the alternative coupled expressions of photoabsorption cross sections.

关键词： condensed-phase photoabsorption Kramers-Kronig transformation dynamic polarizability

Triterpene saponins with XOD inhibitory activity from the roots of Ilex pubescens

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Chinese Chemical Letters 2011年第6期22卷 697-700页

作者： Li Ping Lin Wei qu Jing yu Liang Department of Natural Medicinal Chemistry China Pharmaceutical University Nanjing 210009 China

A new triterpene saponin with 28-nor-urs-12（13）,18（17）-dien-3β-ol as aglycone,named ilexsaponin C（1） was isolated from the roots of Ilex pubescens,together with three known saponins 2,3 and *** structure of 1 was elucidated on the basis of spectral analysis including 1D and 2D NMR and *** 1 and 4 exhibited significant XOD inhibitory activity in the test.

关键词： Triterpene saponin Ilex pubescens Ilexsaponin C Xanthine oxidase

Triggering a [2]rotaxane molecular shuttle through hydrogen sulfide

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Science China Chemistry 2018年第3期61卷 306-310页

作者： Shun Yang Zhoulin Luan Chuan Gao Jingjing yu Dahui qu Key Laboratory for Advanced Materials and Institute of Fine Chemicals East China University of Science and Technology

A novel chemically-controlled [2]rotaxane molecular shuttle was successfully designed and synthesized. A H_2 S-responsive bulk barrier was introduced between the two identical recognition stations of the [2]rotaxane to prevent dynamic shuttling of the macrocycle. Upon addition of H_2 S, the complete intramolecular cascade reaction occurs in a controllable manner, resulting in removal of the bulk barrier and the shuttling motion of the macrocycle between the two stations recovers.

关键词： rotaxane molecular shuttle chemically-controlled hydrogen sulfide stimuli-responsive