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Joined AZ31B Magnesium Alloys with Ag Interlayer by Ultrasonic-Induced Transient Liquid Phase Bonding in Air

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Acta Metallurgica Sinica(English Letters) 2024年第7期37卷 1177-1185页

作者： qian Wang Peng yu Haoran Lin Chongzhi Guo Xiaoqiang Hu Ganjiang Innovation Academy Chinese Academy of SciencesGanzhou341119China School of Rare Earths University of Science and Technology of ChinaHefei230026China Shenyang 7D New Materials Equipment Co.LTD. Shenyang110076China Shenyang National Laboratory of Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang110016China

AZ31B magnesium alloys are commonly used in lightweight structures of automobile and aerospace *** this work,the ultrasonic-induced transient liquid phase bonding technique is deployed to joint AZ31B magnesium alloys at 490℃ with Ag interlayer in the *** effect of ultrasonic vibration on microstructure and mechanical properties of welding seam is *** vibration duration increases,the width of the welding seam increases firstly and then *** the ultrasound vibration sustained for one second,the eutectic reaction occurred in the contacting interface between Ag interlayer and the base metal AZ31B,resulting in formation of liquid phase and metallurgical *** the ultrasound vibration sustained for seven second,the width of the welding seam increased to a maximum of about 303.1μm and the average shear bond strength of the welding joint attained the peak value of about 66.87 *** the ultrasound vibration sustained over seven seconds,the liquid phase is gradually squeezed out and the width of the welding seam decreases.α-Mg and AgMg_(3) can be observed in the welding *** analysis shows thatα-Mg has a certain strengthening *** whole process of appearance,growth and integration ofα-Mg is analyzed.

关键词： Ultrasonic bonding Magnesium alloy Silver Microstructure Intermetallic compound

The mechanisms of thermal solidification agent promoting steam diversion in heavy oil reservoirs

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Petroleum Science 2024年第3期21卷 1902-1914页

作者： Zhan-Xi Pang qian-Hui Wang qiang Meng Bo Wang dong Liu State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing102249China Liaohe Oilfield Institute CNPC ChinaPanjin124000LiaoningChina Henan Oilfield Institute Sinopec ChinaNanyang473400HenanChina Tianjin Branch of China National Offshore Oil Company(CNOOC)Ltd. Tianjin300452China

At high cycles of steam huff&puff,oil distribution in reservoirs becomes stronger heterogeneity due to steam *** solidification agent can be used to solve this *** solution is a lowviscosity liquid at normal temperature,but it can be solidified above 80℃.The plugging degree is up to 99%at 250℃.The sweep efficiency reaches 59.2%,which is 7.3%higher than pure steam *** addition,simultaneous injection of viscosity reducer and/or nitrogen foams can further enhance oil *** mechanism of this technology depends on its strong plugging ability,which changes the flowing pattern of steam to effectively mobilize remaining *** reducer and nitrogen foams further expand the sweep range and extends the effective ***,thermal solidification agent can plug steam channeling paths and adjust steam flowing direction to significantly enhance oil recovery at high cycles of steam huff&puff.

关键词： Heavy oil reservoir Steam huff&puff Steam channeling Steam diversion Plugging performance Mechanism analysis

SsdchA is a novel secretory cellobiohydrolase driving pathogenicity in Sclerotinia sclerotiorum

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The Crop Journal 2024年第2期12卷 493-502页

作者： Yangui Chen Yijuan Ding Siqi Zhao Nan Yang Zhaohui Wu Ping Zhang Hongmei Liao Mengquan dong Yang yu Huafang Wan Wei qian Integrative Science Center of Germplasm Creation in Western China(Chongqing)Science City College of Agronomy and BiotechnologySouthwest UniversityChongqing 400715China Academy of Agricultural Sciences Southwest UniversityChongqing 400715China Engineering Research Center of South Upland Agriculture Ministry of EducationChongqing 400715China College of Plant Protection Southwest UniversityChongqing 400715China

The necrotrophic fungus, Sclerotinia sclerotiorum, employs an array of cell wall-degrading enzymes(CWDEs), including cellulase, to dismantle host cell walls. However, the molecular mechanisms through which S. sclerotiorum degrades cellulose remain elusive. Here, we unveil a novel secretory cellobiohydrolase, SsdchA, characterized by a signal peptide and a Glyco_hydro_7(GH7) domain. SsdchA exhibits a robust expression of during early infection stages. Interestingly, colony morphology and growth rates remain unaffected across the wild-type, SsdchA deletion strains and SsdchA overexpression strains on potato dextrose agar(PDA) medium. Nevertheless, the pathogenicity and cellobiohydrolase activity decreased in the SsdchA deletion strains, but enhanced in the SsdchA overexpression strains. Moreover,the heterologous expression of SsdchA in Arabidopsis thaliana leads to reduced cellulose content and heightened susceptibility to S. sclerotiorum. Collectively, our data underscore the pivotal role of the novel cellobiohydrolase SsdchA in the pathogenicity of S. sclerotiorum.

关键词： Cellobiohydrolase Cellulose Pathogenicity Sclerotinia sclerotiorum Secretory protein SsdchA

Unstructured Big Data Threat Intelligence Parallel Mining Algorithm

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Big Data Mining and Analytics 2024年第2期7卷 531-546页

作者： Zhihua Li Xinye yu Tao Wei Junhao qian School of Artificial Intelligence and Computer Science Jiangnan UniversityWuxi 214122China School of IoT Engineering Jiangnan UniversityWuxi 214122China

To efficiently mine threat intelligence from the vast array of open-source cybersecurity analysis reports on the web,we have developed the Parallel Deep Forest-based Multi-Label Classification(PDFMLC)***,open-source cybersecurity analysis reports are collected and converted into a standardized text ***,five tactics category labels are annotated,creating a multi-label dataset for tactics *** the limitations of low execution efficiency and scalability in the sequential deep forest algorithm,our PDFMLC algorithm employs broadcast variables and the Lempel-Ziv-Welch(LZW)algorithm,significantly enhancing its acceleration ***,our proposed PDFMLC algorithm incorporates label mutual information from the established dataset as input *** captures latent label associations,significantly improving classification ***,we present the PDFMLC-based Threat Intelligence Mining(PDFMLC-TIM)*** results demonstrate that the PDFMLC algorithm exhibits exceptional node scalability and execution ***,the PDFMLC-TIM method proficiently conducts text classification on cybersecurity analysis reports,extracting tactics entities to construct comprehensive threat *** a result,successfully formatted STIX2.1 threat intelligence is established.

关键词： unstructured big data mining parallel deep forest multi-label classification algorithm threat intelligence

Gastric cancer immunotherapy:A scientometric and clinical trial review

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World Journal of Gastroenterology 2024年第2期30卷 196-198页

作者： qian-Cheng Du Xin-yu Wang Hua yu Thoracic Surgery Shanghai Xuhui Central HospitalShanghai 200031China Thyroid Breast and Vascular SurgeryShanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China Department of General Surgery Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China

This letter is intended to arouse your interest in a recent review of comprehensive scientometrics and clinical trials on immunotherapy for gastric cancer(GC).Our study reviews recent advances in immunotherapy in the field of GC and highlights its new prospects as a treatment for *** research reveals China’s leadership in this field,as well as new therapeutic strategies such as immune checkpoint inhibitors,cellular immunotherapy,and *** combined findings highlight the potential of immunotherapy to improve survival and quality of life in patients with stomach *** believe that this study will provide important guidance for the future direction of the GC treatment field.

关键词： Gastric cancer Immunotherapy Bibliometrics Comment Therapeutic strategies

High-speed railway track components inspection framework based on YOLOv8 with high-performance model deployment

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High-Speed Railway 2024年第1期2卷 42-50页

作者： Youzhi Tang yu qian Department of Civil and Environmental Engineering University of South CarolinaColumbia 29208USA

Railway inspection poses significant challenges due to the extensive use of various components in vast railway networks,especially in the case of high-speed *** networks demand high maintenance but offer only limited inspection *** response,this study focuses on developing a high-performance rail inspection system tailored for high-speed railways and railroads with constrained inspection *** system leverages the latest artificial intelligence advancements,incorporating YOLOv8 for *** research introduces an efficient model inference pipeline based on a producer-consumer model,effectively utilizing parallel processing and concurrent computing to enhance *** deployment of this pipeline,implemented using C++,TensorRT,float16 quantization,and oneTBB,represents a significant departure from traditional sequential processing *** results are remarkable,showcasing a substantial increase in processing speed:from 38.93 Frames Per Second(FPS)to 281.06 FPS on a desktop system equipped with an Nvidia RTX A6000 GPU and from 19.50 FPS to 200.26 FPS on the Nvidia Jetson AGX Orin edge computing *** proposed framework has the potential to meet the real-time inspection requirements of high-speed railways.

关键词： High-speed railway Track inspection Computer vision Deep learning Edge computing Real-time decision making

Design and discovery of a highly potent ultralong-acting GLP-1 and glucagon co-agonist for attenuating renal fibrosis

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1283-1301页

作者： qian Zhao Jiale dong Han Liu Hui Chen Huan yu Shuyin Ye Shuangjin yu yu Li Longhui Qiu Nazi Song Hongjiao Xu Qi Liu Zhiteng Luo yuyi Li Rui Wang Guodong Chen Xianxing Jiang School of Pharmaceutical Sciences Guangdong Provincial Key Laboratory of Chiral Molecule and Drug DiscoverySun Yat-sen UniversityGuangzhou 510006China Organ Transplant Center the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510006China Zhongshan School of Medicine Sun Yat-sen UniversityGuangzhou 510006China Shenzhen Turier Biotech.Co. Ltd.Shenzhen 518118China School of Life Sciences Key Laboratory of Preclinical Study for New Drugs of Gansu ProvinceSchool of Basic Medical Sciences&Research Unit of Peptide ScienceChinese Academy of Medical SciencesLanzhou UniversityLanzhou 730000China

The role of co-agonists of glucagon-like peptide-1 receptor(GLP-1R)and glucagon receptor(GCGR)in chronic kidney disease(CKD)remains *** we found that GLP-1R and GCGR expression levels were lower in the kidneys of mice with CKD compared to healthy mice and were correlated with disease ***,GLP-1R or GCGR knockdown aggravated the progression of kidney injury in both diabetic db/db mice and non-diabetic mice undergoing unilateral ureteral obstruction(UUO).Based on the importance of GLP-1R and GCGR in CKD,we reported a novel monomeric peptide,1907-B,with dual-agonism on both GLP-1R and *** data confirmed that 1907-B had a longer half-life than long-acting semaglutide in rats or cynomolgus monkeys(~2-3 fold)and exhibited better therapeutic contribution to CKD than best-in-class monoagonists,semaglutide,or glucagon,in db/db mice and UUO *** lock-of-function models,including selective pharmacological activation and genetic knockdown,confirmed that 1907-B’s effects on ameliorating diabetic nephropathy in db/db mice,as well as inhibiting kidney fibrosis in UUO mice,were mediated through GLP-1 and glucagon *** findings highlight that 1907-B,a novel GLP-1R and GCGR co-agonist,exerts multifactorial improvement in kidney injuries and is an effective and promising therapeutic option for CKD treatment.

关键词： GLP-1 receptor Glucagon receptor Chronic kidney disease Diabetic nephropathy Kidney fibrosis Dual-agonism

Mechanical properties and thermal deformation behavior of low-cost titanium matrix composites prepared by a structure-optimized Y_(2)O_(3) crucible

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Journal of Iron and Steel Research International 2024年第3期31卷 738-751页

作者： qian Dang Gang Huang Ye Wang Chi Zhang Guo-huai Liu Zhao-dong Wang The State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819LiaoningChina School of Materials Science and Chemical Engineering Harbin University of Science and TechnologyHarbin 150004HeilongjiangChina School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870LiaoningChina

A porous yttrium oxide crucible with both thermal shock resistance and erosion resistance was developed by structural *** structure-optimized yttrium oxide crucible was proved to be suitable for melting highly reactive titanium ***-cost(TiB+Y2O_(3))-reinforced titanium matrix composites were prepared by vacuum induction melting using the prepared *** thermal deformation behavior and microstructure evolution of(TiB+Y2O_(3))-reinforced tita-nium matrix composites were investigated at deformation temperatures of 900-1100℃with strain rates of 0.001-1 *** results showed that the prepared yttrium oxide crucible had both thermal shock and erosion resistance,the low-cost titanium matrix composites could be prepared by the developed yttrium oxide crucibles which were homogeneous in composition and highly sensitive to strain rate and deformation temperature,and the peak and theological stresses decreased with increasing deformation temperature or decreasing strain *** addition,the average thermal deformation activation energy of the composites was calculated to be 574.6 kJ/mol by establishing the Arrhenius constitutive equation in consideration of the strain variables,and the fitting goodness between the predicted stress value and the measured value was 97.624%.The calculated analysis of the hot processing map showed that the best stable thermal deformation zone was located in the deformation temperature range of 1000-1100℃and strain rate range of 0.001-0.01 s^(-1),where the peak dissipation coefficient wasη=71%.In this zone,the deformation of the reinforcement and matrix was harmonious,the reinforcement was less likely to fracture,dynamic recrystallization occurred more fully and the alloy exhibited near steady rheological characteristics.

关键词： Yttrium oxide crucible Titanium matrix composite Thermal deformation behavior Constitutive equation Hot processing map Microstructure evolution

An improved positioning model of deep-seafloor datum point at large incidence angle

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Journal of Oceanology and Limnology 2024年第1期42卷 90-100页

作者： qianqian LI Shoulian CAO Fanlin YANG yu LUO qian TONG College of Underwater Acoustic Engineering Harbin Engineering UniversityHarbin 150000China College of Geodesy and Geomatics Shandong University of Science and TechnologyQingdao 266590China Key Laboratory of Ocean Geomatics Ministry of Natural ResourcesQingdao 266590China

The inhomogeneous sound speed in seawater causes refraction of sound waves,and the elimination of the refraction effect is essential to the accuracy of underwater acoustic *** raytracing method is an indispensable tool for effectively handling ***,this method has a conflict between localization accuracy and computational *** equivalent sound speed profile(ESSP)method uses a simple sound speed profile(SSP)instead of the actual complex SSP,which can improve positioning precision but with residual *** residual error is especially non-negligible in deep water and at large beam incidence *** analyzing the residual error of the ESSP method through a simulation,an empirical formula of error is *** data collected in the sailing circle mode(large incidence angle)of the South China Sea are used for *** experiments show that compared to the ESSP method,the improved algorithm has higher positioning precision and is more efficient than the ray-tracing method.

关键词： underwater acoustic positioning seafloor datum points large incident angle equivalent sound speed profile(ESSP) deep water