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Surgical management of fungal endophthalmitis resulting from fungal keratitis

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International Journal of Ophthalmology(English edition) 2016年第6期9卷 848-853页

作者： Yan Gao Nan Chen Xiao-Guang dong gong-Qiang yuan Bin yu Li-Xin Xie Qingdao University Medical College Qingdao 266071Shandong ProvinceChina Qingdao Eye Hospital Shandong Eye InstituteShandongAcademy of Medical SciencesQingdao 266071Shandong ProvinceChina Shandong Eye Hospital Shandong Eye InstituteShandongAcademy of Medical SciencesJinan 250021Shandong ProvinceChina

AIM： To report the fungal organisms, clinical features, surgical treatment strategies, and outcomes of patients with culture-proven exogenous fungal endophthalmitis （EFE） secondary to keratitis, and evaluate the role of surgery in the treatment. METHODS： The clinical records of 27 patients （27 eyes） with culture-proven EFE resulting from fungal keratitis treated at Shandong Eye Institute from January 2007 to January 2015 were retrospectively reviewed. Information about fungal culture results, clinical features, surgical procedures, and final visual acuity was obtained. RESULTS： There were 39 positive culture results from samples of cornea, hypopyon, vitreous and lens capsule, accounting for 56%, 26%, 15% and 2.5%, respectively. Fusarium was identified in 44% （12/27） of the eyes, followed by Aspergillus in 22% （6/27）. Posterior segment infection was involved in 78% （21127） of the patients. The corneal infection was larger than 3 mmx3 mm in 89% （24/ 27） of the patients, and 22% （6/27） of them had the entire cornea, and even the sclera involved. Three eyes had silicone oil tamponade, and two eyes had retinal detachment. Twenty-two eyes （81.5%） underwent penetrating keratoplasty （PKP）, and over half of them （545%） were operated within 3d from the onset of antifungal therapy. Fourteen eyes （52%） underwent intracameral antifungal drug injection, and three of them required repeated injections. Fifteen eyes （55.6%） underwent pars plana vitrectomy （PPV）. The rate of the eyes undergoing PPV as the initial surgical procedure was 60% （9/15）, lower than 77% in PKP. Intravitreal injection was given in 59% of the eyes （16/27）, and 75% of them required repeated injections. The final visual acuity was 20/100 or better in 37% of the eyes, and better than counting fingers in 55.6% of the eyes. Five eyes （18.5%） were eviscerated. In the two eyes with concurrent retinal detachment, one achieved retinal reattachment, and the other was eviscerated. In the three eyes with silicone oil ta

关键词： exogenous fungal endophthalmitis fungalkeratitis penetrating keratoplasty vitrectomy antifungaltherapy retinal detachment surgery

High-dimensional quantum information processing on programmable integrated photonic chips

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Science China(Information Sciences) 2023年第8期66卷 5-22页

作者： yulin CHI yue yu Qihuang gong Jianwei WANG State Key Laboratory for Mesoscopic Physics School of Physics Peking University Frontiers Science Center for Nano-optoelectronics and Collaborative Innovation Center of Quantum Matter Peking University Peking University Yangtze Delta Institute of Optoelectronics Collaborative Innovation Center of Extreme Optics Shanxi University Hefei National Laboratory

This study reviews the recent progress of high-dimensional quantum information processing with photons. We first introduce the basic language of high-dimensional quantum information, including the representation of quantum dits(qudits), unitary operations of qudit states, and the general format of quantum algorithms with qudits. We discuss experimental implementations of high-dimensional quantum information processing and quantum computing in photonic systems, particularly in integrated quantum photonic platforms. We also discuss how qudit-based quantum photonic devices and systems can be adopted for further improving qubit-based quantum computation and quantum simulation.

关键词： high-dimensional quantum information processing quantum computation integrated quantum photonics

Temperature/salt tolerance and oil recovery of xanthan gum solution enhanced by surface-modified nanosilicas

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Petroleum Science 2023年第1期20卷 577-589页

作者： Long Xu Xu Liu Hong-yu Ding Huan Zhang Lei Liu Jing-Hui Li Hou-Jian gong Ming-Zhe dong Shandong Key Laboratory of Oilfield Chemistry School of Petroleum EngineeringChina University of Petroleum(East China)QingdaoShandong266580China Key Laboratory of Unconventional Oil&Gas Development(China University of Petroleum(East China)) Ministry of EducationQingdaoShandong266580China Northwest Company of China Petroleum and Chemical Corporation SINOPECUrumqiXinjiang830011China

Amide-and alkyl-modified nanosilicas(AANPs)were synthesized and introduced into Xanthan gum(XG)solution,aiming to improve the temperature/salt tolerance and oil *** rheological behaviors of XG/AANP hybrid dispersions were systematically studied at different concentrations,temperatures and inorganic *** high temperature(75C)and high salinity(10,000 mg,L1 NaCl),AANPs increase the apparent viscosity and dynamic modulus of the XG solution,and XG/AANP hybrid dispersion exhibits elastic-dominant *** most effective concentrations of XG and AANP interacting with each other are 1750 mg·L^(-1) and 0.74 wt%,*** temperature tolerance of XG solution is not satisfactory,and high temperature further weakens the salt tolerance of ***,the AANPs significantly enhance the viscoelasticity the XG solution through hydrogen bonds and hydrophobic *** reservoir conditions,XG/AANP hybrid recovers approximately 18.5%more OOIP(original oil in place)than AANP and 11.3%more OOIP than *** enhanced oil recovery mechanism of the XG/AANP hybrid is mainly increasing the sweep coefficient,the contribution from the reduction of oil-water interfacial tension is less.

关键词： Temperature/salt tolerance Rheology Surface-modified nanosilicas Xanthan gum Enhanced oil recovery Synergy

Co-templating Ionothermal Synthesis and Crystal Structure of a New Layered Aluminophosphate from a Protic Deep Eutectic Solvent

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Chinese Journal of Chemistry 2016年第4期34卷 419-424页

作者： yuan Li Xiangdong gong Lei Liu Jinxiang dong Research Institute of Special Chemicals Taiyuan University of Technology Taiyuan Shanxi 030024 China

Protic deep eutectic mixtures are usually composed of organic amine hydrochloride salts and hydrogen bond donors in a specific molar ratio. Ionothermal synthesis of aluminophosphate as an example, herein, was reported for the first time from an urea-based protic eutectic mixture, consisting of diethylammonium chloride （DEACI） and 1,3-dimethyl urea （DMU）. As a result, a new two dimensional aluminophosphate with 4.8-network, [CH3NH3]2[（C2H5）2NH2]Al3（PO4）4, has been successfully synthesized by co-templating the DEA and methylamine in situ generated from the decomposition of DMU in the absence of HF. Compared to alkyl quaternary ammonium salts with more alkyl-group connected with N atom, this kind of organic amine salts are more likely as the struc- ture-directing agents to synthesize aluminophosphates in urea-based deep eutectic mixtures. It was also found that HF is crucial to the phase selectivity, a known compound with chain-like structure was obtained with the single methylamine as a structure-directing agent in the presence of HF. These materials were characterized by powder XRD, SEM, TG-DSC, 13C CP-MAS NMR and CHN analyses.

关键词： structure-directing agent ionothermal synthesis deep eutectic solvent crystal structure

Nonlinear optics in the electron-hole continuum in 2D semiconductors:two-photon transition, second harmonic generation and valley current injection

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Science Bulletin 2019年第15期64卷 1036-1043页

作者： Pu gong Hongyi yu Yong Wang Wang Yao Department of Physics and Center of Theoretical and Computational Physics The University of Hong KongHong KongChina School of Physics Nankai UniversityTianjin 300350China

We investigate two-photon transitions to the electron-hole scattering continuum in monolayer transition-metal dichalcogenides, and identify two contributions to this nonlinear optical process with opposite circularly polarized valley selection rules. In the non-interacting limit, the competition between the two contributions leads to a crossover of the selection rule with the increase of the two-photon energy. With the strong Coulomb interaction between the electron and hole, the two contributions excite electron-hole scattering states in orthogonal angular momentum channels, while the strength of the transition can be substantially enhanced by the interaction. Based on this picture of the two-photon transition, the second harmonic generation(SHG) in the electron-hole continuum is analyzed, where the Coulomb interaction is shown to greatly alter the relative strength of different cross-circular polarized SHG processes. Valley current injection by the quantum interference of one-photon and two-photon transition is also investigated in the presence of the strong Coulomb interaction, which significantly enhances the injection rate.

关键词： 2D semiconductors Nonlinear optics Electron-hole continuum Two-photon transition Second-harmonic generation Valley current injection

Internal Structure of Cambrian Fossil Embryo Markuelia Revealed in the Light of Synchrotron Radiation X-ray Tomographic Microscopy

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Acta Geologica Sinica(English Edition) 2011年第1期85卷 81-90页

作者： CHENG gong PENG Fan DUAN Baichuan dong Xiping School of Earth and Space Sciences Peking University Beijing 100871 China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and Palaeontology Chinese Academy of Sciences Nanjing 210008 China

In the light of Synchrotron Radiation X-ray Tomographic Microscopy （SRXTM）, the internal structure of Markuelia hunanensis is revealed. In one example, vitrification and peeling show the annuli hidden under the chorion. Sectioning and 3-D reconstruction display an intact digestive tract from the inverted introvert to the terminal anus. The inverted introvert forms a rugby cavum. The following digestive tract is rope-like coiling, parallel to the body axis, about 650 μm in length, and uniform in diameter （-80 μm）. An exquisitely preserved pipe-like structure is hidden in the middle of the rope-like structure, diameter 20--40 lam, with a length of -120 μm. We interpret this pipe-like structure as the possible epidermis of the gut and its surroundings as the possible residue of musculature, similar to that in Priapulans. The two symmetrical rod-shape structures connecting the body wall and digestive tract are interpreted as the possible retractor muscles. After comparing the well preserved Left-form and Right-form Body of Markuelia, we suggest that they may represent a dimorphism. Counted directly, one sample of Markuelia hunanensis possesses 62 annulations and the other 68.

关键词： Markuelia Synchrotron Radiation X-ray Tomographic Microscopy (SRXTM),dimorphism

Microhydration of Alanine in Gas Phase Studied by Quantum Chemical Method and ABEEMσπ~/MM Fluctuating Charge Model

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Chemical Research in Chinese Universities 2013年第2期29卷 344-350页

作者： LU Li-nan LIU Cui gong Li-dong Chemistry and Chemical Engineering Faculty Liaoning Normal University Dalian 116029 P. R. China

A fluctuating charge interaction potential function for alanine-water was constructed in the spirit of newly developed ABEEMax/MM（atom-bond electronegativity equalization method at the azc level fused into molecular mechanics）. The properties of gaseous neutral alanine-（H20）n（n=l--7） clusters were systematically investigated by quantum mechanics（QM） and the constructed ABEEMax/MM potential, such as conformations, hydrogen bonds （H-bonds）, interaction energies, charge distributions, and so on. The results of ABEEM^rrc/MM model are in fair agreement with those of QM and available experimental data. For isolated alanine, compared with those of experi- mental structure, the average absolute deviations（AAD） of bond length and bond angle are 0.002 nm and 1.4~, re- spectively. For alanine-water clusters, the AAD of interaction energies and H-bond lengths are only 3.77 kJ/mol and 0.012 nm, respectively, compared to the results of MP2/aug-cc-pVDZ//MP2/6-31 I＋G＊＊ method. The ABEEMa charges fluctuate with the changing conformation of the system, and can accurately and reasonably reflect the inter- polarization between water and alanine. The presented alanine-water potential function may provide a basis for fur- ther simulations on related aqueous solutions ofbiomolecules.

关键词： Alanine-water cluster ABEEMazc/MM fluctuating charge model Quantum chemical calculation Hydrogenbond Interaction energy

Microstructure and Stress-Rupture Property of Large-Scale Complex Nickel-Based Single Crystal Casting

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Acta Metallurgica Sinica(English Letters) 2018年第8期31卷 887-896页

作者： Min Huang gong Zhang dong Wang Jia-Sheng dong Li Wang Lang-Hong Lou Institute of Metal Research Chinese Academy of SciencesShenyang 110016China University of Chinese Academy of Sciences Beijing 100049China

The microstructure and stress-rupture property of the large-scale complex single crystal（SX） casting DD10 were investigated in high-rate solidification process. It is found that the primary dendrite arm spacing（PDAS） does not increase monotonically with the height increase. When across the platform, the temperature gradient increases due to the effect of platform, and the corresponding PDAS decreases. The distribution of eutectic volume fraction in large-scale complex SX casting is affected by PDAS, solid back diffusion, and the development of high order dendrites. The eutectic volume fraction contained in the sample taken below the platform decreases with the height increase. While the eutectic volume fraction contained in the sample taken upper the platform increases gradually with the height increase. After heat treatment,most of the γ/γ＇ eutectics are eliminated and the components are distributed uniformly. The similar stress rupture properties of the samples at different heights in the same direction are obtained.

关键词： Large-scale single crystal Platform Primary dendrite arm spacing Eutectic volume fraction Stress-rupture property

Contribution of phylogenetics to understanding the evolution and epidemiology of dengue virus

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Animal Models and Experimental Medicine 2022年第5期5卷 410-417页

作者： Xi yu gong Cheng Tsinghua-Peking Center for Life Sciences School of MedicineTsinghua UniversityBeijingChina Institute of Infectious Diseases Shenzhen Bay LaboratoryShenzhenChina Institute of Pathogenic Organisms Shenzhen Center for Disease Control and PreventionShenzhenChina School of Life Sciences Tsinghua UniversityBeijingChina

Dengue virus(DENV)is one of the most important arboviral pathogens in the tropics and subtropics,and nearly one-third of the world's population is at risk of *** transmission of DENV involves a sylvatic cycle between nonhuman primates(NHP)and Aedes genus mosquitoes,and an endemic cycle between human hosts and predominantly Aedes *** belongs to the genus Flavivirus of the family Flaviviridae and consists of four antigenically distinct serotypes(DENV-1-4).Phylogenetic analyses of DENV have revealed its origin,epidemiology,and the drivers that determine its molecular evolution in *** review discusses how phyloge-netic research has improved our understanding of DENV evolution and how it affects viral ecology and improved our ability to analyze and predict future DENV emergence.

关键词： dengue virus(DENV) evolution flavivirus phylogenetics