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Bioenergetic alteration in gastrointestinal cancers:The good,the bad and the ugly

World Journal of Gastroenterology 2023年第29期29卷 4499-4527页

作者： yu-de chu chun-Wei Chen Ming-Wei Lai Siew-Na Lim Wey-Ran Lin Liver Research Center Linkou Chang Gung Memorial HospitalTaoyuan 333TaiwanChina department of Gastroenterology and Hepatology Linkou Chang Gung Memorial HospitalTaoyuan 333TaiwanChina department of Pediatrics Linkou Chang Gung Memorial HospitalTaoyuan 333TaiwanChina department of Neurology Linkou Chang Gung Memorial HospitalTaoyuan 333TaiwanChina department of Medicine Chang Gung UniversityTaoyuan 333TaiwanChina

Cancer cells exhibit metabolic reprogramming and bioenergetic alteration,utilizing glucose fermentation for energy production,known as the Warburg ***,there are a lack of comprehensive reviews summarizing the metabolic reprogramming,bioenergetic alteration,and their oncogenetic links in gastrointestinal(GI)***,the efficacy and treatment potential of emerging anticancer drugs targeting these alterations in GI cancers require further *** review highlights the interplay between aerobic glycolysis,the tricarboxylic acid(TCA)cycle,and oxidative phosphorylation(OXPHOS)in cancer cells,as well as hypotheses on the molecular mechanisms that trigger this *** role of hypoxia-inducible transcription factors,tumor suppressors,and the oncogenetic link between hypoxia-related enzymes,bioenergetic changes,and GI cancer are also *** review emphasizes the potential of targeting bioenergetic regulators for anti-cancer therapy,particularly for GI *** the potential of targeting bioenergetic regulators for GI cancer therapy,the review categorizes these regulators into aerobic glycolysis/lactate biosynthesis/transportation and TCA cycle/coupled *** also detail various anti-cancer drugs and strategies that have produced pre-clinical and/or clinical evidence in treating GI cancers,as well as the challenges posed by these *** we highlight that understanding dysregulated cancer cell bioenergetics is critical for effective treatments,although the diverse metabolic patterns present challenges for targeted *** research is needed to comprehend the specific mechanisms of inhibiting bioenergetic enzymes,address side effects,and leverage high-throughput multi-omics and spatial omics to gain insights into cancer cell heterogeneity for targeted bioenergetic therapies.

关键词： Energy metabolism Mitochondria Hypoxia Oxidative phosphorylation Glycolysis Gastrointestinal neoplasms

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Perception field based imitation learning for unlabeled multi-agent pathfinding

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Science China(Information Sciences) 2024年第5期67卷 115-135页

作者： Wenjie chu Ailun yu Wei ZHANG Haiyan ZHAO Zhi JIN School of Computer Science Peking University Key Laboratory of High-Confidence Software Technologies (Peking University) Ministry of Education

This paper proposes an imitation learning method to learn a universal agent policy for unlabeled multi-agent pathfinding(unlabeled MAPF) in grid environments. The method transforms the unlabeled MAPF problem into a series of temporal-independent homogeneous classification problems for each *** on this transformation, a neural network is designed to imitate a distance-optimal expert *** neural network consists of two successive modules: perception field learner and field integrating *** former refines and encodes the current system state into a perception field for each agent by combining a set of learnable field-generating functions. The latter takes an agent's perception field as input and decides the agent's next action based on a triplet cross-attention mechanism. We evaluate our method on a diverse set of unlabeled MAPF tasks. Compared with state-of-the-art counterparts, the experimental results manifest the superiority of the proposed method in both generalization ability and scalability.

关键词： unlabeled multi-agent pathfinding perception field triplet cross-attention multi-agent imitation learning learning-based planning

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developing risk models and subtypes of autophagy-associated LncRNAs for enhanced prognostic prediction and precision in therapeutic approaches for liver cancer patients

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Oncology Research 2024年第4期32卷 703-716页

作者： LU ZHANG JINGUO chu yuSHAN yu department of General Practice The First Affiliated Hospital of Ningbo UniversityNingboChina

Background:Limited research has been conducted on the influence of autophagy-associated long non-coding RNAs(ARLncRNAs)on the prognosis of hepatocellular carcinoma(HCC).Methods:We analyzed 371 HCC samples from TCGA,identifying expression networks of ARLncRNAs using autophagy-related *** for prognostically relevant ARLncRNAs involved univariate Cox regression,Lasso regression,and multivariate Cox regression.A Nomogram was further employed to assess the reliability of Riskscore,calculated from the signatures of screened ARLncRNAs,in predicting ***,we compared drug sensitivities in patient groups with differing risk levels and investigated potential biological pathways through enrichment analysis,using consensus clustering to identify subgroups related to ***:The screening process identified 27 ARLncRNAs,with 13 being associated with HCC ***,a set of signatures comprising 8 ARLncRNAs was successfully constructed as independent prognostic factors for *** in the high-risk group showed very poor prognoses in most clinical *** Riskscore was closely related to immune cell scores,such as macrophages,and the deGs between different groups were implicated in metabolism,cell cycle,and mitotic ***,high-risk group patients demonstrated a significantly lower IC50 for Paclitaxel,suggesting that Paclitaxel could be an ideal treatment for those at elevated risk for *** further identified C2 as the Paclitaxel subtype,where patients exhibited higher Riskscores,reduced survival rates,and more severe clinical ***:The 8 signatures based on ARLncRNAs present novel targets for prognostic prediction in *** drug candidate Paclitaxel may effectively treat HCC by impacting ARLncRNAs *** the identification of ARLncRNAsrelated isoforms,these results provide valuable insights for clinical exploration of autophagy mechanisms in HCC pathogenesis and offer potential av

关键词： Autophagy Hepatocellular carcinoma(HCC) Prognosis Precision medicine Paclitaxel

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Atomic-level insights into the initial oxidation mechanism of high-entropy diborides by first-principles calculations

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Journal of Materiomics 2024年第2期10卷 423-430页

作者： Yiwen Liu Hulei yu Hong Meng Yanhui chu School of Materials Science and Engineering South China University of TechnologyGuangzhou510641China

Understanding the initial oxidation mechanism is critical for studying the oxidation resistance of high-entropy ***,related studies are ***,the initial oxidation mechanism of(Zr_(0.25)Ti_(0.25)Nb_(0.25)Ta_(0.25))B_(2)high-entropy diborides(HEB_(2)-1)is investigated by first-principles calculations at the atomic *** employing the two-region model method,the most stable surface of HEB_(2)-1 is determined to be(1120)*** dissociative adsorption process of the oxygen molecule on the HEB_(2)-1-(1120)surface is predicted to proceed spontaneously,where OeO bond breaks and each oxygen atom is chemisorbed on the most preferable hollow *** adsorption energy and the diffusion barrier of the oxygen atom on the(1120)surface of HEB_(2)-1 are in the vicinity of the average level of the cor-responding four individual *** addition,ab initio molecular dynamics simulations indicate a high initial oxidation resistance of HEB_(2)-1 at 1000 *** results are beneficial to further designing the high-entropy diborides with excellent oxidation resistance.

关键词： High-entropy diborides Oxidation First-principles calculations

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Bioinspired Polarized Optical Flow Enables Turbid Underwater Target Motion Estimation

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Journal of Ocean University of China 2024年第4期23卷 915-923页

作者： CHENG Haoyuan ZHAO Shujie ZHU Jinchi yu Hao chu Jinkui College of Engineering Ocean University of ChinaQingdao 266100China Key Laboratory for Micro/Nano Technology and System of Liaoning Province Dalian University of TechnologyDalian 116024China

Underwater target motion estimation is a challenge for ocean military and scientific *** this work,we propose a method based on the combination of polarization imaging and optical flow for turbid underwater target *** imaging can reduce the influence of backscattered light and obtain high-quality images *** optical flow shows the motion and structural information of the *** use polarized optical flow to obtain the optical flow field and estimate the target *** experimental results of different targets under varying water turbidity levels illustrate that our method is realizable and *** precision is verified by comparing the results with the precise displacement data and calculating two error *** proposed method based on polarized optical flow can obtain accurate displacement information and a good recognition *** target segmentation based on the Otsu method further proves the superiority of the polarized optical flow under turbid *** study is valuable for target detection and motion estimation in scattering environments.

关键词： turbid underwater motion estimation polarization imaging optical flow

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Data-driven discovery of formation ability descriptors for high-entropy rare-earth monosilicates

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Journal of Materiomics 2024年第3期10卷 738-747页

作者： Hong Meng Peng Wei Zhongyu Tang Hulei yu Yanhui chu School of Materials Science and Engineering South China University of TechnologyGuangzhou510641China

Herein we establish formation ability descriptors of high-entropy rare-earth monosilicates(HEREMs)via the data-driven discovery based on the high-throughput solid-state reaction and machine learning(ML)***,adequate high-quality data are generated with 132 samples synthesized by the self-developed high-throughput solid-state reaction apparatuses,and 30 potential descriptors are considered in ML *** classifications are proposed to study the phase formation of HEREMs via the ML approach combined with the genetic algorithm:(Ⅰ)to distinguish pure HEREMs(X)from other phases and(Ⅱ)to categorize the detail phases of HEREMs(X2,X1,or X2+X1).Four formation ability descriptors(r_(Me),EF,d_(Eg),and d_(Z*))with a high validation accuracy(96.2%)are proposed as the optimal combination for Classification I,where a smaller r_(Me)is determined to have the most significant influence on the formation of *** ClassificationⅡ,a 100%validation accuracy is achieved by using only two formation ability descriptors(rion and d_(Z*)),where the rion is analyzed to be the dominant feature and a lower rion is beneficial to the formation of *** on our established formation ability descriptors,6,045 unreported multicomponent silicates are explored,and 3,478 new HEREMs with 2,700 X2-and 423 X1-HEREMs are predicted.

关键词： High-entropy rare-earth monosilicates Formation ability descriptors High-throughput experiments Machine learning

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High-performance Bi_(2)S_(3)/ZnO photoanode enabled by interfacial engineering with oxyanion for efficient photoelectrochemical water oxidation

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Nano Research 2024年第7期17卷 5996-6005页

作者： Ying-chu Chen Hsiang-yu Jui Yichen Feng yun-Hsiang Lu yu-Kuei Hsu department of Chemical Engineering&Biotechnology "National Taipei University of Technology"No.1Sec.3Zhong-Xiao E.Rd.Da'an Dist.Taipei City 10608TaiwanChina department of Opto-Electronic Engineering "National Dong Hwa University"No.1Sec.2Da Hsueh RoadShoufengHualien 97401TaiwanChina China-UK Low Carbon College Shanghai Jiao Tong UniversityNo.3Yinlian RoadLingangShanghai 201306China

In the present contribution,we demonstrate that the sluggish kinetics of oxygen evolution reaction(OER)over the bismuth sulfide(Bi_(2)S_(3))photoanode,which severely restricts its photoelectrochemical activity,is markedly accelerated by employing a sulfatecontaining ***-principle calculation points to the spontaneous adsorption of sulfate(SO_(4)^(2−))on Bi_(2)S_(3)and its capacity of stabilizing the OER intermediates through hydrogen bonding,which is further reinforced by increasing the local density of states near the Fermi level of Bi_(2)S_(3).Meanwhile,the electron transfer is also promoted to synergistically render the ratedetermining step(from O*to OOH*)of OER over Bi_(2)S_(3)kinetically *** but not least,benefitting from such enhanced OER activity and efficient charge separation resulted from depositing Bi_(2)S_(3)on the zinc oxide nanorods(ZnO NRs),forming a core–shell heterojunction,its photocurrent density achieves 8.61 mA·cm^(−2)at 1.23 VRHE,far surpassing those reported for additional Bi_(2)S_(3)-based and several state-of-the-art photoanodes in the literature and further exceeding their theoretical *** great promise of the Bi_(2)S_(3)/ZnO NRs is in view of such outperformance,the superior Faradaic yield of oxygen of more than~80%and the outstanding half-cell applied bias photon-to-current efficiency of~1%well corroborated.

关键词： photoelectrochemical water oxidation oxyanion adsorption electronic structure regulation oxygen evolution reaction(OER)intermediates stabilization Bi_(2)S_(3)

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Investigation of the active ingredients and mechanism of Shuangling extract in dextran sulfate sodium salt induced ulcerative colitis mice based on network pharmacology and experimental verification

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Journal of Traditional Chinese Medicine 2024年第3期44卷 478-488页

作者： chu Mengzhen WANG yu LIN Zhijian Lyu Jintao ZHANG Xiaomeng ZHANG Bing department of Clinical Chinese Pharmacy School of Chinese Materia MedicaBeijing University of Chinese MedicineBeijing 102488China

OBJECTIVE: To explore the pharmacodynamic effects and potential mechanisms of Shuangling extract against ulcerative colitis(UC). METHODS: The bioinformatics method was used to predict the active ingredients and action targets of Shuangling extract against UC in mice. And the biological experiments such as serum biochemical indexes and histopathological staining were used to verify the pharmacological effect and mechanism of Shuangling extract against UC in mice. RESULTS: The Shuangling extract reduced the levels of seruminterleukin-1β(IL-1β), tumor necrosis factor-α(TNF-N), interleukin-6(IL-6) and other inflammatory factors in UC mice and inhibited the inflammatory response. AKT Serine/threonine Kinase 1 and IL-6 may be the main targets of the anti-UC action of Shuangling extract, and the TNF signaling pathway, Forkhead box O signaling pathway and T-cell receptor signaling pathway may be the main signaling pathways. CONCLUSION: The Shuangling extract could inhibit the inflammatory response induced by UC and regulate intestinal immune function through multiple targets and multiple channels, which provided a new option and theoretical basis for anti-UC.

关键词： colitis ulcerative pharmacodynamic study network pharmacology molecular docking simulation Shuangling extract

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River width and depth as key factors of diurnal activity energy expenditure allocation for wintering Spot-billed Ducks in the Xin'an River Basin

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Avian Research 2024年第1期15卷 116-122页

作者： Chao yu Xuying Lu deli Sun Mengnan chu Xueyun Li Qun Li College of Life and Environmental Sciences Huangshan UniversityHuangshan245021China Environment Conservation Research Centre of Xin’an River Basin Huangshan UniversityHuangshan 245021China department of Resources Conservation Southern Anhui National Wildlife Rescue CenterXiuning 245400China

Rivers are important habitats for wintering ***,they are easily influenced by natural and human *** important approach for waterbirds to adapt to habitats is adjusting the activity time and energy expenditure allocation of diurnal *** compensatory foraging hypothesis predicts that increased energy expenditure leads to longer foraging time,which in turn increases food intake and helps maintain a constant energy ***,it is unclear whether human-disturbed habitats result in increased energy expenditure related to safety or *** this study,the scan sample method was used to observe the diurnal behavior of the wintering Spot-billed Duck(Anas poecilorhyncha) in two rivers in the Xin’an River Basin from October 2021 to March *** allocation of time and energy expenditure for activity in both normal and disturbed environments was *** results showed that foraging accounted for the highest percentage of time and energy ***,foraging decreased in the disturbed environment than that in the normal *** behavior showed the opposite trend,while other behaviors were similar in both *** total diurnal energy expenditure of ducks in the disturbed environment was greater than that in the normal environment,with decreased foraging and resting time percentage and increased behaviors related to immediate safety(swimming and alert) and *** results oppose the compensatory foraging hypothesis in favor of increased *** optimal diurnal energy expenditure model included river width and water depth,which had a positive relationship;an increase in either of these two factors resulted in an increase in energy *** study provides a better understanding of energy allocation strategies underlying the superficial time allocation of wintering waterbirds according to environmental *** these changes can help understand the maximum fitness of wi

关键词： Diurnal behavior activities River factors Time and energy expenditure allocation Wintering Spot-billed Duck Xin’an River Basin

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Unveiling the Contribution of Lactic Acid to the Passivation Behavior of Ti-6Al-4V Fabricated by Laser Powder Bed Fusion in Hank’s Solution

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Acta Metallurgica Sinica(English Letters) 2024年第1期37卷 102-118页

作者： yu-Hang chu Liang-yu Chen Bo-yuan Qin Wenbin Gao Fanmin Shang Hong-yu Yang Lina Zhang Peng Qin Lai-Chang Zhang School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang212100China Foshan(Southern China)Institute for New Materials Foshan528200China Key Laboratory of Automobile Materials Ministry of Education and Department of Materials Science and EngineeringJilin UniversityChangchun130025China Centre for Advanced Materials and Manufacturing School of EngineeringEdith Cowan University270 Joondalup DriveJoondalupPerthWA6027Australia

In actual physiological environments,bacteria can activate the immune system and release lactic ***,the detailed contribution of lactic acid to the passivation behavior of titanium(Ti)alloys is still *** current work investigated the in vitro passivation behavior of Ti-6Al-4V(TC4)alloys fabricated by laser powder bed fusion in Hank's solution with and without adding lactic *** methods,inductively coupled plasma atomic emission spectrometer,and X-ray photoelectron spectroscopy were jointly *** lactic acid decreases the corrosion resistance of samples by degrading the formed passive *** film formed in the(lactic acid)-containing solution exhibits a higher level of oxygen vacancies and a lower thickness,attributed to the suppressed formation of Ti^(4+)transformed from Ti^(3+)and Ti^(2+).Moreover,the presence of lactic acid would increase the open circuit potential,relieve the ions release,and hinder the deposition of calcium phosphates within 24 h immersion.

关键词： Titanium alloy Corrosion behavior Passive film Lactic acid Laser powder bed fusion

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