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Role of metabolic dysfunction and inflammation along the liver-brain axis in animal models with obesity-induced neurodegeneration

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Neural Regeneration Research 2025年第4期20卷 1069-1076页

作者： Evridiki Asimakidou Eka Norfaishanty Saipuljumri Chih hung Lo Jialiu Zeng Department of Clinical Neurosciences University of CambridgeCambridgeUK School of Applied Science Republic PolytechnicSingaporeSingapore Lee Kong Chian School of Medicine Nanyang Technological UniversitySingaporeSingapore

The interaction between metabolic dysfunction and inflammation is central to the development of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s ***-related conditions like type 2 diabetes and non-alcoholic fatty liver disease exacerbate this *** lipid accumulation,particularly in the liver,initiates a cascade of inflammatory processes that extend to the brain,influencing critical metabolic regulatory *** and palmitate,key lipid components,along with lipid transporters lipocalin-2 and apolipoprotein E,contribute to neuroinflammation by disrupting blood–brain barrier integrity and promoting *** insulin resistance further exacerbates brain insulin resistance and *** interventions targeting peripheral lipid metabolism and insulin signaling pathways have shown promise in reducing neuroinflammation in animal ***,translating these findings to clinical practice requires further investigation into human *** conclusion,metabolic dysfunction,peripheral inflammation,and insulin resistance are integral to neuroinflammation and *** these complex mechanisms holds potential for identifying novel therapeutic targets and improving outcomes for neurodegenerative diseases.

关键词： Alzheimer’s disease inflammatory cytokines insulin resistance lipid

Scattering Phase Correction for Semiclassical Quantization Rules in Multi-Dimensional Quantum Systems

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Communications in Theoretical Physics 2010年第2期53卷 250-256页

作者： HUANG Wen-Min MOU chung-yu CHANG Cheng-hung Department of Physics National Tsing-Hua University Hsinchu Taiwan physics Division National Center for Theoretical Sciences Hsinchu Taiwan Institute of Physics National Chiao Tung University Hsinchu Taiwan Institute of Mathematical Modeling and Scientific Computing National Chiao Tung University Hsinchu Taiwan

While the scattering phase for several one-dimensional potentials can be exactly derived, less is known in multi-dimensional quantum systems. This work provides a method to extend the one-dimensional phase knowledge to multi-dimensional quantization rules. The extension is illustrated in the example of Bogomolny＇s transfer operator method applied in two quantum wells bounded by step potentials of different heights. This generalized semiclassical method accurately determines the energy spectrum of the systems, which indicates the substantial role of the proposed phase correction. Theoretically, the result can be extended to other semiclassical methods, such as Gutzwiller trace formula, dynamical zeta functions, and semielassical Landauer Buttiker formula. In practice, this recipe enhances the applicability of semiclassical methods to multi-dimensional quantum systems bounded by general soft potentials.

关键词： Bogomolny's transfer operator semiclassical quantization rules quantum chaos

Numerical characteristics of the full operator hybrid simulation method

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Earthquake Engineering and Engineering Vibration 2011年第3期10卷 453-463页

作者： chung-Chan hung Yong-Song Chen Department of Civil Engineering Central University （NCU） Chinese Taipei Department of Mechanical Engineering Chung Cheng University （NCCU） Chinese Taipei

The full operator method （FOM） has been proposed to overcome some of the shortcomings of the commonly used operator splitting method （OSM）. In particular, the FOM is improved by increasing the accuracy of both the predictor and corrector using the estimated tangent stiffness of the tested structure. The numerical characteristics of the FOM, including stability and accuracy, are investigated in this study. It is shown that FOM is conditionally stable. The stability and accuracy characteristics are dependent on the accuracy of the estimated tangent stiffness and the parameters associated with the acceleration variation in the time-stepping integration method. Mass-spring systems with different types of nonlinearity, including hardening, stiffening, and softening behavior, are used to evaluate the performance of the FOM. It is found that the FOM can capture these types of nonlinearity with satisfactory accuracy. Using a prototype 12-story composite coupled wall system, the influences of the strong nonlinearity of the system as well as the displacement control errors from hydraulic actuators on the performance of the FOM are explored. The results show that the FOM is capable of generating reasonably accurate results despite the presence of strong structural nonlinearity and displacement control errors.

关键词： hybrid simulation tangent stiffness numerical characteristic composite coupled wall system collapse behavior nonlinear behavior

Functional Design of A Series of Submerged Breakwaters for Coastal Protection Against Waves

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China Ocean Engineering 2010年第3期24卷 553-564页

作者： Li-hung TSAI Chih-chung WEN Center of Harbor and Marine Technology Institute of TransportationMinistry of Transportation and Communications Department of Safety Health and Environmental EngineeringHungkuang University

The purpose of this paper is to develop a functional method for designing a series of submerged breakwaters on practical topography. The method is used to verify the feasibility and effectiveness of Bragg breakwaters for coastal protection by using field topography. The first part of this paper provides definitions and procedures needed in the design process for applying the mechanism of Bragg reflection. Next, Bragg breakwaters are designed on the basis of the cross-sectional topography and then on the plane topography of the Mi-Tuo coast by following the proposed process and procedure. Numerical modeling （Hsu et al., 2003; Wen and Tsai, 2008） was used as a design and assessment tool. Finally, the effectiveness and feasibility of a Bragg breakwater was assessed by practical cases. Based on the mechanism of Bragg reflection, an optimum layout for a series of submerged breakwaters is proposed to protect the Mi-Tuo coast. The results indicate that the proper layout of a series of submerged creakwaters can achieve the objective of beach protection.

关键词： a series of submerged breakwaters Bragg reflection coastal protection

Numerical Simulation of Bragg Reflection Based on Linear Waves Propagation over A Series of Rectangular Seabed

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China Ocean Engineering 2008年第1期22卷 71-86页

作者： Chih-chung WEN Li-hung TSAI Department of Environmental Engineering Hungkuang University Center of Harbor and Marine Technology Institute of TransportationMinistry of Transportation and Communications

A numerical model, Evolution Equation of Mild-Slope Equation （EEMSE） developed by Hsu et al. （2003）, was applied to study the Bragg reflection of water waves over a series of rectangular seabed. Three key parameters of the Bragg reflection including the peak coefficient of primary Bragg reflection, its corresponding relative wavelength, and the bandwidth, have shown to be effective in describing the characteristics of the primary Bragg reflection. The characteristics of the Bragg reflection were investigated under the various conditions comprising number, height, and spacing interval of a series of rectangular seabed. The results reveal that the peak of Bragg reflection increases with the increase of rectangular seabed height and number, the bandwidth and the shift value of the Bragg reflection depend on the increase of the rectangular seabed height as well as the decrease of rectangular seabed number, and the relative rectangular seabed spacing in the rang of 3 and 4 could produce higher Bragg reflection. Finally, a correlative and regressive analysis is performed by use of the calculated data. Based on the results of the analysis, empirical equations were established. Our study results can provide an appropriate choice of a series of rectangular seabed field for a practical design.

关键词： Bragg reflection mild-slope equation rectangular seabed bandwidth of the Bragg reflection rapidly varying component

Grain size altering yielding mechanisms in ultrafine grained high-Mn austenitic steel:Advanced TEM investigations

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Journal of Materials Science & Technology 2021年第27期86卷 192-203页

作者： Chang-yu hung yu Bai Nobuhiro Tsuji Mitsuhiro Murayama Department of Materials Science and Engineering Virginia TechBlacksburgVA24061USA Department of Materials Science and Engineering Kyoto UniversityYoshida-honmachiSakyo-kuKyoto606-8501Japan Elements Strategy Initiative for Structural Materials Kyoto UniversityYoshida-honmachiSakyo-kuKyoto606-8501Japan Institute for Materials Chemistry and Engineering Kyushu UniversityKasugaFukuoka8168580Japan

The underlying mechanism of discontinuous yielding behavior in an ultrafine-grained(UFG)Fe-31 Mn-3 Al-3 Si(wt.%)austenitic TWIP steel was investigated by the use of advanced TEM technique with taking the plastic deformation mechanisms and their correlation with grains size near the macroscopic yield point into *** yield drop mechanisms such as the dislocation locking by the Cottrell atmosphere due to the presence of interstitial impurities cannot explain the origin of this phenomenon in the UFG high-Mn austenitic TWIP ***,we experimentally revealed that the plastic deformation mechanisms in the early stage of deformation,around the macroscopic yield point,show an obvious association with grain *** specifically,the main mechanism shifts from the conventional slip in grain interior to twinning nucleated from grain boundaries with decreasing the grain size down to less than 1μ*** observation indicates that the grain size dependent deformation mechanisms transition is also deeply associated with the discontinuous yielding behavior as it could govern the changes in the grain interior dislocation density of mobile dislocations around the macroscopic yield point.

关键词： Ultrafine grains TWIP steel Yield-drop phenomenon Deformation twin nucleation Structural defects Transmission electron microscopy

A FRAMEWORK OF SETTING UP GOAL CONTROL LIMITS OF TARGET COSTING FOR NON-NORMAL DISTRIBUTIONS

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Journal of Systems Science and Systems Engineering 2007年第4期16卷 424-433页

作者： Hsin-hung WU Fong-Jung yu Department of Business Administration National Changhua University of Education Changhua Taiwan China Department of Industrial Engineering and Technology Management Da-Yeh University Changhua Taiwan China

This study provides a framework of target costing to extend its original scope when the underlying distribution is non-normal. The new specification limits can be derived by listening to the market price from Taguchi loss function. Later, the new specification limits can be linked through the non-normality-based C^^pk value along with non-normality-based X^^-Rcontrol charts to derive goal control limits. Moreover, an example is provided to illustrate the usefulness of the proposed framework of target costing by relentlessly reducing cost and improving product quality to gain competitiveness in the marketplace.

关键词： Target costing Taguchi loss function goal control limit process capability index non-normal distribution

An Improved Modeling of TDR Signal Propagation for Measuring Complex Dielectric Permittivity

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Journal of Earth Science 2015年第6期26卷 827-834页

作者： Chih-Ping Lin Shr-Hong Tang Chun-hung Lin Chih-chung chung Civil Engineering National Chiao Tung University Information Management St.Mary's Medicine Nursing and Management College Disaster Prevention and Water Environment Research Center National Chiao Tung University Civil Engineering National Central University

Time domain reflectometry（TDR） is a measurement technique based upon transmission line theory. The solutions of transmission line equations are reformulated in terms of independent physical properties, instead of coupled per-unit-length circuit parameters. The complete TDR response is effectively modeled by a non-uniform transmission line using the non-recursive ABCD matrix approach. Approaches to calibrate line parameters and perform TDR measurements based upon such model are introduced with an example on dielectric spectroscopy. TDR modeling in terms of decoupled physical parameters and non-recursive algorithm allows more convenient calibration of line parameters and facilitates interpretation of TDR measurements.

关键词： time domain reflectometry transmission line theory transmission line measurements dielectric measurements spectroscopy soll measurements.

Prevalence and risk factors for Barrett’s esophagus in Taiwan

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World Journal of Gastroenterology 2019年第25期25卷 3231-3241页

作者： Yan-Hua Chen Hsien-chung yu Kung-hung Lin Huey-Shyan Lin Ping-I Hsu Division of Gastroenterology and Hepatology Department of Internal MedicineKaohsiung Veterans General HospitalKaohsiung 81362Taiwan Health Evaluation Center Kaohsiung Veterans General HospitalKaohsiung 81362Taiwan Department of Nursing Meiho UniversityNeipu TownshipPingtung County 91202Taiwan Institute of Health Care Management Department of Business ManagementNational Sun Yat-Sen UniversityKaohsiung 80424Taiwan Department of Health-Business Administration Fooyin UniversityKaohsiung 83102Taiwan National Yang Ming University Taipei 12221Taiwan

BACKGROUND Barrett’s esophagus(BE)is a pre-malignant condition associated with the development of esophageal *** prevalence of BE in the general populations of Asian countries ranges from 0.06%to 1%.However,with lifestyle changes in Asian countries and adoption of western customs,the prevalence of BE might have *** To determine the current prevalence of BE in Taiwan,and to investigate risk factors predicting the presence of *** This retrospective study was conducted at the Health Evaluation Center of Kaohsiung Veterans General Hospital in *** January 2015 and December 2015,3385 subjects undergoing routine esophagogastroduodenoscopy examinations as part of a health check-up at the Health Evaluation Center were *** characteristics and endoscopic findings were carefully *** with endoscopic findings consistent with BE awaiting histological evaluation were judged as endoscopically suspected esophageal metaplasia(ESEM).BE was defined based on extension of the columnar epithelium≥1 cm above the gastroesophageal junction and was confirmed based on the presence of specialized intestinal metaplasia(IM)in the metaplastic esophageal *** factors of subjects with BE and subjects without BE were compared,and the risk factors predicting BE were *** A total of 3385 subjects(mean age,51.29±11.42 years;57.1%male)were included in the study,and 89 among them were confirmed to have IM and presence of goblet cells via biopsy *** majority of these individuals were classified as short segment BE(n=85).The overall prevalence of BE was 2.6%.Multivariate analysis disclosed that old age[odds ratio(OR)=1.033;95%confidence interval(CI):1.012-1.055;P=0.002],male gender(OR=2.106;95%CI:1.145-3.872;P=0.017),ingestion of tea(OR=1.695;95%CI:1.043-2.754;P=0.033),and presence of hiatal hernia(OR=3.037;95%CI:1.765-5.225;P<0.001)were significant risk factors predicting *** independent risk facto

关键词： Barrett’s esophagus Prevalence Risk factors Intestinal metaplasia Taiwan