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Synthesis and Crystal Structure of a Three-dimensional (3D) Complex Mn(H_2O)_2(HNic)_2 (HNic=2-Hydroxynicotinic Acid)

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Chinese Journal of Structural chemistry 2006年第5期25卷 572-576页

作者： LI yu-Mei che yun-Xia ZHENG Ji-Min Department of chemistry Nankai University Tianjin 300071 China

The title complex Mn（H2O）2（HNic）2 （C22H12MnN2O8, Mr = 367.18） crystallizes in monoclinic, space group P21/c with a = 7.5735（8）, b = 12.5295（13）, c = 7.6466（8）A.β = 101.2790（10）°, Z = 2, V= 711.59（13） A^3, D, = 1.714 g/cm^3,μ（MoKa） = 0.974 mm^-1, F（000） = 374, R1 （1255 observed reflections （Ⅰ 〉 2σ（Ⅰ）） = 0.0250） and wR2 = 0.0662 （all data）. In this paper, we report the complexation of Mn（Ⅱ） by the bidentate ligand 2-hydroxynicotinic acid （HNic）. In the crystal the Mn（Ⅱ） ion exhibits a deformed octahedron structure. The title complex Mn（H2O）2（HNic）2 has a three-dimensional （3D） network structure extended by hydrogen bonds, which are formed by two typical eight-membered hydrogen-bonded rings.

关键词： complex crystal structure three-dimensional network

Two Different Burster Spatial Distributions of Gamma-Ray Bursts?

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Chinese Physics Letters 1996年第12期13卷 957-960页

作者： che Hai-hong LI Ti-pei YANG yu-xuan Shannxi Astronomical Observatory Chinese Academy of SciencesLintong 710600 Cosmic Ray and High Energy Astrophysics Laboratory Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100039 Department of Astronomy Beijing Normal UniversityBeijing 100875

By using the first,second and third electronic burst and transcient source experiment catalogs,a joint analysis of spatial and temporal distributions and hardness ratios of gamma-ray bursts is *** point features at C_(max)/C_(min) ~6 are *** probably indicates the existence of two components of burster population which have distinct spatial distributions.

关键词： trans Turning Spatial

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin Yin Yalan Xu Jie Mu yu Leng Lei Ma yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

Contribution to the taxonomy of the genus Lycodon *** in Fitzinger,1827(Reptilia:Squamata:Colubridae)in China,with description of two new species and resurrection and elevation of Dinodon septentrionale chapaense Angel,Bourret,1933

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Zoological Research 2021年第1期42卷 62-86页

作者： Kai Wang Zhong-Bin yu Gernot Vogel Jing che State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Sam Noble Oklahoma Museum of Natural History Department of BiologyUniversity of OklahomaNormanOklahoma 73072USA Kunming College of Life Science University of the Chinese Academy of SciencesKunmingYunnan 650204China Society for Southeast Asian Herpetology Heidelberg D-69115Germany

While considerable progress has been made in the taxonomic studies of the genus Lycodon in Asia,questions remain to be clarified regarding the taxonomy of certain groups,particularly those containing species in *** only do many regions in China remain overlooked by herpetologists,resulting in the possibility of undiscovered new species,but the surveyed areas also have suspicious records of recognized congeners that require taxonomic *** both morphological and genetic data,we tackle these outstanding issues in the taxonomy of Lycodon in *** particular,we discover two new species of Lycodon:one from the previously neglected hot-dry valley in the northern Hengduan Mountain Region close to Tibet,and another recluse and cryptic species from the *** complex in the downtown park of a major city in southern Sichuan ***,we clarify the distribution of *** in China and resurrect and elevate its junior synonym subspecies,Dinodon septentrionale chapaense,as a full,valid species,and we synonymize the recently described *** to the resurrected *** ***..Lycodon chapaensis *** represents a new national record of reptilian fauna of ***,based on literature review,we also correct some of the erroneous records of *** and *** in China,point out remaining taxonomic issues of the genus for future research,and update the dichotomous key and distribution of the 20 species of Lycodon currently recorded from China.

关键词： Erroneous records Guangdong Hunan Misidentification Serpentes Sichuan Wolf Snake yunnan

Characteristics of long period microtremor and validation of microtremor array measurements in inland areas of China

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Journal of Mountain Science 2016年第11期13卷 1910-1922页

作者： che Ai-lan ZHANG Teng-yu FENG Shao-kong School of Naval Architecture Ocean and Civil Engineering Shanghai Jiaotong University 800 Dongchuan-Road Shanghai 200240 China

To study the characteristics of long period microtremor and applicability of microtremor survey,we have made microtremor observations using long period seismometers of the China's mainland from coastal cities like Shanghai and Tianjin through Beijing,Xi'an,to the far inland cities of Lanzhou and *** observation shows that the level of power spectrum of long period microtremors reduced rapidly from the coast to the inland ***,the energy of long period microtremors in Beijing,Xi'an,Lanzhou and Tianshui area are only approximately ten-thousandth to thousandth of that in *** at the complexity of the underground structure in the far inland,a series of underground structure models with different distributions were assessed using three-dimensional,dynamic finite element method(FEM) *** results were used to evaluate microtremor survey methods and their limitations with regard to aggregate variability and thickness ***-wave reflections between layers with the change of underground structure distribution occurred,which have significant effect on the performance of the different field *** over a broad spectrum from which velocity-depth profiles were produced via inversion *** the thickness nor the shear waveVelocity V of the subsurface layer inversion results appeared over a large evaluation with increasing slope *** particular,when the angle of the model reached 45°,it could not be accurately evaluated using one-dimensional inversion ***,the array microtremor survey(AMS) was carried out in Shanghai City,*** AMS techniques do not have the layer sensitivity or accuracy(velocity and layer thickness) of borehole techniques,the obtained shear wave velocity structure is especially useful for earthquake disaster prevention and seismic analysis.

关键词： Long period microtremor Array Microtremor survey Power spectrum Inversion S-wave velocity structure

Radio frequency transistors based on ultra-high purity semiconducting carbon nanotubes with superior extrinsic maximum oscillation frequency

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Nano Research 2016年第2期9卷 363-371页

作者： yu Cao yuchi che Hui Gui Xuao Oao Chongwu Zhou Department of Electrical Engineering University of Southern California Los Angeles CA 90089 USA Department of chemical Engineering and Materials Science University of Southern California Los Angeles CA 90089 USA

In this paper, we report polyfluorene-separated ultra-high purity semiconducting carbon nanotube radio frequency transistors with a self-aligned T-shape gate structure. Because of the ultra-high semiconducting tube purity and self-aligned T-shape gate structure, these transistors showed an excellent direct current and radio frequency performance. In regard to the direct current characteristics, these transistors showed a transconductance up to 40μS/μm and an excellent current saturation behavior with an output resistance greater than 200 kΩ·μm. In terms of the radio frequency characteristics, an extrinsic maximum oscillation frequency （fmax） of 19 GHz was achieved, which is a record among all kinds of carbon nanotube transistors, and an extrinsic current gain cut-off frequency （fT） of 22 GHz was achieved, which is the highest among transistors based on carbon nanotube networks. Our results take the radio frequency performance of carbon nanotube transistors to a new level and can further accelerate the application of carbon nanotubes for future radio frequency electronics.

关键词： carbon nanotube ultra-high purity radio frequency transistors maximum oscillation frequency T-shape gate

Cohort study on the treatment of BRAF V600E mutant metastatic colorectal cancer with integrated Chinese and western medicine

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World Journal of Clinical Oncology 2025年第1期16卷 25-33页

作者： Jiang-yu Bian yu-Fang Feng Wen-Ting He Tong Zhang Department of Oncology Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing 100091China Department of Oncology The Fourth Clinical Medical College of Xinjiang Medical UniversityUrumqi 830001China Department of Oncology Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical UniversityUrumqi 830001China

BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor *** the previous cohort study on mCRC conducted by our team,it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival(OS)of patients with colorectal ***,we further explored the survival benefits in the population with BRAF V600E mutant *** To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal *** A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December *** patients were divided into two *** A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically significant difference(P=0.038,hazard ratio=0.46).The 1-3-year survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,*** analysis showed statistically significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy,and first-line treatment subgroups(Pchemotherapy,and first-line treatment.

关键词： Metastatic colorectal cancer BRAF V600E mutation Integrated Chinese and Western medicine Cohort study

Bioinspired Ultrasensitive Flexible Strain Sensors for Real-Time Wireless Detection of Liquid Leakage

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NANO-MICRO LETTERS 2025年第1期17卷 1-18页

作者： Zhou, Weilong Du, yu chen, Yingying Zhang, Congyuan Ning, Xiaowei Xie, Heng Wu, Ting Hu, Jinlian Qu, Jinping Huazhong Univ Sci & Technol Sch Chem & Chem Engn Key Lab Mat Chem Energy Convers & Storage Minist EducHubei Key Lab Mat Chem & Serv Failure Wuhan 430074 Peoples R China Huazhong Univ Sci & Technol Hubei Engn Res Ctr Biomat & Med Protect Mat Sch Chem & Chem Engn Wuhan 430074 Peoples R China Wuhan Inst Technol Sch Mat Sci & Engn Wuhan 430205 Peoples R China City Univ Hong Kong Dept Biomed Engn Hong Kong 999077 Peoples R China

Micro-extrusion compression molding and surface modification were proposed for the mass fabrication of a superhydrophobic thermoplastic polyurethane sensor (TCGS).Inspired by scorpions, TCGS features Archimedean spiral crack arrays and micropores, achieving 218.13 sensitivity at 2% strain, a 4300% increase, and over 5000 usage cycles of *** robust superhydrophobicity of TCGS improves sensitivity and stability for detecting small-scale liquid leakage, allowing precise monitoring across various sizes and compositions while providing early warnings in various scenarios. Liquid leakage of pipeline networks not only results in considerable resource wastage but also leads to environmental pollution and ecological imbalance. In response to this global issue, a bioinspired superhydrophobic thermoplastic polyurethane/carbon nanotubes/graphene nanosheets flexible strain sensor (TCGS) has been developed using a combination of micro-extrusion compression molding and surface modification for real-time wireless detection of liquid leakage. The TCGS utilizes the synergistic effects of Archimedean spiral crack arrays and micropores, which are inspired by the remarkable sensory capabilities of scorpions. This design achieves a sensitivity of 218.13 at a strain of 2%, which is an increase of 4300%. Additionally, it demonstrates exceptional durability by withstanding over 5000 usage cycles. The robust superhydrophobicity of the TCGS significantly enhances sensitivity and stability in detecting small-scale liquid leakage, enabling precise monitoring of liquid leakage across a wide range of sizes, velocities, and compositions while issuing prompt alerts. This provides critical early warnings for both industrial pipelines and potential liquid leakage scenarios in everyday life. The development and utilization of bioinspired ultrasensitive flexible strain sensors offer an innovative and effective solution for the early wireless detection of liquid leakage.

关键词： Thermoplastic polyurethane Bioinspired Cracks Liquid leakage Flexible strain sensor

Differences in Organic C Mineralization Between Aerobic and Submerged Conditions in Paddy Soils of Southern Jiangsu Province,China

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Agricultural Sciences in China 2011年第9期10卷 1410-1418页

作者： HAO Rui-jun LI Zhong-pei che yu-ping State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil Science Chinese Academy of Sciences Nanjing 210008 P.R. China Shanghai Institute of Landscape Gardening Shanghai 200232 P.R.China

Moisture regime plays a crucial role in the mineralization of soil organic carbon （SOC）. In this paper, the dynamics of SOC mineralization in typical paddy soils of Changshu, Jiangsu Province, China, was investigated by incubation test in laboratory. The differences in SOC mineralization under aerobic and submerged conditions of paddy soils were also studied. Results showed that the daily mineralization of SOC under different moisture regimes was significantly different in the whole incubation period, at the beginning of the incubation, it decreased quickly under aerobic condition, but increased rapidly under submerged condition, and both remained constant after 10 d of incubation. The differences in SOC mineralization were found to be mainly at the beginning period of the incubation and decreased along with the incubation time. Thus, the difference was not significantly different at the later incubation period. The respiration intensity, daily and cumulative mineralization of SOC under aerobic condition was 2.26-19.11, 0.96-2.41, and 0.96-2.41 times than those .under submerged condition, respectively. Statistic analyses showed that the higher the contents of microbial biomass carbon and nitrogen, the more significant difference in respiration intensity between aerobic and submerged conditions, but the higher the contents of microbial biomass nitrogen and dissolved organic carbon, the more significant difference in daily mineralization of SOC between the two conditions. The decrease in soil microbial activity under submerged condition was the main reason leading to the decrease in respiration intensity, but the decrease in SOC mineralization was also correlated with the changes in dissolved organic carbon over the whole incubation period.

关键词： moisture regime paddy soil SOC mineralization aerobic condition submerged condition difference