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Pharmacophore-based design,synthesis,and biological evaluation of novel 3-((3,4-dichlorophenyl)(4-substituted benzyl)amino)propanamides as cholesteryl ester transfer protein(CETP)inhibitors

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Chinese Chemical Letters 2014年第2期25卷 299-304页

作者： Dong-Mei Zhao Wen-Yan Li yu-Fang Shi Xu-Qiong Xiong Shuai Song Chen-Zhou Hao mao-Sheng Cheng Jing-Kang Shen Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education School of Pharmaceutical EngineeringShenyang Pharnmaceutical University Central Research Institute Shanghai Pharmaceuticals Holding Co.Ltd.

Cholesteryl ester transfer protein （CETP） is a plasma glycoprotein that plays an important role in decreasing high-density lipoprotein cholesterol （HDL-C） levels and increasing low-density lipoprotein cholesterol （LDL-C） levels. Inhibition of CETP may be a new therapy for treating atherosclerosis. Herein, we report the development of a ligand-based pharmacophore model and pharmacophore-based virtual screening of the ZINC/big-n-greasy database, leading to the identification of compound H-10 as a potential CETP inhibitor in vitro. Based on H-10, a series of 3-（（3,4-dichlorophenyl）（4-substituted benzyl）amino） propanamides were designed, synthesized, and evaluated against CETP. Compound 41 was found to have the best activity, resulting in 85.0% inhibition of CETP at l0 μmol/L.

关键词： Cholesteryl ester transfer protein CETP inhibitors Pharmacophore Virtual screening Synthesis

浙江金华翠冠梨花期气温演变及低温灾害特征分析

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中国南方果树 2024年第2期53卷 159-162页

作者：舒素芳鹿翔范瑜越毛俊萱夏园锋金华市气象局浙江金华321000

利用金华国家基本气象站1953—2022年气温观测数据和金华国家农业气象一级基本站2013—2022年翠冠梨物候观测数据,开展了翠冠梨花期特征和花期气温演变规律分析,依据低温灾害指标分析了翠冠梨花期低温灾害发生演变特征。结果表明,金华... 详细信息

利用金华国家基本气象站1953—2022年气温观测数据和金华国家农业气象一级基本站2013—2022年翠冠梨物候观测数据,开展了翠冠梨花期特征和花期气温演变规律分析,依据低温灾害指标分析了翠冠梨花期低温灾害发生演变特征。结果表明,金华翠冠梨花期持续8~12 d,最早始花期为3月14日,最迟谢花末期为4月10日;从20世纪90年代起,3月中旬至4月上旬(翠冠梨花期时段)气温呈现明显上升趋势;翠冠梨花期时段,低温灾害天气发生频率在20世纪50年代和70年代较高,20世纪80年代次之,20世纪60年代、90年代及21世纪相对较小;1953—2022年翠冠梨花期时段极端最低气温年际间波动大,在气候显著变暖背景下遭遇低温灾害频率约为4年一遇,一旦出现低温灾害,低温强度较强,需警惕防范。研究结果为浙江金华梨产业发展和防灾减灾提供了一定的依据。

关键词：翠冠梨花期气温低温灾害金华市

维普期刊数据库博看期刊

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对甲基苯甲醛合成技术研究进展

精细石油化工 2024年第2期41卷 69-72页

作者：李泽壮刘经伟徐骏杨丽华茆瑞佳中国石化扬子石油化工有限公司南京研究院江苏南京210048

介绍了甲苯羰基化、对二甲苯卤代水解氧化、对二甲苯间接电氧化和对二甲苯直接氧化等对甲基苯甲醛合成技术研究现状。对催化剂发展进行了评述,指出对二甲苯间接电氧化与太阳能光伏发电产业结合和对二甲苯直接液相氧化并联产对甲基苯甲... 详细信息

介绍了甲苯羰基化、对二甲苯卤代水解氧化、对二甲苯间接电氧化和对二甲苯直接氧化等对甲基苯甲醛合成技术研究现状。对催化剂发展进行了评述,指出对二甲苯间接电氧化与太阳能光伏发电产业结合和对二甲苯直接液相氧化并联产对甲基苯甲酸工艺,具有工业开发前景。

关键词：甲苯对二甲苯对甲基苯甲醛催化剂

Network correlation between investor’s herding behavior and overconfidence behavior

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Chinese Physics B 2020年第4期29卷 571-581页

作者： mao Zhang Yi-Ming Wang School of Economics Peking UniversityBeijing 100871China Key Laboratory of Mathematical Economics and Quantitative Finance Peking UniversityBeijing 100871China

It is generally accepted that herding behavior and overconfidence behavior are unrelated or even mutually ***,these behaviors can both lead to some similar market anomalies,such as excessive trading volume and volatility in the stock *** to the limitation of traditional time series analysis,we try to study whether there exists network relevance between the investor’s herding behavior and overconfidence behavior based on the complex network *** the investor’s herding behavior is based on market trends and overconfidence behavior is based on past performance,we convert the time series data of market trends into a market network and the time series data of the investor’s past judgments into an investor ***,we update these networks as new information arrives at the market and show the weighted in-degrees of the nodes in the market network and the investor network can represent the herding degree and the confidence degree of the investor,*** stock transaction data of Microsoft,US S&P 500 stock index,and China Hushen 300 stock index,we update the two networks and find that there exists a high similarity of network topological properties and a significant correlation of node parameter sequences between the market network and the investor ***,we theoretically derive and conclude that the investor’s herding degree and confidence degree are highly related to each other when there is a clear market trend.

关键词： complex network time series herding behavior overconfidence behavior

基于监督下降法的大地电磁二维反演及应用研究

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物探与化探 2024年第1期48卷 175-184页

作者：付兴谭捍东董岩汪茂中国地质大学(北京)地球物理与信息技术学院北京100083

传统的大地电磁二维反演方法较为成熟,但仍存在反演结果依赖初始模型和正则化参数选取、容易陷入局部极小值等问题。监督下降法是一种学习平均下降方向来预测数据残差的机器学习算法。本文尝试采用监督下降法解决传统的大地电磁二维反... 详细信息

传统的大地电磁二维反演方法较为成熟,但仍存在反演结果依赖初始模型和正则化参数选取、容易陷入局部极小值等问题。监督下降法是一种学习平均下降方向来预测数据残差的机器学习算法。本文尝试采用监督下降法解决传统的大地电磁二维反演存在的问题,基于监督下降法理论开发了大地电磁二维反演算法,设计理论模型合成算例验证了算法的正确性,并对西藏高原实测数据进行反演,检验了监督下降法的实用性。理论模型合成数据和实测数据反演结果表明,相较于传统的非线性共轭梯度反演,基于监督下降法的反演具有收敛速度快、反演效果好、抗噪能力强等特点。

关键词：大地电磁法二维反演机器学习监督下降法非线性共轭梯度反演

RNF6 promotes myeloma cell proliferation and survival by inducing glucocorticoid receptor polyubiquitination

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中国药理学与毒理学杂志 2019年第10期 886-887页

作者： REN Ying XU Xin mao Chen-yu HAN Kun-Kun XU yu-Jia CAO Bi-Yin ZHANG Zu-Bin SETHI Gautam TANG Xiao-Wen mao Xin-Liang Department of Pharmacology College of Pharmaceutical Sciences Soochow University School of Medicine South University of Science and Technology Department of Pharmacology Yong Loo Lin School of Medicine National University of Singapore Key Laboratory of Protein Modification and Degradation School of Basic Medical Sciences Affiliated Cancer Hospital & Institute of Guangzhou Medical University Department of Hematology the First Affiliated Hospital of Soochow University

OBJECTIVE To elucidate the action and specific mechanisms of RNF6 in MM. METHODS Co-immunoprecipitation was used for the interaction between RNF6 and glucocorticoid receptor(GR). Immunoblotting was employed for protein expression. Luciferase assay was used for GR transcriptional activity and lentiviral infection was applied for RNF6 function in MM *** The expression levels of RNF6 in multiple myeloma(MM) were significantly elevated compared to the bone marrow cells of healthy donors. Overexpression of RNF6 in LP1 and PRMI-8266 MM cell lines promoted cell proliferation, whereas knockdown of RNF6 led to apoptosis of MM cells. Furthermore, we revealed that RNF6, as a ubiquitin ligase, interacted with glucocorticoid receptor(GR) and induced its K63-linked polyubiquitination. Different from current knowledge, RNF6 increased GR stability at both endogenous and exogenous *** an action greatly promoted GR transcriptional activity,which was confirmed by luciferase assays and by the increased expression levels of pro-survival genes including Bcl-x L and Mcl-1, two typical downstream genes of the GR pathway. Consistent with these findings, ectopic expression of RNF6 in MM cells conferred resistance to dexamethasone, a typical anti-myeloma agent. CONCLUSION RNF6 promotes MM cel proliferation and survival by inducing atypical polyubiquitination to GR, and RNF6 could be a promising therapeutic target for the treatment of MM.

关键词： GR RNF6 ubiquitin proteasome pathway multiple myeloma dexamethasone

Generation of Maximally Entangled States for Many Two-Level Atoms in a Thermal Cavity

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Communications in Theoretical Physics 2007年第3期47卷 557-560页

作者： JIANG Chun-Lei FANG mao-Fa College of Physics and Information Science Hunan Normal University Changsha 410081 China

We propose a scheme for generating maximally entangled states for two or more two-level atoms in a thermal cavity. The cavity frequency is large-detuned from the atomic transition frequency, so the Hamiltonian can be expressed as an effective form. The photon-number-dependent parts in the effective Hamiltonian are cancelled with the assistance of a strong classical field, thus the scheme is insensitive to both the cavity decay and the thermal field. The scheme can be used to generate multi-atom Bell-state and Greenberger-Horne-Zeiliner （GHZ） state.

关键词： entanglement GHZ state large-detune

Analysis of the independent-and interactive-photo-thermal effects on soybean flowering

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Journal of Integrative Agriculture 2015年第4期14卷 622-632页

作者： WU Ting-ting LI Jin-yu WU Cun-xiang SUN Shi mao Ting-ting JIANG Bing-jun HOU Wen-sheng HAN Tian-fu Key Laboratory of Soybean Biology(Beijing) Ministry of Agriculture/Institute of Crop ScienceChinese Academy of Agricultural Sciences

Soybean（Glycine max（L.） Merr.） is a typical short-day and warm season plant, and the interval between emergence and flowering has long been known to be regulated by environmental factors, primarily photoperiod and temperature. While the effects of photoperiod and temperature on soybean flowering have been extensively studied, a dissection of the component photo-thermal effects has not been documented for Chinese germplasm. Our objective of the current study was to evaluate the independent- and interactive-photo-thermal responses of 71 cultivars from 6 ecotypes spanning the soybean production regions in China. These cultivars were subjected in pot experiments to different temperature regimes by planting in spring（low temperature（LT）） and summer（high temperature（HT））, and integrating with short day（SD, 12 h）, natural day（ND, variable day-length）, and long day（LD, 16 h） treatments over two years. The duration of the vegetative phase from emergence to first bloom（R1） was recorded, and the photo-thermal response was calculated. The outcome of this characterization led to the following conclusions：（1） There were significant differences in photo-thermal response among the different ecotypes. High-latitude ecotypes were less sensitive to the independent- and interactive-photo-thermal effects than low-latitude ecotypes; and（2） there was an interaction between photoperiod and temperature, with the effect of photoperiod on thermal sensitivity being greater under the LD than the SD condition, and with the effect of temperature on photoperiodic sensitivity being greater under the LT than the HT condition. The strengths and limitations of this study are discussed in terms of implications for current knowledge and future research directions. The study provides better understanding of photo-thermal effects on flowering in soybean genotypes from different ecotypes throughout China and of the implications for their adaptation more broadly.

关键词： soybean flowering photoperiod temperature photo-thermal response

以红色文化铸牢中华民族共同体意识的实践进路——基于西藏红色音乐的考察研究

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高原文化研究 2024年第1期2卷 10-17页

作者：廖洪刚才旦卓玛西藏大学艺术学院西藏拉萨850000

红色文化作为中国共产党执政兴国的文化底色,具有重要的历史意义与现实价值。红色文化作为铸牢中华民族共同体意识的重要媒介,是中国共产党用优秀文化创造中华现代文明的重要历史手段,既有助于红色革命文化基因的赓续,也有助于各民族的... 详细信息

红色文化作为中国共产党执政兴国的文化底色,具有重要的历史意义与现实价值。红色文化作为铸牢中华民族共同体意识的重要媒介,是中国共产党用优秀文化创造中华现代文明的重要历史手段,既有助于红色革命文化基因的赓续,也有助于各民族的相互交往交流交融,促进“五个认同”和“民族共同体”意识的生成。西藏当代红色音乐是红色文化的重要组成部分。艺术家主要以和平解放西藏为契机,围绕和平解放、民主改革、社会发展等重要主题创作出大量脍炙人口的红色音乐作品。这些作品反映了西藏当代各时期、各族人民对伟大领袖毛主席、伟大祖国、中国共产党、中国人民解放军、中国特色社会主义制度等的深厚情感,以歌曲形式对“五个认同”进行了全方位的历史书写。文章通过对西藏当代红色音乐铸牢中华民族共同体意识的历史梳理,挖掘红色音乐的当代价值,讲述音乐产生的历史背景、感人故事,让西藏各族人民直观地感受到红色音乐鲜活的历史,生成中华民族命运共同、命运共生、荣辱同在的集体意识,促进各民族的交往交流交融,凝聚民族共情,为社会主义新西藏的发展增添活力。

关键词：西藏红色音乐铸牢中华民族共同体意识民族团结