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儿童友好视角下南京市老旧住区公共空间改造策略研究——以东升沿一村等三个住区为例

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智能建筑与智慧城市 2024年第4期 63-65页

作者：蔡雨辰胡振宇宁娇荣南京工业大学建筑学院

文章聚焦城市老旧住区公共空间,选取南京市三个典型的老旧住区进行调研,分析其现状与问题。依据儿童生理和心理需求理论,探讨公共空间改造成儿童友好空间的可能性,进而提出改造策略。

关键词：城市更新改造策略儿童友好老旧住区公共空间

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基于慢病管理的扩增药学随访在高血压患者中的应用及影响因素分析

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中国处方药 2024年第6期22卷 56-59页

作者：蔡玉辰尚聪赵彦葛慧沈鸣鸣南通市口腔医院江苏南通226006 南通大学附属南通第三医院江苏南通226006

目的在慢病管理基础上给予高血压患者扩增药学随访干预,评价干预前后高血压患者的血压控制效果并探讨其影响因素。方法选取2020年3月~2022年6月在本地区某医疗机构接受治疗的116例高血压患者,对其建立药学服务档案,给予扩增药学随访干预... 详细信息

目的在慢病管理基础上给予高血压患者扩增药学随访干预,评价干预前后高血压患者的血压控制效果并探讨其影响因素。方法选取2020年3月~2022年6月在本地区某医疗机构接受治疗的116例高血压患者,对其建立药学服务档案,给予扩增药学随访干预,干预时间6个月,对每位患者自身干预前后进行对照研究,观察高血压患者调查前后血压变化情况、生活方式以及影响血压控制的单因素与多因素分析。结果在慢病管理基础上给予高血压患者扩增药学随访干预后,高血压患者中不服药人数显著减少(P<0.05),在用药依从性中,规律用药患者显著增多(P<0.05),漏服药或不服药患者显著减少(P<0.05);高血压患者掌握合理用药、遵医行为达标及血压控制达标的人数均显著增加(P<0.05);单因素分析结果显示,高血压患者的年龄、病程、干预后用药数量、干预后用药次数及干预后用药依从性是患者血压控制满意的影响因素(P<0.05);多因素Logstic分析显示,患者年龄≥65岁、干预后用药次数为1次/天或≥2次/天、干预后依从性为漏(不)服药是患者血压控制的独立影响因素。结论在慢病管理基础上给予高血压患者扩增药学随访干预,一方面能提高高血压患者用药依从性,让患者用药规律,另一方面能显著帮助患者提高遵医嘱行为更好地控制血压,在慢病管理基础上给予高血压患者扩增药学随访干预具有重要的意义。

关键词：扩增药学服务高血压慢病管理单因素分析多因素分析

Dynamic Update Scheme of Spectrum Information Based on Spectrum Opportunity Incentive in the Database-Assisted Dynamic Spectrum Management

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China Communications 2024年第3期21卷 75-90页

作者： Zhang yu chen Yong He Panfeng cai yueming Sixty-third Research Institute National University of Defense TechnologyNanjing 210007China College of Communications Engineering Army of Engineering UniversityNanjing 210007China

To solve the problem of delayed update of spectrum information(SI) in the database assisted dynamic spectrum management(DB-DSM), this paper studies a novel dynamic update scheme of SI in DB-DSM. Firstly, a dynamic update mechanism of SI based on spectrum opportunity incentive is established, in which spectrum users are encouraged to actively assist the database to update SI in real time. Secondly, the information update contribution(IUC) of spectrum opportunity is defined to describe the cost of accessing spectrum opportunity for heterogeneous spectrum users, and the profit of SI update obtained by the database from spectrum allocation. The process that the database determines the IUC of spectrum opportunity and spectrum user selects spectrum opportunity is mapped to a Hotelling model. Thirdly, the process of determining the IUC of spectrum opportunities is further modelled as a Stackelberg game by establishing multiple virtual spectrum resource providers(VSRPs) in the database. It is proved that there is a Nash Equilibrium in the game of determining the IUC of spectrum opportunities by VSRPs. Finally, an algorithm of determining the IUC based on a genetic algorithm is designed to achieve the optimal IUC. The-oretical analysis and simulation results show that the proposed method can quickly find the optimal solution of the IUC, and ensure that the spectrum resource provider can obtain the optimal profit of SI update.

关键词： database-assisted dynamic spectrum management Hotelling information updating contribution spectrum information updating Stackelberg

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World Journal of Gastroenterology 2011年第43期17卷 4779-4786页

作者： Gui-Fang Guo Wen-Qi Jiang Bei Zhang yu-chen cai Rui-Hua Xu Xu-Xian chen Fang Wang Liang-Ping Xia State Key Laboratory of Oncology Cancer Center Sun Yat-Sen University Guangzhou 510060 Guangdong Province China

AIM:To investigate the utility of Beclin-1 and LC3,two autophagy-related proteins,in predicting the cetuximab efficacy in advanced colorectal cancer(ACRC) . METHODS:The data of 85 patients with ACRC treated at the Sun Yat-sen University Cancer Center from March 1,2005 to December 31,2008 were studied,including 45 cases treated with cetuximab-containing chemotherapy and 40 cases treated with non-cetuximab-containing ***-1 and LC3 expression was evaluated by immunohistochemistry,and KRAS status was evaluated by polymerase chain reaction. RESULTS:Beclin-1 and LC3 expression in ACRC wassignificantly correlated(r=0.44,P<0.01);however,LC3 was more highly expressed in cancerous tissues than in normal tissues(Z=-2.63,P<0.01) .In the cetuximab-containing chemotherapy group,patients with low LC3 expression had higher objective response rates(ORRs) than those with high LC3 expression(52.9%vs 17.9%,P=0.01) ,and patients with low Beclin-1 expression had a longer median progressionfree survival(PFS) than their counterparts with higher Beclin-1 expression(9.0 mo vs 3.0 mo,P=0.01) . However,neither of these predictive relationships was detected in the group treated with non-cetuximabcontaining *** with wild-type KRAS had higher ORRs(42.3%vs 9.1%,P=0.049) and disease control rates(DCRs)(73.1%vs 36.4%,P= 0.035) ,and longer median PFS(5.5 mo vs 2.5 mo,P= 0.02) than those with mutant KRAS in the cetuximabcontaining chemotherapy *** Beclin-1(P= 0.52) nor LC3(P=0.32) expression was significantly correlated with KRAS status. CONCLUSION:Patients with low Beclin-1 expression had a longer PFS than those with high Beclin-1 expression,and patients with low LC3 expression had a higher ORR in ACRC patients treated with cetuximab-containing chemotherapy.

关键词： Beclin-1 Cetuximab Colorectal neoplasms Drug therapy LC3

Quantifying freeze-melt dynamics of lakes on the Tibetan Plateau using Sentinel-1 synthetic aperture radar imagery

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Journal of Mountain Science 2024年第3期21卷 805-819页

作者： JIN Lu chen Jun cai yu KONG Yecheng WANG Yongfeng DUAN Zheng School of Environment and Energy Engineering Anhui Jianzhu UniversityHefei 230601China Anhui Engineering and Technology Research Center for Smart City Anhui Jianzhu UniversityHefei 230601China School of Geographic and Oceanographic Sciences Nanjing UniversityNanjing 210023China Department of Physical Geography and Ecosystem Science Lund UniversityLund 22362Sweden

The ice phenology of alpine lakes on the Tibetan Plateau(TP)is a rapid and direct responder to climate changes,and the variations in lake ice exhibit high temporal frequency *** and passive microwave data are widely used to monitor lake ice changes with high temporal ***,the low spatial resolutions make it difficult to effectively quantify the freeze-melt dynamics of *** work used Sentinel-1 synthetic aperture radar(SAR)data to derive high-resolution ice maps(about 6 days),then with the aid of Sentinel-2 optical images to quantify freeze-melt processes in three typical lakes on the TP(*** Co,Ayakekumu Lake,and Nam Co).The results showed that three lakes had an average annual ice period of 125-157 days and a complete ice cover period of 72-115 days,from 2018 to *** exhibit different ice phenology *** Co is characterized by repeated episodes of freezing,melting,and refreezing,resulting in a prolonged freeze-up ***,the break-up period of Nam Co lasts for a longer duration(about 19 days),and the break-up exhibits a smooth ***,Ayakekumu Lake showed more significant inter-annual fluctuations in the freeze-up period,with deviations of up to 28 days observed among different *** to the other two lakes,Selin Co experienced a relatively short freeze-up and break-up *** short,Sentinel-1 SAR data can effectively monitor the weekly and seasonal variations in lake ice on the ***,this data facilitates quantification of the freeze-melt dynamics.

关键词： Lake ice Sentinel-1 SAR Tibetan Plateau Climate change

The prognostic value of Tiam1 proteinexpression in head and neck squamous cellcarcinoma:a retrospective study

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癌症 2015年第12期34卷 614-621页

作者： Hang Yang yu-chen cai Ye Cao Ming Song Xin An Yi Xia Jing Wei Wen-Qi Jiang Yan-Xia Shi State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer Center Department of Medical Oncology Sun Yat-sen University Cancer Center Department of Medical Oncology Ruikang HospitalGuangxi Traditional Chinese Medical University Clinical Trial Center Sun Yat-sen University Cancer Center Department of Head and Neck Surgery Sun Yat-sen University Cancer Center

Introduction:Head and neck squamous cell carcinoma(HNSCC)is a common cancer worldwide and has a poor prognosis.A biomarker predicting the clinical outcome of HNSCC patients could be useful in guiding treatment *** of the T lymphoma invasion and metastasis 1(Tiam1) protein has been implicated in the migration and invasion of ***,its role in HNSCC progression needs to be further *** detected the expression of Tiam1 in normal and tumor tissues and determined its association with clinical outcomes in patients with ***:We measured the expression ofTiam1 in normal and cancerous tissue samples from the patients with HNSCC treated at Sun Yat-sen University Cancer Center between 2001 and *** Tiam1 expression was scored from 0 to 12 based on the percentage of positively stained cells and the staining *** then determined the diagnostic performance of this score in predicting overall survival(OS) and disease-free survival(DFS).Results:Of the 194 evaluable patients,those with advanced disease,lymph node metastasis at diagnosis,and recurrence or metastasis during follow-up had a higher tendency of having high Tiam1 expression as compared with their counterparts(P<0.05).The proportion of samples with high Tiam1 expression was also higher in cancerous tissues than in non-cancerous tissues(57.7%vs.13.9%,P<0.001).Cox proportional hazards regression analysis revealed that Tiaml expression scores of 5 and greater independently predicted short OS and ***:The Tiaml expression is shown as a promising biomarker of clinical outcomes in patients with HNSCC and should be evaluated in prospective trials.

关键词： Tiam1 Head and neck squamous cell carcinoma Prognosis

Activation of Nrf2 attenuates pulmonary vascular remodeling via inhibiting endothelial-to-mesenchymal transition

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中国药理学与毒理学杂志 2018年第4期32卷 275-276页

作者： yu-cai chen Tian-yi yuAN Di chen Lian-hua FANG Yang Lyu Guan-hua DU Beijing Key Laboratory of Drug Targets Identification and Drug Screening Beijing Key Laboratory of Polymorphic Drugs Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 China

OBJECTIVE To investigate the pharmacological effect and mechanism of Salvianolic acid A(SAA) on pulmonary vascular *** In current study,we conducted a series of experiments to clarify the effect of SAA,a kind of polyphenol compound,in the process of EndMT in human pulmonary arterial endothelial cells and in vivo therapeutic efficacy on vascular remodeling in monocrotaline(MCT)-induced *** was also induced by TGF-β1 in human pulmonary arterial endothelial cells(HPAECs) in *** SAA significantly attenuated EndMT,*** inhibited cell migration and reactive oxygen species(ROS) *** MCT-induced pulmonary arterial hypertension(PAH) model,SAA improved vascular function,decreased TGF-β1 level and *** ***,SAA stimulated Nrf2 translocation and subsequent heme ***-1(HO-1) *** effect of SAA on EndMT in vitro was abolished by ZnPP,a HO-1 *** This study indicates a deleterious impact of oxidative stress on *** antioxidant treatment may provide an adjunctive action to alleviate pulmonary vascular remodeling via inhibiting EndMT.

关键词：丹酚酸肺血管药理作用药物分析

Target Detection Algorithm in Foggy Scenes Based on Dual Subnets

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Computers, Materials & Continua 2024年第2期78卷 1915-1931页

作者： yuecheng yu Liming cai Anqi Ning Jinlong Shi Xudong chen Shixin Huang School of Computer Science Jiangsu University of Science and TechnologyZhenjiang212100China Information Department China Merchants Heavy IndustryNantong226116China

Under the influence of air humidity,dust,aerosols,etc.,in real scenes,haze presents an uneven *** this way,the image quality and contrast will *** this case,It is difficult to detect the target in the image by the universal detection ***,a dual subnet based on multi-task collaborative training(DSMCT)is proposed in this ***,in the training phase,the Gated Context Aggregation Network(GCANet)is used as the supervisory network of YOLOX to promote the extraction of clean information in foggy *** the test phase,only the YOLOX branch needs to be activated to ensure the detection speed of the ***,the deformable convolution module is used to improve GCANet to enhance the model’s ability to capture details of non-homogeneous ***,the Coordinate Attention mechanism is introduced into the Vision Transformer and the backbone network of YOLOX is *** this way,the feature extraction ability of the network for deep-level information can be *** experimental results on artificial fog data set FOG_VOC and real fog data set RTTS show that the map value of DSMCT reached 86.56%and 62.39%,respectively,which was 2.27%and 4.41%higher than the current most advanced detection *** DSMCT network has high practicality and effectiveness for target detection in real foggy scenes.

关键词： Target detection fog target detection YOLOX twin network multi-task learning

MALDI coupled with laser-postionization and trapped ion mobility spectrometry contribute to the enhanced detection of lipids in cancer cell spheroids

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Chinese Chemical Letters 2024年第4期35卷 464-468页

作者： Jing chen Peisi Xie Pengfei Wu yu He Zian Lin Zongwei cai Ministry of Education Key Laboratory of Analytical Science for Food Safety and Biology Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food SafetyCollege of ChemistryFuzhou UniversityFuzhou 350116China Department of Chemistry State Key Laboratory of Environmental and Biological AnalysisHong Kong Baptist UniversityHong KongChina College of Forestry Nanjing Forestry UniversityNanjing 210018China

Cancer cell spheroids(CCS) are a valuable three-dimensional cell model in cancer studies because they could replicate numerous characteristics of solid tumors. Increasing researches have used matrix-assisted laser desorption/ionization mass spectrometry imaging(MALDI-MSI) to investigate the spatial distribution of endogenous compounds(e.g., lipids) in CCS. However, only limited lipid species can be detected owing to a low ion yield by using MALDI. Besides, it is still challenging to fully characterize the structural diversity of lipids due to the existence of isomeric/isobaric species. Here, we carried out the initial application of MALDI coupled with laser-postionization(MALDI-2) and trapped ion mobility spectrometry(TIMS) imaging in HCT116 colon CCS to address these challenges. We demonstrated that MALDI-2 is capable of detecting more number and classes of lipids in HCT116 colon CCS with higher signal intensities than MALDI. TIMS could successfully separate numerous isobaric/isomeric species of lipids in CCS. Interestingly, we found that some isomeric/isobaric species have totally different spatial distributions in colon CCS. Further MS/MS imaging analysis was employed to determine the compositions of fatty acid chains for isomeric species by examining disparities in signal intensities and spatial distributions of product ions. This work stresses the robust ability of TIMS and MALDI-2 imaging in analyzing endogenous lipids in CCS, which could potentially become powerful tools for future cancer studies.

关键词： Matrix-assisted laser desorption/ionization(MALDI) Mass spectrometry imaging MALDI coupled with laser-postionization Trapped ion mobility spectrometry Cancer cell spheroids