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Non-Hodgkin's Lymphoma Primarily Presenting with Fanconi Syndrome and Acute Kidney Injury

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Chinese Medical Sciences Journal 2010年第3期25卷 185-188页

作者： wen-ling Ye bing Han bing-yan Liu Chan Meng Wei Ye yu-bing wen Hang Li Xue-mei Li Department of Medicine Department of Hematology Peking Union Medica College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 China

KIDNEY involvement is common in non-Hodgkin＇s lymphoma （NHL） with incidence up to 30%-40% in autopsy studies. However, it us- ually occurs late in the course of the diseaseand is clinically silent. Clinically overt renal disease including acute kidney injury （AKI） as its primary manifestation is rarely reported, moreover, Fanconi syndrome （FS） is extremely rare as the main manifestation in NHL. In this report, we presented a case of NHL primarily presenting with FS and AKI due to diffuse interstitial infiltration of NHL cells and emphasized the important role of renal biopsy, especially renal immunohistochemical analysis in the diagnosis of renal diffuse lymphoma.

关键词： non-Hodgkin's lymphoma Fanconi syndrome acute kidney injury

LUPUS NEPHRITIS COMPLICATED WITH MALIGNANT HYPERTENSION:FROM RENAL VASCULAR PATHOLOGY TO CLINICAL RELEVANCE

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Chinese Medical Sciences Journal 2008年第2期23卷 81-87页

作者： Jian-ling Tao Hang Li yu Tang yu-bing wen Xue-wang Li Department of Nephrology Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730

Objective To investigate the clinical and pathological characteristics of lupus nephritis patients complicated with malignant *** We retrospectively studied 19 patients with lupus nephritis complicated with malignant hypertension who underwent renal biopsy between January 2002 and December *** Of 19 patients,3 were men and 16 were women,with a mean age of 24.4±7.7 years *** had positive antinuclear antibodies and low serum complement was found in 13 *** were anemic and 12 of them were *** renal function was found in 17 patients with an average serum creatinine of 184.5±88.9 μmol/*** intrarenal arteriolar lesion was found in all *** patients had lupus vasculopathy,11 patients had renal thrombotic microangiopathy lesion,2 had severe *** patients received steroids and immunosuppressive drugs,15 received angiotensin-converting enzyme inhibitor(ACEI)/angiotensin receptor blocker(ARB)with resultant well-controlled blood *** and hemolytic anemia resolved *** renal function improved or recovered in 14 of 17 patients,and 3 developed end-stage renal disease on maintenance *** Severe intrarenal vascular lesion complicated with renal nephritis parallels clinical manifestation of malignant *** pathology is the key of treatment strategy emphasizing on the significance of renal vascular involvement and *** the basis of immunosuppressive drugs and steroids to control systemic lupus activity,timely initiation of ACEI/ARB could be of benefit to blood pressure control and long term renal survival.

关键词： lupus nephritis malignant hypertension renal pathology renal vascular involvement thrombotic microangiopathy

Exogenous Hematin Alleviates Mercury-induced Oxidative Damage in the Roots of Medicago sativa

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Journal of Integrative Plant Biology 2007年第12期49卷 1703-1713页

作者： Yi Han Wei Xuan Tian yu wen-bing Fang Tian-Ling Lou Yin Gao Xiao-yue Chen XiaoXiao wen-Biao Shen College of Life Sciences Laboratory of Nanjing Agricultural University and Carl Zeiss Far East Nanjing Agricultural University Nanjing 210095 China

In the present study, we evaluated the protective effect of exogenous heme oxygenase-1 （HO-1 EC 1.***.99.3） inducer hematin against mercury-induced oxidative damage in the roots of Alfalfa （Medicago sativa L.）. Plants exposed to mercury （HgCl2） exhibited a significant increase of lipid peroxidation, as well as inhibition of root elongation. However, hematin （50 μM） supplementation to HgCl2 （100 μmol/L） treated plants effectively reduced the lipid peroxidation and partially increased the root elongation. These responses were mimicked by the application of aqueous solution of carbon monoxide （CO） with 50% saturation. Also, treatment with hematin could result in the potent induction of HO-1 transcript in the root tissues, as detected 12h following treatment. Moreover, the activation of anti-oxidant enzyme, including glutathione reductase, monodehydroascorbate reductase and superoxide dismutase activities, and the decrease of lipoxygenase activity, were induced by hematin at 12h or 24h, which was further confirmed by histochemical staining for the detection of lipid peroxidation and loss of membrane integrity. Whereas, ascorbate peroxidase and guaiacol peroxidase isozyme activities or their transcripts were reduced, respectively, indicating that hydrogen peroxide might act as a signal to mediate Hg- tolerance at the beginning of treatment. The ameliorating effects of hematin were specific, since the CO scavenger hemoglobin differentially reversed the above actions. Taken together, our results suggested that hematin exhibits a vital role in protecting the plant against Hg-induced oxidative damage.

关键词： carbon monoxide hematin Medicago sativa mercury toxicity oxidative stress.

Underlying IgM heavy chain amyloidosis in treatment-refractory IgA nephropathy: A case report

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World Journal of Clinical Cases 2019年第19期7卷 3055-3061页

作者： Hai-Ting Wu yu-bing wen Wei Ye bing-Yan Liu Kai-Ni Shen Rui-Tong Gao Ming-Xi Li Department of Nephrology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Hematology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

BACKGROUND Monoclonal immunoglobulin can cause renal damage,with a wide spectrum of pathological changes and clinical manifestations without hematological evidence of *** disorders can be missed,especially when combined with other kidney *** SUMMARY A 61-year-old woman presented with moderate proteinuria with normal renal *** was diagnosed with IgA nephropathy combined with monoclonal gammopathy of undetermined significance after the first renal *** having received immunosuppressive treatment for 3 years,the patient developed nephrotic *** renal biopsy and laser microdissection/mass spectrometry analysis confirmed heavy chain *** nine cycles of bortezomib,cyclophosphamide and dexamethasone,she achieved very good partial hematological and kidney *** Renal injury should be monitored closely in monoclonal gammopathy patients without obvious hematological malignancy,especially in patients with other preexisting renal diseases.

关键词： Monoclonal gammopathy IgA nephropathy Renal biopsy Laser microdissection/mass spectrometry Case report

Lightweight,Strong and High Heat-Resistant Poly(lactide acid)Foams via Microcellular Injection Molding with Self-Assembly Nucleating Agent

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Chinese Journal of Polymer Science 2024年第6期42卷 739-750页

作者： Xiao-Hu bing wen-yu Ma Ming-Hui Wu Peng Gao Xiao Zhou Hai-Bin Luo Long Wang wen-Ge Zheng School of materials Science and Engineering Shanghai UniversityShanghai200444China Ningbo Key Lab of Polymer Materials Ningbo Institute of Material Technology and EngineeringChinese Academy of SciencesNingbo315201China University of Chinese Academy of Sciences Beijing100049China

Poly(lactide acid)(PLA)foams have shown considerable promise as eco-friendly alternatives to nondegradable plastic foams,such as polystyrene(PS)***,PLA foam typically suffers from low heat-resistance and poor cellular structure stemming from its inherent slow crystallization rate and low melt *** this study,a high-performance PLA foam with well-defined cell morphology,exceptional strength and enhanced heat-resistance was successfully fabricated via a core-back microcellular injection molding(MIM)*** scanning calorimetry(DSC)results revealed that the added hydrazine-based nucleating agent(HNA)significantly increased the crystallization temperature and accelerated the crystallization process of ***,the addition of a 1.5 wt%of HNA led to a significant reduction in PLA’s cell size,from 43.5µm to 2.87µm,and a remarkable increase in cell density,from 1.08×10^(7)cells/cm^(3)to 2.15×10^(10)cells/cm^(3).This enhancement resulted in a final crystallinity of approximately 55.7%for the PLA blend foam,a marked improvement compared to the pure PLA ***,at 1.5 wt%HNA concentration,the tensile strength and tensile toughness of PLA blend foams demonstrated remarkable improvements of 136%and 463%,***,the Vicat softening temperature of PLA blend foam increased significantly to 134.8°C,whereas the pure PLA foam exhibited only about 59.7℃.These findings underscore the potential for the preparation of lightweight injection-molded PLA foam with enhanced toughness and heat-resistance,which offers a viable approach for the production of high-performance PLA foams suitable for large-scale applications.

关键词： Poly(lactide acid) Nucleating agent Microcellular injection molding Heat-resistance Toughness

Glomerular Disease Associated with Takayasu Arteritis:6 Cases Analysis and Review of the Literature

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Chinese Medical Sciences Journal 2009年第2期24卷 69-75页

作者： Xue-mei Li wen-ling Ye yu-bing wen Hang Li Li-meng Chen Dong-yan Liu Xue-jun Zeng Xue-wang Li Department of Nephrology Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 China Department of General Medicine Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 China

Objective To evaluate the clinical features,renal histopathology and therapeutic response to glucocorticoid and immunosuppressive agents in patients with glomerular disease associated with Takayasu arteritis(TA).Methods Patients with TA and renal biopsy-confirmed glomerular disease were investigated *** of them had renal artery stenosis or occlusive *** Six patients with glomerulopathy,accounting for 3.75% of the 160 TA patients admitted to our hospital at the same period,were *** of them were females with a mean age of 35.5 ± 10.0 *** cases presented with lower extremity *** tests showed that one was nephrotic syndrome,three were nephrotic range proteinuria,and two of them had mild renal *** other two patients were asymptomatic microscopic hematuria and *** pathology revealed mild immunoglobulin A nephropathy in two cases,mild mesangial proliferative glomerulonephritis(GN),membranoproliferative GN,minimal change disease,and fibrillary GN in one case *** cases received glucocorticoids and cyclophosphamide *** and microscopic hematuria disappeared in 2 to 4 weeks after the initiation of therapy in three *** patient with membranoproliferative GN also reached complete remission of proteinuria and recovered renal function 6 months after the *** TA may induce glomerular disease as a part of its histological *** from ischemic glomerular disease,glomerular disease should be suspected when TA patients have microscopic hematuria or proteinuria,that may be therapeutically responsive to glucocorticoids and immunosuppressive agent in relative early phase.

关键词： Takayasu arteritis glomerular disease glomerulonephritis

Computer-assisted optimization for the selection of mobile phase in semi-preparative HPLC

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Chinese Journal of Chemistry 1993年第1期11卷 71-75页

作者： WANG,Qin-Sun GAO,Ru-yu YAN,bing-wen National Laboratory of Elemento-Organic Chemistry,Nankai University,Tianjin 300071 National Laboratory of Elemento‐Organic Chemistry Nankai University Tianjin 300071

A computer-assisted method is presented for optimization for the selection of mobile phase composition in semi-preparative *** optimization for the expected separation is based on a polynomial estimation from five preliminary *** scanning technique was used for *** criteria simulation system (DCSS) is established for chromatographic perfor- mance measurement in this *** validity of the optimization strategy is confirmed by applying it to a technical Cypermethrin *** agreement is obtained between the predicted and experimental results.

关键词： Computer-assisted optimization for the selection of mobile phase in semi-preparative HPLC

Optimization of two-factor(pH and ion concentration)simultaneous selection in HPLC using a statistical method

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Chinese Journal of Chemistry 1992年第2期10卷 143-149页

A computer-assisted method is presented for simultaneous optimization of pH and ion con- centration selection for the optimal separation in reversed-phase *** method is based on a polynomial estimation from nine preliminary experiments according to two-factor rectangular design. This is followed by a two-dimension computer scanning *** is used as the selection *** agreement was obtained between predicted data and experimental results.

关键词： pH and ion concentration)simultaneous selection in HPLC using a statistical method Optimization of two-factor HPLC

Visible-light-driven photocatalysis degradation of antibiotic pollutants by La-doped CeO_(2) nanorods:synergy of La doping and oxygen vacancy

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Rare Metals 2024年第7期43卷 3134-3145页

作者： Shi-Hai Cao Jing-Ru Qu yu-Qi Zhao yun-Tong Sun wen-Tong Gao bing Han Yao Lu College of Environmental Engineering Nanjing Institute of TechnologyNanjing 211167China School of Materials Science and Engineering Nanjing Institute of TechnologyNanjing 211167China School of Chemistry Chemical Engineering and BiotechnologyNanyang Technological UniversitySingapore 637459Singapore Institute of Environmental Health and Ecological Security School of Environment and Safety EngineeringJiangsu UniversityZhenjiang 212013China Jiangsu Collaborative Innovation Center of Technology and Material of Water Treatment Suzhou University of Science and TechnologySuzhou215009China

Elemental doping is an effective strategy to enhance photocatalytic activity and extend the light absorption range of single-component *** this work,a series of La-doped CeO_(2) nanorods(La-CeO_(2)-x) with La content of 1 wt%-15 wt% are synthesized by a simple hydrothermal method and further used as photocatalyst for sulfamerazine(SMR) *** prepared La-CeO_(2)-x nanorods exhibit a great improvement in electron-hole pair migration and visible-light response due to the synergistic effect of abundant oxygen vacancies and heterogeneous elements(La).Consequently,La-CeO_(2)-x exhibited excellent visible-light photocatalytic performances and chemical stability for SMR degradation,the La-CeO_(2)-5 sample achieved the highest SMR degradation rate of 81%,which was 3.4 times higher than that of the original CeO_(2).Furthermore,three possible degradation pathways of SMR in La-CeO_(2) photocatalytic reactions were proposed by liquid chromatography-mass spectrometry ***,density functional theory calculations were carried out to provide an in-depth understanding of the structure-performance *** its excellent properties and better photocatalytic performance,this study demonstrates that La doping in CeO_(2) is an effective way to increase oxygen vacancy and improve the photochemical properties of photocatalysts.

关键词： CeO_(2)nanorod La-doped Photocatalysis Oxygen vacancy Sulfamerazine