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Developing risk models and subtypes of autophagy-associated LncRNAs for enhanced prognostic prediction and precision in therapeutic approaches for liver cancer patients

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Oncology Research 2024年第4期32卷 703-716页

作者： LU zhang JINGUO CHU yuSHAN yu Department of General Practice The First Affiliated Hospital of Ningbo UniversityNingboChina

Background:Limited research has been conducted on the influence of autophagy-associated long non-coding RNAs(ARLncRNAs)on the prognosis of hepatocellular carcinoma(HCC).Methods:We analyzed 3.1 HCC samples from TCGA,identifying expression networks of ARLncRNAs using autophagy-related *** for prognostically relevant ARLncRNAs involved univariate Cox regression,Lasso regression,and multivariate Cox regression.A Nomogram was further employed to assess the reliability of Riskscore,calculated from the signatures of screened ARLncRNAs,in predicting ***,we compared drug sensitivities in patient groups with differing risk levels and investigated potential biological pathways through enrichment analysis,using consensus clustering to identify subgroups related to ***:The screening process identified 27 ARLncRNAs,with 13.being associated with HCC ***,a set of signatures comprising 8 ARLncRNAs was successfully constructed as independent prognostic factors for *** in the high-risk group showed very poor prognoses in most clinical *** Riskscore was closely related to immune cell scores,such as macrophages,and the DEGs between different groups were implicated in metabolism,cell cycle,and mitotic ***,high-risk group patients demonstrated a significantly lower IC50 for Paclitaxel,suggesting that Paclitaxel could be an ideal treatment for those at elevated risk for *** further identified C2 as the Paclitaxel subtype,where patients exhibited higher Riskscores,reduced survival rates,and more severe clinical ***:The 8 signatures based on ARLncRNAs present novel targets for prognostic prediction in *** drug candidate Paclitaxel may effectively treat HCC by impacting ARLncRNAs *** the identification of ARLncRNAsrelated isoforms,these results provide valuable insights for clinical exploration of autophagy mechanisms in HCC pathogenesis and offer potential av

关键词： Autophagy Hepatocellular carcinoma(HCC) Prognosis Precision medicine Paclitaxel

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Integration of urchin-like MnCo_(2)O_(4)@C core–shell nanowire arrays within porous copper current collector for superior performance Li-ion battery anodes

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Rare Metals 2024年第2期43卷 599-611页

作者： Xue-Ru zhang Qiong Wu Yong zhang Xi-Fei Li Ting Xie yu-Cheng Wu Instrumental Analysis Center Hefei University of TechnologyHefei230009China Key Laboratory of Advanced Functional Materials and Devices of Anhui Province Hefei230009China School of Materials Science and Engineering Hefei University of TechnologyHefei230009China Institute of Advanced Electrochemical Energy Xi’an University of TechnologyXi’an710048China

Spinel MnCo_(2)O_(4) is a promising energy storage candidate as anode materials in lithium-ion batteries owing to synergistic effects of two intrinsic solid-state redox ***,low conductivity,poor rate capacity and rapid capacity fading have seriously impaired its practical *** overcome the inferiorities,urchin-like MnCo_(2)O_(4)@C core–shell nanowire arrays have been fabricated directly within a porous copper current collector via a facile hydrothermal method followed by a chemical vapor deposition carbonization *** a typical nanowire,the core is composed of interconnected MnCo_(2)O_(4)nanoparticles and the shell shows as a thin amorphous carbon *** integrated MnCo_(2)O_(4)@C/Cu structure could act as working anodes without using additives or polymer *** MnCo_(2)O_(4)@C/Cu possesses slightly longer Li-ion insertion/desertion pathway than that of MnCo_(2)O_(4)/Cu,the carbon shell could effectively prevent the pulverization of MnCo_(2)O_(4) and lower down charge transfer resistance and actively participate in Li-ion *** rearrangement of carbon atoms during lithiation/delithiation cycling could inhibit the formation of passive solid electrolyte interphase *** a result,the MnCo_(2)O_(4)@C/Cu electrode presents superior rate capacity(600 mAh·g^(−1) at 1 A·g^(−1)) and better stability(797 mAh·g^(−1) after 200 cycles at 100 mA·g^(−1)).The excellent reversible Li ion storage capacity,cycling stability and rate capacity endow MnCo_(2)O_(4)@C/Cu great potential as stable and high output integrated anode materials in Li-ion batteries.

关键词： MnCo_(2)O_(4)@C Urchin-like nanowire arrays Core-shell Integrated anode materials Lithium-ion batteries

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Controllable nucleation and deformation of skyrmions on surface of magnetic nanotubular monolayer

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Rare Metals 2024年第7期43卷 3250-3259页

作者： Xin-Xin zhang Chen-yu zhang Yi-Xin Xing Chao Man Jiao Liu Yong Hu Department of Physics College of SciencesNortheastern UniversityShenyang 110819China School of Materials and Mineral Resources Engineering Universiti Sains MalaysiaEngineering Campus14300 Nibong TebalPenangMalaysia State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang110819China

Magnetic skyrmions emerge when the energy of ferromagnetic exchange interaction promoting parallel alignment of spins enters in competition with energies favoring non-collinear alignment of spins such as Dzy aloshinskii-Moriya interaction(DMI),long-rang dipole-dipole interaction(DDI),or higher-order exchange *** perform an unbiased Monte Carlo simulation to study the DMI-based skyrmion nucleation and stabilization on the surface of magnetic nanotubular monolayer controlled by tuning constants of DDI(g) and next-nearest-neighbor antiferromagnetic exchange interaction(j') with appropriate *** g and j',the loosely distributed skyrmions initially nucleate on the surface of nanotube approaching to the magnetic field(h) direction with increasing h in the intermediate ***,the skyrmion size,shape,density,distribution and crystal structure,as well as its driven field range,are tailored by g and j'.This work demonstrates the skyrmion nucleation mechanisms in three-dimensional magnetic nanostructures with curvature effect and multiple interactions,serving as a benchmark for a guide to experimentalists for preparation of samples in magnetic skyrmion states.

关键词： Magnetic nanotube Magnetic skyrmion Dzyaloshinskii-Moriya interaction Dipole-dipole interaction Monte Carlo simulation

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Tribological properties and tribomechanism of nickel nanoparticles in-situ synthesized in rapeseed oil

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Friction 2024年第3期12卷 474-489页

作者： Wenya XU Guangbin YANG Shengmao zhang Jun XU yujuan zhang Tianhua SUN Ningning SONG Laigui yu Pingyu zhang Engineering Research Center for Nanomaterials Henan UniversityKaifeng 475004China State Key Laboratory of Tribology in Advanced Equipment Tsinghua UniversityBeijing 100084China

Nickel(Ni)nanoparticles can be enriched on the surface of iron-based frictional pairs,which provides the possibility to get rid of the competitive adsorption between the polar species of vegetable oil and the surface-active nano-additives *** this paper,nickel acetylacetonate was used as a precursor to in-situ synthesize nickel nanoparticles with an average diameter of about 12 nm in rapeseed oil(RO)as the reducing agent,surface modifier,and solvent as *** tribological properties of the as-synthesized Ni nanoparticles were evaluated with a four-ball tribometer,and their tribomechanism was investigated based on the characterizations of the tribofilm on rubbed steel surfaces by the scanning electron microscopy(SEM),transmission electron microscopy(TEM),and X-ray photoelectron spectroscopy(XPS).It was found that the Ni nanoparticles in-situ prepared in the RO with a mass fraction of 0.3.can reduce the wear scar diameter(WSD)of the steel ball by 3.%.This is because,on the one hand,the Ni nanoparticles are adsorbed on the rubbed steel surfaces to repair or fill up the micro-pits and grooves *** the other hand,Ni nanoparticles participate in tribochemical reactions with atmospheric O and steel substrate to form the tribochemical reaction film on the rubbed steel surfaces with the assistance of friction-induced heat and applied normal *** addition,an amorphous carbon film is formed on the rubbed surface via the carbonization of base oil under the catalysis of Ni *** adsorbed Ni layer,the tribochemical reaction film,and the carbon layer comprise a composite tribofilm composed of amorphous carbon,polar fatty acid,metallic nickel,iron oxides,and nickel oxides on the rubbed steel surfaces,which contributes to significantly improving the antiwear ability and load-carrying capacity of the RO for the steel-steel sliding pair.

关键词： nickel(Ni)nanoparticles rapeseed oil(RO) in-situ synthesis tribological properties tribomechanism

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Highly efficient pH-universal hydrogen evolution reaction catalyzed by rapidly reconstructed bimetallic cobalt-molybdenum alloy cuboids arrays

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Nano Research 2024年第8期17卷 6977-6983页

作者： Daolian Liu Zihao Wang Yan zhang Haiqing Zhou Yong zhang Dongyang Li Fang yu Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Key Laboratory for Matter Microstructure and Function of Hunan ProvinceDepartment of Physics and Synergetic Innovation Center for Quantum Effects and ApplicationsHunan Normal UniversityChangsha 410081China State Key Laboratory of Marine Resource Utilization in South China Sea and Department of Materials Science and EngineeringHainan UniversityHaikou 570228China Institute of Interdisciplinary Studies Hunan Normal UniversityChangsha 410081China

Given the inherent potential of seawater,industrial wastewater,and residential water as inherent feedstocks for hydrogen production through water electrolysis,there is a critical demand for the exploration of robust and stable hydrogen-evolving catalysts that can operate effectively across a diverse range of pH ***,the pursuit of hydrogen-evolving electrocatalysts that demonstrate both good stability and high efficiency over a wide pH range remains a formidable *** we report the rational design and synthesis of an outstanding nanoporous hybrid electrocatalyst consisting of intermetallic cobalt-molybdenum alloy particles anchoring on MoO2 cuboid arrays,which demands very low overpotentials of 72,123.and 13. mV to deliver a current density of−100 mA·cm^(−2)for hydrogen evolution reaction under alkaline,neutral and acidic conditions,*** catalytic activities are superior to most non-precious-metal-based catalysts documented in the literatures,and are even comparable to noble metal *** particular,this alloy electrocatalyst exhibits excellent stability at 50 or 3.0 mA·cm^(−2)without obvious activity degradation,which is further supported by the undetectable changes in the surface chemical valence states on the basis of in-situ X-ray photoelectron spectroscopic *** study provides an innovative strategy for the design and synthesis of effective non-noble intermetallic catalysts for pH-universal hydrogen evolution over a wide pH range.

关键词： electrocatalyst hydrogen evolution reaction pH-universal non-noble water splitting

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Modified NiFe-MOF with defects induced by-NH_(2)and-SH for enhanced adsorption and photocatalytic reduction of CO_(2)

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Journal of Materials Science & Technology 2024年第3期170卷 167-176页

作者： Ruting Huang Yeyin zhang Wenqiang Li Wanxia zhang Yong Fang Wenrui zhang Anqi Cui {3. Ying Xianyang Shi Information Materials and Intelligent Sensing Laboratory of Anhui Province Anhui Province Key Laboratory of Wetland Ecosystem Protection and RestorationSchool of Resource and Environmental EngineeringAnhui UniversityHefei230601China Key Laboratory of Nutrient Cycling Resources and Environment of Anhui Institute of Soil and FertilizerAnhui Academy of Agricultural SciencesHefei230001China

In this study,a Ni-Fe metal-organic framework modified by-NH_(2)and-SH was synthesized using a sim-ple hydrothermal process for enhancing photocatalytic CO_(2)*** expected,the N2S-NiFe(NH_(2)-BDC/H_(4)DSBDC,2:1)displayed excellent photocatalytic CO_(2)reduction activity and high CO selectivity(12,412.23.mol g^(−1)h^(−1))under visible light irradiation(λ≥420 nm),which is 5 times that of ***,the excellent photocatalytic performance of N2S-NiFe can benefit from the rich defect trap site caused by the introduction of amino and sulfhydryl groups,accelerating charge transfer and promoting space charge separation,as supported by the photo-electrochemical *** better understand the CO_(2)adsorption mechanism,density functional theory calculations were performed,which revealed that the Niov site has more negative adsorption energy compared with the Feov *** study provides a simple strategy to establish efficient photocatalysts for CO_(2)reduction through the modification of organic ligands.

关键词： NiFe-MOF CO_(2)reduction Defect structure Photocatalytic

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A Brief of Cold Spell Warning Actions of the National Meteorological Center of China Meteorological Administration

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China CDC weekly 2024年第5期6卷 88-91页

作者： Taiyuan zhang Mengxue zhang Qiutong Li yu Lan Huafeng Meteorological Media Group of China Meteorological Administration(CMA) BeijingChina National Institute of Environmental Health Chinese Center for Disease Control and PreventionBeijingChina The National Meteorological Center of China Meteorological Administration(CMA) BeijingChina

The“Outline for High-Quality Development of Meteorology(2022-203.)”was published by the State Council of the People’s Republic of China in April 2022(1).This publication highlights the essential role of meteorological disaster warnings,particularly cold spell warnings,in preventing and mitigating *** outline also sets forth stricter expectations for enhancing the overall capacity of society in terms of meteorological disaster preparedness and response.

关键词： disaster meteorological warning

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Spatiotemporal variations of parameters of internal solitary waves in the northern South China Sea

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Journal of Oceanology and Limnology 2024年第2期42卷 421-438页

作者： yu’ang LIU Yifei JIANG Xiaojiang zhang Zhiyuan WANG yu CAO Huizan WANG College of Meteorology and Oceanography National University of Defense TechnologyChangsha 410000China

The dynamic parameters for internal solitary waves(ISWs)derived from the extended Korteweg-de Vries(eKdV)equation play an important role in the understanding and prediction of *** spatiotemporal variations of the dynamic parameters of the ISWs in the northern South China Sea(SCS)were studied based on the reanalysis of long-term temperature and salinity *** results for spectrum analysis show that there are definite geographical differences for the periodic variation of the parameters:in shallow water,all parameters vary with a wave period of one year,while in deep water wave components of the parameters at other frequencies *** wavelet analysis,the wavelet power spectral densities in deep water exhibited an inter-annual variation *** example,the wave component of the dispersion coefficient with a wave period of about half a year reached its power peak once every two *** on previous work,this inter-annual variation pattern was deduced to be caused by dynamic *** further work on the regulatory mechanisms,empirical orthogonal function(EOF)decomposition was *** was found that the modes of the dispersion coefficient have different geographical distributions,explaining the reason why the wave components in different frequencies appeared in different *** numerical simulation results confirm that the variations in the parameters of the ISWs derived from the eKdV equation could affect the waveforms significantly because of changes in the polarity of the ***,the periodic variations of the dynamic parameters are related to the geographical location because of dynamic processes operating.

关键词： internal solitary waves(ISWs) dynamic parameters eKdV equation spatiotemporal variation polarity empirical orthogonal function(EOF)decomposition

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Photostriction effect and electric properties of La-doped PMN-PT transparent ferroelectric ceramics

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International Journal of Smart and Nano Materials 2024年第2期15卷 296-311页

作者： Zhiqiang Song Zhuo zhang Yirong yu Dabin Lin Department of Automation and Robotics Engineering School of AutomationWuxi UniversityWuxiChina School of Optoelectronic Engineering Xian Technological UniversityXi'anChina

Ferroelectric ceramics display a remarkable photostriction effect,which could facilitate the prevention of electromagnetic interference and promote the integration and miniaturization of actuator systems,indicating potential applications in glim-mer *** this work,highly transparent La-doped 0.9Pb(Mg1/3.b2/3.O3.0.1PbTiO3.0.9PMN-0.1PT)ceramicswere synthesized using a solid-state reaction method in an oxyge-nated *** and SEM were used to analyze the phase structure of the dense samples,which displayed a pure perovskite structure,with no trace of a pyrochlore *** La doping,the phase transitiontemperature shows a decreasing trend,and its dielectric constant could reach up to 20,*** P-E loop of the samples was gradually refined into a straight line with an increase in the doping *** La doping,the transparency of the 0.9PMN-0.1PT cera-mics was significantly enhanced and reached up to 61%at the near-infrared ***,the photogenerated voltage and deformation of the La-doped 0.9PMN-0.1PT ceramics were investigated under ultraviolet light of various *** 20 s of irradiation at an intensity of 800 mW/cm²,the max-imum voltage and deformation,with values of 40 V and 250 nm,respectively,were both found in the 1%La-doped 0.9PMN-0.1PT ceramics.

关键词： Photostriction ferroelectric Raman piezoelectric

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Communication-robust multi-agent learning by adaptable auxiliary multi-agent adversary generation

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Frontiers of Computer Science 2024年第06期18卷 186331-186331页

作者： yuAN Lei CHEN Feng zhang Zongzhang yu Yang National Key Laboratory for Novel Software Technology Nanjing University Polixir Technologies

Communication can promote coordination in cooperative Multi-Agent Reinforcement Learning (MARL). Nowadays, existing works mainly focus on improving the communication efficiency of agents, neglecting that real-world communication is much more challenging as there may exist noise or potential attackers. Thus the robustness of the communication-based policies becomes an emergent and severe issue that needs more exploration. In this paper, we posit that the ego system trained with auxiliary adversaries may handle this limitation and propose an adaptable method of Multi-Agent Auxiliary Adversaries Generation for robust Communication, dubbed MA3., to obtain a robust communication-based policy. In specific, we introduce a novel message-attacking approach that models the learning of the auxiliary attacker as a cooperative problem under a shared goal to minimize the coordination ability of the ego system, with which every information channel may suffer from distinct message attacks. Furthermore, as naive adversarial training may impede the generalization ability of the ego system, we design an attacker population generation approach based on evolutionary learning. Finally, the ego system is paired with an attacker population and then alternatively trained against the continuously evolving attackers to improve its robustness, meaning that both the ego system and the attackers are adaptable. Extensive experiments on multiple benchmarks indicate that our proposed MA3. provides comparable or better robustness and generalization ability than other baselines.

关键词： multi-agent communication adversarial training robustness validation reinforcement learning

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