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Process-driven susceptibility assessment of glacial lake outburst debris flow in the Himalayas under climate change

Advances in Climate Change Research 2024年第3期15卷 500-514页

作者： Bin ZHOU Qiang ZOU Hu JIANG Tao YANG Wen-Tao ZHOU si-yu CHEN Hong-Kun YAO Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610041China University of Chinese Academy of Sciences Beijing 100049China School of Environment and Resource Southwest University of Science and TechnologyMianyang 621010China

Global warming is causing glaciers to retreat and glacial lakes to expand in the Himalayas,which amplifies the risk of glacial lake outburst debris flows(GLODFs)and poses a significant threat to downstream lives and ***,the complex interplay between GLODF occurrences and associated indicators,coupled with the lack of a comprehensive susceptibility indicator system that considers the entire GLODF process,presents a substantial challenge in assessing GLODF susceptibility in the *** study proposes a process-driven GLODF susceptibility assessment indicator system responding to climate change that considers the complete process of GLODF formation,incorporating relevant parameters about upstream,themselves,and downstream of glacial ***,to mitigate subjective factors associated with traditional evaluation methods,we developed three novel hybrid machine-learning models by integrating classic machine-learning algorithms with the whale optimization algorithm(WOA)to delineate the distribution of GLODF susceptibility in the *** the hybrid models effectively predicted the GLODFs occurrence,with the WOA-SVC model demonstrating the highest prediction *** 34%of the catchments exhibit high and very high susceptibility levels,primarily concentrated along the north and south sides of the Himalayan ridge,particularly in the eastern and central *** capturing the physical formation process of hazards,such as topographic potential(highest relative importance value of 40%),can precisely identify GLODF.A total of 128 catchments pose potential transboundary threats,with 24 classified as having a very high susceptibility level and 25 as having a high susceptibility ***,the border region between China and Nepal is a prominent hotspot for transboundary threats of *** findings can provide valuable clues for disaster prevention,mitigation,and cross-border coordination in the Himalayas.

关键词： Glacial lake outburst debris flow Susceptibility assessment Climate change Himalayas

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Chronic sleep deprivation induces alterations in DNA and RNA modifications by liquid chromatography-mass spectrometry analysis

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Chinese Chemical Letters 2024年第8期35卷 413-417页

作者： Tian Feng yun-Ling Gao Di Hu Ke-yu yuan Shu-Yi Gu Yao-Hua Gu si-yu yu Jun Xiong yu-Qi Feng Jie Wang Bi-Feng yuan School of Public Health Research Center of Public HealthRenmin Hospital of Wuhan UniversityWuhan UniversityWuhan 430071China Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan UniversityWuhan UniversityWuhan 430071China Key Laboratory of Magnetic Resonance in Biological Systems State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsNational Center for Magnetic Resonance in WuhanWuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of Sciences-Wuhan National Laboratory for OptoelectronicsWuhan 430071China University of Chinese Academy of Sciences Beijing 101408China Institute of Neuroscience and Brain Diseases Xiangyang Central HospitalAffiliated Hospital of Hubei University of Arts and ScienceXiangyang 441000China Phase I Clinical Trial Laboratory Zhongnan Hospital of Wuhan UniversityWuhan 430071China

Sleep deprivation(SD)is a widespread issue that disrupts the lives of millions of *** effects ini-tiate as changes within neurons,specifically at the DNA and RNA level,leading to disruptions in neuronal plasticity and the dysregulation of various cognitive functions,such as learning and *** acid epigenetic modifications that could regulate gene expression have been reported to play crucial roles in this ***,there is a lack of comprehensive research on the correlation of SD with nucleic acid epigenetic *** the current study,we aimed to systematically investigate the landscape of modifications in DNA as well as in small RNA molecules across multiple tissues,including the heart,liver,kidney,lung,hippocampus,and spleen,in response to chronic sleep deprivation(CSD).Using liquid chromatography-tandem mass spectrometry(LC-MS/MS)analysis,we characterized the dynamic changes in DNA and RNA modification profiles in different tissues of mice under CSD ***,we ob-served a significant decrease in the level of 5-methylcytosine(5mC)and a significant increase in the level of 5-hydroxymethylcytosine(5hmC)in the kidney in CSD *** RNA modifications,we observed an overall increased trend for most of these significantly changed modifications across six tis-sues in CSD *** study sheds light on the significance of DNA and RNA modifications as crucial epigenetic markers in the context of CSD-induced stress.

关键词： Sleep deprivation Epigenetics Mass spectrometry DNA modification RNA modification Small RNA

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Improved photocatalytic performance of acetaldehyde degradation via crystal plane regulation on truncated octahedral CeO_(2)

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Rare Metals 2024年第5期43卷 2026-2038页

作者： Bin Xu Lu Jia Hui Yang yue Wang si-yu Fan Sai-Sai yuan Qi-TaoZhang Ming Zhang Teruhisa Ohno School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China College of Environmental Science and Engineering Yangzhou UniversityYangzhou225127China Department of Applied Chemistry Faculty of EngineeringKyushu Institute of TechnologyKitakyushu804-8550Japan School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212000China National&Local Joint Engineering Research Center for Mineral Salt Deep Utilization Huaiyin Institute of TechnologyHuaian 223003China School of Materials Science and Engineering Henan University of Science and TechnologyLuoyang 471000China International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education Institute of Microscale OptoelectronicsShenzhen UniversityShenzhen 518060China

In this study,the truncated octahedral CeO_(2)(CeO_(2)-to)with special morphology was prepared by the solvothermal method with oleic acid(OA)and oleamine(OM)as the morphology-directing ***-resolution transmission electron microscopy(HRTEM)results show that CeO_(2)-to exposes composite{100}and{111}facets,while CeO_(2)cubic(CeO_(2)-c)and CeO_(2)octahedral(CeO_(2)-o)only expose single crystal facets of{100}plane and{111}plane,***,this CeO_(2)-to photocatalyst exhibits remarkable photooxidation performance of gaseous acetaldehyde(CH_(3)CHO)degradation,in which CO_(2)generation value reaches 1.78 and 7.97-times greater than that of CeO_(2)-c and CeO_(2)-o,*** addition,the active species trapping experiment signifies that superoxide(·O_(2)^(-))and holes(h^(+))are the main reactive substances during the CH_(3)CHO degradation process,and the electron paramagnetic resonance(EPR)spectra indicates that the former is the major ***,the electron transfer mechanism between CeO_(2)-to{100}and{111}facets and the surface oxygen adsorption ability are revealed via density functional theory(DFT)*** is also confirmed that{100}facets are more conducive to the absorption of acetaldehyde than{111}***,a reasonable mechanism for improved photocatalytic CH_(3)CHO degradation on CeO_(2)-to is proposed based on relevant experiments and DFT *** study demonstrates that the systematic development of surface homojunction structured photocatalysts can efficiently increase the degradation activity for volatile organic compounds(VOCs).It also offers additional direction for optimizing the photocatalytic activity of other ceriumbased photocatalysts.

关键词： Truncated octahedral CeO_(2)(CeO_(2)-to) Composite crystal faces Surface energy level Efficient electrontransfer

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Homochirality in Ferroelectrochemistry

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Chinese Journal of Chemistry 2024年第10期42卷 1133-1144页

作者： Hang Peng Jun-Chao Qi yu-si Liu Jia-Mei Zhang Wei-Qiang Liao Ren-Gen Xiong Ordered Matter Science Research Center Nanchang UniversityNanchangJiangxi 330031China

What is the most favorite and original chemistry developed in your research group?We originally proposed the design principle for molecular ferroelectrics:ferroelectrochemistry,including quasi-spherical theory,the introduction of homochirality,and H/F *** changed the blind search for molecular ferroelectrics into targeted chemical design,which will develop into a new discipline.

关键词： Molecular ferroelectrics Homochirality Ferroelectricity Chemical design Point groups

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From macroautophagy to mitophagy:Unveiling the hidden role of mitophagy in gastrointestinal disorders

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World Journal of Gastroenterology 2024年第23期30卷 2934-2946页

作者： Duo-Lun Gao Meng-Ran Lin Nan Ge Jin-Tao Guo Fan Yang si-yu Sun Department of Gastroenterology Engineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic TechniquesShengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

In this editorial,we comment on an article titled“Morphological and biochemical characteristics associated with autophagy in gastrointestinal diseases”,which was published in a recent issue of the World Journal of *** focused on the statement that“autophagy is closely related to the digestion,secretion,and regeneration of gastrointestinal cells”.With advancing research,autophagy,and particularly the pivotal role of the macroautophagy in maintaining cellular equilibrium and stress response in the gastrointestinal system,has garnered extensive ***,the significance of mitophagy,a unique selective autophagy pathway with ubiquitin-dependent and independent variants,should not be *** recent decades,mitophagy has been shown to be closely related to the occurrence and development of gastrointestinal diseases,especially inflammatory bowel disease,gastric cancer,and colorectal *** interplay between mitophagy and mitochondrial quality control is crucial for elucidating disease mechanisms,as well as for the development of novel treatment *** the pathogenesis behind gastrointestinal diseases and providing individualized and efficient treatment for patients are subjects we have been *** article reviews the potential mechanism of mitophagy in gastrointestinal diseases with the hope of providing new ideas for diagnosis and treatment.

关键词： Mitophagy Gastrointestinal diseases Parkin Autophagic receptor Colorectal cancer Gastric cancer Inflammatory bowel disease

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High-precision X-ray polarimeter based on channel-cut crystals

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Nuclear Science and Techniques 2024年第3期35卷 30-39页

作者： Shang-yu si Zhong-Liang Li Wen-Hong Jia Lian Xue Hong-Xin Luo Jian-Cai Xu Bai-Fei Shen Lin-Gang Zhang Liang-Liang Ji yu-Xin Leng Ren-Zhong Tai Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China Shanghai Institute of Optics and Fine Mechanics Chinese Academy of SciencesShanghai 201800China

We report on using synthetic silicon for a high-precision X-ray polarimeter comprising a polarizer and an analyzer,each based on a monolithic channel-cut crystal used at multiple Brewster reflections with a Bragg angle very close to 45°.Experiments were performed at the BL09B bending magnet beamline of the Shanghai Synchrotron Radiation Facility using a si(800)crystal at an X-ray energy of 12.914 keV.A polarization purity of 8.4×10^(-9)was *** result is encouraging,as the measured polarization purity is the best-reported value for the bending magnet ***,this is the firstly systematic study on the hard X-ray polarimeter in China,which is crucial for exploring new physics,such as verifying vacuum birefringence.

关键词： X-ray polarimeter Vacuum birefringence Synchrotron radiation Channel-cut crystal

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Preparation and interaction mechanism analysis of single‑chain fragment variables against phenylethanolamine A

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Animal Diseases 2024年第2期4卷 127-137页

作者： Long Li Ren Hou Huaming Li Shiyun Han Jixiang Liang yu si Dapeng Peng State Key Laboratory of Agricultural Microbiology National Reference Laboratory of Veterinary Drug Residues(HZAU)and MOA Key Laboratory for Detection of Veterinary Drug ResiduesHuazhong Agricultural UniversityWuhan 430070PR China Key Laboratory of Preventive Veterinary Medicine in Hubei Province The Cooperative Innovation Center for Sustainable Pig ProductionWuhan 430070China Hubei Topgene Biotechnology Co. Ltd.Wuhan BranchWuhanHubei 430070China Shenzhen Institute of Nutrition and Health Huazhong Agricultural UniversityShenzhenGuangdong 518000China Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhenGuangdong 518000China

This is the first report on the screening,expression,and recognition mechanism analysis of single-chain fragment variable(scFv)against phenylethanolamine A(PEAA),a newly emergedβ-adrenergic agonist illegally used as a feed additive for growth *** PEAA-specific scFv scFv,called scFv-32,was screened from hybridoma cell lines by phage display and was found to be optimally expressed in the *** *** ic-ELISA results revealed an IC_(50)value of 10.34μg/L for scFv-32 and no cross-reactivity with otherβ-adrenergic *** modeling and molecular docking revealed the key binding sites VAL178,TYP228,and *** hydrogen bond,two pisigma bonds,and one pi-pi bond maintain the formation of the antibody‒drug *** scanning mutagenesis of the three predicted key binding sites showed that the mutants completely lost their recognition activity,which confirmed the accuracy of the theoretical *** results are valuable for the preparation of scFvs and the analysis of the molecular recognition mechanism of antigen-antibodies.

关键词： Phenylethanolamine A ScFv Recognition mechanism Homology modeling Molecular docking

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Arbitrary topological charge vortex beams from carbon dots random lasers

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Rare Metals 2024年第8期43卷 3844-3853页

作者： Xiang-Dong Wang Xiao-Bo Mi Jiu-Ru He Feng-Ying Ma Jun-Qiao Wang Li Song Yong-Qiang Zhang si-yu Lu Yong-Sheng Hu School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China State Key Laboratory of Reliability and Intelligence of Electrical Equipment and Tianjin Key Laboratory of Electronic Materials and Devices School of Electronics and Information EngineeringHebei University of TechnologyTianjin 300401China Green Catalysis Center College of ChemistryZhengzhou UniversityZhengzhou450001China

Vortex beams have attracted great attention due to their promising applications in the fields of high-capacity optical communication,optical micromanipulation,and quantum information ***,we demonstrate vortex beams with flexible control of the topological charge and modes in a carbon dots random laser for the first *** beams with different types,including the Laguerre-Gaussian(LG),Bessel-Gaussian(BG),LG-superposition,and polarized vortex beams with topological charges up to 50,have been successfully ***,vortex beams can be well realized in carbon dots random lasers with different emission wavelengths covering from 465 to 612 *** work would not only enrich the types of vortex laser,especially for solution-processable lasers,but also provide a new route to realizing multicolor and wavelength-tunable vortex lasers.

关键词： Carbon dots Random lasers Vortex beam Topological charge Spatial light modulator

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Layered(C5H6ON)2[Sb2O(C2O4)3]with a large birefringence derived from the uniform arrangement of π-conjugated units

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结构化学 2024年第6期43卷 50-55页

作者： Dong-Xue Jiao Hui-Li Zhang Chao He si-yu Chen Ke Wang Xiao-Han Zhang Li Wei Qi Wei College of Chemistry and Chemical Engineering Qingdao UniversityShandong266071PR China College of Science Hebei University of Science and TechnologyShijiazhuangHebei050018PR China

An organic-inorganic hybrid antimony(Ⅲ)oxalate(C5H6ON)2[Sb2O(C2O4)3]has been successfully obtained by simultaneous combination of a-conjugated 4-hydroxypyridine and(C2O4)2-group with stereochemical active Sb(Ⅲ)*** compound features a layered structure,and the equatorial planes of SbO6 units,π-conjugated(C2O4)2-and(C5H6ON)+groups are closer to a planar arrangement,representing strong structural anisotropy that favors a large *** expected,(C5H6ON)2[Sb2O(C2O4)3]exhibits a large birefringence of 0.279 at 546 *** and theoretical analyses indicate that the combination of multiple π-conjugated units is a feasible approach for designing and exploring new superior birefringent materials.

关键词： Organic π-conjugated unit Birefringence Stereochemically active lone pair Layered structure

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The role of botanical triterpenoids and steroids in bile acid metabolism,transport,and signaling:Pharmacological and toxicological implications

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Acta Pharmaceutica sinica B 2024年第8期14卷 3385-3415页

作者： Zichen Luo Wei Zhou Tong Xie Weichen Xu Chen Shi Zihan Xiao yu si Yan Ma Qingling Ren Liuqing Di Jinjun Shan Medical Metabolomics Center Institute of PediatricsJiangsu Key Laboratory of Children’s Health and Chinese MedicineNanjing University of Chinese MedicineNanjing 210023China State Key Laboratory of Natural Medicines School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 210009China Jiangsu CM Clinical Medicine Innovation Center for Obstetrics Gynecologyand ReproductionAffiliated Hospital of Nanjing University of Chinese MedicineNanjing 210001China National Institute of Biological Sciences Beijing 102206China Jiangsu Engineering Research Center for Efficient Delivery System of TCM School of PharmacyNanjing University of Chinese MedicineNanjing 210023China

Bile acids(BAs)are synthesized by the host liver from cholesterol and are delivered to the intestine,where they undergo further metabolism by gut microbes and circulate between the liver and intestines through various *** serve to emulsify dietary lipids and act as signaling molecules,regulating the host’s metabolism and immune homeostasis through specific ***,disruptions in BA metabolism,transport,and signaling are closely associated with cholestasis,metabolic disorders,autoimmune diseases,and *** triterpenoids and steroids share structural similarities with BAs,and they have been found to modulate BA metabolism,transport,and signaling,potentially exerting pharmacological ortoxicological ***,we have updated the research progress on BA,with a particular emphasis on new-found microbial ***,the latest advancements in targeting BA metabolism and signaling for disease treatment are ***,the roles of botanical triterpenoids in BA metabolism,transport,and signaling are examined,analyzing their potential pharmacological,toxicological,or drug interaction effects through these ***,a research paradigm is proposed that utilizes the gut microbiota as a link to interpret the role of these important natural products in BA signaling.

关键词： Bile acid Triterpenoid Phytosterol Saponin Gut microbes Cholestasis Metabolic disorders Rheumatoid arthritis

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