检索结果-南通市图书馆

Bridging the Fabry–Perot cavity and asymmetric Berreman mode for long-wave infrared nonreciprocal thermal emitters

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Technological Sciences 2024年第10期67卷 3285-3293页

作者： chen ZiHe yu ShiLv HU Run School of Energy and Power Engineering Huazhong University of Science and Technology Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Department of Applied Physics Kyung Hee University

The long-wave infrared band(8–14 μm) is essential for several applications, such as infrared detection, radiative cooling, and near-field heat transfer. However, according to Kirchhoff's law, the intrinsic balance between thermal absorption and emission limits the further improvement of photon energy conversion and thermal management. Thus, breaking Kirchhoff's balance and achieving nonreciprocal thermal radiation in the long-wave infrared band are necessary. Most existing designs for nonreciprocal thermal emitters rely on grating or photonic crystal structures to achieve nonreciprocal thermal radiation at narrow peaks, which are relatively complex and typically realize bands larger than 14 μm. Here, a sandwich structure consisting of an epsilon-nearzero(ENZ) magneto-optical layer(MOL), a dielectric layer(DL), and a metal layer is proposed to achieve a strong nonreciprocal effect in the long-wave infrared band, which is mainly attributed to the strengthening of the asymmetric Berreman mode by the Fabry–Perot cavity. In addition, the impact of the incident angle, DL thickness, and DL refractive index on the nonreciprocal thermal radiation has been investigated. Moreover, by replacing the ENZ MOL with the gradient ENZ MOL, the existence of the DL can further improve the nonreciprocity of the broadband nonreciprocal thermal radiation. The proposed work promotes the development and application of nonreciprocal energy devices.

关键词： long-wave infrared band nonreciprocal thermal radiation sandwich structure Fabry–Perot cavity asymmetric berreman mode

Photoredox-catalyzed C-glycosylation of peptides with glycosyl bromides

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第6期35卷 263-267页

作者： chen Li Ziyuan Zhao Shouyun yu State Key Laboratory of Analytical Chemistry for Life Science Jiangsu Key Laboratory of Advanced Organic MaterialsChemistry and Biomedicine Innovation Center(ChemBIC)School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

Glycosyl radicals,produced under mild photoredox conditions,show unique utility in the preparation of C-linked *** herein report the construction of C-glycosidic bonds on α,β-dehydroalanine(DHA)of peptides with easily available glycosyl bromides as glycosyl radical precursors under highly anomeric control,leading to C-glycosylation modifications of *** method not only has outstanding functional group compatibility,but also is feasible in near-physiological conditions(pH~7 and temperature T≤37℃ in aqueous media).

关键词： Glycosylation C-Glycosides Glycopeptides Dehydroalanine Photoredox catalysis

Integrating sequence and graph information for enhanced drug-target affinity prediction

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2024年第2期67卷 325-326页

作者： Haohuai HE Guanxing chen Calvin yu-Chian chen Artificial Intelligence Medical Research Center School of Intelligent Systems EngineeringShenzhen Campus of Sun Yat-sen University

Drug discovery is a pivotal discipline involving the identification and development of innovative pharmaceuticals designed to combat a wide array of illnesses. It plays a crucial role in advancing global health outcomes and improving the standard of living for individuals worldwide. However,drug discovery often relies on laborious in vitro experiments,

关键词：

Advances in large viewing angle and achromatic 3D holography

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2024年第7期13卷 1224-1225页

作者： Jiaming Huang yu chen Guixin Li Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Institute for Applied Optics and Precision Engineering Southern University of Science and TechnologyShenzhen 518055China

Optical holography is a promising technique to achieve a naked-eye 3D ***,the narrow viewing angle and chromatic aberration are the two key issues that usually limit the holographic display performance.A recent work proposes a novel way to circumvent these constraints by introducing a color liquid crystal grating into a timesequenced holography system.

关键词： angle chromatic holographic

scEpiTools: a database to comprehensively interrogate analytic tools for single-cell epigenomic data

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2024年第4期51卷 462-465页

作者： Zijing Gao Xiaoyang chen Zhen Li Xuejian Cui qun Jiang Keyi Li Shengquan chen Rui Jiang Ministry of Education Key Laboratory of Bioinformatics Bioinformatics Division at the Beijing National Research Center for Information Science and TechnologyCenter for Synthetic and Systems BiologyDepartment of AutomationTsinghua UniversityBeijing 100084China School of Mathematical Sciences and LPMC Nankai UniversityTianjin 300071China

Recent advances in single-cell sequencing technologies provide significant implications for understanding cellular heterogeneity,developmental biology,and disease *** fully exploit the potential of these data,numerous tools have been proposed for upstream and downstream *** the the single-cell RNA sequencing(scRNA-seq)community,scRNA-tools(Zappia et al.,2018)was proposed to help researchers navigate the plethora of tools by *** its inception,scRNA-tools has been widely used and its updated version further reveals trends in the field with over 1000 collected tools(Zappia and Theis,2021),providing a valuable guidance in selecting tools for analyses.

关键词： analytic selecting Tools

Current status and trends in small nucleic acid drug development:Leading the future

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第9期14卷 3802-3817页

作者： yuxi Miao chen Fu Zhaojin yu Lifeng yu yu Tang Minjie Wei Department of Pharmacology School of PharmacyChina Medical UniversityShenyang 110122China Liaoning Key Laboratory of Molecular Targeted Anti-Tumor Drug Development and Evaluation China Medical UniversityShenyang 110122China Liaoning Medical Diagnosis and Treatment Center Shenyang 110000China Department of Oncology Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital and InstituteShenyang 110042China

Small nucleic acid drugs,composed of nucleotides,represent a novel class of pharmaceuticals that differ significantly from conventional small molecule and antibody-based *** agents function by selectively targeting specific genes or their corresponding messenger RNAs(mRNAs),further modulating gene expression and regulating translation-related *** examples within this category include antisense oligonucleotides(ASO),small interfering RNAs(siRNAs),micro-RNAs(miRNAs),and *** emergence of small nucleic acid drugs as a focal point in contemporary biopharmaceutical research is attributed to their remarkable specificity,facile design,abbreviated development cycles,expansive target spectrum,and prolonged *** challenges such as poor stability,immunogenicity,and permeability issues have been addressed through the integration of chemical modifications and the development of drug delivery *** review provides an overview of the current status and prospective trends in small nucleic acid drug *** with a historical context,we introduce the primary classifications and mechanisms of small nucleic acid ***,we delve into the advantages of the *** and Drug Administration(FDA)approved drugs and mainly discuss the challenges encountered during their *** from researching chemical modification and delivery system that efficiently deliver and enrich small nucleic acid drugs to target tissues,promoting endosomal escape is a critical scientific question and important research direction in siRNA drug *** directions in this field will prioritize addressing these challenges to facilitate the clinical transformation of small nucleic acid drugs.

关键词： Small nucleic acid drugs Oligonucleotide drugs siRNA ASO miRNA Aptamer RNAi Drug development

Near real-time gravitational wave data analysis of the massive black hole binary with TianQin

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 175-186页

作者： Hong-yu chen Xiang-yu Lyu En-Kun Li Yi-Ming Hu MOE Key Laboratory of TianQin Mission TianQin Research Center for Gravitational Physics&School of Physics and AstronomyFrontiers Science Center for TianQinGravitational Wave Research Center of CNSASun Yat-sen University(Zhuhai Campus)Zhuhai 519082China

Space-borne gravitational wave(GW)detectors can detect the merger of massive black *** early warning and localization of GW events before merging can be used to inform electromagnetic telescopes and conduct multimessenger ***,this requires real-time data transmission and analysis *** geocentric orbit of the space-borne GW detector Tian Qin makes it possible to conduct real-time data *** this study,we develop a search and localization pipeline for massive black hole binaries(MBHBs)with Tian Qin under both regular and real-time data transmission *** demonstrate that,with real-time data transmission,MBHBs can be accurately localized on the *** the approaching merger,each analysis can be finished in only 40 *** an MBHB system at a distance of 1 Gpc,if we receive data every hour,then we can pinpoint its location to within less than 1 deg^(2)on the final day before the merger.

关键词： gravitational wave detectors and experiments black holes data analysis algorithms and implementation data management

Chemical Constituents and Pharmacological Properties of Frankincense:Implications for Anticancer Therapy

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2024年第8期30卷 759-767页

作者： WU Yong-rong XIONG Wei DONG Ying-jing chen Xin ZHONG yuan-yuan HE Xin-ling WANG yu-jia LIN qun-fang TIAN Xue-fei ZHOU Qing College of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha410208China Department of Andrology the First Hospital of Hunan University of Chinese MedicineChangsha41007China College of Medicine Hunan University of Chinese MedicineChangsha410208China College of Traditional Chinese and Western Medicine Hunan University of Chinese MedicineChangsha410208China Hunan Provincial Key Laboratory of Traditional Chinese Medicine Prescription and Transformation Changsha410208China Hunan Sexual and Reproductive Health Clinical Medical Research Center of Traditional Chinese Medicine Changsha410021China

The discovery of novel antitumor agents derived from natural plants is a principal objective of anticancer drug ***,a widely recognized natural antitumor medicine,has undergone a systematic review encompassing its species,chemical constituents,and diverse pharmacological activities and *** different species of frankincense include Boswellia serrata,Somali frankincense,Boswellia frereana,and Boswellia *** frankincense extracts and compounds exhibit antitumor,anti-inflammatory,and hepatoprotective properties and antioxidation,memory enhancement,and immunological regulation *** also have comprehensive effects on regulating *** and its principal chemical constituents have demonstrated promising chemoprophylactic and therapeutic abilities against *** review provides a systematic summary of the mechanism of action underlying the antitumor effects of frankincense and its major constituents,thus laying the foundations for developing effective tumor-combating targets.

关键词： frankincense species chemical constituents anticancer therapy Chinesemedicine

Stability of water yield in watersheds

在线全文

学校读者我要写书评

暂无评论

Science China Earth Sciences 2024年第2期67卷 483-496页

作者： yu YAN Zhiyong LIU Xiaohong chen Liyan HUANG Center for Water Resources and Environment School of Civil EngineeringSun Yat-Sen UniversityGuangzhou510275China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai519082China

The hydrological system of a watershed is intricately influenced by both underlying characteristics and climate *** the variability in water yield is essential for effective water resources management and water security in the context of changing *** this study,we adopted the Budyko framework and leveraged simulations from the CMIP6 model to investigate the compensation effects of climate and underlying characteristics on watershed water *** on Taylor expansion and Budyko framework,we estimated the sensitivity of watershed water yield to climate and underlying characteristics(the first-and second-order partial derivatives).By combining external watershed characteristics(e.g.,water yield ratios and underlying characteristics)with internal sensitivity coefficients,this study further used vine copula and principal component analysis to quantify the stability of watershed water *** findings show:(1)Water-yield changes related to underlying characteristics could be offset by climate-related water-yield changes across all climate zones,maintaining the water yield ratio steady(i.e.,the compensation effects).(2)However,global watersheds will turn more sensitive to underlying characteristics and less sensitive to climate variation in the *** climate-and underlying-related sensitivities increase in watersheds with arid climates.(3)The stability of watershed water yield will gradually diminish in the *** 1901–1950to 2051–2100,the global stability of 280 watersheds drops from 0.054 to 0.021(i.e.,stability index identified by the joint probability).Particularly,the largest change in stability of water yield reaches-0.347±0.18 in arid *** semi-arid,semihumid,and humid regions,the changes are-0.039±0.010,-0.028±0.005,and-0.005±0.002,*** findings provide a reference for the future sustainable water resources development under climate change,highlighting the vulnerability of the water resources in ari

关键词： Hydrological system stability Compensation effects on water yield Sensitivities Budyko-Fu decomposition framework Global watersheds