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Advances in Bioscience and Biotechnology 2013年第3期4卷 455-468页

作者： yu matsuoka Kazuyuki Shimizu Department of Bioscience and Bioinformatics Kyushu Institute of Technology Fukuoka Japan Institute of Advanced Bioscience Keio University Tokyo Japan

Effect of the specific gene knockout on the main metabolism in Escherichia coli was reviewed, and the regulation mechanisms were clarified based on different levels of information such as gene expressions, enzyme activities, intracellular metabolite concentrations, and metabolic fluxes together with fermentation data. The effects of the knockout of such genes as pflA, pta, ppc, pykF, adhE, and ldhA on the metabolic changes were analyzed for the case under anaerobic condition. The effects of the knockout of such genes as pgi, zwf, gnd, ppc pck, pyk, and lpdA on the metabolic changes were also analyzed for the case under aerobic condition. The metabolic regulation analysis was made focusing on the roles of transcription factors.

关键词： Metabolic Regulation Single-Gene Knockout Mutant Escherichia coli

Scirrhous hepatocellular carcinoma displaying atypical findings on imaging studies

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World Journal of Gastroenterology 2009年第18期15卷 2296-2299页

作者： Soo Ryang Kim Susumu Imoto Taisuke Nakajima Kenji Ando Keiji Mita Katsumi Fukuda Ryo Nishikawa yu-ichiro Koma Toshiyuki matsuoka Masatoshi Kudo Yoshitake Hayashi Department of Gastroenterology Kobe Asahi HospitalKobe653-0801Japan Department of Radiology Osaka City University Medical SchoolOsaka545-8585Japan Department of Gastroenterology and Hepatology Kinki University School of MedicineOsaka-Sayama589-8511Japan Division of Molecular Medicine & Medical Genetics International Center for MedicalResearch and Treatment(ICMRT)Kobe University Graduate School of MedicineKobe650-0017Japan

We describe a 15-mm scirrhous hepatocellular carcinoma （HCC） in a 60-year-old man with B-type cirrhosis. Ultrasound disclosed a 15-mm hypoechoic nodule in segment 7. Contrast-enhanced US revealed heterogeneous, not diffuse, hypervascularity in the early phase and a defect in the Kupffer ***-enhanced computed tomography （CT） revealed a heterogeneous hypervascular nodule in the early phase and a low-density area in the late *** resonance imaging （MRI） revealed iso- to hypointensity at T1 and high intensity at T2-weighted sequences. Contrast-enhanced MRI also revealed a heterogeneous hypervascular nodule in the early phase and washout in the late phase. Super-paramagnetic iron oxide-MRI revealed a hvoerintense nodule. CT during hepatic arteriography and CT during arterial portography revealed heterogeneous hyperattenuation and a perfusion defect, respectively. Based on these imaging findings the nodule was diagnosed as a mixed well-differentiated and moderately-differentiated ***, the nodule was moderately-differentiated HCC characterized by typical cytological and structural atypia with dense fibrosis. Immunohistochemically,the nodule was positive for heterochromatin protein 1 and alpha-smooth muscle actin, and negative for cytokeratin 19. From the above findings, the nodule was diagnosed as scirrhous HCC. Clinicians engaged in hepatology should exercise caution with suspected scirrhous HCC when imaging studies reveal atypical findings, as shown in our case on the basis of chronic liver disease.

关键词： Scirrhous hepatocellular carcinoma Contrast-enhanced computed tomography Contrast-enhanced magnetic resonance imaging Contrast-enhanced ultrasound Computed tomography duringhepatic arteriography Computed tomography duringarterial portography Heterogeneous hypervascularity

Spatial Distribution of Radiation Belt Protons Deduced from Solar Cell Degradation of the Arase Satellite

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International Journal of Astronomy and Astrophysics 2018年第4期8卷 306-322页

作者： Honoka Toda Wataru Miyake Yoshizumi Miyoshi Hiroyuki Toyota yu Miyazawa Iku Shinohara Ayako matsuoka Department of Aeronautics and Astronautics Tokai University Kanagawa Japan Institute for Space-Earth Environmental Research Nagoya University Nagoya Japan Institute of Space and Astronautical Science JAXA Kanagawa Japan

Analysis of solar-cell array panel (SAP) data from the Arase satellite orbiting in the inner magnetosphere showed a clear degradation of solar cells that could be attributed to trapped protons with energies greater than 6 MeV. Proton fluence was determined based on variations in the open-circuit voltage (Voc) of the solar cells, which we compared with that expected based on various distribution models (AP8MAX, AP9 mean and CRRESPRO quiet) of trapped protons. We found a general agreement, confirming the major contribution of trapped protons to the degradation, as well as a slight difference in the fluence expected based on the model calculations. To minimize this difference, we slightly modified the models, and found that concentrating the energetic protons on the magnetic equator provided a better agreement. Our results indicate that >6 MeV protons also has the equatorial concentration as reported for >18 MeV protons from the Van Allen Probes observation, and are interpreted as two components of the trapped protons, i.e., those of solar energetic particle (SEP) origin have an anisotropic pitch-angle distribution and are confined near the magnetic equator.

关键词： Arase Satellite Proton Radiation Belt Solar Cell Degradation

蛋黄与大豆卵磷脂对高脂饲料大鼠肝脏脂肪酸谱的影响

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营养学报 2020年第6期42卷 586-591,596页

作者：尹明雨张彩霞松冈亮辅奚印慈王锡昌上海海洋大学食品学院上海201306 上海海洋大学食品科学技术研究室上海201306

目的以体重、脏器指数、甘油三酯水平以及肝脏脂肪酸谱为观测指标,探究蛋黄卵磷脂与大豆卵磷脂对高脂血症大鼠肝脏脂肪酸谱变化的治疗作用。方法将24只雄性SD大鼠随机分为对照组、高脂模型组、蛋黄卵磷脂干预组(Egg-PL)和大豆卵磷脂干预... 详细信息

目的以体重、脏器指数、甘油三酯水平以及肝脏脂肪酸谱为观测指标,探究蛋黄卵磷脂与大豆卵磷脂对高脂血症大鼠肝脏脂肪酸谱变化的治疗作用。方法将24只雄性SD大鼠随机分为对照组、高脂模型组、蛋黄卵磷脂干预组(Egg-PL)和大豆卵磷脂干预组(Soy-PL)。比较分析大豆卵磷脂与蛋黄卵磷脂以及其复配饲料中脂肪酸的含量,监测实验期间大鼠每日体重增长情况、血清与肝脏中甘油三酯(TG)的含量、脏器指数和肝脏脂肪酸谱。结果相较于对照组,摄入高脂饲料大鼠体重增长速度增加,体重增加总量极显著增大(P<0.001),肝脏指数(Liver index,LI)与腹部脂肪指数(Adiposeindex,AI)显著增加(P<0.05),脂肪酸谱发生改变;Egg-PL组降低了增长速度,Soy-PL组提升增长速度;Egg-PL组与Soy-PL组均降低了LI、血清和肝脏中TG的含量(P<0.05);正交偏最小二乘法分析发现Egg-PL与Soy-PL干预后抑制了肝脏脂肪酸谱中C18:0,C18:1N9C,C22:6NS的改变。结论不同源的卵磷脂都能够对高脂饮食引起的高脂血症大鼠体重变化、脂质代谢紊乱、肝脏脂肪酸谱起到保护作用。

关键词：卵磷脂蛋黄大豆高脂血症脂肪酸谱

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卵磷脂的生物活性及其应用研究进展

包装工程 2020年第13期41卷 31-39页

作者：尹明雨张彩霞松冈亮辅奚印慈王锡昌上海海洋大学上海201306 日本丘比株式会社东京1820002

目的介绍卵磷脂的功能特性和开发利用的研究进展,为磷脂及其功能性食品开发提供一定的思路和依据。方法通过查阅国内外前沿文章对卵磷脂的来源分布、物化性质、功能活性及其机制进行全面概述,总结目前磷脂的应用现状,并对其未来发展前... 详细信息

目的介绍卵磷脂的功能特性和开发利用的研究进展,为磷脂及其功能性食品开发提供一定的思路和依据。方法通过查阅国内外前沿文章对卵磷脂的来源分布、物化性质、功能活性及其机制进行全面概述,总结目前磷脂的应用现状,并对其未来发展前景予以展望。结果卵磷脂具有降血脂、调节血糖、预防心脑血管疾病等功能,可以缓释药物的递质、机能的维护,同时可作为功能食品的开发、食品包装涂膜的最优选材料。结论从未来的发展趋势看,卵磷脂这种具有多重功能的天然活性成分必将拥有更加广阔的发展前景,在食品中的应用将更加广泛。

关键词：卵磷脂降血脂脂质代谢认知能力抗氧化

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西藏南部放射虫微体古生物研究进展

微体古生物学报 2002年第2期19卷 105-111页

作者：杨群松冈笃王玉净中国科学院南京地质古生物研究所南京210008 日本新泻大学地质系新泻950-2181

西藏南部的雅鲁藏布蛇绿岩带以及该带之南的沉积地层带 (特提斯沉积区、北喜马拉雅亚区 )中广泛发育着大量含放射虫地层。放射虫研究在确定该区蛇绿岩的形成时代、解释造山带复杂的地层层序以及揭示印度板块与欧亚板块在古近纪碰撞之前... 详细信息

西藏南部的雅鲁藏布蛇绿岩带以及该带之南的沉积地层带 (特提斯沉积区、北喜马拉雅亚区 )中广泛发育着大量含放射虫地层。放射虫研究在确定该区蛇绿岩的形成时代、解释造山带复杂的地层层序以及揭示印度板块与欧亚板块在古近纪碰撞之前的古海洋盆地的演化历史等方面发挥了重要作用。根据已发表的文献以及我们正在进行中的初步成果显示 ,藏南地区的含放射虫地层的时代分布为中三叠世 (安尼期 )至晚白垩世 (土仑期 )。这些地层的岩性包括硅质岩、硅质泥岩、凝灰质细碎屑岩和泥晶灰岩等。尽管藏南的放射虫研究已取得一些成果 ,但系统的放射虫研究与地层研究仍然有待于进一步深入开展。

关键词：西藏南部放射虫微体古生物研究进展中生代

Novel Soil Strength Criterion Compared with Conventional Criteria

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Geomaterials 2017年第1期7卷 25-39页

作者： Shuai Shao Shengjun Shao yu Zhang Changlu Chen Institute of Geotechnical Engineering Xi’an University of Technology Xi’an China Shaanxi Key Laboratory of Loess Mechanics and Engineering Xi’an China

A novel soil strength criterion is proposed based on the shear stress ratio on a new spatially mobilized plane, where the cube root of principal stresses is constant. The strength failure surface depicted in the principal stress space by this criterion was smoothly conical, with a curved triangle shape on the octahedral plane. A comparative analysis of the strength failure surfaces of the Mohr-Coulomb (M-C), the Drucker-Prager (D-P), the matsuoka-Nakai (M-N), the Lade-Duncan (L-D), the new criteria, and the shear strength laws of different criteria with parameter b on the π plane showed that the L-D criterion and the new spatially mobilized plane strength criterion were comparable, which revealed the physical essence of the L-D criterion. Comparing the new strength criterion with the measured results of true triaxial tests of 4 kinds of intact loess under conditions of consolidation and drain, the strength law of loess could be described by the new strength criterion under complex stress conditions, and the rationality and reliability of the strength criterion were verified by the correspondence between the criterion and experimental values.

关键词： Spatially Mobilized Plane Physical Essence of L-D Criterion Strength of Loess True Triaxial Test

应用卫星与气象数据及其关系研究黄河流域的荒漠化现状(英文)

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遥感学报 2007年第5期11卷 742-747页

作者：王秀峰松冈延浩于贵瑞何洪林谷宏松村伸二北海道大学农学研究院千叶大学园艺学部中国科学院地理科学与资源研究所香川大学农学部

本文应用20年(1981—2000年)的卫星数据反演归一化差值植被指数(NDVI),同时获取地面格网的温度与降雨数据,并分析这些数据之间的关系。基于地面的温度和降雨格网数据将研究区划分为8个气候区域,再利用NDVI数据把降雨量最少的3个气候区... 详细信息

本文应用20年(1981—2000年)的卫星数据反演归一化差值植被指数(NDVI),同时获取地面格网的温度与降雨数据,并分析这些数据之间的关系。基于地面的温度和降雨格网数据将研究区划分为8个气候区域,再利用NDVI数据把降雨量最少的3个气候区——区1,2,3各划分为10个等级。此外,分析这3个气候区在1983—1998年15年间的NDVI变化状况,结果显示出研究区荒漠化状况的加剧。

关键词：加剧 NDVI 降雨量气温

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平面应变条件下土的强度准则分析及验证

岩土力学 2015年第9期36卷 2501-2509页

作者：张玉邵生俊王丽琴马林西安理工大学岩土工程研究所陕西西安710048 西安工业大学北方信息工程学院陕西西安710032

应用Mohr-Coulomb、Lade-Duncan、广义Mises、matsuoka-Nakai、AC-SMP强度准则,以及平面应变条件和相关联流动法则,建立了平面应变条件下土的强度准则。通过分析不同平面应变条件强度准则,确定最大、最小主应力比随土的内摩擦角的变化规... 详细信息

应用Mohr-Coulomb、Lade-Duncan、广义Mises、matsuoka-Nakai、AC-SMP强度准则,以及平面应变条件和相关联流动法则,建立了平面应变条件下土的强度准则。通过分析不同平面应变条件强度准则,确定最大、最小主应力比随土的内摩擦角的变化规律,分析了各强度准则的适用性。当内摩擦角小于30°时,各强度准则的差异性较小;当内摩擦角大于30°时,各强度准则的差异逐渐增大;内摩擦角较大时,广义Mises平面应变强度准则已不适用于描述土的破坏应力条件。同时,考虑黏聚力的作用,将无黏性土平面应变强度准则推广应用于黏性土,根据黄土的平面应变试验结果对各强度准则进行了初步验证,结果表明:matsuoka-Nakai强度准则适用于描述砂土的强度,Lade-Duncan、AC-SMP强度准则可以很好地描述黄土的强度。

关键词：强度准则平面应变中主应力空间滑动面

土的σ(1/2)~3空间滑动面强度准则及其与传统准则的比较研究

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岩土工程学报 2015年第4期37卷 577-585页

作者：邵生俊张玉陈昌禄邵帅西安理工大学岩土工程研究所陕西西安710048 陕西省黄土力学与工程重点实验室陕西西安710048

土的抗剪强度与其剪切破坏面上的正应力一般呈线性关系,反映了土的剪切强度本质特性。常用的强度准则有Mohr–Coulomb准则、Drucker–Prager屈服准则、matsuoka–Nakai准则,分别对应于与大主应力呈45°+ω/2的剪切破坏面、八面体面和空... 详细信息

土的抗剪强度与其剪切破坏面上的正应力一般呈线性关系,反映了土的剪切强度本质特性。常用的强度准则有Mohr–Coulomb准则、Drucker–Prager屈服准则、matsuoka–Nakai准则,分别对应于与大主应力呈45°+ω/2的剪切破坏面、八面体面和空间滑动面(SMP)上的剪应力比为常数的关系。本文提出了一种由σ1k(1/2)~3,σ2k(1/2)~3,σ3k(1/2)~3确定土单元大、中、小主应力轴交点的空间滑动面,称为σ(1/2)~3空间滑动面;建立了σ(1/2)~3空间滑动面剪应力比为常数的准则,称为σ(1/2)~3空间滑动面强度准则,该准则在应力空间描述的强度破坏面为π平面上呈曲边三角形形态的光滑锥面。进行了Mohr–Coulomb强度准则、Drucker–Prager强度准则、matsuoka–Nakai强度准则与Lade–Duncan强度准则、σ(1/2)~3空间滑动面强度准则在应力空间描述强度破坏面的比较分析,以及不同π平面上Lade–Duncan准则和σ(1/2)~3空间滑动面强度准则随b值的变化规律。结果表明Lade–Duncan强度准则与σ(1/2)~3空间滑动面强度准则近似一致,从而揭示了Lade–Duncan强度准则的物理本质基础:Lade–Duncan强度准则实质上近似服从土破坏时σ(1/2)~3空间滑动面上剪应力与正应力呈线性变化的规律。即Lade–Duncan强度准则描述土单元剪切破坏时的空间滑动面近似为σ(1/2)~3空间滑动面。根据4种原状黄土固结排水条件下的真三轴压缩试验结果,验证了σ(1/2)~3空间滑动面强度准则的合理性与可靠性。

关键词：土的强度 σ(1/2)~3空间滑动面 σ(1/2)~3空间滑动面准则黄土真三轴试验