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Gastric submucosa-invasive carcinoma associated with EpsteinBarr virus and endoscopic submucosal dissection: A case report

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World Journal of Gastrointestinal Oncology 2019年第10期11卷 925-932页

作者： yu kobayashi Takehito Kunogi Hiroki Tanabe yuki Murakami Takuya Iwama Takahiro Sasaki Keitaro Takahashi Katsuyoshi Ando Yoshiki Nomura Nobuhiro Ueno Shin Kashima Kentaro Moriichi Hidehiro Takei Mikihiro Fujiya Toshikatsu Okumura Division of Gastroenterology and Hematology/Oncology Department of Medicine Asahikawa Medical UniversityAsahikawa 078-8510Japan Pathological Department of Asahikawa Medical University Hospital Asahikawa Medical UniversityAsahikawa 078-8510Japan

BACKGROUND Epstein-Barr virus(EBV)-associated carcinoma is a gastric cancer subtype with a morphology characterized by gastric carcinoma with lymphoid stroma(GCLS).Clinicopathological studies have indicated a better prognosis for GCLS than for common gastric *** previous cases of early gastric cancer associated with EBV had been diagnosed by endoscopic *** SUMMARY We present two GCLS cases subjected to endoscopic submucosal dissection(ESD)for a definitive diagnosis.A protruded gastric lesion was identified by routine endoscopic examination,but forceps biopsy showed no atypical cells before *** resected specimen showed a poorly differentiated adenocarcinoma with lymphoid cells involving the mucosa and *** final diagnosis was submucosa-invasive poorly differentiated gastric ***,additional gastrectomy was recommended to obtain a complete *** patient underwent additional distal gastrectomy with lymph node dissection,but the other was refused because of cardiovascular *** patients remained in remission for more than half a *** positivity was determined by EBV-encoded RNA in situ *** also conducted a literature review of cases of early gastric cancer associated with EBV that had been diagnosed by *** Submucosa-invasive GCLS could be dissected using ESD,and EBV positivity should be subsequently assessed to determine whether or not any additional curative surgery is *** prospective investigations on the prevalence of lymph node metastasis in EBV-associated carcinoma should be performed to expand the indications for endoscopic resection.

关键词： Herpesvirus 4 Human Stomach neoplasms Gastric carcinoma with lymphoid stroma Epstein-Barr virus-associated gastric carcinoma Case report

Local recurrence after successful endoscopic submucosal dissection for rectal mucinous mucosal adenocarcinoma:A case report

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World Journal of Gastrointestinal Oncology 2023年第1期15卷 186-194页

作者： yuki Murakami Hiroki Tanabe yusuke Ono yuya Sugiyama yu kobayashi Takehito Kunogi Takahiro Sasaki Keitaro Takahashi Katsuyoshi Ando Nobuhiro Ueno Shin Kashima Sayaka yuzawa Kentaro Moriichi yusuke Mizukami Mikihiro Fujiya Toshikatsu Okumura Division of Metabolism and Biosystemic Science Department of Gastroenterology and Hematology/OncologyDepartment of MedicineAsahikawa Medical UniversityAsahikawa 078-8510HokkaidoJapan Institute of Biomedical Research Sapporo-Higashi Tokushukai HospitaSapporo 065-0033HokkaidoJapan Department of Diagnostic Pathology Asahikawa Medical UniversityAsahikawa 078-8510HokkaidoJapan

BACKGROUND Mucinous adenocarcinoma of the colorectum is a rare histological subtype characterized by an abundant mucinous *** tumors are frequently diagnosed at an advanced stage,which indicates an aggressive ***,few case reports have been published,and little information is available concerning genetic alterations in mucinous *** SUMMARY A 76-year-old man underwent en bloc endoscopic submucosal dissection(ESD)for the management of a type 0-Is+IIa *** examination revealed an intramucosal mucinous adenocarcinoma with signet-ring cell carcinoma and well-to-moderately differentiated tubular *** years after the ESD,local recurrence was detected by an endoscopic examination,revealing a new 0-Is+IIa lesion with a phenotype similar to the previously resected ***-ESD was chosen for the management of the recurrent tumor,and the histological examination showed positive tumor infiltration at the vertical *** surgical resection was performed for the curative *** analysis showed pathogenic alterations in RNF43 and TP53 in the adenoma and an additional SMAD4 alteration in the *** This mucinous mucosal adenocarcinoma case was suggested to have an aggressive phenotype and a careful and close follow-up are required.

关键词： Rectal cancer Mucinous adenocarcinoma Endoscopic submucosal dissectio TP53 Colitic cancer pathway Case report

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桑枝化学成分的研究

中成药 2017年第9期39卷 1861-1866页

作者：艾文何厚洪杜昕王建方谭林威李元园小林裕太王如伟浙江现代中药与天然药物研究院有限公司浙江杭州310052 浙江康恩贝制药股份有限公司(浙江省中药制药技术重点实验室) 浙江杭州310052 浙江大学药学院浙江杭州310058 杭州医学院药学系浙江杭州310053 岛根医科大学医学院

目的研究桑Morus alba L.枝的化学成分。方法桑枝60%乙醇提取液采用ODS、Sephadex LH-20、半制备柱进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到10个化合物,分别鉴定为4'-O-β-D-吡喃葡萄糖基-2'-羟基... 详细信息

目的研究桑Morus alba L.枝的化学成分。方法桑枝60%乙醇提取液采用ODS、Sephadex LH-20、半制备柱进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到10个化合物,分别鉴定为4'-O-β-D-吡喃葡萄糖基-2'-羟基大花藜芦酚3-(6-O-β-D-吡喃葡萄糖基-β-D-吡喃葡萄糖苷)(1)、3-O-β-D-吡喃葡萄糖基-2'-羟基大花藜芦酚4'-(6-O-β-D-吡喃葡萄糖基-β-D-吡喃葡萄糖苷)(2)、桑皮苷A(3)、桑皮苷E(4)、桑皮苷F(5)、反式氧化白藜芦醇-4-O-β-D-吡喃葡萄糖苷(6)、反式氧化白藜芦醇-3-O-β-D-吡喃葡萄糖苷(7)、顺式桑皮苷A(8)、3,4-二甲氧基苯基β-D-呋喃芹糖基-(1→6)-β-D-吡喃葡萄糖苷(9)、kelampayoside A(10)。结论化合物9、10为首次从桑属植物中分离得到,化合物1、2、4~7为首次从该植物中分离得到。

关键词：桑枝化学成分分离鉴定

Oval mucosal opening bloc biopsy after incision and widening by ring thread traction for submucosal tumor

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World Journal of Gastroenterology 2017年第39期23卷 7185-7190页

作者： Hirohito Mori Hideki Kobara yu Guan Yasuhiro Goda Nobuya kobayashi Noriko Nishiyama Tsutomu Masaki Department of Gastroenterology and Neurology Kagawa University Departments of Pharmacology Kagawa University

Gastric submucosal tumors(SMTs) less than 2 cm are generally considered benign neoplasms, and endoscopic observation is recommended, but SMTs over 2 cm, 40% of which are gastrointestinal stromal tumors(GISTs), have malignant potential. Although the Japanese Guidelines for GIST recommend partial surgical resection for GIST over 2 cm with malignant potential as well as en bloc large tissue sample to obtain appropriate and large specimens of SMTs, several reports have been published on tissue sampling of SMTs, such as with endoscopic ultrasound sound fine needle aspiration, submucosal tunneling bloc biopsy, and the combination of bite biopsy and endoscopic mucosal resection. Because a simpler, more accurate method is needed for appropriate treatment, we developed oval mucosal opening bloc biopsy after incision and widening by ring thread traction for submucosal tumor(OMOB) approach. OMOB was simple and enabled us to obtain large samples under direct procedure view as well as allowed us to restore to original mucosa.

关键词： Gastric submucosal tumors Gastrointestinal stromal tumor Reversible opening biopsy Endoscopic ultrasonography Large sample

Applications of quantum computing for investigations of electronic transitions in phenylsulfonyl-carbazole TADF emitters

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npj Computational Materials 2021年第1期7卷 619-627页

作者： Qi Gao Gavin O.Jones Mario Motta Michihiko Sugawara Hiroshi CWatanabe Takao kobayashi Eriko Watanabe yu-ya Ohnishi Hajime Nakamura Naoki Yamamoto Mitsubishi Chemical Corporation Science&Innovation CenterYokohamaJapan Quantum Computing Center Keio UniversityYokohamaJapan IBM Quantum IBM Research-AlmadenSan JoseCAUSA Materials Informatics Initiative Yokkaichi Research CenterJSR CorporationYokkaichiMieJapan IBM Research-Tokyo TokyoJapan Department of Applied Physics and Physico-Informatics Keio UniversityYokohamaJapan

A quantum chemistry study of the first singlet(S_(1))and triplet(T_(1))excited states of phenylsulfonyl-carbazole compounds,proposed as useful thermally activated delayed fluorescence(TADF)emitters for organic light emitting diode(OLED)applications,was performed with the quantum Equation-Of-Motion Variational Quantum Eigensolver(qEOM-VQE)and Variational Quantum Deflation(VQD)algorithms on quantum simulators and *** quantum simulations were performed with double zeta quality basis sets on an active space comprising the highest occupied and lowest unoccupied molecular orbitals(HOMO,LUMO)of the TADF *** differences in energy separations between S_(1) and T_(1)(ΔEST)predicted by calculations on quantum simulators were found to be in excellent agreement with experimental *** of 17 and 88 mHa with respect to exact energies were found for excited states by using the qEOM-VQE and VQD algorithms,respectively,to perform simulations on quantum devices without error *** utilizing state tomography to purify the quantum states and correct energy values,the large errors found for unmitigated results could be improved to differences of,at most,4 mHa with respect to exact ***,excellent agreement could be found between values ofΔEST predicted by quantum simulations and those found in experiments.

关键词： quantum excited occupied

Anti-Hyperglycemic Effect of Single Administered Gardeniae Fructus in Streptozotocin-Induced Diabetic Mice by Improving Insulin Resistance and Enhancing Glucose Uptake in Skeletal Muscle

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Chinese Medicine 2013年第4期4卷 157-165页

作者： Qing yu Tatsuo Takahashi Masaaki Nomura Shinjiro kobayashi Department of Clinical Pharmacy Faculty of Pharmaceutical Sciences Hokuriku University 3-Ho Kanagawa-Machi Kanazawa Japan Department of Education Center of Clinical Pharmacy Faculty of Pharmaceutical Sciences Hokuriku University 3-Ho Kanagawa-Machi Kanazawa Japan

The mechanisms of Gardeniae Fructus (GF) for anti-hyperglycemic action were demonstrated in streptozotocin (STZ)-diabetic mice. Six hours after single intraperitoneal administration of GF (300 mg/kg) or H2O into 3 hour-fasted STZ-diabetic mice, glucose and insulin tolerances were assessed by intraperitoneal glucose (1.5 g/kg) tolerance test (IPGTT) and intraperitoneal insulin (0.65 U/kg) tolerance test (IPITT), respectively. Effects of GF on insulin signaling pathways in soleus muscle such as glucose uptake, expression of glucose transporter 4 (GLUT4) in the plasma membrane and phosphorylation of Akt (P-Akt) in cytosolic fraction were examined in STZ-diabetic mice. In IPGTT test, GF significantly accelerated clearance of exogenous glucose and its glucose-lowering action was greater than H2O-treated controlin STZ-diabetic mice. GF also promoted an exogenous glucose-increased insulin level in STZ-diabetic mice. In IPITT test, GF decreased glucose level to the greater extent than H2O-treated control in STZ-diabetic mice. Furthermore, GF significantly decreased high HOMA-IR in STZ-diabetic mice from 21.6 ± 2.4 to 12.4 ± 1.9 (mg/dl × μU/ml). These results implied that GF improved insulin resistance in STZ-diabetic mice. GF increased glucose uptake of soleus muscle 1.5 times greater than H2O-treated control in STZ-diabetic mice. GF enlarged insulin (10 nmol/ml)-increased glucose uptake to 1.8 time-greater. Correspondingly, GF increased expression of GLUT4 in the plasma membrane of soleus muscle to 1.4 time-greater, and P-Akt in the cytosolic fraction of soleus muscle to 1.9 time-greater than those in H2O-treated control. In conclusion, the improvement of GF on insulin resistance is associated with the repair of insulin signaling via P-Akt, GLUT4 and glucose uptake pathway in soleus muscle of STZ-diabetic mice.

关键词： Gardeniae Fructus (GF) Streptozotocin (STZ) Soleus Muscle Insulin Resistance Glucose Uptake Glucose Transporter 4 (GLUT4) Phosphorylation of Akt (P-Akt)

Pancreatic cancer secondary to intraductal papillary mucinous neoplasm with collision between gastric cancer and B-cell lymphoma: A case report

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World Journal of Clinical Cases 2021年第10期9卷 2400-2408页

作者： yu-Hong Ma Tatsuya Yamaguchi Tomoki Yasumura Toru Kuno Shoji kobayashi Takashi Yoshida Takeshi Ishida Yasuaki Ishida Shinya Takaoka Jiang-Lin Fan Nobuyuki Enomoto Department of Gastroenterology Ningxia Hui Autonomous Region People’s HospitalYinchuan 750021Ningxia Hui Autonomous RegionChina Department of the First Internal Medicine Faculty of MedicineUniversity of YamanashiChuo 409-3898YamanashiJapan Department of Molecular Pathology Interdisciplinary Graduate School of Medicine and EngineeringUniversity of YamanashiChuo 409-3898YamanashiJapan

BACKGROUND Patients with intraductal papillary mucinous neoplasm(IPMN)have an increased risk of pancreatic and extrapancreatic *** are rare extrapancreatic malignancies,and in situ collisions of early gastric cancer and diffuse large B-cell lymphoma(DLBCL)are even ***,we report the first case of pancreatic cancer comorbid with in situ collision of extrapancreatic malignancies(early gastric cancer and DLBCL)in a follow-up IPMN ***,we have made innovations in the treatment of such *** SUMMARY An 81-year-old Japanese female diagnosed with IPMN developed elevated carbohydrate antigen(CA)19-9 levels during *** her CA19-9 levels continued to rise,endoscopic ultrasound(EUS)was performed and revealed a suspicious lesion at the pancreatic ***,lesions in the pancreas were not found by computed tomography,magnetic resonance imaging,or endoscopic retrograde *** make an exact pathological diagnosis,EUS-guided fine needle aspiration was *** our supprise,early gastric cancer was found in preoperative *** gastric cancer was completely resected through endoscopic submucosal dissection before postoperative pathology identified early adenocarcinoma collided with *** EUS-guided fine needle aspiration provided pathological support forthe pancreatic cancer diagnosis, and then laparoscopic distal pancreatectomy andsplenectomy were performed. CA19-9 levels returned to normal *** Endoscopic submucosal dissection is appropriate for submucosal lymphomas inpatients intoleratant of chemotherapy. EUS can detect small IPMN-relatedpancreatic tumors.

关键词： Stomach neoplasms Pancreatic intraductal neoplasms Pancreatic neoplasms B-cell lymphoma Treatment Case report

Prognostic factors in heart failure patients with cardiac cachexia

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Journal of Geriatric Cardiology 2020年第1期17卷 26-34页

作者： yu Sato Akiomi Yoshihisa yusuke Kimishima Tetsuro Yokokawa Satoshi Abe Takeshi Shimizu Tomofumi Misaka Shinya Yamada Takamasa Sato Takashi Kaneshiro Masayoshi Oikawa Atsushi kobayashi Takayoshi Yamaki Hiroyuki Kunii Yasuchika Takeishi Department of Cardiovascular Medicine Fukushima Medical UniversityFukushimaJapan Department of Advanced Cardiac Therapeutics Fukushima Medical UniversityFukushimaJapan

Objective To clarify whether cardiac cachexia(CC)alters the prognostic impact of other general risk factors in patients with heart failure(HF).Methods This was an observational *** was defined as the combination of a body mass index of5 mg/L;hemoglobin<12 g/dL;and/or albumin<3.2 g/d *** divided 1608 hospitalized HF patients into a CC group(n=176,10.9%)and a non-CC group(n=1432,89.1%).The primary endpoints were cardiac event and all-cause *** The presence of CC showed significant interactions with other risk factors including cancer,estimated glomerular filtration rate(eGFR),and sodium in predicting these *** Cox proportional analysis revealed that use of a blockers[hazard ratio(HR)=1.900,95%confidence interval(CI):1.045–3.455,P=0.035]and eGFR(HR=0.989,95%CI:0.980–0.998,P=0.018)were independent predictors of cardiac event in the CC group,while age(HR=1.020,95%CI:1.002–1.039,P=0.029)and hemoglobin(HR=0.844,95%CI:0.734–0.970,P=0.017)were independent predictors of all-cause *** survival classification and regression tree analysis showed the optimal cut-off points for cardiac event(eGFR:59.9 m L/min per 1.73 m^2)and all-cause death(age,83 years old;hemoglobin,10.1 g/dL)in the CC *** In predicting prognosis,CC showed interactions with several risk *** function,age,and hemoglobin were pivotal markers in HF patients with CC.

关键词： Body mass index Cachexia Heart failure Mortality Prognosis

The efficacy of recovery care with cool veil serum

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Health 2010年第12期2卷 1425-1429页

作者： yu yumoto Takehiko yukishita Keiko Lee Hiroyuki kobayashi 不详

The purpose of this study was to investigate the efficacy of post-exercise treatment with “Cool Veil Serum (CVS)” developed by Madre:X Co. Ltd. (Shibuya, Tokyo) to prevent exercise-induced muscle swelling. Calf circumferences and mus-cle stiffness of both legs were measured in 10 healthy female. The measurements were made on before 5-minute exercise, after the exercise, and after 10-minute recovery care with CVS and 5-minute rest. The recovery care was applied only on right leg of the subjects. Then, multiple comparisons of calf circumference and muscle stiffness on each leg among pre-exer-cise, post-exercise, and final measurements were carried out. Exercise caused a significant increase in calf circumference and muscle stiff-ness. The recovery care with CVS rapidly re-duced postexercise calf circumference to pre-exercise level. Relationship between reduc-ing muscle swelling after exercise and prevent-ing sport injury should be explored in further studies.

关键词： Recovery Care Cool Veil Serum Massage After Exercise Calf Circumference Muscle Stiffness