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Glaucoma secondary to systemic lupus erythematosus

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Chinese Medical Journal 2014年第19期127卷 3428-3431页

作者： Zhang Jing Huang Wenbin Gao Xinbo Che Huixin yu keming Zhang Xiulan Zhongshan Ophthalmic Center State Key Laboratory ofOphthalmology Sun Yat-Sen University Guangzhou Guangdong510060 China Third Affiliated Hospital of Liaoning Medical College JinzhouLiaoning 121001 China Glaucoma Department Clinical Research Center Institution of DrugClinical Trials State Key Laboratory of Ophthalmology Sun Yat-senUniversity Guangzhou Guandong 510060 China

Background Glaucoma secondary to systemic lupus erythematosus （SLE - an uncommon but serious complication that threatens vision and therefore cannot be neglected. A few cases of second, y glaucoma resulting from lupus-induced or iatrogenic ocular impairments have been reported in association with SLE. However, a systematic analysis of the diagnosis and treatment of glaucoma secondary to SLE has not been reported in the literature. The aim of this study is to further investigate the relationship between glaucoma and SLE. Methods In this study, we reviewed nine eyes of five patients diagnosed with secondary glaucoma associated with SLE, including one case of neovascular glaucoma and four cases of steroid-induced glaucoma. Results Neovascular glaucoma was successfully treated by Ahmed glaucoma valve implantation surgery with adjunctive ranibizumab intravitreal injection, followed by panretinal photocoagulation （PRP）. The steroid-induced glaucoma in eight eyes of four cases were controlled by trabeculectomy along with antiproliferative agents. Conclusion Regular follow-up ocular examinations should be conducted to ensure early diagnosis and treatment of secondary glaucoma in SLE patients to improve the prognosis of vision.

关键词： systemic lupus erythematosus neovascular glaucoma steroid-induced glaucoma

考虑移动式储能调度的配电网灾后多源协同孤岛运行策略

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电力系统自动化 2024年第3期48卷 62-72页

作者：王育飞李可铭薛花于艾清米阳上海电力大学电气工程学院上海市200090 国网上海市电力公司金山供电公司上海市201500

针对极端事件导致的配电网大面积停电现象,在路-电耦合背景下,提出一种考虑移动式储能调度的配电网灾后多源协同孤岛运行策略。首先,基于路-电耦合背景下的灾后运行框架,以加权切负荷量最小为目标,同时考虑交通流量的变化对移动式储能... 详细信息

针对极端事件导致的配电网大面积停电现象,在路-电耦合背景下,提出一种考虑移动式储能调度的配电网灾后多源协同孤岛运行策略。首先,基于路-电耦合背景下的灾后运行框架,以加权切负荷量最小为目标,同时考虑交通流量的变化对移动式储能调度过程的影响,建立多源协同孤岛运行模型;然后,根据所建模型的特点以及决策需求,基于两阶段优化框架制定孤岛运行决策流程,确保失电孤岛区域与含本地电源区域负荷恢复的协调进行;最后,采用IEEE 33节点配电网与29节点交通路网相耦合的算例进行分析,验证所提策略的有效性。结果表明,所提孤岛运行策略可以充分发挥各电源在配电网灾后恢复时的协同能力,实现了有限电能的最优分配和转移,有效提升了配电网灾后恢复效果。

关键词：有源配电网移动式储能系统调度路-电耦合多源协同孤岛运行两阶段优化

Glycogen synthase kinase-3β inhibitor SB216763 promotes DNA repair in ischemic retinal neurons

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Neural Regeneration Research 2021年第2期16卷 394-400页

作者： Zhang Jing Lai Zhipeng Chen Pei Ying Yang Zhuang Jing yu keming Zhongshan Ophthalmic Center Sun Yat-sen University State Key Laboratory of Ophthalmology Guangdong Guangzhou

Glycogen synthase kinase-3β(GSK-3β) has been shown to attenuate DNA damage in nerve cells, thereby enhancing neuronal survival under pathological conditions;however, the underlying mechanism remains unclear. An in vitro serum-starvation retinal neuron model and in vivo ischemia/reperfusion retina injury rat model were established and treated with SB216763, a GSK-3β inhibitor. SB21673 decreased the formation of γ-H2 A histone family member X foci and enhanced the viability of ischemic retinal neurons. In addition, SB216763 upregulated expression of phosphorylated-CREB1, a ligase IV transcription factor, and significantly increased the transcriptional activity of ligase IV in ischemic retinal neurons. These results were confirmed in rat retinas following ischemia/reperfusion injury. Furthermore, we found that unlike lithium chlorine(a well-known direct inhibitor of GSK-3β), SB216763 inhibited GSK-3β activity by suppressing its phosphorylation. Taken together, our results suggest that GSK-3β inhibition enhances repair of DNA double-strand breaks by upregulating ligase IV expression in ischemic retinal neurons. This study was approved by the Institutional Animal Care and Use Committee of Zhongshan Ophthalmic Center on February 18, 2018.

关键词： factor GSK-3β in vitro injury ligase IV neuroprotection optic nerve pathways protein repair

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基于贝叶斯分位数回归研究大学生体测指标

淮北师范大学学报（自然科学版） 2024年第2期45卷 8-14页

作者：陈润玉虞克明安庆师范大学数理学院安徽安庆246003

为深入了解大学生身体素质现状及体测指标之间的相关性,采用贝叶斯分位数回归法,对某高校2020级学生的体质健康测试数据进行研究。首先对体质测试指标进行相关性检验和显著性检验,然后针对相关性较强的指标数据进行二次分位数拟合分析... 详细信息

为深入了解大学生身体素质现状及体测指标之间的相关性,采用贝叶斯分位数回归法,对某高校2020级学生的体质健康测试数据进行研究。首先对体质测试指标进行相关性检验和显著性检验,然后针对相关性较强的指标数据进行二次分位数拟合分析。女生的肺活量与身高、50 m短跑与立定跳远、男生的50 m短跑与1000 m长跑、50 m短跑与立定跳远以及1000 m长跑与体测总分之间的关系拟合效果较好,当分位点等于0.25时,模型精度最高。实验表明,贝叶斯分位数回归能全面反映大学生群体体测特征,具有较高的检测精度和良好的稳健性。

关键词：贝叶斯分位数回归体育统计体质健康大学生

Effects of confined space and near vision stimulation on refractive status and vitreous chamber depth in adolescent rhesus monkeys

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Science China(Life Sciences) 2010年第12期53卷 1433-1439页

作者： LENG yunXia LAN WeiZhong yu keming LIU BingQian YANG ZhiKuan LI Zheng ZHONG XingWu ZHANG ShaoChong GE Jian State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060China

This study aimed to investigate the effects of sustained near vision stimulation,on the refractive development and elongation of the vitreous chamber in adolescent rhesus monkeys.A total of 12 adolescent rhesus monkeys(1.5-2.0 years old) were randomly assigned to 3 groups.In groups A(n=4) and B(n=4),monkeys were reared in close-vision cages for 8 and 4 h d-1,respectively;tiny granules were added on the cage floor to avoid visual deprivation and to encourage near gaze.In group C(n=4),monkeys were reared in open-vision cages,with non-granule food as a control.Vitreous chamber depth,refractive status,and corneal refractive power were assessed over 18 months.Paired t-test was used to compare the differences and a P-value<0.05 was considered to be statistically significant.In group A,vitreous chamber depth and optical axis elongated significantly,and refractive error shifted towards myopia during the observation period.In group B,vitreous chambers and optical axis elongated but the refractive power did not show significant changes.In group C,there was no significant elongation in vitreous chambers and optical axis,and the refractive power changed slightly towards hypermetropia.There were no significant changes in corneal refractive power in each group.Sustained near vision can promote vitreous chamber growth and induce myopic shifts in refractive power in adolescent monkeys.Our results demonstrate the potential for a primate model of near-work-related myopia.

关键词： myopia near vision primate refractive development

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渤海渔业生物重金属污染及风险评价

渔业科学进展 2024年第2期45卷 39-49页

作者：李奇龙夏斌隋琪曲克明朱琳李玉江苏海洋大学海洋技术与测绘学院江苏连云港222005 中国水产科学研究院黄海水产研究所山东青岛266071 崂山实验室海洋生态与环境科学功能实验室山东青岛266237

重金属污染是渤海长期面临的环境问题之一,同时对渤海海产品安全和人体健康构成潜在风险。为了解渤海海域鱼类重金属污染状况,在该海域采集的渔业生物中随机选取了10种144条鱼类样本,运用电感耦合等离子体质谱法测定了鱼类肌肉组织中重... 详细信息

重金属污染是渤海长期面临的环境问题之一,同时对渤海海产品安全和人体健康构成潜在风险。为了解渤海海域鱼类重金属污染状况,在该海域采集的渔业生物中随机选取了10种144条鱼类样本,运用电感耦合等离子体质谱法测定了鱼类肌肉组织中重金属Cu、Zn、Pb、Cd、Cr和As的含量;采用单因子污染指数法、内梅罗综合污染指数法和金属污染指数法评价了单一重金属和综合重金属污染情况;采用每日摄入量和目标危害系数评估了渤海鱼类重金属污染对人体的食用安全风险。研究结果显示,渤海鱼类肌肉中重金属Cu、Zn、Pb、Cd、Cr和As的平均含量分别为(0.702±0.680)、(9.697±5.279)、(0.035±0.059)、(0.029±0.035)、(0.093±0.091)和(0.959±0.813)mg/kg。与我国其他海域相比,渤海鱼类重金属含量处于较高水平。鱼类重金属污染评价结果显示,Cd和无机As(iAs)为渤海鱼类重金属污染的主要元素,细纹狮子鱼(Liparistanakae)受到重金属综合污染的程度最大。食用风险评估结果表明,摄食渤海鱼类带来的重金属每日摄入量处于较低水平,所有鱼类样本单一重金属和综合重金属目标危害系数值均<1,表明正常摄食渤海鱼类不会对消费者构成健康风险。本研究结果有助于加深理解渤海渔业生物的重金属污染状况,同时为保障渤海水产品的食用安全提供科学依据。

关键词：重金属渤海渔业生物污染指数人体健康

High rodent abundance increases seed removal but decreases scatter-hoarding and seedling recruitment along an elevational gradient

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Integrative Zoology 2023年第5期18卷 843-858页

作者： Fei yu Linjun ZHANG Yang WANG Xianfeng YI Shuang ZHANG Jianmin MA Zimei DONG Guangwen CHEN keming MA State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijingChina College of Life Sciences Henan Normal UniversityXinxiangChina College of Life Sciences Qufu Normal UniversityQufuChina

The distributions of small rodents in mountainous environments across different elevations can provide important information regarding the effects of climate change on the dispersal of plant species.However,few studies of oak forest ecosystems have compared the elevational patterns of sympatric rodent diversity,seed dispersal,seed bank,and seedling abundance.Thus,we tested the differences in the seed disperser composition and abundance,seed dispersal,seed bank abundance,and seedling recruitment for Quercus wutaishanica along 10 elevation levels in the Taihang Mountains,China.Our results provide strong evidence that complex asymmetric seed dispersal and seedling regeneration exist along an elevational gradient.The abundance of rodents had a significant negative correlation with the elevation and the seed removal rates peaked and then declined with increasing elevation.The seed removal rates were higher at middle and lower elevations than higher elevations but acorns were predated by 5 species of seed predators at middle and lower elevations,and thus,there was a lower likelihood of recruitment compared with those dropped beneath mother oaks at higher elevations.More importantly,the number of individual seeds in the seed bank and seedlings increased with the elevation,although dispersal services were reduced at sites lacking rodents.As conditional mutualists,the rodents could possibly act as antagonistic seed predators rather than mutualistic seed dispersers at low and middle elevations,thereby resulting in the asymmetric pattern of rodent and seedling abundance with increasing elevation to affect the community assembly and ecosystem functions on a large spatial scale.

关键词： elevation rodent seed bank seed dispersal seedling distribution

潜在有毒元素和抗生素复合污染形成与治理研究的教学实践

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实验技术与管理 2024年第4期41卷 200-208页

作者：余彬彬杨克明王进军陈丹王小治钱晓晴扬州大学农业农村部耕地质量监测与评价重点实验室江苏扬州225127 扬州大学环境科学与工程学院江苏扬州225127

该实验以小麦(Triticum aestivum L.)为研究对象,采用水培方法,形象直观地展现了潜在有毒元素Cu^(2+)、Zn^(2+)和抗生素土霉素(oxytetracycline,OTC)、磺胺嘧啶(sulfadiazine,Sul)单一及复合污染对小麦种子根和芽的毒性差异,以期为土壤... 详细信息

该实验以小麦(Triticum aestivum L.)为研究对象,采用水培方法,形象直观地展现了潜在有毒元素Cu^(2+)、Zn^(2+)和抗生素土霉素(oxytetracycline,OTC)、磺胺嘧啶(sulfadiazine,Sul)单一及复合污染对小麦种子根和芽的毒性差异,以期为土壤潜在有毒元素和抗生素复合污染防治和土壤生态系统安全提供理论依据。实验表明,小麦种子的根和芽对单一污染的敏感程度依次为:Sul>Cu^(2+)>OTC>Zn^(2+);复合处理对小麦种子根伸长和芽长呈现“低促高抑”规律,且根长和芽长抑制率都随处理浓度的增大而增大。该实验从小麦种子的根和芽对环境污染物胁迫的直观感受,到环境污染物如何影响作物生长科学问题的提出与解决,加深了学生对复合污染影响植物生长的理解,激发了学生对环境学课程的热情和兴趣。

关键词：潜在有毒元素抗生素复合污染小麦种子发芽

Evolution of Meteorological Conditions during a Heavy Air Pollution Event under the Influence of Shallow Foehn in Urumqi, China

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Advances in Atmospheric Sciences 2023年第1期40卷 29-43页

作者： Xia LI keming ZHAO Shiyuan ZHONG Xiaojing yu Zhimin FENG yuting ZHONG Ayitken MAULEN Shuting LI Institute of Desert Meteorology China Meteorological AdministrationUrumqi 830002China Xinjiang Meteorological Observatory Urumqi 830002China Department of Geography Environment and Spatial SciencesMichigan State UniversityEast Lansing 48823-5243USA LASG Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Urumqi Meteorological Satellite Ground Station Urumqi 830011China

The air pollution in Urumqi which is located on the northern slope of the Tianshan Mountains in northwestern China,is very serious in winter.Of particular importance is the influence of terrain-induced shallow foehn,known locally as elevated southeasterly gale(ESEG).It usually modulates atmospheric boundary layer structure and wind field patterns and produces favorable meteorological conditions conducive to hazardous air pollution.During 2013-17,Urumqi had an average of 50 d yr-1 of heavy pollution(daily average PM2.5 concentration>150μg m-3),of which 41 days were in winter.The majority(71.4%)of heavy pollution processes were associated with the shallow foehn.Based on microwave radiometer,wind profiler,and surface observations,the surface meteorological fields and boundary layer evolution during the worst pollution episode in Urumqi during 16-23 February 2013 are investigated.The results illustrate the significant role of shallow foehn in the building,strengthening,and collapsing of temperature inversions.There were four wind field patterns corresponding to four different phases during the whole pollution event.The most serious pollution phase featured shallow foehn activity in the south of Urumqi city and the appearance of an intense inversion layer below 600 m.Intense convergence caused by foehn and mountain-valley winds was sustained during most of the phase,resulting in pollutants sinking downward to the lower boundary layer and accumulating around urban area.The key indicators of such events identified in this study are highly correlated to particulate matter concentrations and could be used to predict heavy pollution episodes in the feature.

关键词： foehn elevated southeasterly gale(ESEG) heavy air pollution boundary layer structure wind field pattern complex terrain