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Journal of Modern Physics 2013年第12期4卷 1574-1582页

作者： yu hasegawa Takahiro Maehira Takashi Hotta 1Department of Physics Tokyo Metropolitan University Tokyo Japan 2Advanced Science Research Center Japan Atomic Energy Agency Ibaraki Japan Department of Physics Tokyo Metropolitan University Tokyo Japan Faculty of Science University of the Ryukyus Okinawa Japan

In order to promote our understanding on electronic structure of actinide dioxides, we construct a tight-binding model composed of actinide 5f and oxygen 2p electrons, which is called f-p model. After the diagonalization of the f-p model, we compare the eigen-energies in the first Brillouin zone with the results of relativistic band-structure calculations. Here we emphasize a key role of f-p hybridization in order to understand the electronic structure of actinide dioxides. In particular, it is found that the position of energy levels of Г7 and Г8 states determined from crystalline electric field (CEF) potentials depends on the f-p hybridization. We investiagte the values of the Slater-Koster integrals for f-p hybridization, (fpσ) and (fpπ), which reproduce simultaneously the local CEF states and the band-structure calculation results. Then, we find that the absolute value of (fpπ) should be small in comparison with (fpσ) = 1 eV. The small value of |(fpπ)| is consistent with the condition to obtain the octupole ordering in the previous analysis of the f-p model.

关键词： Tight-Binding Approximation Actinide Dioxides f-p Hybridization Crystalline Electric Field Potential

Influence of Previous Abdominal and Pelvic Surgeries on Uterine Artery Embolization

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Open Journal of Radiology 2023年第4期13卷 246-255页

作者： yu hasegawa Juliana yumi Ishisaki Hitomi Kato Yoshiki Kuwatsuru Rie Ozaki Mari Kitade Ryohei Kuwatsuru Department of Radiology Graduate School of Medicine Juntendo University Tokyo Japan Department of Radiology School of Medicine Juntendo University Tokyo Japan Department of Obstetrics and Gynecology School of Medicine Juntendo University Tokyo Japan Department of Obstetrics and Gynecology Graduate School of Medicine Juntendo University Tokyo Japan

Objective: To assess the influence of previous abdominal and pelvic surgeries on uterine artery embolization (UAE). We hypothesize that the formation of postoperative adhesions can impose technical difficulties for UAE, resulting in longer fluoroscopy time and less reduction of uterus and largest tumor volumes after the procedure. Methods: We retrospectively reviewed the medical records of 122 consecutive patients who underwent uterine artery embolization for the treatment of uterine fibroids in our department. Patients were divided into two groups according to the presence or absence of previous abdominal or pelvic surgery. Fluoroscopy time, change in symptoms, and volume variation of uterus and largest tumor were compared between groups. Results: Forty-seven patients underwent abdominopelvic surgery before UAE (Group 1) and 75 did not (Group 2). Median (IQR) fluoroscopy time was 22 minutes (IQR: 18 - 26.4) for Group 1, and 23.3 minutes (IQR: 19.05 - 28.25) for Group 2. No difference was found between the groups (P = 0.17). Regarding the results after UAE, neither the change in symptoms (P = 0.30) nor the volume variation for uterus (P = 0.41) and largest fibroid (P = 0.18) showed significant difference. Conclusions: In this study, previous abdominopelvic surgeries had no significant influence on fluoroscopy time, and overall outcomes of uterine artery embolization.

关键词： Female Uterine Artery Embolization Leiomyoma Uterus Fluoroscopy

The Phosphate Transporter PHT4;6 Is a Determinant of Salt Tolerance that Is Localized to the Golgi Apparatus of Arabidopsis

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Molecular Plant 2009年第3期2卷 535-552页

作者： Beatriz Cubero yuko Nakagawa Xing-yu Jiang Ken-Ji Miura Fang Li Kashchandra G. Raghothama Ray A. Bressan Paul M. hasegawa Jose M. Pardo Instituto de Recursos Naturales y Agrobiologia Consejo Superior de Investigaciones Cientificas Avda Reina Mercedes 10 Sevilla-41012 Spain Center for Environmental Stress Physiology Department of Horticulture and Landscape Architecture Purdue University West Lafayette IN 47907-2010 USA Present address: Ichinoseki National College of Technology Department of Chemical Engineering Takanashi Hagisyo Ichinoseki 021-8511 Japan Present address: Graduate School of Life and Environmental Sciences Gene Research Center 220 1-1-1 Ten-nou dai University of Tsukuba Tsukuba 305-8572 Japan

Insertion mutations that disrupt the function of PHT4;6 （At5g44370） cause NaCI hypersensitivity of Arabidopsis seedlings that is characterized by reduced growth of the primary root, enhanced lateral branching, and swelling of root tips. Mutant phenotypes were exacerbated by sucrose, but not by equiosmolar concentrations of mannitol, and attenuated by low inorganic phosphate in the medium. Protein PHT4;6 belongs to the Major Facilitator Superfamily of permeases that shares significant sequence similarity to mammalian type-I Pi transporters and vesicular glutamate transporters, and is a member of the PHT4 family of putative intracellular phosphate transporters of plants. PHT4;6 localizes to the Golgi membrane and transport studies indicate that PHT4;6 facilitates the selective transport of Pi but not of chloride or inorganic anions. Phenotypic similarities with other mutants displaying root swelling suggest that PHT4;6 likely functions in protein N-glycosylation and cell wall biosynthesis, which are essential for salt tolerance. Together, our results indicate that PHT4;6 transports Pi out of the Golgi lumenal space for the re-cycling of the Pi released from glycosylation processes.

关键词： Phosphate transport Golgi glycosylation salt stress.

Immunogenicity of DNA and Recombinant Sendai Virus Vaccines Expressing the HIV-1 gag Gene

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Virologica Sinica 2008年第4期23卷 295-304页

作者： Xia FENG Shuang-qing yu Tsugumine Shu Tetsuro Matano Mamoru hasegawa Xiao-li WANG Hong-tao MA Hong-xia LI Yi ZENG State Key Laboratory for Infectious Disease Prevention and Control National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing 100052 China DNA VEC Corporation Tsukuba 305-0051 Japan Department of Microbiology Graduate School of Medicine University of Tokyo Tokyo 113-0033 Japan College of Life Science and Bioengineering Beijing University of Technology Beijing 100022 China

Combinations of DNA and recombinant-viral-vector based vaccines are promising AIDS vaccine methods because of their potential for inducing cellular immune responses. It was found that Gag-specific cytotoxic lymphocyte (CTL) responses were associated with lowering viremia in an untreated HIV-1 infected cohort. The main objectives of our studies were the construction of DNA and recombinant Sendai virus vector (rSeV) vaccines containing a gag gene from the prevalent Thailand subtype B strain in China and trying to use these vaccines for therapeutic and prophylactic vaccines. The candidate plasmid DNA vaccine pcDNA3.1(+)-gag and recombinant Sendai virus vaccine (rSeV-gag) were constructed separately. It was verified by Western blotting analysis that both DNA and rSeV-gag vaccines expressed the HIV-1 Gag protein correctly and efficiently. Balb/c mice were immunized with these two vaccines in different administration schemes. HIV-1 Gag-specific CTL responses and antibody levels were detected by intracellular cytokine staining assay and enzyme-linked immunosorbant assay (ELISA) respectively. Combined vaccines in a DNA prime/rSeV-gag boost vaccination regimen induced the strongest and most long-lasting Gag-specific CTL and antibody responses. It maintained relatively high levels even 9 weeks post immunization. This data indicated that the prime-boost regimen with DNA and rSeV-gag vaccines may offer promising HIV vaccine regimens.

关键词： HIV-1 vaccines gag gene DNA vector Sendai virus

Automated liver tumor detection in abdominal ultrasonography with a modified faster region-based convolutional neural networks(Faster R-CNN)architecture

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Hepatobiliary Surgery and Nutrition 2022年第5期11卷 675-683,I0001页

作者： Kenji Karako yuichiro Mihara Junichi Arita Akihiko Ichida Sung Kwan Bae Yoshikuni Kawaguchi Takeaki Ishizawa Nobuhisa Akamatsu Junichi Kaneko Kiyoshi hasegawa yu Chen Department of Human and Engineered Environmental Studies Graduate School of Frontier SciencesThe University of TokyoChibaJapan Artificial Organ and Transplantation Surgery Division Department of SurgeryGraduate School of MedicineThe University of TokyoTokyoJapan

Background:Although diagnostic ultrasound can non-invasively capture the image of abdominal viscera,diagnosis of the continuous ultrasound liver images to detect a liver tumor effectively and to determine whether the detected is benign or malignant is *** order to minimize the gaps in diagnostic accuracy depending on doctor’s proficiency,we built an automated system to support the ultrasonography of liver tumors by employing deep learning ***:We constructed a neural network model for the automated detection of tumor tissues and blood vessels from the sequential liver ultrasound *** region-based convolutional neural networks(Faster R-CNN)is employed as a base model for the object detection,which can output the detection results in 4 frames per second and enable the system to be particularly suitable for the real time ***,we proposed a new neural network architecture feeding both the current and previous images into Faster *** training the models,intraoperative ultrasound images obtained from one hepatocellular carcinoma(HCC)patient were *** obtained image was a multifaceted observation of the liver and includes one HCC and some blood *** labeled 91 images with the help of a liver *** compared the tumor detection performance of the plain Faster R-CNN model with that of the proposed ***:We find that both the models performed well in detecting HCC and blood vessels,after training with 400 epochs using ***,the mean precision of our model reaches 0.549,which is 0.019 better than that of the plain Faster R-CNN,and the mean sensitivity of our model about HCC reaches 0.623±0.385 for 30 scenes of sequential liver ultrasound images,which is also 0.146 better than that of the plain Faster R-CNN ***:The comparison between the proposed model and the plain Faster R-CNN model shows that we achieved better accuracy in tumor detection,in terms of the mean precision a

关键词： Liver deep learning ultrasonography object detection hepatocellular carcinoma(HCC)

Complications of CAD/CAM Fabricated Surgical Template for Static Computer-Aided Implant Surgery

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Open Journal of Stomatology 2022年第4期12卷 103-107页

作者： yu Kishimoto yuka hasegawa Yasunori Kanemitsu Kuniteru Nagahara Tetsuji Nakamoto Department of Maxillofacial Implant Asahi University School of Dentistry Mizuho Japan Asahi University Medical and Dental Center Mizuho Japan

Purpose: Surgical templates produced by digital simulation and CAD/CAM allow for three-dimensional control of implant placement. However, due to clinical limitations, there are complications during the use of the template. The purpose of this study was to summarize the complications associated with the use of surgical templates for static computer-aided implant surgery. Methods: Complications were collected during the observation period, and then their implant sites were reanalyzed with simulation software. Results: There were 104 cases during the observation period, 5 cases had complications. Mechanical complications were observed in four cases, including three cases in which the frame of the template fractured during implant placement surgery and one case in which the sleeve fell off the surgical template. In one case, there was an error in the planned position. All cases were mandibular molar cases, and all cases of frame fracture were at the free end defect site. All cases had a Hounsfield unit of more than 700 at the implant site, and some of them had a significantly small jaw opening. Conclusion: Although the spread of CAD/CAM surgical templates has made it possible to avoid problems caused by the position of the implant, it has been difficult to avoid fractures in cases of mandibular free end defects with high Hounsfield unit.

关键词： CAD/CAM Surgical Template Static Computer-Aided Implant Surgery

A Study of Plaque Adhesion during Implant Treatment of Missing Molars

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Open Journal of Stomatology 2022年第3期12卷 96-102页

作者： yuka hasegawa yu Kishimoto Yasunori Kanemitsu Toshiichiro Tanabe Kuniteru Nagahara Tetsuji Nakamoto Department of Maxillofacial Implant School of Dentistry Asahi University Mizuho Japan Medical and Dental Center Asahi University Mizuho Japan

Purpose: In implant treatment, the abutments and superstructures form a transmucosal area. In addition to providing appropriate cleaning instructions to patients, its material properties must be carefully considered. It is not clear how much plaque adhesion occurs at each site during treatment process, and the effect of materials on plaque adhesion. Methods: In this study, 33 patients, 13 maxillary cases and 20 mandibular cases, who had implants placed in the missing molars were evaluated for the plaque adhesion of provisional restorations made of acrylic resin and monolithic zirconia final restoration after a period of more than 4 weeks. In addition, oral hygiene instructions were thoroughly given for 12 cases at the time of staining after the provisional restorations, and re-evaluated in 4 weeks. Results: About 20% of the buccal-lingual area of the prosthetic device fabricated with acrylic resin showed plaque staining, whereas about 40% of the area of the mesial and distal. On the other hand, for the zirconia final restorations, the percentage of staining was about 5% for buccal and lingual surface and 10% for mesial and distal surface. The stained area ratio of the provisional restoration correlated with the zirconia superstructure area ratio. Even with careful oral hygiene, it became clear that the amount of plaque adhesion due to the difference in materials could not be overcome. Conclusion: The zirconia superstructure is extremely good from the viewpoint of plaque adhesion, but cases with a large stained area at the time of provisional restoration should be carefully followed up.

关键词： Superstructure Dental Plaque Yttria-Stabilized Zirconia Polymethyl Methacrylate

Local advanced rectal cancer perforation in the midst of preoperative chemoradiotherapy:A case report and literature review

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World Journal of Clinical Cases 2017年第1期5卷 18-23页

作者： Nobuhisa Takase Kimihiro Yamashita Yasuo Sumi Hiroshi hasegawa Masashi Yamamoto Shingo Kanaji Yoshiko Matsuda Takeru Matsuda Taro Oshikiri Tetsu Nakamura Satoshi Suzuki yu-Ichiro Koma Masato Komatsu Ryohei Sasaki Yoshihiro Kakeji Division of Gastrointestinal Surgery Department of Surgery Kobe University Graduate School of Medicine Division of Pathology Department of Pathology Kobe University Graduate School of Medicine Division of Diagnostic Pathology Department of Pathology Kobe University Graduate School of Medicine Department of Surgery Hyogo Cancer Center Department of Radiation Oncology Kobe University Graduate School of Medicine

Standard chemoradiotherapy(CRT) for local advanced rectal cancer(LARC) rarely induce rectal perforation. Here we report a rare case of rectal perforation in a patient with LARC in the midst of preoperative CRT. A 56-year-old male was conveyed to our hospital exhibiting general malaise. Colonoscopy and imaging tests resulted in a clinical diagnosis of LARC with direct invasion to adjacent organs and regional lymphadenopathy. Preoperative 5-fluorouracil-based CRT was started. At 25 d after the start of CRT, the patient developed a typical fever. Computed tomography revealed rectal perforation, and he underwent emergency sigmoid colostomy. At 12 d after the surgery, the remaining CRT was completed according to the original plan. The histopathological findings after radical operation revealed a wide field of tumor necrosis and fibrosis without lymph node metastasis. We share this case as important evidence for the treatment of LARC perforation in the midst of preoperative CRT.

关键词： Local advanced rectal cancer Preoperative chemoradiotherapy Rectal perforation 5-fluorouracil Tumor necrosis

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World Journal of Clinical Cases 2019年第21期7卷 3553-3561页

作者： Takeshi Mizusawa Kenya Kamimura Hiroki Sato Takeshi Suda Hiroyuki Fukunari Go hasegawa Osamu Shibata Shinichi Morita Akira Sakamaki Junji Yokoyama yu Saito Yoshihisa Hori yuduru Maruyama Fumitoshi Yoshimine Takahiro Hoshi Shinichi Morita Tsutomu Kanefuji Masaaki Kobayashi Shuji Terai Department of Internal Medicine Niigata Prefectural Tokamachi HospitalTokamachiNiigata 948-0065Japan Division of Gastroenterology and Hepatology Graduate School of Medical and Dental SciencesNiigata UniversityNiigata 951-8122Japan Department of Gastroenterology and Hepatology Uonuma Institute of Community Medicine Niigata University HospitalMinami UonumaNiigata 949-7302Japan Department of Surgery Niigata Prefectural Tokamachi HospitalTokamachiNiigata 948-0065Japan Department of Pathology Uonuma Institute of Community Medicine Niigata University HospitalMinami UonumaNiigata 949-7302Japan Department of Internal Medicine Tokamachi Central ClinicTokamachiNiigata 948-0065Japan

BACKGROUND Immunosuppression is effective in treating a number of diseases,but adverse effects such as bone marrow suppression,infection,and oncogenesis are of *** is a key immunosuppressant used to treat rheumatoid *** it is effective for many patients,various side effects have been reported,one of the most serious being methotrexate-related lymphoproliferative *** this may occur in various organs,liver involvement is *** on these liver lesions,including clinical characteristics,course,and imaging studies,has not been summarized to *** SUMMARY We present a case of 70-year-old woman presented with a 2-wk history of fever and abdominal *** had had rheumatoid arthritis for 5 years and was being treated with medication including ***-enhanced computed tomography revealed multiple low density tumors in the liver and the histological analyses showed significant proliferation of lymphocytes in masses that were positive on immunohistochemical staining for CD3,CD4,CD8,and CD79a but negative for CD20 and *** for Epstein-Barr virus-encoded RNA was *** based on these findings,the liver tumors were diagnosed as Methotrexate-related lymphoproliferative disorders.A timedependent disappearance of the liver tumors after stopping methotrexate supported the *** The information obtained from our case and a review of 9 additional cases reported thus far assist physicians who may face the challenge of diagnosing and managing this disorder.

关键词： Arthritis Rheumatoid Methotrexate Malignant lymphoma Case report

下胸椎黄韧带骨化减压后效果分析:16例随访

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中国组织工程研究与临床康复 2008年第33期12卷 6579-6582页

作者：顾树明 hasegawa 马玉泉强华王飞王显军首都医科大学附属北京同仁医院骨科北京市100730 日本新瀉脊柱外科中心

下胸椎黄韧带骨化症患者16例，男9例，女7例，年龄39～75岁。患者临床症状呈多样化，术前影像学检查显示病变及非病变节段的椎间盘为广泛退行性变。均采取后路全椎板薄层减压，保留小关节突外侧1／2。16例患者均获得随访。15例术后症状... 详细信息

下胸椎黄韧带骨化症患者16例，男9例，女7例，年龄39～75岁。患者临床症状呈多样化，术前影像学检查显示病变及非病变节段的椎间盘为广泛退行性变。均采取后路全椎板薄层减压，保留小关节突外侧1／2。16例患者均获得随访。15例术后症状立即缓解，无术后加重期。1例经过7d的加重期后逐渐缓解，考虑为术中器械震动所致。术后发生脑脊液漏1例，经脑脊液引流和换药愈合。感觉障碍及下肢麻木、疼痛完全恢复12例，大部分恢复2例，部分恢复1例，1例无明显缓解。

关键词：下胸椎黄韧带骨化