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Cohort study on the treatment of BRAF V600E mutant metastatic colorectal cancer with integrated Chinese and western medicine

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World Journal of Clinical Oncology 2025年第1期16卷 25-33页

作者： Jiang-yu Bian yu-fang Feng Wen-Ting He Tong Zhang Department of Oncology Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing 100091China Department of Oncology The Fourth Clinical Medical College of Xinjiang Medical UniversityUrumqi 830001China Department of Oncology Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical UniversityUrumqi 830001China

BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor *** the previous cohort study on mCRC conducted by our team,it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival(OS)of patients with colorectal ***,we further explored the survival benefits in the population with BRAF V600E mutant *** To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal *** A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December *** patients were divided into two *** A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically significant difference(P=0.038,hazard ratio=0.46).The 1-3-year survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,*** analysis showed statistically significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy,and first-line treatment subgroups(P<0.05).CONCLUSION Integrated Chinese and Western medicine can prolong the survival and reduce the risk of death in patients with BRAF V600E mutant metastatic colorectal cancer,with more pronounced benefits observed in patients with right colon involvement,liver metastasis,combined chemotherapy,and first-line treatment.

关键词： Metastatic colorectal cancer BRAF V600E mutation Integrated Chinese and Western medicine Cohort study

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A generalized dilatancy angle equation of granular soil

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Journal of Mountain Science 2022年第5期19卷 1456-1463页

作者： yu fang-wei Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610041China Center for Excellence in Tibetan Plateau Earth Sciences Chinese Academy of SciencesBeijing 100101China China-Pakistan Joint Research Center on Earth Sciences CAS-HECIslamabad 45320Pakistan University of Chinese Academy of Sciences Beijing 100049China Department of Civil Engineering The University of TokyoTokyo 113-8656Japan

This paper presents a generalized dilatancy angle equation of granular soil to cover not only the drained tests but also the undrained tests by introducing a generalized structure of soil:soil skeleton formed by soil particles and the fluid in soil voids,under the assumptions of the incompressibility of soil particles and the compressibility of the fluid in soil *** the drained tests,the generalized dilatancy angle equation of granular soil would be degenerated to its current dilatancy angle ***,for the undrained tests,the generalized dilatancy angle equation of granular soil was derived with aλparameter that was related to the stress-strain state of soil and the nature of the fluid in soil ***λparameter was determined by the initial dilatancy angles of granular soil at the onset of shearing on the same initial state of the soil in the drained and undrained *** addition,the generalized dilatancy angle equation of granular soil was verified for application in calculation of the dilatancy angles of sands in the drained and undrained tests.

关键词： Elastoplastic theory Dilatancy Granular soil Sands Soil Skeleton Triaxial tests

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Instantaneous visual imaging of latent fingerprints in water

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Science China Chemistry 2022年第10期65卷 1841-1842页

作者： yu fang Key Laboratory of Applied Surface and Colloid Chemistry of Ministry of Education School of Chemistry and Chemical EngineeringShaanxi Normal UniversityXi’an 710119China

Fingerprints are widely acknowledged as crucial evidence for personal identification and security,among which the invisible latent fingerprints(LFPs)is one of the most common and arduous proofs in investigations of crime scenes[1].Conventional imaging techniques suffer from various limitations like low contrast and sensitivity[2],which can only recognize macroscopic features of LFPs,including shape,core,ending,bifurcation,and island(Levels 1 and 2).Alternatively,aggregation-induced emission(AIE)materials[3]have shown great potential in visualizing LFPs with microscopic details,like pores,ridges and their edges(Level 3),due to their strong fluorescence,easy functionalization,and intrinsic AIE characteristics[4].Despite these advances,several issues still hamper the practical application of AIE probes in this field:(1)organic solvents rather than environmentally more benign water are used in most cases with extended incubation time;(2)cheap,general,and colortunable probes for LFPs are still missing[5],which hampered their practical application for different scenarios;(3)in-depth understanding of the plausible mechanism for the visual imaging of LFPs at molecular level is still underdeveloped in most cases.

关键词： visual latent details

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STRUCTURE AND RESTRUCTURING OF BEIJING-TIANJIN-HEBEI MEGALOPOLIS IN CHINA

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Chinese Geographical Science 2006年第1期16卷 1-8页

作者： yu Tao-fang School of Architecture Tsinghua University Beijing 100084 P. R. China

Scott proposes to use the term global city-regions to designate the phenomena that bear some resemblance to the "world cities" firstly identified by Hall and Friedmann and Wolff, and to the "global cities" of Sassen but whose essential social logic and contextual characteristics have evolved considerably since these pioneering studies were published. In simple geographical terms, a global city-region can be refered to comprise any major metropolitan area or any contiguous set of metropolitan areas together with a surrounding hinterland of variable extent-itself a locus of scattered urban settlements-whose internal economic and political affairs are bound up in intricate ways in intensifying and far-flung extra-national relationships. Scott refers to these extra-national relationships as a symptom of "globalization". As economic motors and political actors, the global city regions have been regarded as crucial parts of development strategies in China. In the "Eleventh Five-year Plan" issued by the National Development and Reform Commission of P. R. China, the Beijing-Tianjin-Hebei Province (Jing-Jin-Ji) region, one of the typical megalopolises or global city regions in the East Coastal China is paid more attention. This paper first analyzes the regional structure of the Jing-Jin-Ji region based on data of the fifth national population census of China. And then through the changes of the population growth, the dynamic process and mechanisms of the regional restructuring in the Jing-Jin-Ji is explored and discussed.

关键词： regional structure regional restructuring Beijing-Tianjin-Hebei (Jing-Jin-Ji)

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A stable biocompatible porous coordination cage promotes in vivo liver tumor inhibition

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Nano Research 2021年第10期14卷 3407-3415页

作者： yu Liang yu fang Yong Cui Hongcai Zhou State Key Laboratory for Chemo/Bio-Sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative Molecules and State Key Laboratory of Metal Matrix CompositesShanghai Jiao Tong UniversityShanghai 200240China Department of Chemistry Texas A&M UniversityCollege StationTX 77843USA

Many emerging strategies in chemo-,gene-,and immunotherapy require the accumulation of reagents in the cell ***,their delivery into the nucleus is often *** delivery could be enhanced with a rationally designed cargo-delivery scaffold,but this approach has rarely been successfully ***,a stable,biocompatible molecular capsule that encapsulates and delivers camptothecin,a DNA topoisomerase I inhibitor,into the nucleus of living cells was *** delivery is facilitated by the ultra-small diameter,zero net charge,and hydrophobicity of the *** encapsulated drug complex displays superior toxicity towards multiple cancer cells over the free drug,the Food and Drug Administration(FDA)approved drugs,as well as conventionally reported drug ***,it inhibits liver cancer tumor growth in a xenograft mouse *** of the properties of such molecular capsules may make it possible to design therapeutic strategies that target specific cell organelles.

关键词： metal-organic polyhedron biocompatible cage compound cavity drug delivery

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The Efficient Computation of Aircraft Range Problem

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Acta Mathematicae Applicatae Sinica 2019年第4期35卷 862-872页

作者： fang yu Jin-chuan CUI Beijing University of Chinese Medicine Beijing 102488 China Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100190 China

The goal of efficient computation is to determine reasonable computing cost in polynomial time by using data structure of instance, and analyze the computing cost of satisfactory solution which can meet user’s requirements. When faced with NP-hard problem, we usually assess computational performance in the worst case. Polynomial algorithm cannot handle with NP-hard problem, so we research on NP-hard problem from efficient computation point of view. The work is intended to fill the blank of computational complexity *** focus on the cluster structure of instance data of aircraft range problem. By studying the partition and complexity measurement of cluster, we establish a connection between the aircraft range problem and N-vehicle exploration problem, and construct the efficient computation mechanism for aircraft range problem. The last examples show that the effect is significant when we use efficient computation mechanism on aircraft range problem. Decision makers can calculate the computing cost before actually computing.

关键词： computational complexity efficient computation mechanism aircraft range problem cluster

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Trudinger–Moser Inequalities on a Closed Riemann Surface with a Symmetric Conical Metric

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Acta Mathematica Sinica,English Series 2024年第9期40卷 2263-2284页

作者： yu fang yun Yan YANG College of Teacher Education Quzhou UniversityQuzhou 324003P.R.China Department of Mathematics Renmin University of ChinaBeijing 100872P.R.China

This is a continuation of our previous work(*** ***.,20,1295–1324,2020).Let(Σ,g)be a closed Riemann surface,where the metric g has conical singularities at finite *** G is a group whose elements are isometries acting on(Σ,g).Trudinger–Moser inequalities involving G are established via the method of blow-up analysis,and the corresponding extremals are also *** extends previous results of Chen(***.,1990),Iula–Manicini(Nonlinear Anal.,2017),and the authors(2020).

关键词： Trudinger-Moser inequality blow-up analysis conical singularity

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DC performance and AC loss of cable-in-conduit conductors for International Thermonuclear Experimental Reactor

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Nuclear Science and Techniques 2016年第3期27卷 176-185页

作者： Wei Zhou Xin-yu fang Jin fang Bo Liu School of Electrical Engineering Beijing Jiaotong UniversityBeijing 100044China Department of Electrical and Computer Engineering University of VictoriaVictoriaBC V8W2Y2Canada Institute of Plasma Physics Chinese Academy of SciencesHefei 230031China

A reliable prediction of AC loss is essential for the application of International Thermonuclear Experimental Reactor(ITER) cable-in-conduit conductors(CICCs);however,the calculation of AC loss of ITER CICCs is a cumbersome task due to the complicated geometry of the multistage cables and the extreme operating conditions in *** this paper,we described the models developed for hysteresis and coupling loss calculation,which can be suitable for the construction of ITER magnetic ***,we compared the results of theoretical analysis with the SULTAN test result to evaluate the numerical model we *** addition,we introduced the n-value and AC loss with transport current for CICCs based on the DC measurement results at SULTAN,which lays the foundation for the further study.

关键词：国际热核聚变实验堆交流损耗电缆导体电缆导管直流测量 ITER计划国际热核实验反应堆性能

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Preface:special topic on fluorescent chemical/biological sensors and imaging

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Science China Chemistry 2016年第1期59卷 1-2页

作者： Shu Wang yu fang Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences Key Laboratory of Applied Surface and Colloid Chemistry (Ministry of Education) School of Chemistry and Chemical Engineering Shaanxi Normal University

There is currently considerable interest in the development of fluorescent molecular probes for use in sensitive sensing and imaging *** design,synthesis and application of fluorescent molecular probes that selectively and specifically respond to the presence of a specific analyte is a multidisciplinary research area involving numerous fields of modern science and medicine,

关键词：生物传感器成像光化学荧光分子探针现代科学多学科应用

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AMC-based resource allocation in adaptive frequency reused OFDMA-relay networks

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The Journal of China Universities of Posts and Telecommunications 2011年第2期18卷 59-64,71页

作者： CHEN yu fang Xu-ming School of Information Science and Technology Southwest Jiaotong University Chengdu 610031 China

In orthogonal frequency division multiple access（OFDMA） relay system,for supporting relay transmission,the base station（BS）-the relay station（RS） link must consume an extra part of resource,which may result in serious resource *** order to improve resource utilization,this paper proposes a dynamic resource allocation scheme in adaptive frequency reused OFDMA-relay system based on adaptive modulation and coding（AMC） *** this scheme,relay nodes have two independent antennas and operate in decode-and-forward（DF） and full-duplex *** the BS and RSs share the same subcarriers by spatial multiplexing by two independent *** resource allocation problem is formulated for system downlink throughput *** the optimal solution couldn＇t be obtained easily,a sub-optimal algorithm is *** adaptive frequency reused algorithm with two independent antennas RS improves the system throughput about 24.3 % compared with the orthogonal frequency allocation with single-antenna model,and increases the system throughput 10.4 % compared with adaptive frequency reused algorithms with single-antenna *** is proved that both of the RS with two-antenna model and adaptive frequency reused scheme can improve the system throughput significantly.

关键词： AMC resource allocation adaptive frequency reuse OFDMA relay

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