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Influence of transcatheter arterial embolization on symptom distress and fatigue in liver cancer patients

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 810-818页

作者： Xu-Min yang Xu-Yan yang Xin-yu Wang yue-Xia Gu department of Nursing The First Affiliated Hospital of Naval Medical University(Changhai Hospital)Shanghai 200433China department of Thyroid Breast and Vascular SurgeryShanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China department of Nursing Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China

BACKGROUNd Hepatocellular carcinoma(HCC)is a prevalent malignancy,and transcatheter arterial embolization(TAE)has emerged as a pivotal therapeutic ***-ever,TAE may induce symptom distress and fatigue,adversely affecting the quality of life of *** To investigate symptom distress,fatigue,and associated factors in HCC patients undergoing *** We used a cross-sectional design and purposive sampling to enroll HCC patients who underwent TAE at our institution from January to december ***-naires were utilized to collect data on symptom distress and fatigue scores from the first to the third day after *** Our study revealed a significant reduction in fatigue and symptom distress among patients after ***,fatigue,insomnia,fever and abdominal dis-tension were the most common symptoms troubling patients during the first 3 d *** status,presence of family support,physical functional status,age,and symptom distress were identified as predictors of fatigue in *** Healthcare professionals should educate HCC patients on symptom distress and INTROdUCTION Hepatocellular carcinoma(HCC)ranks as the fifth most prevalent cancer and the third leading cause of cancer-related mortality *** intervention remains the cornerstone of HCC treatment;however,due to the challenges associated with early diagnosis and the lack of specific diagnostic markers,a considerable proportion of patients are diagnosed at advanced stages,rendering them ineligible for surgical *** arterial embolization(TAE)is an interventional therapeutic approach involving the insertion of a fine catheter via the femoral artery to reach the vasculature near the tumor *** aims to obstruct the arterial supply to the tumor by deploying embolic agents,thereby inducing necrosis in cancer *** procedure is suitable for patients with good liver function and overall health,particularly those with large HCCs that ha

关键词： Transcatheter arterial embolization Fatigue Symptom distress Hepatocellular carcinoma Influencing factors

Construction and manipulation of origami-inspired tubular structures with controlled mechanical buckling for collection and transportation of microspheres based on optically induced electrokinetics

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Science China(Technological Sciences) 2024年第9期67卷 2954-2964页

作者： yang WenGuang WANG WenHao TENG Xiangyu QIAO ZeZheng yu HaiBo School of Electromechanical and Automotive Engineering Yantai UniversityYantai 264005China State Key Laboratory of Robotics Shenyang Institute of AutomationChinese Academy of SciencesShenyang 110016China

The development of microengineered hydrogels has opened up unlimited possibilities for designing complex structures at the microscale. In this study, we constructed an origami-inspired tubular structure with controlled mechanical buckling based on optically induced electrokinetics(OEK). By inducing a stress gradient in the thickness, a tubular structure can be formed from a poly(ethylene glycol) diacrylate(PEGdA) hydrogel film of various shapes that have been custom fabricated. To achieve an ideal three-dimensional(3d) structure, the amplitude of the tubular structure can be controlled by adjusting the aspect ratios or polymerization time. Furthermore, the tubular structure can be manipulated for the collection and transportation of *** summary, we provide an effective method for designing 3d structures at the micro-nano scale. This forming method holds great potential for achieving various functions in tissue engineering, drug packaging, and transportation in the future.

关键词： origami-inspired tubular structures optically induced electrokinetics microfabrication mechanical buckling

Vehicle Abnormal Behavior detection Based on dense Block and Soft Thresholding

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Computers, Materials & Continua 2024年第6期79卷 5051-5066页

作者： yuanyao Lu Wei Chen Zhanhe yu Jingxuan Wang Chaochao yang School of Information Science and Technology North China University of TechnologyBeijing100144China School of Electrical and Control Engineering North China University of TechnologyBeijing100144China

With the rapid advancement of social economies,intelligent transportation systems are gaining increasing *** to these systems is the detection of abnormal vehicle behavior,which remains a critical challenge due to the complexity of urban roadways and the variability of external *** research on detecting abnormal traffic behaviors is still nascent,with significant room for improvement in recognition *** address this,this research has developed a new model for recognizing abnormal traffic *** model employs the R3d network as its core architecture,incorporating a dense block to facilitate feature *** approach not only enhances performance with fewer parameters and reduced computational demands but also allows for the acquisition of new features while simplifying the overall network ***,this research integrates a self-attentive method that dynamically adjusts to the prevailing traffic conditions,optimizing the relevance of features for the task at *** temporal analysis,a Bi-LSTM layer is utilized to extract and learn from time-based data *** research conducted a series of comparative experiments using the UCF-Crime dataset,achieving a notable accuracy of 89.30%on our test *** results demonstrate that our model not only operates with fewer parameters but also achieves superior recognition accuracy compared to previous models.

关键词： Vehicle abnormal behavior deep learning ResNet dense block soft thresholding

Microstructure evolution,mechanical properties and fracture behavior of Al-xSi/AZ91d bimetallic composites prepared by a compound casting

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Journal of Magnesium and Alloys 2024年第5期12卷 1944-1964页

作者： Guangyu Li Wenming Jiang Feng Guan Junwen Zhu yang yu Zitian Fan State Key Laboratory of Materials Processing and die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

In this paper,the effect of the Si content on microstructure evolution,mechanical properties,and fracture behavior of the Al-xSi/AZ91d bimetallic composites prepared by compound casting was investigated *** obtained results showed that all the Al-xSi/AZ91d bimetallic composites had a metallurgical reaction layer(MRL),whose thickness increased with increasing Si content for the hypoeutectic Al-Si/AZ91d composites,while the hypereutectic Al-Si/AZ91d composites were *** MRL included eutectic layer(E layer),intermetallic compound layer(IMC layer)and transition region layer(T layer).In the IMC layer,the hypereutectic Al-Si/AZ91d composites contained some Si solid solution and flocculent Mg_(2)Si+Al-Mg IMCs phases not presented in the hypoeutectic Al-Si/AZ91d ***,increasing Si content,the thickness proportion of the T layer increased,forming an inconsistent preferred orientation of the *** shear strengths of the Al-xSi/AZ91d bimetallic composites enhanced with increasing Si content,and the Al-15Si/AZ91d composite obtained a maximum shear strength of 58.6 MPa,which was 73.4% higher than the Al-6Si/AZ91d *** fractures of the Al-xSi/AZ91d bimetallic composites transformed from the T layer into the E layer with the increase of the Si *** improvement of the shear strength of the Al-xSi/AZ91d bimetallic composites was attributed to the synergistic action of the Mg_(2)Si particle reinforcement,the reduction of oxidizing inclusions and the ratio of Al-Mg IMCs as well as the orientation change of the MRL.

关键词： Al/Mg bimetallic composites Si content Mg_(2)Si reinforcement Microstructure Mechanical properties Fracture behavior

Biomimicking synovial joints trans-scale structured AgQds/MXene/SiOC achieving macroscale high lubrication and superior wear resistance

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Journal of Materials Science & Technology 2024年第7期174卷 63-73页

作者： yu Zhao Hui Mei Peng Chang yubo yang Laifei Cheng Litong Zhang Science and Technology on Thermostructural Composite Materials Laboratory School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an710072China School of Textile Science and Engineering Xi’an Polytechnic UniversityXi’an710048China

Naturally optimized successful synovial joints with lightweight,high load-carrying,ultra-low friction and wear have attracted tribological communities to constantly imitate and *** impressive advances in cartilage lubrication,extending such extraordinary performance advantages to macroscale solid lubrication remains a ***,inspired by the fascinating interplay of synovial joints,a novel kind of trans-scale hierarchical structured ceramic-based composite was ***-ducing microscale Ag microspheres(AgMs)“cartilage”layer and nanoscale Ag quantum dots/MXene(AgQds/MXene)“synovial fluid”into the interior and exterior of printed macroscale SiOC“hard bone”realistically restores the gradient structure of synovial joint *** resulted composite with ideal compressive strength(70.44 MPa)can achieve a 60.53%friction reduction and a low wear rate(2.05×10^(−6)mm 3 N^(−1)m^(−1))in dry tribo-contact for 3600 sliding cycles,while also maintaining considerable low friction(∼0.11)over 10,000 sliding cycles and long-term stable lubrication(∼0.13)for up to 50,000 re-ciprocating *** extraordinary performance can be explained by the division of macro contacts,full loading of AgMs and AgQds/MXene,abrasive debris capture and removal,as well as the shear rolling effect induced by friction *** work opens a new avenue to develop structural lubricating mate-rials for complex engineering applications.

关键词： 3d printing Synovial joints trans-scale structure AgQds/MXene/SiOC High lubrication Superior wear resistance

A Video Captioning Method by Semantic Topic-Guided Generation

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Computers, Materials & Continua 2024年第1期78卷 1071-1093页

作者： Ou Ye Xinli Wei Zhenhua yu Yan Fu Ying yang College of Computer Science and Technology Xi’an University of Science and TechnologyXi’an710054China

In the video captioning methods based on an encoder-decoder,limited visual features are extracted by an encoder,and a natural sentence of the video content is generated using a ***,this kind ofmethod is dependent on a single video input source and few visual labels,and there is a problem with semantic alignment between video contents and generated natural sentences,which are not suitable for accurately comprehending and describing the video *** address this issue,this paper proposes a video captioning method by semantic topic-guided ***,a 3d convolutional neural network is utilized to extract the spatiotemporal features of videos during the ***,the semantic topics of video data are extracted using the visual labels retrieved from similar video *** the decoding,a decoder is constructed by combining a novel Enhance-TopK sampling algorithm with a Generative Pre-trained Transformer-2 deep neural network,which decreases the influence of“deviation”in the semantic mapping process between videos and texts by jointly decoding a baseline and semantic topics of video *** this process,the designed Enhance-TopK sampling algorithm can alleviate a long-tail problem by dynamically adjusting the probability distribution of the predicted ***,the experiments are conducted on two publicly used Microsoft Research Video description andMicrosoft Research-Video to Text *** experimental results demonstrate that the proposed method outperforms several state-of-art ***,the performance indicators Bilingual Evaluation Understudy,Metric for Evaluation of Translation with Explicit Ordering,Recall Oriented Understudy for Gisting Evaluation-longest common subsequence,and Consensus-based Image description Evaluation of the proposed method are improved by 1.2%,0.1%,0.3%,and 2.4% on the Microsoft Research Video description dataset,and 0.1%,1.0%,0.1%,and 2.8% on the Microsoft Research-Video to Text dataset

关键词： Video captioning encoder-decoder semantic topic jointly decoding Enhance-TopK sampling

designing macrophage membrane-engineered ruthenium/selenium nanoparticles to block bone metastasis of breast cancer

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Nano Research 2024年第8期17卷 7504-7512页

作者： Meijin yang Zhiying Tang Xiaoying Li Yanzi yu Lizhen He Tianfeng Chen College of Chemistry and Materials Science Department of Oncology of The First Affiliated HospitalJinan UniversityGuangzhou 510632China

Bone metastasis along with osteolysis is a common complication of advanced breast cancer,which directly destroys bone function and becomes one of the major causes of cancer-related *** is crucial to develop a new strategy to achieve effective cancer therapy and inhibition of osteolytic bone *** ruthenium(Ru)complexes exhibit therapeutic potential in cancer ***,the clinical applications of Ru complexes were limited by poor bioavailability,lacking targeting,nonspecific ***,in this study,engineering of cell membrane biomimetic modification was used to construct a highly biocompatible nanoplatform with carrying Ru metal complex of RuPOP and Se nanoparticles(SeNPs).Strikingly,the obtained RPSR nanoparticles can efficiently inhibit the proliferation,invasion and migration of breast cancer cells(MdA-MB-231 cells)in *** importantly,RPSR nanoparticles can induce cycle arrest,apoptosis by generating excessive intracellular(reactive oxygen species,ROS)to disrupt the normal redox balance and induce dNA damage in tumor ***,RPSR nanoparticles can also reshape bone microenvironment by regulating selenoproteins to inhibit osteoclasts and avoid osteolytic bone metastasis induced by tumor *** together,this study not only provides an effective cell membrane biomimetic strategy to enhance the shortcomings of metal complexes,but also demonstrates potential clinical significance for the combined treatment of anti-cancer and bone metastasis inhibition.

关键词： cell membrane nanoparticles biomimetic modification ruthenium complexes selenium nanoparticles tumor bone metastasis

Electrospun carbon nanofiber-supported V_(2)O_(3) with enriched oxygen vacancies as a free-standing high-rate anode for an all-vanadium-based full battery

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Carbon Energy 2024年第9期6卷 15-28页

作者： Qi Lai Bincen Yin yu dou Qing Zhang yunhai Zhu Yingkui yang School of Chemistry and Materials Science South-Central Minzu UniversityWuhanChina State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhanChina

Synergistic regulation of hierarchical nanostructures and defect engineering is effective in accelerating electron and ion transport for metal oxide ***,carbon nanofiber-supported V_(2)O_(3) with enriched oxygen vacancies(OV-V_(2)O_(3)@CNF)was fabricated using the facile electrospinning method,followed by thermal *** from the traditional particles embedded within carbon nanofibers or irregularly distributed between carbon nanofibers,the free-standing OV-V_(2)O_(3)@CNF allows for V_(2)O_(3) nanosheets to grow vertically on one-dimensional(1d)carbon nanofibers,enabling abundant active sites,shortened ion diffusion pathway,continuous electron transport,and robust structural ***,density functional theory calculations confirmed that the oxygen vacancies can promote intrinsic electron conductivity and reduce ion diffusion energy ***,the OV-V_(2)O_(3)@CNF anode delivers a large reversible capacity of 812 mAh g^(-1) at 0.1 A g^(-1),superior rate capability(405 mAh g^(-1) at 5 A g^(-1)),and long cycle life(378 mAh g^(-1) at 5 A g^(-1) after 1000 cycles).Moreover,an all-vanadium full battery(V2O5//OV-V_(2)O_(3)@CNF)was assembled using an OV-V_(2)O_(3)@CNF anode and a V2O5 cathode,which outputs a working voltage of 2.5 V with high energy density and power density,suggesting promising practical *** work offers fresh perspectives on constructing hierarchical 1d nanofiber electrodes by combining defect engineering and electrospinning technology.

关键词： electrospun electrode full battery oxygen vacancy vanadium trioxide

Highly efficient labelling of extracellular vesicles for enhanced detection on a microfluidic platform

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Chinese Chemical Letters 2024年第2期35卷 441-445页

作者： Shi Hu Rui Hao Zitong yu Huitao Zhang Hui yang Bionic Sensing and Intelligence Center Institute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

developing precise extracellular vesicles(EVs)labelling techniques with minimal disturbance is of great importance to the follow-up EVs detection and ***,currently available methods such as using probes to conjugate phospholipids or membrane proteins have certain limitations due to EV steric hindrance,dye aggregation,***,we present a microfluidic platform to enhance EVs’labelling efficiency and improve their *** platform provides excellent sample throughput and high-efficiency EV labelling at lower label concentrations with an optimized flowing *** cytometry analysis(FCM)and cellular uptake results show that EV labelling by utilizing this platform possesses the merits of a higher labelling efficiency with 64.1%relative improvement than conventional co-incubation method and a lower background ***,this technique maintains EVs’size,morphology and biological *** the recipient cells uptake the EVs treated by the microfluidic platform,the spatial and temporal distribution of EVs in the cells are clearly *** results demonstrate that our method holds great potential in efficient labelling of EVs,which is essential to subsequent EV quantification and analysis.

关键词： Microfluidic platform Extracellular vesicles Labelling PKH dye Flow cytometry