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Maximal Subgroups in the Classical Groups Normalizing Solvable Subgroups

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Acta Mathematica Sinica,English Series 2021年第5期37卷 740-752页

作者： yu cheng yang Shang Zhi LI School of Mathematics and Systems Science Beihang UniversityBeijing 100191P.R.China

Let G be a classical group over an arbitrary field F,acting on an n-dimensional vector space V=V(n,F)over a field *** this paper,we classify the maximal subgroups of G,which normalizes a solvable subgroup N of GL(L,F)... 详细信息

关键词： Classical group over arbitrary field maximal subgroup solvable subgroup

DNA Damage,Apoptosis and C-myc,C-fos,and C-jun Overexpression Induced by Selenium in Rat Hepatocytes

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Biomedical and Environmental Sciences 2006年第3期19卷 197-204页

作者： RI-AN yu cheng-FENG yang XUE-MIN CHEN Department of Occupational and Environmental Health MOE Key Laboratory of Environment and Health School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 Hubei China

Objective To study the effects of selenium on DNA damage, apoptosis and c-myc, c-fos, and c-jun expression in rat hepatocytes. Methods Sodium selenite at the doses of 5, 10, and 20 μmol/kg was given to rats by i.p. and there were 5 male SD rats in each group. Hepatocellular DNA damage was detected by single cell gel electrophoresis （or comet assay）. Hepatocellular apoptosis was determined by TUNEL （TdT-mediated dUTP nick end labelling） and flow cytometry. C-myc, c-fos, and c-jun expression in rat bepatocytes were assayed by Northern dot hybridization. C-myc, c-fos, and c-jun protein were detected by immunohistochemical method. Results At the doses of 5, 10, and 20μmol/kg, DNA damage was induced by sodium selenite in rat hepatocytes and the rates of comet cells were 34.40%, 74.80%, and 91.40% respectively. Results also showed an obvious dose-response relationship between the rates of comet cells and the doses of sodium selenite （r=0.9501, P〈0.01）. Sodium selenite at the doses of 5, 10, and 20μmol/kg caused c-myc, c-fos, and c-jun overexpression obviously. The positive brown-yellow signal for proteins of c-myc, c-fos, and c-jun was mainly located in the cytoplasm of bepatocytes with immunohistocbemical method. TUNEL-positive cells were detected in selenium-treated rat livers. Apoptotic rates （%） of selenium-treated liver cells at the doses of 5, 10, and 20 μmol/kg were （3.72±1.76）, （5.82±1.42）, and （11.76±1.87） respectively, being much higher than those in the control. Besides an obvious dose-response relationship between apoptotic rates and the doses of sodium selenite （r=0.9897, P〈0.01）, these results displayed a close relationship between DNA damage rates and apoptotic rates, and the relative coefficient was 0.9021, P〈0.01. Conclusion Selenium at 5-20μmol/kg can induce DNA damage, apoptosis, and overexpression of c-myc, c-fos, and c-jun in rat hepatocytes.

关键词： Selenium DNA damage Apoptosis C-myc C-fos C-jun

Experimental investigation on dynamic response and damage models of circular RC columns subjected to underwater explosions

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Defence Technology（防务技术） 2020年第4期16卷 856-875页

作者： Tie-shuan Zhuang Ming-yang Wang Jun Wu cheng-yu yang Tao Zhang Chao Gao State Key Laboratory of Disaster Prevention and Mitigation of Explosion and Impact Army Engineering University of PLANanjing210007China Research Institute for National Defense Engineering of Academy of Military Science PLALuoyang471023China

Reinforced concrete(RC) columns are widely used as supporting structures for high-piled *** study of damage model of a RC column due to underwater explosion is a critical issue to assess the wharfs antiknock *** this study,the dynamic response and damage model of circular RC columns subjected to underwater explosions were investigated by means of scaled-down experiment *** were carried out in a 10.0 m diameter tank with the water depth of 2.25 m,under different explosive quantities(0.025 kg-1.6 kg),stand-off distances(0.0 m-7.0 m),and detonation depths(0.25 m-2.0 m).The shock wave load and dynamic response of experiment models were measured by configuring sensors of pressure,acceleration,strain,and ***,the load distribution characteristics,time history of test data,and damage models related to present conditions were obtained and *** damage models,including bending failure,bending-shear failure and punching failure,were *** addition,the experie nce model of shock wave loads on the surface of a RC column was proposed for engineering application.

关键词： Underwater explosion Reinforced concrete(RC)columns Load distribution characteristics Dynamic response Damage models

Efficacy,safety and treatment satisfaction of transition to a regimen of insulin degludec/aspart:A pilot study

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World Journal of Diabetes 2025年第1期16卷 65-73页

作者： Na yang Lu Lv Shu-Meng Han Li-yun He Zi-Yi Li yu-cheng yang Fan Ping Ling-Ling Xu Wei Li Hua-Bing Zhang yu-Xiu Li Department of Endocrinology Key Laboratory of Endocrinology of National Health CommissionPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Allergy Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic DiseasesNational Clinical Research Center for Dermatologic and Immunologic DiseasesPeking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100730China

BACKGROUND There is a lack of clinical evidence on the efficacy and safety of transitioning from a thrice-daily pre-mixed insulin or basal-prandial regimen to insulin degludec/aspart(IDegAsp)therapy,with insufficient data from the Chinese *** To demonstrate the efficacy,safety,and treatment satisfaction associated with the transition to IDegAsp in type 2 diabetes mellitus(T2DM).METHODS In this 12-week open-label,non-randomized,single-center,pilot study,patients with T2DM receiving thrice-daily insulin or intensive insulin treatment were transitioned to twice-daily injections of insulin *** doses,hemoglobin A1c(HbA1c)levels,fasting blood glucose(FBG),hypoglycemic events,a Diabetes Treatment Satisfaction Questionnaire,and other parameters were assessed at baseline and *** This study included 21 participants.A marked enhancement was observed in the FBG level(P=0.02),daily total insulin dose(P=0.03),and overall diabetes treatment satisfaction(P<0.01)in the participants who switched to *** was a decrease in HbA1c levels(7.6±1.1 vs 7.4±0.9,P=0.31)and the frequency of hypoglycemic events of those who switched to IDegAsp decreased,however,there was no statistically significant *** The present findings suggest that treatment with IDegAsp enhances clinical outcomes,particularly FBG levels,daily cumulative insulin dose,and overall satisfaction with diabetes treatment.

关键词： Insulin degludec/aspart Type 2 diabetes management Basal-bolus insulin therapy Pre-mixed insulin Diabetes treatment satisfaction questionnaire

Texture development of mesophase in reservoir pyrobitumen and the temperature-pressure converting of the gas reservoir in the Chuanzhong Uplift, Southwestern China

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Petroleum Science 2023年第2期20卷 721-732页

作者： cheng-yu yang Mei-Jun Li Tie-Guan Wang Ning-Ning Zhong Rong-Hui Fang Long Wen State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing102249China Oil&Gas Survey China Geological SurveyBeijing100083China The Key Laboratory of Unconventional Petroleum Geology China Geological SurveyBeijing100083China Exploration and Development Research Institute of Southwest Oil&Gasfield Company PetroChinaChengduSichuan610041China

The Neoproterozoic-Lower Paleozoic dolostone gas reservoirs in the Chuanzhong Uplift in Southwestern China contain the mesophase pyrobitumen (pyrobitumen with mesophase). The mesophase in the pyrobitumen is mostly composed of a mixture of condensed macromolecule polycyclic aromatic hydrocarbons (PAH), and has been mostly converted to various grain, flow, and domain textures. The volcanic activity nearby the Chuanzhong Uplift may have generated very hot (over 300 °C) hydrothermal fluid, with migration of the fluid into the dolostone reservoir transforming the hydrocarbons in the reservoir into an anisotropic carbon by-product, which formed under high temperature and pressure conditions;over 300 °C and 200 MPa according to fluid inclusion analysis. The high temperature-pressure in reservoir was caused by sudden devolatilization of the hydrocarbons due to hydrothermal heating, which formed the unusual texture of the mesophase. The elliptical mesophase grains (EG), the honeycomb structure of pyrobitumen, and the occurrence of polarized classes of mesophase in single pyrobitumen deposits are all unusual textures. This study investigates the texture development of this pressure-affected pyrobitumen. Observation and study of the mesophase suggest that the class of mesophase in pyrobitumen is determined by temperature, while pressure (assessed from associated fluid inclusions) significantly affected the texture. Analysis of the texture of the pyrobitumen in conjunction with previous thermometry results from methane inclusions suggests that the high class mesophase of the pyrobitumen could be applied as a temperature indicator for geological conditions. Furthermore, the unusual textures of the pyrobitumen including elliptical mesophase grains (EG), the honeycomb structure of pyrobitumen, and the occurrence of polarized classes of mesophase in single pyrobitumen could reflect the abnormal high formation pressure.

关键词： Pyrobitumen Mesophase Optical texture Pressure affect Oil reservoir Chuanzhong Uplift

NUMERICAL RESEARCH ON WATER GUIDE BEARING OF HYDRO-GENERATOR UNIT USING FINITE VOLUME METHOD

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Journal of Hydrodynamics 2007年第5期19卷 635-642页

作者： PENG yu-cheng CHEN Xi-yang ZHANG Ke-wei HOU Guo-xiang School of Energy and Power. Engineering Huazhong University of Science and Technology Wuhan 430074 China School of Traffic Science and Engineering Huazhong University of Science and Technology Wuhan 430074 China

With the consideration of the geometry of tilting pad journal bearing, a new form of the Reynolds equation was derived in this article. The film thickness, the squeeze motion of the journal and the rotation motion of the pad were explicitly contained in the equation. Based on this equation, together with the equilibrium equation of pad pivot, the water guide bearing used in the Gezhouba 10 F hydro-generator unit was numerically researched. The new Reynolds equation for the lubricating film was solved using Finite Volume （FV） discretization, Successive Over-Relaxation （SOR） iteration method and C＋＋ code are included. According to the numerical solution, and the stability of the film and the influences of the film thickness, the journal squeeze effect and the pad rotation effect on film force were discussed. The results indicate that the squeeze effect can not be neglected, although the rotation effect is negligible for both low-speed and high-speed bearings, so the computing time could be greatly reduced.

关键词： hydro-generator unit Reynolds equation,tilting pad journal bearing Finite Volume (FV) method

The Comparative and Functional Study between Two Construction Methods of shRNA Expression Vector Targeted LMP1 Gene Encoded by EBV

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中国病毒学 2007年第3期22卷 241-247页

作者： Yi-qin WANG　 yu-cheng yang　 Wen-lu ZHANG　 Su-ling HONG Department of Otolaryngology First Affiliated Hospital Chongqing Medical University Chongqing 400016 Chian Key Laboratory of Molecular Biology on Infectious Diseases of Chongqing Medical University Chongqing 400016 China

To look for a more stable and convenient way of constructing short hairpin RNA expression vectors targeting the latent membrane protein-1(LMP-1)encoded by Epstein-Barr virus(pshLMP1),and to study the inhibition function of pshLMP1 expression vectors in HNE1 cells,we designed the pshLMP1 expression cassette and pshLMP1 expression vectors by both the annealing method and PCR method and then co-transfected with pEGFP-N1-1158 into HNE1 cells to observe the mRNA and protein levels of LMP-1 genes by green fluorescence analysis,RT-PCR and western ***1 expression vectors were successfully obtained by both methods but better cloning efficiency was achieved and fewer deletions and mutations of nucleotides were achieved with the PCR ***,the mRNA and protein levels of LMP-1 genes were down-regulated by pshLMP1 expression *** to our research,we found that the PCR method provides a more efficient way to construct pshLMP1 expression vectors which have the ability to inhibit the function of LMP-1 genes expressed in HNE1 cells,and also provides a novel application of RNA interference technology against-EBV.

关键词： RNA干涉 LMP1基因基因表达爱泼斯坦病毒功能

NUMERICAL STUDY OF CAVITATION ON THE SURFACE OF THE GUIDE VANE IN THREE GORGES HYDROPOWER UNIT

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Journal of Hydrodynamics 2010年第5期22卷 703-708页

作者： PENG yu-cheng CHEN Xi-yang CAO Yan HOU Guo-xiang School of energy and Power Engineering Huazhong University of Science and Technology Wuhan 430074 China College of Electronic Information Engineering Wuhan Polytechnic Wuhan 430074 China School of Traffic Science and Engineering Huazhong University of Science and Technology Wuhan 430074 China

Large-area erosions such as rust and obvious cavitation were found on the surface of the guide vane in Three Gorges hydropower units. A numerical explanation of the cavitation is given in this article. At first, based on the characteristic performance curves of the prototype hydro-turbine supplied by ALSTOM together with the actual operating conditions, an operating point is chosen for numerical analysis using the Reynolds-Averaged Navier-Stokes （RANS） equations. The flow passages from the inlet of the spiral case to the outlet of the draft tube are included in the computational domain. The results show that the static pressure on the guide vane surface is much higher than the critical pressure of cavitation. Secondly, a tiny protrusion on the guide vane surface is considered and the problem is simplified to a 2-D problem to study the local detailed flow near the guide vane surface. The protrusion is 0.5 mm in height and is 5.0 mm in width. On the basis of the results of RANS simulations, the 2-D problem is studied using the Large Eddy Simulation （LES）. It is shown that there exists a region in which the static pressure reaches a level below the vapor pressure of the water. Thirdly, a cavitation model is included for the 0.5 mm protrusion case and another tiny pit case, with a tiny pit 0.3 mm in depth and 1.0 mm in width. The results show that vapor bubble exists at the protrusion entrance and the pit exit as the low pressure regions.

关键词： cavitation guide vane numerical analysis

Triceps skinfold thickness trajectories and the risk of all-cause mortality:A prospective cohort study

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World Journal of Clinical Cases 2024年第15期12卷 2568-2577页

作者： Na yang Li-yun He Zi-Yi Li yu-cheng yang Fan Ping Ling-Ling Xu Wei Li Hua-Bing Zhang yu-Xiu Li Department of Endocrinology Key Laboratory of Endocrinology of National Health CommissionPeking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

BACKGROUND The measurement of triceps skinfold(TSF)thickness serves as a noninvasive metric for evaluating subcutaneous fat *** its clinical utility,the TSF thickness trajectories and their correlation with overall mortality have not been thoroughly *** To explore TSF thickness trajectories of Chinese adults and to examine their associations with all-cause *** This study encompassed a cohort of 14747 adults sourced from the China Health and Nutrition *** class trajectory modeling was employed to identify distinct trajectories of TSF *** were classified into subgroups reflective of their respective TSF thickness *** utilized multivariate Cox regression analyses and mediation examinations to explore the link between TSF thickness trajectory and overall mortality,including contributory *** Upon adjustment for multiple confounding factors,we discerned that males in the‘Class 2:Thin-stable’and‘Class 3:Thin-moderate’TSF thickness trajectories exhibited a markedly reduced risk of mortality from all causes in comparison to the‘Class 1:Extremely thin’*** the mediation analyses,the Geriatric Nutritional Risk Index was found to be a partial intermediary in the relationship between TSF thickness trajectories and *** females,a lower TSF thickness pattern was significantly predictive of elevated all-cause mortality risk exclusively within the non-elderly *** In males and non-elderly females,lower TSF thickness trajectories are significantly predictive of heightened mortality risk,independent of single-point TSF thickness,body mass index,and waist circumference.

关键词： Triceps skinfold thickness Trajectory All-cause mortality Body mass index Geriatric Nutritional Risk Index