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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin Yin Yalan Xu Jie Mu yu Leng Lei Ma yu zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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Small modifications of endo-functionalized cavities lead to large changes in molecular interaction in water

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Science China Chemistry 2025年第01期 369-376页

作者： Song-Meng Wang Hao Nian Yan-Fang Wang Li-Shuo zheng yu-Tao zheng Yi-Wei Dong Liping Huang Xiaoping Wang Wei Jiang Liu-Pan Yang Department of Chemistry Southern University of Science and Technology School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal ResourcesGuangxi Normal University School of Pharmaceutical Science Hengyang Medical School University of South China

Studying molecular recognition in aqueous environments is crucial for understanding biological processes. Herein, we present a series of N-doped endo-functionalized anthracene-based cavities by introducing inward-directed pyridine units. The subtle modifications can significantly affect the binding properties of these receptors, which is similar to the mutations in biological systems. Combining theoretical calculations and molecular recognition experiments demonstrated that these “mutations” have an impact on the hydrophobicity and charge distribution of the hosts, consequently significantly influencing molecular *** is crucial for understanding the intricate mechanisms of molecular-level interactions in biological receptors.

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Ubiquitination in diabetes and its complications:A perspective from bibliometrics

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World Journal of Diabetes 2025年第1期16卷 187-203页

作者： Li-yuan Xiong Wei Zhao Fa-Quan Hu Xue-Mei Zhou yu-Jiao zheng College of Traditional Chinese Medicine Anhui University of Chinese MedicineHefei 230012Anhui ProvinceChina

BACKGROUND Diabetes has a substantial impact on public health,highlighting the need for novel ***,an intracellular protein modification process,is emerging as a promising strategy for regulating pathological *** hypothesize that ubiquitination plays a critical role in the development and progression of diabetes and its complications,and that understanding these mechanisms can lead to new therapeutic *** To uncover the research trends and advances in diabetes ubiquitination and its complications,we conducted a bibliometric *** Studies on ubiquitination in diabetes mellitus and its complications were retrieved from the Web of Science Core *** mapping analysis was conducted using the CiteSpace *** We gathered 791 articles published over the past 23 years,focusing on ubiquitination in diabetes and its associated *** articles originated from 54 countries and 386 institutions,with China as the leading *** Jiao Tong University has the highest number of publications in this *** most prominent authors contributing to this research area include Wei-Hua Zhang,with Zhang Y being the most frequently cited ***,The Journal of Biological Chemistry is noted as the most cited in this *** predominant keywords included expression,activation,oxidative stress,phosphorylation,ubiquitination,degradation,and insulin *** The role of ubiquitination in diabetes and its complications,such as diabetic nephropathy and cardiomyopathy,is a key research ***,these areas require further investigations.

关键词： Diabetes mellitus Ubiquitination Bibliometric analysis CiteSpace Research trends

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Urban computing： enabling urban intelligence with big data

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Frontiers of Computer Science 2017年第1期11卷 1-3页

作者： yu zheng Microsoft Research Beijing 100080 China School of Computer Science and Technology Xidian University Xi'an 710071 China Shenzhen Institutes of Adv.anced Technology Chinese Academy of Sciences Shenzhen 518055 China

Urban computing is a process of acquisition, integration and analysis of big and heterogeneous data generated by a diver- sity of sources in urban spaces, such as sensors, devices, ve- hicles, buildings and humans, to tackle the major issues that cities face, e.g., air pollution, energy consumption and traffic congestion. Urban computing connects unobtrusive and ubiq- uitous sensing technologies, advanced data management and analytics models, and novel visualization methods.

关键词： analysis big heterogeneous

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The Hamiltonian Canonical Form for Euler-Lagrange Equations

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Communications in Theoretical Physics 2002年第10期38卷 385-394页

作者： zheng yu Department of Mathematics East China Normal University Shanghai 200062 China

Based on the theory of calculus of variation, some suffcient conditions are given for some Euler-Lagrangcequations to be equivalently represented by finite or even infinite many Hamiltonian canonical equations. Meanwhile,some further applications for equations such as the KdV equation, MKdV equation, the general linear Euler Lagrangeequation and the cylindric shell equations are given.

关键词： Euler-Lagrange equations, Lagrange multiplier, Hamiltonian system, Hamiltonian operator, Helmholtz condition

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Range resolution and sampling frequency trade-off for GPS passive radar

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Journal of Systems Engineering and Electronics 2022年第1期33卷 28-37页

作者： ZHANG Zhuxian zheng yu zheng Linhua ZHU Peidong College of Electronic Science National University of Defense TechnologyChangsha 410073China College of Electronic Communication and Electrical Engineering Changsha UniversityChangsha 410022China

In a global positioning system(GPS)passive radar,a high resolution requires a high sampling frequency,which increases the computational *** the computational load and the range resolution is *** paper presents a method to trade off the range resolution and the computational load by experimentally determining the optimal sampling frequency through an analysis of multiple sets of GPS satellite data at different sampling *** test data are used to construct a range resolution-sampling frequency trade-off model using least-squares *** theoretical analysis shows that the experimental data are the best fit using smoothing and nthorder derivative *** field GPS C/A code signal-based GPS radar,the trade-off between the optimal sampling frequency is determined to be in the 20461.25–24553.5 kHz range,which supports a resolution of 43–48 *** with the conventional method,the CPU time is reduced by approximately 50%.

关键词： global positioning system(GPS)radar range resolution sampling frequency trade-off

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Mott physics, sign structure, ground state wavefunction, and high- Tc superconductivity

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Frontiers of physics 2011年第4期6卷 370-378页

作者： zheng-yu Weng Institute for Advanced Study Tsinghua University Beijing 100084 China

In this article I give a pedagogical illustration of why the essential problem of high-Tc superconductivity in the cuprates is about how an antiferromagnetically ordered state can be turned into a short-range state by doping. I will start with half-filling where the antiferromagnetic ground state is accurately described by the Liang Doucot-Anderson （LDA） wavefunction. Here the effect of the Fermi statistics becomes completely irrelevant due to the no double occupancy constraint. Upon doping, the statistical signs reemerge, albeit much reduced as compared to the original Fermi sta- tistical signs. By precisely incorporating this altered statistical sign structure at finite doping, the LDA ground state can be recast into a short-range antiferromagnetic state. Superconducting phase coherence arises after the spin correlations become short-ranged, and the superconducting phase transition is controlled by spin excitations. I will stress that the pseudogap phenomenon naturally emerges as a crossover between the antiferromagnetic and superconducting phases. As a characteristic of non Fermi liquid, the mutual statistical interaction between the spin and charge degrees of freedom will reach a maximum in a high-temperature ＂strange metal phase＂ of the doped Mott insulator.

关键词： Mott physics high-Tc cuprates ground state wavefunction sign structure

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Dynamic defenses in cyber security:Techniques,methods and challenges Author links open overlay panel

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Digital Communications and Networks 2022年第4期8卷 422-435页

作者： yu zheng zheng Li Xiaolong Xu Qingzhan Zhao School of Computer and Software Nanjing University of Information Science and TechnologyNanjing210044JiangsuChina Key Laboratory for Novel Software Technology Nanjing UniversityNanjing210023JiangsuChina College of Information Science and Technology Shihezi University Geospatial Information Engineering Research CenterChina

Driven by the rapid development of the Internet of Things,cloud computing and other emerging technologies,the connotation of cyberspace is constantly expanding and becoming the fifth dimension of human ***,security problems in cyberspace are becoming serious,and traditional defense measures(e.g.,firewall,intrusion detection systems,and security audits)often fall into a passive situation of being prone to attacks and difficult to take effect when responding to new types of network attacks with a higher and higher degree of coordination and *** constructing and implementing the diverse strategy of dynamic transformation,the configuration characteristics of systems are constantly changing,and the probability of vulnerability exposure is ***,the difficulty and cost of attack are increasing,which provides new ideas for reversing the asymmetric situation of defense and attack in ***,few related works systematically introduce dynamic defense mechanisms for cyber *** related concepts and development strategies of dynamic defense are rarely analyzed and *** bridge this gap,we conduct a comprehensive and concrete survey of recent research efforts on dynamic defense in cyber ***,we firstly introduce basic concepts and define dynamic defense in cyber ***,we review the architectures,enabling techniques and methods for moving target defense and mimic *** is followed by taxonomically summarizing the implementation and evaluation of dynamic ***,we discuss some open challenges and opportunities for dynamic defense in cyber security.

关键词： Cyber security Dynamic defense Moving target defense Mimic defense

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The Logarithmic Sobolev Inequality for a Submanifold in Manifolds with Nonnegative Sectional Curvature

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Chinese Annals of Mathematics,Series B 2024年第3期45卷 487-496页

作者： Chengyang YI yu zheng School of Mathematical Sciences East China Normal UniversityShanghai 200241China

The authors prove a sharp logarithmic Sobolev inequality which holds for compact submanifolds without boundary in Riemannian manifolds with nonnegative sectional curvature of arbitrary dimension and *** the Michael-Simon Sobolev inequality,this inequality includes a term involving the mean *** extends a recent result of Brendle with Euclidean setting.

关键词： Logarithmic Sobolev inequality Nonnegative sectional curvature Submanifold

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Enhanced cooperative packet retransmission employing joint cooperative diversity and symbol mapping diversity

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第8期9卷 1090-1098页

作者： Wei JI Bao-yu zheng Electronic Engineering Department Shanghai Jiao Tong University Shanghai 200240 China Institute qf Signal Processing and Transmission Nanjing University of Posts ＆ Telecommunications Nanjing 210003 China

A joint cooperation diversity and symbol mapping diversity (SMD) strategy is proposed for cooperative packet retransmission system with high-order modulation such as 16QAM. Substantial SER/BER (symbol error rate/bit error rate) gains result from multiple packet transmissions over independent paths and distinct bit-to-symbol mappings for each packet transmis-sion. The SER/BER performance of relay assisted retransmission system is analyzed. Simulation results show that the joint-diversity strategy can provide more BER gains than other relaying strategies (i.e., decode-and-forward and constellation rearrangement relaying strategies) when no relay makes a decision error; but if some relays make decision errors, the joint-di-versity strategy outperforms other relaying strategies only when the relays are closer to the source than to the destination.

关键词： Cooperative retransmission Hybrid automatic repeat request (HARQ) Cooperative diversity Symbol mapping diversity (SMD)

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