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Multicenter study of endoscopic preoperative biliary drainage for malignant distal biliary obstruction

World Journal of Gastroenterology 2016年第14期22卷 3793-3802页

作者： Naoki Sasahira Tsuyoshi Hamada Osamu Togawa Ryuichi Yamamoto Tomohisa Iwai Kiichi Tamada Yoshiaki Kawaguchi Kenji Shimura Takero Koike yu yoshida Kazuya Sugimori Shomei Ryozawa Toshiharu Kakimoto Ko Nishikawa Katsuya Kitamura Tsunao Imamura Masafumi Mizuide Nobuo Toda Iruru Maetani yuji Sakai Takao Itoi Masatsugu Nagahama Yousuke Nakai Hiroyuki Isayama Department of Gastroenterology JCHO Tokyo Takanawa HospitalTokyo 108-8606Japan Department of Gastroenterology Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan Department of Gastroenterology Saitama International Medical CenterSaitama Medical UniversitySaitama 350-1298Japan Department of Gastroenterology and Hepatology Saitama Medical University International Medical CenterSaitama 350-8550Japan Department of Gastroenterology Kitasato UniversityKanagawa 252-0375Japan Department of Gastroenterology Jichi Medical UniversityTochigi 329-0498Japan Department of Gastroenterology Tokai UniversityKanagawa 259-1193Japan Department of Gastroenterology Asahi General HospitalChiba 289-2511Japan Department of Internal Medicine Japanese Red Cross Ashikaga HospitalTochigi 326-0843Japan Department of Gastroenterology Kimitsu Central HospitalChiba 292-8535Japan Department of Gastroenterology Yokohama City University Medical CenterKanagawa 232-0024Japan Department of Gastroenterology Showa University Northern Yokohama HospitalKanagawa 242-0032Japan Department of Gastroenterology Saitama City HospitalSaitama 336-8522Japan Department of Gastroenterology Ageo Central General HospitalSaitama 362-8588Japan Division of Gastroenterology Department of MedicineShowa University School of MedicineTokyo 142-8666Japan Department of Gastroenterology Toranomon HospitalTokyo 105-0001Japan Department of Gastroenterology Gunma UniversityGunma 371-0034Japan Department of Gastroenterology Mitsui Memorial HospitalTokyo 101-8643Japan Division of Gastroenterology and Hepatology Department of Internal MedicineToho University Ohashi Medical CenterTokyo 153-0044Japan Department of Gastroenterology Chiba UniversityChiba 260-0856Japan Department of Gastroenterology Tokyo Medical UniversityTokyo 160-0023Japan Department of Gastroenterology Showa University Fujigaoka HospitalKanagawa 227-8501Japan

AIM: To determine the optimal method of endoscopic preoperative biliary drainage for malignant distal biliary ***: Multicenter retrospective study was conducted in patients who underwent plastic stent (PS) or nasobiliary catheter (NBC) placement for resectable malignant distal biliary obstruction followed by surgery between January 2010 and March 2012. Procedure-related adverse events, stent/catheter dysfunction (occlusion or migration of PS/NBC, development of cholangitis, or other conditions that required repeat endoscopic biliary intervention), and jaundice resolution (bilirubin level < 3.0 mg/dL) were evaluated. Cumulative incidence of jaundice resolution and dysfunction of PS/NBC were estimated using competing risk analysis. Patient characteristics and preoperative biliary drainage were also evaluated for association with the time to jaundice resolution and PS/NBC dysfunction using competing risk regression ***: In total, 419 patients were included in the study (PS, 253 and NBC, 166). Primary cancers included pancreatic cancer in 194 patients (46%), bile duct cancer in 172 (41%), gallbladder cancer in three (1%), and ampullary cancer in 50 (12%). The median serum total bilirubin was 7.8 mg/dL and 324 patients (77%) had ≥ 3.0 mg/dL. During the median time to surgery of 29 d [interquartile range (IQR), 30-39 d]. PS/NBC dysfunction rate was 35% for PS and 18% for NBC [Subdistribution hazard ratio (SHR) = 4.76; 95%CI: 2.44-10.0, P < 0.001]; the pig-tailed tip was a risk factor for PS dysfunction. Jaundice resolution was achieved in 85% of patients and did not depend on the drainage method (PS or NBC).CONCLUSION: PS has insufficient patency for preoperative biliary drainage. Given the drawbacks of external drainage via NBC, an alternative method of internal drainage should be explored.

关键词： Endoscopic preoperative biliary drainage Malignant distal biliary obstruction Periampullary cancer Plastic stent Nasobiliary drainage

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镧对Cu_6Sn_5长大驱动力及焊点可靠性的影响

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中国稀土学报 2001年第4期19卷 354-356页

作者：马鑫钱乙余 yoshida F 信息产业部电子第五研究所电子元器件可靠性物理及其应用技术国家重点实验室广东广州510610 哈尔滨工业大学现代焊接生产技术国家重点实验室黑龙江哈尔滨150001 广岛大学工学部

在Sn60 Pb40钎料合金中加入微量稀土元素镧可以抑制表面组装焊点界面处Cu6 Sn5金属间化合物的生长 ,进而使焊点热疲劳寿命提高两倍。基于扩散动力学的热力学计算结果表明 ,添加微量稀土元素镧可降低Cu6 Sn5金属间化合物的长大驱动力 ,... 详细信息

在Sn60 Pb40钎料合金中加入微量稀土元素镧可以抑制表面组装焊点界面处Cu6 Sn5金属间化合物的生长 ,进而使焊点热疲劳寿命提高两倍。基于扩散动力学的热力学计算结果表明 ,添加微量稀土元素镧可降低Cu6 Sn5金属间化合物的长大驱动力 ,但存在一个镧的有效局部摩尔分数范围 ,0 18%是其极限值 ,0 0 8%是其最佳值。

关键词：稀土镧 Cu6Sn5金属间化合物焊点可靠性热力学铜锡合金热疲劳寿命扩散动力学

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A 2-D mesoscopic model for the evaluation of creep damage induced by void growth in polycrystalline metals

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Acta Metallurgica Sinica(English Letters) 2011年第3期24卷 213-219页

作者： Tao yu Kimiaki yoshida Huiji SHI Key Laboratory of Applied Mechanics Department of Engineering Mechanics Tsinghua University Beijing 100084 China v Research Laboratory Ishikawajima-Harima Heary Industries Co. Ltd. Tokyo Japan

At elevated temperature, creep failures of polycrystalline metals after long-term constant loading are often caused by the nucleation, growth and coalescence of creep voids on the grain boundaries. Void h＇action is an important parameter for the evaluation of creep damage level of structural materials operating at high temperature. In this paper, a 2-D numerical simulation method was developed for analyzing the void fraction evolution during the process of creep, based on some hypothesis from experiments. The model was implemented and then was used to predict the evolution of void fraction in the 2.25Cr-1Mo steel of uniaxial creep experiment at 570 ℃, in which the simulation results showed good agreement with the experimental results.

关键词： Creep damage Grain boundary Void fraction Voronoi tessellation

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Clinical outcomes of endoscopic ultrasonography-guided transmural drainage using plastic stent and nasocystic drain for pancreatic and peripancreatic collections

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Hepatobiliary & Pancreatic Diseases International 2019年第1期18卷 96-99页

作者： Katsuya Kitamura Akira Yamamiya yu Ishii yuta Mitsui Hitoshi yoshida Division of Gastroenterology Department of Medicine Showa University School of Medicine

To the Editor:Pancreatic and peripancreatic collections(PCs)develop from acute pancreatitis(AP),chronic pancreatitis,surgery,or *** 2012 revised Atlanta classification[1]of AP classified local complications into the following 4 PC types:acute peripancreatic fluid collection(<4 weeks after the onset of acute interstitial edematous pancreatitis),acute necrotic collection(<4 weeks after the onset of acute necrotizing pancreatitis),pancreatic pseudocyst(PPC;≥4 weeks after the onset of acute interstitial edematous pancreatitis),and walled-off necrosis(WON;≥4 weeks after the onset of acute necrotizing pancreatitis).Endoscopic ultrasonographyguided transmural drainage(EUS-TD)has been reported to be a minimally invasive procedure for patients with PCs[2–4].This study aimed to investigate the clinical outcomes of EUS-TD for PCs.

关键词： peripancreatic EUS-TD

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Detection of large color variation in the potentially hazardous asteroid(297274) 1996 SK

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Research in Astronomy and Astrophysics 2014年第3期14卷 311-318页

作者： Chien-Hsien Lin Wing-Huen Ip Zhong-Yi Lin Fumi yoshida yu-Chi Cheng Space Science Institute Macao University of Science and Technology Institute of Astronomy National Central University National Astronomical Observatory Osawa MitakaTokyo

Low-inclination near-earth asteroid （NEA）（297274） 1996 SK, which isalso classified as a potentially hazardous asteroid, has a highly eccentric orbit. Itwas studied by multi-wavelength photometry within the framework of an NEA colorsurvey at Lulin Observatory. Here, we report the finding of large color variationacross the surface of （297274） 1996 SK within one asteroidal rotation period of4.656 ± 0.122 hours and classify it as an S-type asteroid according to its averagecolors ofB - V = 0.767 ± 0.033, V - R = 0.482 ± 0.021, V - I = 0.801 ± 0.025and the corresponding relative reflectance spectrum. These results might be indica-tive of differential space weathering or compositional inhomogeneity in the surfacematerials.

关键词： minor planets, asteroids: individual: PHA (297274) techniques: photometric

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Feasibility of initial endoscopic common bile duct stone removal in patients with acute cholangitis

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World Journal of Clinical Cases 2017年第7期5卷 280-285页

作者： Akira Yamamiya Katsuya Kitamura yu Ishii yuta Mitsui Tomohiro Nomoto Hitoshi yoshida Division of Gastro- enterology Department of MedicineShowa University School of Medicine

AIM To investigate the feasibility of initial endoscopic common bile duct(CBD) stone removal in patients with acute cholangitis(AC).METHODS A single-center,retrospective study was conducted between April 2013 and December 2014 and was approved by the Medical Ethics Committee at our *** informed consent was obtained from each patient prior to the *** cohort comprised 31 AC patients with CBD stones who underwent endoscopic biliary drainage(EBD) for na?ve papilla within 48 h after AC *** retrospectively divided the participants into two groups: 19 patients with initial endoscopic CBD stone removal(initial group) and 12 patients with delayed endoscopic CBD stone removal(delayed group).We evaluated the feasibility of initial endoscopic CBD stone removal in patients with *** We observed no significant differences between the groups regarding patient *** to the assessments based on the Tokyo Guidelines,the AC severity of patients with initial endoscopic CBD stone removal was mild to *** use of antithrombotic agents before EBD was less frequent in the initial group than in the delayed group(11% vs 58%,respectively; P = 0.004).All the patients underwent successful endoscopic CBD stone removaland adverse events did not differ significantly between the *** number of endoscopic retrograde cholangiopancreatography procedures was significantly lower in the initial group than in the delayed group [median(interquartile range) 1(1-1) vs 2(2-2),respectively; P < 0.001].The length of hospital stay was significantly shorter for the initial group than for the delayed group [10(9-15) vs 17(14-20),respectively; P = 0.010].CONCLUSION Initial endoscopic CBD stone removal in patients with AC may be feasible when AC severity and the use of antithrombotic agents are carefully considered.

关键词： Acute cholangitis Common bile duct stone Feasibility Initial endoscopic common bile stone removal Endoscopic retrograde cholangiopancreatography

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Thermal physiological response to local heating and cooling during sleep

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Frontiers of Architectural Research 2012年第1期1卷 51-57页

作者： yu Hibino Shuichi Hokoi Katsuaki yoshida Satoru Takada Masanori Nakajima Miho Yamate KVOtO University Japan Kobe University Japan The Kansai Electric Power Co. Inc. Japan

For a healthy and productive life, good steep is essential, which has prompted studies on how comfortable sleep can be achieved. Understanding the relationship between thermal environment and physiological responses such as skin and core temperatures, and psychological responses such as thermal and sleep sensations is necessary to identify the most suitable thermal environment for steep. As an energy-saving and practical method of creating the most appropriate thermal environment for sleep, local heating or cooling is sometimes used, which takes into consideration the differences in local thermal responses. We performed this study to identify the most effective thermal environment for inducing comfortable sleep by identifying the physiological responses during sleep on the basis of sleep experiments conducted under local body heating or cooling conditions. We also used a human thermal model, which can be applied for predicting physiological responses. In the experiments, the feet of the subject were the primary area to be heated or cooled, which was achieved by installing a flexible duct with an outlet placed close to the subject＇s feet and inlet connected to an air conditioner. Differences in the fluctuation of body temperature and sleep stage depended on the airflow direction from the duct to the feet. When air was blown downward towards the feet, body temperature decreased and the subject was able to sleep well. Measured skin and core temperatures were calculated using an improved 27-node human thermal model that was originally developed for use in subjects who are not in steep. Although skin

关键词： Sleep Thermal environ-ment Local air conditioning Physiologicalresponse Human thermal mode[

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Thermodynamic Assessment of Interaction Relation between Lanthanum and Constituent Elements in Sn-Pb Alloy

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Journal of Rare Earths 2001年第2期19卷 107-109页

作者：薛松柏马鑫钱乙余 Harbin Inst Technol Natl Key Lab Welding Harbin 150001 Peoples R China Minist Informat Ind Natl Key Lab Reliabil Phys Elect Prod Guangzhou 510610 Peoples R China Hiroshima Univ Dept Mech Engn Hiroshima 739 Japan

The interaction relation between lanthanum and the constituent elements of Sn-Pb alloy system was analyzed by using the thermodynamic models including Miedema formation energy model for binary system, Tanaka modification by excess entropy and the Chou geometric model for ternary system. The thermodynamic calculaton results show that lanthanum has higher affinity for Sn in the Sn-Pb system. This is an important foundation for the improvement of the metallurgical properties of Sn-Pb solder alloy by adding rare earth elements.

关键词： rare earths lanthanum Sn-Pb alloy interaction thermodynamic

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Pancreatic cancer secondary to intraductal papillary mucinous neoplasm with collision between gastric cancer and B-cell lymphoma: A case report

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World Journal of Clinical Cases 2021年第10期9卷 2400-2408页

作者： yu-Hong Ma Tatsuya Yamaguchi Tomoki Yasumura Toru Kuno Shoji Kobayashi Takashi yoshida Takeshi Ishida Yasuaki Ishida Shinya Takaoka Jiang-Lin Fan Nobuyuki Enomoto Department of Gastroenterology Ningxia Hui Autonomous Region People’s HospitalYinchuan 750021Ningxia Hui Autonomous RegionChina Department of the First Internal Medicine Faculty of MedicineUniversity of YamanashiChuo 409-3898YamanashiJapan Department of Molecular Pathology Interdisciplinary Graduate School of Medicine and EngineeringUniversity of YamanashiChuo 409-3898YamanashiJapan

BACKGROUND Patients with intraductal papillary mucinous neoplasm(IPMN)have an increased risk of pancreatic and extrapancreatic *** are rare extrapancreatic malignancies,and in situ collisions of early gastric cancer and diffuse large B-cell lymphoma(DLBCL)are even ***,we report the first case of pancreatic cancer comorbid with in situ collision of extrapancreatic malignancies(early gastric cancer and DLBCL)in a follow-up IPMN ***,we have made innovations in the treatment of such *** SUMMARY An 81-year-old Japanese female diagnosed with IPMN developed elevated carbohydrate antigen(CA)19-9 levels during *** her CA19-9 levels continued to rise,endoscopic ultrasound(EUS)was performed and revealed a suspicious lesion at the pancreatic ***,lesions in the pancreas were not found by computed tomography,magnetic resonance imaging,or endoscopic retrograde *** make an exact pathological diagnosis,EUS-guided fine needle aspiration was *** our supprise,early gastric cancer was found in preoperative *** gastric cancer was completely resected through endoscopic submucosal dissection before postoperative pathology identified early adenocarcinoma collided with *** EUS-guided fine needle aspiration provided pathological support forthe pancreatic cancer diagnosis, and then laparoscopic distal pancreatectomy andsplenectomy were performed. CA19-9 levels returned to normal *** Endoscopic submucosal dissection is appropriate for submucosal lymphomas inpatients intoleratant of chemotherapy. EUS can detect small IPMN-relatedpancreatic tumors.

关键词： Stomach neoplasms Pancreatic intraductal neoplasms Pancreatic neoplasms B-cell lymphoma Treatment Case report

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Legionella dumoffii Tex-KL Mutated in an Operon Homologous to traC-traD is Defective in Epithelial Cell Invasion

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Biomedical and Environmental Sciences 2016年第6期29卷 424-434页

作者： QIN Tian Iida Ken-ichiro REN Hong yu ZHOU Hai Jian Shin-ichi yoshida State Key Laboratory for Infectious Disease Prevention and Control National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention beijing 102206 China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Hangzhou 310003 Zhejiang China Departments of Bacteriology Faculty of Medical Sciences Kyushu University Higashi-ku Fukuoka 812-8582 Japan

Objective To understand the mechanism of invasion by Legionella dumoffii. Methods The L. dumoffii strain Tex-KL was mutated using the Tn903 derivative, Tn903 d IIlac Z. After screening 799 transposon insertion mutants, we isolated one defective mutant. We then constructed the gene-disrupted mutant, KL16, and studied its invasion of and intracellular growth in He La and A549 cells, and in A/J mice survival experiments. The structure of traC-traD operon was analyzed by RT-PCR. Results The transposon insertion was in a gene homologous to Salmonella typhi tra C, which is required for the assembly of F pilin into the mature F pilus structure and for conjugal DNA transmission. Results from RT-PCR suggested that the traC-traD region formed an operon. We found that when the tra C gene was disrupted, invasion and intracellular growth of L. dumoffii Tex-KL were impaired in human epithelial cells. When mice were infected by intranasal inoculation with a tra C deficient mutant, their survival significantly increased when compared to mice infected with the wild-type strain. Conclusion Our results indicated that the traC-traD operon is required for the invasion and intracellular growth abilities of L. dumoffii Tex-KL in epithelial cells.

关键词： L. dumoffii Tex-KL traC-traD operon Invasion ability Epithelial cells

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