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Evaluating short-term and long-term liver fibrosis improvement in hepatitis C patients after DAA treatment

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Journal of Biomedical Research 2024年第5期38卷 464-472,I0001,I0002页

作者： Yifan Wang Xinyan Ma yanzheng Zou Ming yue Meiling Zhang Rongbin yu Hongbo Chen Peng Huang Department of Infectious Disease Jurong Hospital Affiliated to Jiangsu UniversityJurongJiangsu 212400China Department of Epidemiology Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Infectious Diseases the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China

Despite achieving a high cure rate with the direct-acting antivirals(DAAs)in hepatitis C treatment,further research is needed to identify additional benefits of the DAA *** current study evaluated liver fibrosis improvement in 848 hepatitis C patients treated with DAAs,who also achieved sustained virologic *** the fibrosis-4(FIB-4)index,patients were categorized based on their baseline fibrosis levels,and the improvement in fibrosis was analyzed in both short-term(9-26 weeks)and long-term(≥36 weeks)*** results showed a significant decrease in the FIB-4 index,indicating an improvement in liver fibrosis,in 63.0%and 67.6%of the patients during the short-term and long-term follow-up,***-term improvement was associated with factors including ribavirin usage,blood cholinesterase levels,alanine transaminase levels,albumin levels,and the baseline FIB-4 index,while long-term improvement was associated with factors such as aspartate transaminase levels,total protein level,and the baseline FIB-4 *** current study emphasizes the importance of continuous assessment and post-treatment monitoring of liver fibrosis,which will provide crucial insights for enhancing patient care in hepatitis C management.

关键词： chronic hepatitis C sustained virologic response direct-acting antivirals liver fibrosis

迷走神经结状神经节与心肌细胞联合培养的扫描电镜观察

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神经解剖学杂志 1999年第1期15卷 62-64页

作者： Li Zhenzhong yu yanzheng Peng yuwen Liu Caidong(Department of Anatomy, Shanghai Medical University, Shanghai 200032) 济南山东医科大学解剖学教研室250012

用新生大鼠的迷走神经结状神经节与心肌细胞进行联合培养，用扫描电镜观察了神经纤维或神经终末与心肌细胞之间的关系。在低倍下可见结状神经节组织块长出的神经纤维呈放射状向四周延伸，到达分散的心肌细胞表面；在扫描电镜高倍下所观... 详细信息

用新生大鼠的迷走神经结状神经节与心肌细胞进行联合培养，用扫描电镜观察了神经纤维或神经终末与心肌细胞之间的关系。在低倍下可见结状神经节组织块长出的神经纤维呈放射状向四周延伸，到达分散的心肌细胞表面；在扫描电镜高倍下所观察到的神经纤维或神经终末的形态不同，神经纤维粗细不一，在单个心肌细胞表面相互交织成网状。有的神经纤维在行程中粗细基本均匀一致．而有的神经纤维则在行程中出现膨体样结构。终止于心肌细胞表面的神经终末的形态也不相同，有的末端膨大终止于心肌细胞表面，有的末端膨大并呈扇形展开后紧贴于心肌细胞表面，这种膨大的神经末梢与心肌细胞之间的关系似比在体时更为密切。

关键词：扫描电镜结状神经节心肌细胞新生大鼠

Linear-Quadratic Pareto Cooperative Game for Mean-Field Backward Stochastic System

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Journal of Systems Science & Complexity 2024年第3期37卷 947-964页

作者： WANG yu School of Control Science and Engineering Shandong UniversityJinan 250061China

This paper focuses on a Pareto cooperative differential game with a linear mean-field backward stochastic system and a quadratic form cost functional. Based on a weighted sum optimality method, the Pareto game is equivalently converted to an optimal control problem. In the first place,the feedback form of Pareto optimal strategy is derived by virtue of decoupling technology, which is represented by four Riccati equations, a mean-field forward stochastic differential equation(MF-FSDE),and a mean-field backward stochastic differential equation(MF-BSDE). In addition, the corresponding Pareto optimal solution is further obtained. Finally, the author solves a problem in mathematical finance to illustrate the application of the theoretical results.

关键词： Backward stochastic differential equation linear-quadratic control mean-field Pareto optimality

Approximate analytical solutions for threedimensional ascent trajectory of a solid-fuel launch vehicle with time-varying mass flow rate

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Chinese Journal of Aeronautics 2024年第10期37卷 275-293页

作者： Qi yu Wanchun CHEN Wenbin yu School of Astronautics Beihang UniversityBeijing 102206China

In the scenario that a solid-fuel launch vehicle maneuvers in outer space at high angles of attack and sideslip for energy management,Approximate Analytical Solutions(AAS)for the threedimensional(3D)ascent flight states are derived,which are the only solutions capable of considering time-varying Mass Flow Rate(MFR)at *** uneven MFR makes the thrust vary nonlinearly and thus increases the difficulty of the problem *** AAS are derived based on a 3D Generalized Ascent Dynamics Model(GADM)with a normalized mass as the independent *** simplify some highly nonlinear terms in the GADM,several approximate functions are introduced carefully,while the errors of the approximations relative to the original terms are regarded as minor ***,a finite series with positive and negative exponents,called Exponent-Symmetry Series(ESS),is proposed for function approximation to decrease the highest exponent in the AAS so as to reduce computer round-off *** calculate the ESS coefficients,a method of seeking the Optimal Interpolation Points(OIP)is proposed using the leastsquares-approximation *** to the artful design of the approximations,the GADM can be decomposed into two analytically solvable subsystems by a perturbation method,and thus the AAS are obtained ***,to help implement the AAS,two indirect methods for measuring the remaining mass and predicting the burnout time in flight are put forward using information from *** results verify the superiority of the AAS under the condition of time-varying MFR.

关键词： Approximate analytical solutions 3D ascent trajectory Solid-fuel launch vehicle Uneven thrust Energy management

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右心室壁内的动脉构筑

解剖学杂志 1989年第3期12卷 194-199页

作者：罗宝国左焕琛于彦铮黄德桥上海医科大学解剖教研室

本文对50例成人离体心标本分别用铸型法、X线造影法和墨汁注射火棉胶切片法作右心室壁内及乳头肌的动脉构筑研究。与左心室柑同,可将右室壁内的动脉分为心外膜支、树枝状支、直支和乳头肌支四种类型。与左心室不同的是树枝状支在右室壁... 详细信息

本文对50例成人离体心标本分别用铸型法、X线造影法和墨汁注射火棉胶切片法作右心室壁内及乳头肌的动脉构筑研究。与左心室柑同,可将右室壁内的动脉分为心外膜支、树枝状支、直支和乳头肌支四种类型。与左心室不同的是树枝状支在右室壁内匍匐斜行一段距离后再分支到右室壁的部分或全层心肌,它也分支到达肉柱。直支以斜行或直角纵主干上发出分支分布于右室壁肌肉并可达肉柱。乳头肌血管类型有钩形和叉形,但类型较左心室乳头肌少。心壁内可见少数心内膜下丛。多数乳头肌至少有二个以上的血管供应,少数小的乳头肌为单一动脉支配呈单支中央型。用图像分析仪对左、右心室壁及乳头肌的毛细血管密度和支数进行了对比。对右室壁内和乳头肌内的小血管和毛细血管形态与心肌的关系作了观察。讨论了它们形态和功能的一致性,以及对心肌梗塞的应用意义。

关键词：心室壁动脉构筑

沿迷走神经传入的心脏感觉纤维在豚鼠左心房的分布

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解剖学杂志 1998年第2期21卷 102-104页

作者：于彦铮彭裕文刘才栋李振中上海医科大学解剖学教研室上诲200032 山东滨州医学院解剖学教研室滨州256603

目的:为厂确定沿迷走神经传入的心脏感觉纤维在左心房的分布情况.将CT-HRP注入豚鼠迷走神经下神经节,顺行标记沿迷走神经传入的心脏感觉纤维在豚鼠左心房的分布.结果:在左心房壁内观察到了大量的HRP阳性的顺行标记神经纤维和终末样分支... 详细信息

目的:为厂确定沿迷走神经传入的心脏感觉纤维在左心房的分布情况.将CT-HRP注入豚鼠迷走神经下神经节,顺行标记沿迷走神经传入的心脏感觉纤维在豚鼠左心房的分布.结果:在左心房壁内观察到了大量的HRP阳性的顺行标记神经纤维和终末样分支:对这一发现与以前用同样方法研究沿交感神经传入的心脏感觉纤维进行了比较,并对这些纤维的意义进行了讨论.

关键词：心脏感觉纤维左心房迷走神经传入

Low-melting mixture solvents: extension of deep eutectic solvents and ionic liquids for broadening green solvents and green chemistry

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Green Chemical Engineering 2024年第4期5卷 409-417页

作者： yu Chen Zhiwu yu MOE Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology Department of ChemistryTsinghua University

Green solvents such as water and ionic liquids(ILs) are pillars of the great mansion of green chemistry and green processing. Initially proposed as a new family of ILs,deep eutectic solvents(DESs) have received fast development in the past two decades. In this contribution,DESs are reviewed critically and the concept is extended to lowmelting mixture solvents(Lo MMSs),which cover all kinds of materials including ionic compounds,molecular compounds,and metals. Six classes of Lo MMSs are proposed as the new classification system and examples are given. Finally,several thermodynamic issues concerning Lo MMSs are discussed. Two new concepts,robustness of Lo MMSs and high-entropy Lo MMSs,are proposed.

关键词： Green solvents Deep eutectic solvents Low transition temperature mixture solvents Phase diagram EGaIn

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人心丛各副丛的解剖学观察

解剖学杂志 1999年第3期22卷 218-221页

作者：李振中于彦铮彭裕文刘才栋山东医科大学解剖学教研室济南250012 上海医科大学解剖学教研室

为了观察心丛各副丛有无个体差异 ,在 4 3(男 2 0 ,女 2 3)例经福尔马林固定的成人尸体上观察了各副丛的神经条数及其分布。结果按左心房神经丛的神经条数及有无直接分布到左心房后壁的神经分为两型。型 (男 10 ,女8) :左心房神经丛... 详细信息

为了观察心丛各副丛有无个体差异 ,在 4 3(男 2 0 ,女 2 3)例经福尔马林固定的成人尸体上观察了各副丛的神经条数及其分布。结果按左心房神经丛的神经条数及有无直接分布到左心房后壁的神经分为两型。型 (男 10 ,女8) :左心房神经丛分布于左心房后壁的神经为 8～ 12条 ,分布于左心房前壁者 5～ 11条 ;右心房神经丛 1～ 3条 ;右冠状动脉神经丛 3～ 7条 ;左冠状动脉神经丛 3～ 7条 ;右肺动脉后神经丛 7～ 11条 ,右肺动脉前神经丛 4～ 7条 ;左肺动脉神经丛 1～ 2条。型 (男 10 ,女 15) :左心房神经丛分布于左心房前壁的神经为 2～ 4条 ;右心房神经丛 1～ 3条 ;右冠状动脉神经丛 3～ 7条 ;左冠状动脉神经丛 4～ 6条 ;右肺动脉后神经丛 5～ 8条 ,右肺动脉前神经丛 3～ 8条 ;左肺动脉神经丛 1～ 3条。左心房神经丛分布于左心房前壁的神经条数、右肺动脉后神经丛和右肺动脉前神经丛的神经条数、两型间有显著性差异。 4 1.86± 7.52 %的左心房有丰富的神经支配 ,这些神经不随血管分布。

关键词：心心丛副丛解剖学交感神经

Topological Stability and Entropy for Certain Set-valued Maps

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Acta Mathematica Sinica,English Series 2024年第4期40卷 962-984页

作者： yu ZHANG yu Jun ZHU School of Mathematical Sciences Xiamen UniversityXiamen 361005P.R.China

In this paper,the dynamics(including shadowing property,expansiveness,topological stability and entropy)of several types of upper semi-continuous set-valued maps are mainly considered from differentiable dynamical systems points of *** is shown that(1)if f is a hyperbolic endomorphism then for eachε>0 there exists a C^(1)-neighborhood U of f such that the induced set-valued map F_(f,U)has theε-shadowing property,and moreover,if f is an expanding endomorphism then there exists a C^(1)-neighborhood U of f such that the induced set-valued map F_(f,U)has the Lipschitz shadowing property;(2)when a set-valued map F is generated by finite expanding endomorphisms,it has the shadowing property,and moreover,if the collection of the generators has no coincidence point then F is expansive and hence is topologically stable;(3)if f is an expanding endomorphism then for eachε>0 there exists a C^(1)-neighborhood U of f such that h(F_(f,U,ε))=h(f);(4)when F is generated by finite expanding endomorphisms with no coincidence point,the entropy formula of F is ***,the dynamics of the set-valued maps based on discontinuous maps on the interval are also considered.

关键词： Set-valued map orbit space hyperbolic endomorphism perturbation shadowing expansiveness topological stability entropy