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NνDEx-100 conceptual design report

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Nuclear Science and Techniques 2024年第1期35卷 18-33页

作者： Xi-Guang Cao Yan-Long Chang Kai Chen Emilio Ciuffoli Li-Min Duan Dong-Liang Fang Chao-Song Gao Surja K.Ghorui Peng-Chong Hu Qiang Hu Si-yuan Huang Ze-yu Huang Lei Lang yu-Lan Li Zhi-Jie Li Tian-yu Liang Jun Liu Chen-Gui Lu Fa-Tai Mai yuan Mei Hao Qiu Xiang-Ming Sun Xiao-Xing Tang Hu-Lin Wang Qian-Ming Wang Le Xiao Mu-yun Xiao Jian-yu Xin Nu Xu Peng yang Yi-Chen yang Zhen yang Zong-yang yu Dong-Liang Zhang Jun-Wei Zhang Cheng-Xin Zhao Dou Zhu NνDEx-100 collaboration Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China Lanzhou University Lanzhou 730000China Central China Normal University Wuhan 430079China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Lawrence Berkeley National Laboratory BerkeleyCA 94720USA North China University of Water Resources and Electric Power Zhengzhou 450045China 不详

Observing nuclear neutrinoless double beta (0vββ) decay would be a revolutionary result in particle *** such a decay would prove that the neutrinos are their own antiparticles,help to study the absolute mass of neutrinos,explore the origin of their mass,and may explain the matter-antimatter asymmetry in our universe by lepton number *** propose developing a time projection chamber (TPC) using high-pressure ^(82)SeF_(6) gas and Topmetal silicon sensors for readout in the China Jinping Underground Laboratory (CJPL) to search for neutrinoless double beta decay of82Se,called the NvDEx *** being located at CJPL with the world’s thickest rock shielding,NvDEx combines the advantages of the high Qββ(2.996 MeV) of82Se and the TPC’s ability to distinguish signal and background events using their different topological *** makes NvDEx unique,with great potential for low-background and high-sensitivity 0 vββ***-100,a NvDEx experiment phase with 100 kg of SeF_(6)gas,is being built,with plans to complete installation at CJPL by *** report introduces 0 vββ physics,the NvDEx concept and its advantages,and the schematic design of NvDEx-100,its subsystems,and background and sensitivity estimation.

关键词： Neutrinoless double beta decay Time projection chamber ^(82)SeF_(6) China Jinping Underground Laboratory

Clinical manifestations and spermatogenesis outcomes in Chinese patients with congenital hypogonadotropic hypogonadism caused by inherited or de novo FGFR1 mutations

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Asian Journal of Andrology 2024年第4期26卷 426-432页

作者： yu-Fan yang Hai-Lu Ma Xi Wang Min Nie Jiang-Feng Mao Xue-Yan Wu Department of Endocrinology Peking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100730China.

Fibroblast growth factor receptor 1(FGFR1)mutations are associated with congenital hypogonadotropic hypogonadism(CHH)through inheritance or spontaneous *** detected FGFR1 mutations in a Chinese cohort of 210 CHH patients at Peking Union Medical College Hospital(Beijing,China)using next-generation and Sanger *** assessed missense variant pathogenicity using six bioinformatics tools and compared clinical features and treatment outcomes between inherited and de novo mutation *** 19 patients with FGFR1 mutations,three were recurrent,and 16 were novel *** of the novel mutations were likely pathogenic according to the American College of Medical Genetics and Genomics(ACMG)guidelines,with the prevalent P366L *** majority of FGFR1 mutations was inherited(57.9%),with frameshift mutations exclusive to the de novo mutation *** inherited mutation group had a lower incidence of cryptorchidism,short stature,and skeletal *** the inherited mutation group,luteinizing hormone(LH)levels were 0.5 IU l−1,follicle-stimulating hormone(FSH)levels were 1.0 IU l−1,and testosterone levels were 1.3 nmol l−*** contrast,the de novo group had LH levels of 0.2 IU l−1,FSH levels of 0.5 IU l−1,and testosterone levels of 0.9 nmol l−1,indicating milder hypothalamus–pituitary–gonadal axis(HPGA)functional deficiency in the inherited *** inherited mutation group showed a tendency toward higher spermatogenesis *** conclusion,this study underscores the predominance of inherited FGFR1 mutations and their association with milder HPGA dysfunction compared to de novo mutations,contributing to our understanding of the genetic and clinical aspects of FGFR1 mutations.

关键词： congenital hypogonadotropic hypogonadism de novo FGFR1 inherited

圆弧形蜂窝夹芯板在低速冲击下的动力响应研究

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振动与冲击 2024年第5期43卷 214-222,238页

作者：余阳付涛昆明理工大学机电工程学院昆明650500

为了研究具有负泊松比特性的圆弧形蜂窝夹芯板的动力响应,基于哈密顿原理和一阶剪切变形理论推导了圆弧形蜂窝夹芯板的运动方程,同时建立两自由度的质量-弹簧模型来获得蜂窝夹芯板与冲击器之间的接触力,利用Navier法和Duhamel积分对圆... 详细信息

为了研究具有负泊松比特性的圆弧形蜂窝夹芯板的动力响应,基于哈密顿原理和一阶剪切变形理论推导了圆弧形蜂窝夹芯板的运动方程,同时建立两自由度的质量-弹簧模型来获得蜂窝夹芯板与冲击器之间的接触力,利用Navier法和Duhamel积分对圆弧形夹芯板的运动方程解析求解。在理论模型有效性验证方面,低速冲击下蜂窝夹芯板中心最大横向位移的理论模型计算结果与ABAQUS有限元仿真结果的最大相对误差为4.9%,同时求得理论模型与已发表文献计算出的接触力最大相对误差为8%,验证了理论模型的有效性。通过理论模型研究了蜂窝胞元参数变化对蜂窝夹芯板动力响应的影响,研究结果表明:随着球形冲击器的冲击速度递增,圆弧形蜂窝夹芯板中心最大横向位移也呈现出递增的规律;圆弧形蜂窝夹芯板的抗冲击特性随着蜂窝胞元半径或角度的增大而减小,当蜂窝胞元半径从5 mm增加至7 mm时,蜂窝夹芯板的抗冲击特性减少40.28%;当蜂窝胞元角度从30°增加至60°时,蜂窝夹芯板的抗冲击特性减少83.64%;蜂窝夹芯板的抗冲击特性随着蜂窝胞元壁厚的增大而增大,当蜂窝胞元壁厚从1 mm增加至3 mm时,蜂窝夹芯板的抗冲击特性提升59.51%。通过减小胞元角度和半径,增加胞元壁厚可以提升圆弧形蜂窝夹芯板的抗冲击特性。

关键词：低速冲击蜂窝夹芯板一阶剪切变形理论质量-弹簧模型 ABAQUS有限元仿真

Comparative transcriptomic analysis reveals the molecular changes of acute pancreatitis in experimental models

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World Journal of Gastroenterology 2024年第14期30卷 2038-2058页

作者： Pan Zheng Xue-yang Li Xiao-yu yang Huan Wang Ling Ding Cong He Jian-Hua Wan Hua-Jing Ke Nong-Hua Lu Nian-Shuang Li Yin Zhu Department of Gastroenterology Digestive Disease HospitalThe First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Acute pancreatitis(AP)encompasses a spectrum of pancreatic inflammatory conditions,ranging from mild inflammation to severe pancreatic necrosis and multisystem organ *** the challenges associated with obtaining human pancreatic samples,research on AP predominantly relies on animal *** this study,we aimed to elucidate the fundamental molecular mechanisms underlying AP using various AP *** To investigate the shared molecular changes underlying the development of AP across varying severity *** AP was induced in animal models through treatment with caerulein alone or in combination with lipopolysaccharide(LPS).Additionally,using Ptf1αto drive the specific expression of the hM3 promoter in pancreatic acinar cells transgenic C57BL/6J-hM3/Ptf1α(cre)mice were administered Clozapine N-oxide to induce ***,we conducted RNA sequencing of pancreatic tissues and validated the expression of significantly different genes using the Gene Expression Omnibus(GEO)*** Caerulein-induced AP showed severe inflammation and edema,which were exacerbated when combined with LPS and accompanied by partial pancreatic tissue *** with the control group,RNA sequencing analysis revealed 880 significantly differentially expressed genes in the caerulein model and 885 in the caerulein combined with the LPS *** Encyclopedia of Genes and Genomes enrichment analysis and Gene Set Enrichment Analysis indicated substantial enrichment of the TLR and NOD-like receptor signaling pathway,TLR signaling pathway,and NF-κB signaling pathway,alongside elevated levels of apoptosis-related pathways,such as apoptosis,P53 pathway,and phagosome *** significantly elevated genes in the TLR and NOD-like receptor signaling pathways,as well as in the apoptosis pathway,were validated through quantitative real-time PCR experiments in animal *** from the GEO database revealed that only MYD88 concurred in both mouse panc

关键词： Acute pancreatitis RNA-sequencing Experimental acute pancreatitis models Inflammatory Apoptosis TLR and NOD-like signaling pathways

Puerarin modulation of CENPA affects downstream PLK1 and CCNB1 expression to inhibit bladder cancer cell proliferation

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Traditional Medicine Research 2024年第9期9卷 32-41页

作者： Hao Xu Wen Gao Deng Pan yu-yang Ma Ruo-Ran Zhang Yong-Li Cao yu-Chuan Zhou Ming-yu Xu Pei-Yong Zhang Kun Pang Department of Urology Xuzhou Central HospitalXuzhou Clinical School of Xuzhou Medical CollegeXuzhou 221009China Graduate School Bengbu Medical UniversityBengbu 233040China Department of Cardiology The Fourth People’s Hospital of JinanJinan 250031China Graduate School Jiangsu UniversityZhenjiang 212013China Department of Urology The Peixian People’s HospitalXuzhou 221699China Department of Clinical Laboratory The First Affiliated Hospital of Harbin Medical UniversityHarbin 150006China

Background:The treatment alternatives for bladder cancer(BLCA),the 10th most prevalent cancer in the world,need to be further investigated,and many active substances like Puerarin in herbal medicine were found to be effective in treating *** purpose of this study was to investigate the potential treating mechanisms of Puerarin on ***:The cell counting kit 8 assay and flow cytometry were performed to confirm Puerarin’s ability to suppress *** differentially expressed proteins(DEPs)were obtained by Tandem Mass Tags technology and functional enrichment analysis performed by R *** most enriched pathways were selected for study and the DEPs were screened ***-protein interaction network maps were created using String and Cytoscape and key proteins,which will be analyzed for survival,expression,and upstream transcription factor prediction,were screened out using the cytoHubba ***3 was used to obtain upstream transcription factor validated by molecular docking and western blotting ***:Cell counting kit 8 showed that Puerarin inhibited BLCA cells,with 50%inhibitory concentration of 218μmol/L in T24 and 198μmol/L in *** cytometry reveals that Puerarin blocks T24 and 5637 cells in G1 phase.1,385 DEPs were obtained and the enrichment analysis revealed that cell cycle and DNA replication were the two main areas in which DEPs were ***-B-cyclin dependent kinase 1(CDK1),cyclin B1(CCNB1),and polo-like kinase 1(PLK1)were identified as key proteins,and their upstream transcription factor was predicted to be centromere protein A(CENPA).Puerarin’s binding energy to CENPA was determined by molecular docking to be−6.3 kcal/mol,indicating a strong binding *** blot showed that Puerarin significantly reduced the expression of ***:We hypothesize that Puerarin may inhibit the proliferation of bladder cancer cells by inhibiting CENPA expression to regulate PLK1 and CCNB1 expression,thereby a

关键词： Puerarin BLCA Tandem Mass Tags cell cycle

Exploring a novel class tryptophan hydroxylase 1 inhibitor derived from Sambucus williamsii Hance for the osteoporosis treatment

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Acupuncture and Herbal Medicine 2024年第1期4卷 102-112页

作者： yu-Xin Zhu Zi-Ling Tang Lu Lu Zuo-Cheng Qiu Dabo Pan yang yu Hui-Hui Xiao Man-Sau Wong State Key Laboratory of Chinese Medicine and Molecular Pharmacology(Incubation) The Hong Kong Polytechnic University Shenzhen Research InstituteShenzhenChina Guangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine School of Traditional Chinese MedicineJinan UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research College of PharmacyJinan UniversityGuangzhouChina Department of Food Science and Nutrition The Hong Kong Polytechnic UniversityHong KongChina Research Center for Chinese Medicine Innovation The Hong Kong Polytechnic UniversityHong KongChina

Objective:Gut-derived serotonin strongly inhibits bone formation by inhibiting osteoblast *** previous study demonstrated that the lignan-rich fraction prepared from Sambucus willimasii Hance,a folk herbal medicine used to treat bone fractures and joint diseases in China,exerted bone-protective effects,and its actions were modulated by suppressing the synthesis of gut-derived serotonin via the inhibition of intestinal tryptophan hydroxylase 1(TPH-1).However,there is no direct evidence for the action of lignans on *** study aimed to verify the direct action of lignans on the TPH-1 and its influence on serotonin synthesis and bone ***:Molecular docking and surface plasmon resonance were performed to determine the affinities of lignans to *** cell viability and the protein activity and expression of TPH-1 were measured in RBL2H3 *** serum serotonin level and bone mineral density upon lignan treatment in ovariectomized mice were ***:The lignans showed high binding scores and binding affinities to TPH-1,inhibited the activity and protein expression of TPH-1,suppressed the serum serotonin levels in ovariectomized mice as well as promoted bone mineral ***:This is the first study to report that lignans are novel TPH-1 inhibitors and that these lignans could be potential agents for the management of serotonin-related diseases,including osteoporosis.

关键词： Lignan Osteoporosis Sambucus williamsii Hance Serotonin TPH-1 inhibitor

Oncological features and prognosis of colorectal cancer in human immunodeficiency virus-positive patients: A retrospective study

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World Journal of Gastrointestinal Surgery 2024年第1期16卷 29-39页

作者： Fu-yu yang Fan He De-Fei Chen Cheng-Lin Tang Saed Woraikat Yao Li Kun Qian Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of General Surgery Chongqing Public Health Medical CenterChongqing 400036China

BACKGROUND Due to the prolonged life expectancy and increased risk of colorectal cancer(CRC)among patients with human immunodeficiency virus(HIV)infection,the prognosis and pathological features of CRC in HIV-positive patients require *** To compare the differences in oncological features,surgical safety,and prognosis between patients with and without HIV infection who have CRC at the same tumor stage and *** In this retrospective study,we collected data from HIV-positive and-negative patients who underwent radical resection for *** random stratified sampling,24 HIV-positive and 363 HIV-negative patients with colorectal adenocarcinoma after radical resection were *** propensity score matching,we selected 72 patients,matched 1:2(HIV-positive:negative=24:48).Differences in basic characteristics,HIV acquisition,perioperative serological indicators,surgical safety,oncological features,and long-term prognosis were compared between the two *** Fewer patients with HIV infection underwent chemotherapy compared to patients ***-positive patients had fewer preoperative and postoperative leukocytes,fewer preoperative lymphocytes,lower carcinoembryonic antigen levels,more intraoperative blood loss,more metastatic lymph nodes,higher node stage,higher tumor node metastasis stage,shorter overall survival,and shorter progression-free survival compared to patients who were *** Compared with CRC patients who are HIV-negative,patients with HIV infection have more metastatic lymph nodes and worse long-term survival after *** treatment options for HIV-positive patients with CRC should be explored.

关键词： Colorectal cancer Human immunodeficiency virus Propensity score matching Oncological features Surgical safety Prognosis

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解开西安城墙历史保护的成功密码

城市规划 2024年第4期48卷 104-112页

作者：于洋中国人民大学公共管理学院城市规划与管理系中国城市规划学会规划实施分会

西安城墙是我国目前规模最大、保护最完整的古城垣,在20世纪下半叶经历了历次拆城浪潮后成功保留至今,不得不说是一个奇迹,是我国在遗产保护领域为数不多的具有成功经验的代表。在对西安城墙保护历程回顾的基础上,本文将详细剖析保护规... 详细信息

西安城墙是我国目前规模最大、保护最完整的古城垣,在20世纪下半叶经历了历次拆城浪潮后成功保留至今,不得不说是一个奇迹,是我国在遗产保护领域为数不多的具有成功经验的代表。在对西安城墙保护历程回顾的基础上,本文将详细剖析保护规划得以顺利实施背后的深层次原因,并思考其中的得失。希望通过对这段尘封历史的探寻与反思,能够起到以史为镜的作用,推动我国文化遗产保护事业进一步发展。

关键词：保护历程规划实施西安城墙反思与启示

Disturbance rejection tube model predictive levitation control of maglev trains

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High-Speed Railway 2024年第1期2卷 57-63页

作者： Yirui Han Xiuming Yao yu yang School of Automation and Intelligence Beijing Jiaotong UniversityBeijing 100044China

Magnetic levitation control technology plays a significant role in maglev *** a controller for the levitation system is challenging due to the strong nonlinearity,open-loop instability,and the need for fast response and *** this paper,we propose a Disturbance-Observe-based Tube Model Predictive Levitation Control(DO-TMPLC)scheme combined with a feedback linearization strategy for the levitation *** proposed strategy incorporates state constraints and control input constraints,i.e.,the air gap,the vertical velocity,and the current applied to the coil.A feedback linearization strategy is used to cancel the nonlinearity of the tracking error ***,a disturbance observer is implemented to actively compensate for disturbances while a TMPLC controller is employed to alleviate the remaining ***,we analyze the recursive feasibility and input-to-state stability of the closed-loop *** simulation results indicate the efficacy of the proposed control strategy.

关键词： Maglev trains Levitation system Constrained control Disturbance observer Model predictive control