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Nutrition impacts of non-solid cooking fuel adoption on under-five children in developing countries

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Journal of Integrative Agriculture 2024年第2期23卷 397-413页

作者： Yalin tang yuhe Guo Gang Xie Chengfang Liu China Center for Agricultural Policy School of Advanced Agricultural SciencesPeking UniversityBeijing 100871China Agricultural Information Institute Chinese Academy of Agricultural SciencesBeijing 100081China

This paper examines the nutrition impacts of using non-solid cooking fuel on under-five children in developing *** draw on data from more than 1.12 million children in 62 developing countries from the Demographic and Health Surveys(DHS).Results from both fixed effects(FE)and instrumental variable(IV)estimates show that using non-solid cooking fuel significantly improves the nutrition outcomes of under-five *** with their peers from households mainly using solid fuel,children from households mainly using non-solid fuel exhibit a lower probability of experiencing stunting(by 5.9 percentage points)and being underweight(by 1.2 percentage points).Our further investigation provides evidence for several underlying mechanisms,such as improved indoor air quality,induced reduction in children’s respiratory symptoms,benefits on maternal health,and reduction in maternal time spent on fuel collection or *** analyses suggest that the nutrition benefits of using non-solid cooking fuel are more prominent among boys,children above three years old,and those from households of lower socioeconomic status,rural areas,and Southeast Asia.

关键词： non-solid cooking fuel nutrition benefits under-five children developing countries

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Morroniside from Corni Fructus ameliorates type 2 diabetes in mice by regulating intestinal microbiota dysbiosis

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Food Science and Human Wellness 2024年

作者： Xueqi tang Yilin Bai Yinxia Wu yue Yang Xiaobo yu Jing Chen Xiaochang Xue Jiefang Kang National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China The Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry， The Ministry of Education College of Life Sciences， Shaanxi Normal University

As one of the most common metabolic diseases， type 2 diabetes (T2D) has become a public health concern with rising global prevalence. Corni fructus (CF)， a traditional Chinese herb utilized for centuries as homologous medicinal and food resources， has been widely used to treat glucose and lipid metabolism disorders. However， as a core active ingredient of CF， whether and how morroniside (MOR) improves T2D is still unclear. This study aimed to explore the pathways by which MOR ameliorates T2D in mice induced by high-fat diet (HFD) and low-dose streptozotocin (STZ) through 16S rRNA gene sequencing. We found that MOR treatment significantly ameliorated body weight loss， hyperglycemia， hyperlipidemia and insulin resistance in T2D mice. In addition， MOR remarkably improved inflammation- and oxidative stress-driven hepatic and pancreatic injuries in the model mice. Mechanistically， MOR rehabilitated the dysregulated diversity and constitution of the gut microbiota in T2D mice， with significant changes in relative abundance in genus such as Lactobacillus， Lachnospiraceae＿NK4A136＿Group， and Lachnospiraceae＿UCG-006 which are believed to be highly correlated with serum parameters and insulin resistance in mice with T2D. Therefore， we infer that MOR improves T2D at least partially by maintaining the host microbiota homeostasis， and MOR may be a promising candidate for T2D treatment.

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Disaster effects of climate change in High Mountain Asia:State of art and scientific challenges Disaster effects of climate change in High Mountain Asia:State of art and scientific challenges

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Advances in Climate Change Research 2024年第3期15卷 367-389页

作者： Hao WANG Bin-Bin WANG Peng CUI Yao-Ming MA Yan WANG Jian-Sheng HAO yu WANG Ya-Mei LI Li-Jun SUN Jiao WANG Guo-Tao ZHANG Wei-Mo LI yu LEI Wen-Qing ZHAO Jin-Bo tang Chao-yue LI Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610041China State Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100101China China‒Pakistan Joint Research Center on Earth Sciences Chinese Academy of SciencesIslamabad 45320Pakistan College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China College of Atmospheric Science Lanzhou UniversityLanzhou 730000China National Observation and Research Station for Qomolongma Special Atmospheric Processes and Environmental Changes Dingri 858200China

High Mountain Asia(HMA)shows a remarkable warming tendency and divergent trend of regional precipitation with enhanced meteorological *** rapid thawing of the HMA cryosphere may alter the magnitude and frequency of nature *** reviewed the influence of climate change on various types of nature hazards in HMA region,including their phenomena,mechanisms and *** reveals that:1)the occurrences of extreme rainfall,heavy snowfall,and drifting snow hazards are escalating;accelerated ice and snow melting have advanced the onset and increased the magnitude of snowmelt floods;2)due to elevating trigger factors,such as glacier debuttressing and the rapid shift of thermal and hydrological regime of bedrock/snow/ice interface or subsurface,the mass flow hazards including bedrock landslide,snow avalanche,ice-rock avalanches or glacier detachment,and debris flow will become more severe;3)increased active-layer detachment and retrogressive thaw slumps slope failures,thaw settlement and thermokarst lake will damage many important engineering structures and infrastructure in permafrost region;4)multi-hazards cascading hazard in HMA,such as the glacial lake outburst flood(GLOF)and avalanche-induced mass flow may greatly enlarge the destructive power of the primary hazard by amplifying its volume,mobility,and impact force;and 5)enhanced slope instability and sediment supply in the highland areas could impose remote catastrophic impacts upon lowland regions,and threat hydropower security and future water *** future,ongoing thawing of HMA will profoundly weaken the multiple-phase material of bedrock,ice,water,and soil,and enhance activities of nature *** and cascading hazards of high magnitude will prevail in *** the glacier runoff overpasses the peak water,low flow or droughts in lowland areas downstream of glacierized mountain regions will became more frequent and *** escalating hazards in the HMA region requires tackling s

关键词： High Mountain Asia Climate change Cryosphere degradation Nature hazards Disaster risk

Synthesis of NO by rotating sliding arc discharge reactor with conical-spiral electrodes

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Plasma Science and Technology 2024年第9期26卷 97-108页

作者： Bingyan CHEN Qi LIU Xu LI Chunyang ZHANG Xiangbin GUO Qingzhou yu Zhicheng tang Xiang HE Wei SU Yongfeng JIANG College of Mechanics and Engineering Science Hohai UniversityNanjing 211100People’s Republic of China College of Mechanical and Electrical Engineering Hohai UniversityChangzhou 213200People’s Republic of China College of Materials Science and Engineering Hohai UniversityChangzhou 213200People’s Republic of China College of Information Science and Engineering Hohai UniversityChangzhou 213200People’s Republic of China

The present work investigates the potential applications of nitrogen oxides(NO_(x)),particularly nitric oxide(NO)and nitrogen dioxide(NO_(2)),generated through discharge plasma in diverse sectors such as medicine,nitrogen fixation,energy,and environmental *** this study,a rotating sliding arc discharge reactor was initially employed to produce high concentrations of gaseous NO_(x),followed by the utilization of a molybdenum wire redox reactor for NO_(2)-to-NO *** outcomes reveal that the discharge states and generations of NO_(x) are affected by varying parameters,including the applied energies,frequencies and airflow states(1.3-2.6 m/s are the laminar flow,2.6-5.2 m/s are the transition state,5.2-6.5 m/s are the turbulent flow),and the concentrations of NO_(x) within the arc discharge are higher than that in the spark ***,the concentrations of NO,NO_(2) and NO_(x) gradually increased,and the concentration ratios of NO/NO_(2) and NO_(x)/NO_(2) decreased with increasing the applied energy for one cycle from 14.8 mJ to 24.3 ***,the concentrations of NO,NO_(2) and NO_(x) gradually decreased,and the concentration ratios of NO/NO_(2) and NO_(x)/NO_(2) first decreased and then increased with increasing the applied frequencies from 5.0 kHz to 9.0 ***,the concentrations of NO,NO_(2) and NO_(x) gradually decreased,and the concentration ratios of NO/NO_(2) and NO_(x)/NO_(2) first increased and then decreased with increasing the air flow speeds from 1.3 m/s to 6.5 m/***,the concentrations of NO increased and NO_(2) decreased with increasing temperature from 25℃ to 400℃ using molybdenum *** findings provide experimental support for the application of plasma in the fields of medicine,nitrogen fixation,energy and environmental protection.

关键词： rotating sliding arc discharge NO_(x) synthesis of NO redox reaction

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Deep simulated annealing for the discovery of novel dental anesthetics with local anesthesia and anti-inflammatory properties

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3086-3109页

作者： Yihang Hao Haofan Wang Xianggen Liu Wenrui Gai Shilong Hu Wencheng Liu Zhuang Miao yu Gan Xianghua yu Rongjia Shi Yongzhen Tan Ting Kang Ao Hai Yi Zhao Yihang Fu Yaling tang Ling Ye Jin Liu Xinhua Liang Bowen Ke State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases West China Hospital of StomatologySichuan UniversityChengdu 610041China College of Computer Science Sichuan UniversityChengdu 610065China Department of Anesthesiology Laboratory of Anesthesia and Critical Care MedicineNational-Local Joint Engineering Research Centre of Translational Medicine of AnesthesiologyFrontiers Science Center for Disease-Related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610041China

Multifunctional therapeutics have emerged as a solution to the constraints imposed by drugs with singular or insufficient therapeutic *** primary challenge is to integrate diverse pharmacophores within a single-molecule *** address this,we introduced DeepSA,a novel edit-based generative framework that utilizes deep simulated annealing for the modification of articaine,a wellknown local *** integrates deep neural networks into metaheuristics,effectively constraining molecular space during compound *** framework employs a sophisticated objective function that accounts for scaffold preservation,anti-inflammatory properties,and covalent *** a sequence of local editing to navigate the molecular space,DeepSA successfully identified AT-17,a derivative exhibiting potent analgesic properties and significant anti-inflammatory activity in various animal *** insights into AT-17 revealed its dual mode of action:selective inhibition of NaV1.7 and 1.8 channels,contributing to its prolonged local anesthetic effects,and suppression of inflammatory mediators via modulation of the NLRP3 inflammasome *** findings not only highlight the efficacy of AT-17 as a multifunctional drug candidate but also highlight the potential of DeepSA in facilitating AI-enhanced drug discovery,particularly within stringent chemical constraints.

关键词： Multifunctional drugs Deep simulated annealing Molecule generation Articaine derivatives AI-enhanced drug discovery

Trends in Incidence of HIV and Syphilis Among Men Who Have Sex with Men—Tianjin Municipality,China,2013-2022

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China CDC weekly 2024年第27期6卷 651-657页

作者： Yan Guo Fangfang Chen Hui Gong Ziming Wu Xinying Zhang Tielin Ning Zhongquan Liu Jianyun Bai Long Li Jie Yang Fangning Zhao Jinyu Hou Maohe yu Houlin tang STD&AIDS Control and Prevention Section Tianjin Center for Disease Control and PreventionTianjinChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijingChina STD&AIDS Control and Prevention department Tianjin Hongqiao District Center for Disease Control and PreventionTianjinChina Tianjin Shenlan Public Health Counseling Service Center TianjinChina Tianjin Key Laboratory of Pathogenic Microbiology of Infectious Disease Tianjin Centers for Disease Control and PreventionTianjinChina

Summary What is already known about this topic?Given the common modes of transmission,outbreaks of both human immunodeficiency virus(HIV)and syphilis are primarily observed in men who have sex with men(MSM).However,minimal research has been conducted to concurrently evaluate the rates and trends of HIV and syphilis incidence within this community in *** is added by this report?

关键词： Incidence primarily immunodeficiency

Adjuvant camrelizumab plus apatinib in resected hepatocellular carcinoma with microvascular invasion:a multi-center real world study

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Hepatobiliary Surgery and Nutrition 2024年第4期13卷 616-631,I0022-I0024页

作者： Jingzhong Ouyang Yi Yang Yanzhao Zhou Xu Chang Zhengzheng Wang Qingjun Li yu tang Jianqiang Cai Jinxue Zhou Zhen Huang Hong Zhao Department of Hepatobiliary and Pancreatic Surgery The Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalZhengzhouChina Department of Hepatobiliary Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Key Laboratory of Gene Editing Screening and Research and Development(R&D)of Digestive System Tumor Drugs Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Interventional Therapy II Shandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical SciencesJinanChina Clinical Trials Center National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Background:It is well known that laparoscopic liver surgery can offer advantages over open liver surgery in selected ***,what type of procedures can benefit most from a laparoscopic approach has been investigated poorly thus *** aim of this study is thus to define the extent of advantages of laparoscopic over open liver surgery for lesions in the anterolateral(AL)and posterosuperior(PS)***:In this international multicentre retrospective cohort study,laparoscopic and open minor liver resections for lesions in the AL and PS segments were compared after propensity score *** differential benefit of laparoscopy over open liver surgery,calculated using bootstrap sampling,was compared between AL and PS resections and expressed as a Delta of the ***:After matching,3,040 AL and 2,336 PS resections were compared,encompassing open and laparoscopic procedures in a 1:1 *** and PS laparoscopic liver resections were more advantageous in comparison to open in terms of blood loss,transfusion rate,complications,and length of ***,AL resections benefitted more from laparoscopy than PS in terms of overall and severe complications(D-difference were 4.8%,P=0.046 and 3%,P=0.046)and blood loss(D-difference was 195 mL,P<0.001).Similar results were observed in the subset for high-volume centres,while in recent years no significant differences were found in the differential benefit between AL and PS ***:The advantage of laparoscopic over open liver surgery is greater in the AL segments than in the PS segments.

关键词： Liver neoplasms hepatectomy laparoscopic liver resection open liver resection

Heterocyclic Molecules Tethered Branched Polymers with Innate Immune Stimulating Activity

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CCS Chemistry 2024年第5期6卷 1278-1288页

作者： Jiayu Zhao Liping Liu Yibo Wang Zichao Huang yu Zhang Ruirui Qiao Thomas P.Davis Zhaohui tang Wantong Song Xuesi Chen Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022 School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026 Laboratory of Chemical Biology Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022 Jilin Biomedical Polymers Engineering Laboratory Changchun 130022 Australian Institute of Bioengineering and Nanotechnology The University of QueenslandBrisbaneQueensland 4072

We report herein an interesting finding that heterocyclic molecules tethered branched polymers exhibit innate immune stimulating *** we conjugated a series of five-,six-,or seven-membered heterocyclic molecules to branched polyethylenimine(bPEI),over 70%of them could induce the secretion of interferon-β(IFN-β)from murine dendritic and human leukemia monocytic(DC2.4 and THP-1)cells through activating the stimulator of interferon genes(STING)*** further proved that this kind of innate stimulating activity was dependent on the macromolecular architecture as heterocyclic molecules tethered linear PEI(lPEI)or dendritic polyamidoamine(PAMAM)induced no or much less IFN-β***,we prepared a series of poly-L-lysine(PLL)-derivatives with different branches to tether with heterocyclic molecules and proved that this kind of bPEI-like structure was important in en hancing the binding affinity with STING proteins and for exhibiting innate stimulating activity.

关键词： bioactive materials polymers heterocycles branched structure immunity

Clinical significance of upregulated Rho GTPase activating protein 12 causing resistance to tyrosine kinase inhibitors in hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4244-4263页

作者： Xiao-Wei Wang yu-Xing tang Fu-Xi Li Jia-Le Wang Gao-Peng Yao Da-Tong Zeng yu-Lu tang Bang-Teng Chi Qin-Yan Su Lin-Qing Huang Di-yuan Qin Gang Chen Zhen-Bo Feng Rong-Quan He Department of Pathology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Pathology Red Cross Hospital of Yulin CityYulin 537000Guangxi Zhuang Autonomous RegionChi Department of Medical Oncology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Computer Science and Technology School of Computer and Electronic InformationGuangxi UniversityNanning 530004Guangxi Zhuang Autonomous RegionChina

BACKGROUND Hepatocellular carcinoma(HCC)is a major health challenge with high incidence and poor survival rates in *** therapies,particularly tyrosine kinase inhibitors(TKIs),are the first-line treatment for advanced HCC,but resistance is *** Rho GTPase family member Rho GTPase activating protein 12(ARHGAP12),which regulates cell adhesion and invasion,is a potential therapeutic target for overcoming TKI resistance in ***,no studies on the expression of ARHGAP12 in HCC and its role in resistance to TKIs have been *** To unveil the expression of ARHGAP12 in HCC,its role in TKI resistance and its potential associated *** This study used single-cell RNA sequencing(scRNA-seq)to evaluate ARHGAP12 mRNA levels and explored its mechanisms through enrichment *** was used to investigate focal adhesion(FA)pathway *** integrated bulk RNA data(RNA-seq and microarray),immunohistochemistry and proteomics to analyze ARHGAP12 mRNA and protein levels,correlating with clinical *** assessed ARHGAP12 expression in TKI-resistant HCC,integrated conventional HCC to explore its mechanism,identified intersecting FA pathway genes with scRNA-seq data and evaluated its response to TKI and *** ARHGAP12 mRNA was found to be highly expressed in malignant hepatocytes and to regulate *** malignant hepatocytes in high-score FA groups,MDK-[integrin alpha 6(ITGA6)+integrinβ-1(ITGB1)]showed specificity in ligand-receptor ***12 mRNA and protein were upregulated in bulk RNA,immunohistochemistry and proteomics,and higher expression was associated with a worse ***12 was also found to be a TKI resistance gene that regulated the FA ***1 was identified as a crossover gene in the FA pathway in both scRNA-seq and bulk *** expression of ARHGAP12 was associated with adverse reactions to sorafenib,cabozantinib and regorafenib,but not to *** ARHGAP12 expre

关键词： Hepatocellular carcinoma Focal adhesion Tyrosine kinase inhibitor Rho GTPase activating protein 12 Drug resistance Molecular mechanism Biomarker