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Biomarkers for the early diagnosis of hepatocellular carcinoma

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World Journal of Gastroenterology 2015年第37期21卷 10573-10583页

作者： Nobuhiro Tsuchiya yu sawada Itaru Endo Keigo Saito Yasushi Uemura Tetsuya Nakatsura Department of Gastroenterological Surgery Graduate School of MedicineYokohama City University Division of Cancer Immunotherapy Exploratory Oncology Research and Clinical Trial Center National Cancer Center

Hepatocellular carcinoma(HCC) is the fifth most common cancer and the second leading cause of cancer-related deaths worldwide. Although the prognosis of patients with HCC is generally poor, the5-year survival rate is > 70% if patients are diagnosed at an early stage. However, early diagnosis of HCC is complicated by the coexistence of inflammation and cirrhosis. Thus, novel biomarkers for the early diagnosis of HCC are required. Currently, the diagnosis of HCC without pathological correlation is achieved by analyzing serum α.fetoprotein levels combined with imaging techniques. Advances in genomics and proteomics platforms and biomarker assay techniques over the last decade have resulted in the identification of numerous novel biomarkers and have improved the diagnosis of HCC. The most promising biomarkers,such as glypican-3, osteopontin, Golgi protein-73 and nucleic acids including microRNAs, are most likely to become clinically validated in the near future. These biomarkers are not only useful for early diagnosis of HCC, but also provide insight into the mechanisms driving oncogenesis. In addition, such molecular insight creates the basis for the development of potentially more effective treatment strategies. In this article,we provide an overview of the biomarkers that are currently used for the early diagnosis of HCC.

关键词： α-fetoprotein α-fetoprotein-L3 Biomarker Des-γ-car

Efficacy of neoadjuvant chemotherapy for initially resectable colorectal liver metastases:A retrospective cohort study

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World Journal of Gastrointestinal Oncology 2022年第7期14卷 1281-1294页

作者： Kazuhisa Takeda yu sawada Yasuhiro Yabushita yuki Honma Takafumi Kumamoto Jun Watanabe Ryusei Matsuyama Chikara Kunisaki Toshihiro Misumi Itaru Endo Gastroenterological Center Yokohama City University Medical CenterYokohama 232-0024Japan Department of Gastroenterological Surgery Yokohama City University Graduate School of MedicineYokohama 236-0004Jordan Department of Biostatistics Yokohama City University Graduate School of MedicineYokohama 236-0004Japan

BACKGROUND The liver is the most common metastatic site of colorectal *** is the mainstay of treatment for patients with colorectal liver metastases(CRLMs).However,there are cases of early recurrence after upfront hepatectomy *** selected high-risk patients,neoadjuvant chemotherapy(NAC)may improve longterm *** To determine the efficacy of NAC for initially resectable *** Among 644 patients who underwent their first hepatectomy for CRLMs at our institution,297 resectable cases were stratified into an upfront hepatectomy group(238 patients)and a NAC group(59 patients).Poor prognostic factors for upfront hepatectomy were identified using multivariate logistic regression *** score matching was used to compare clinical outcomes between the upfront hepatectomy and NAC groups,according to the number of poor prognostic *** curves were estimated using the Kaplan-Meier method and compared using the log-rank *** Preoperative carcinoembryonic antigen levels(≥10 ng/mL)(P=0.003),primary histological type(other than well/moderately differentiated)(P=0.04),and primary lymph node metastases(≥1)(P=0.04)were identified as independent poor prognostic factors for overall survival(OS)in the upfront hepatectomy ***-risk status was defined as the presence of two or more risk *** propensity score matching,50 patients were matched in each *** high-risk patients,the 5-year OS rate was significantly higher in the NAC group(13 patients)than in the upfront hepatectomy group(18 patients)(100%vs 34%;P=0.02).CONCLUSION NAC may improve the prognosis of high-risk patients with resectable CRLMs who have two or more risk factors.

关键词： Colorectal neoplasms Neoadjuvant therapy Neoplasm metastasis Prognosis Risk factors Survival

Supersymmetric sawada-Kotera-Ramani Equation: Bilinear Approach

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Communications in Theoretical Physics 2008年第3期49卷 685-688页

作者： yu Ya-Xuan Department of Mathematics Ningbo University Ningbo 315211 China

In this paper, using the Hirota＇s bilineax method, we consider the N = 1 supersymmetric sawada-Kotera- Ramani equation and obtain the Bazcklund transformation of it. Its one- and two-supersoliton solutions axe obtain... 详细信息

关键词： N = 1 supersymmetric sawada-Kotera-Ramani equation Backlund transformation supersoliton solutions

Integrable System and Motion of Curves in Projective and Similarity Geometries

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Communications in Theoretical Physics 2006年第1期45卷 45-48页

作者： HOU yu-Qing Department of Electronics Northwest University Xi＇an 710069 China

Based on the natural frame in the projective geometry, motions of curves in projective geometry are studied. It is shown that several integrable equations including sawada-Kotera and KK equations arise from motion of plane curves in projective geometries. Motion of space curves described by acceleratlon field and governed by endowing an extra space variable in similarity geometry P^3 is also studied.

关键词： motion of curve similarity geometry projective geometry integrable equation

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堤防地基地震液化的数值模拟

工程力学 2007年第12期24卷 82-87页

作者：黄雨八嶋厚沢田和秀张锋同济大学地下建筑与工程系岐阜大学社会基盤工学科名古屋工业大学都市社会工学科

基于Biot动力耦合理论,采用一个经过广泛验证的砂土循环弹塑性本构模型,建立了平面应变条件下土堤地基的地震液化数值模拟方法。以某河流堤防的实际工程为例,应用该方法对土堤地基的地震液化进行了数值模拟,并对地震作用下的超孔隙水压... 详细信息

基于Biot动力耦合理论,采用一个经过广泛验证的砂土循环弹塑性本构模型,建立了平面应变条件下土堤地基的地震液化数值模拟方法。以某河流堤防的实际工程为例,应用该方法对土堤地基的地震液化进行了数值模拟,并对地震作用下的超孔隙水压力、加速度、位移等动力反应进行了计算分析,得到了一些对于抗震分析有用的结果。

关键词：土堤地震液化循环塑性动力耦合分析有限元

East Asian VLBI Network observations of active galactic nuclei jets:imaging with KaVA+Tianma+Nanshan

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Research in Astronomy and Astrophysics 2021年第8期21卷 220-234页

作者： yu-Zhu Cui Kazuhiro Hada Motoki Kino Bong-Won Sohn Jongho Park Hyun-Wook Ro Satoko sawada-Satoh Wu Jiang Lang Cui Mareki Honma Zhi-Qiang Shen Fumie Tazaki Tao An Ilje Cho Guang-Yao Zhao Xiao-Peng Cheng Kotaro Niinuma Kiyoaki Wajima Ying-Kang Zhang Noriyuki Kawaguchi Juan-Carlos Algaba Shoko Koyama Tomoya Hirota Yoshinori Yonekura Nobuyuki Sakai Bo Xia Yong-Bin Jiang Lin-Feng yu Wei Gou Ju-Yeon Hwang Yong-Chen Jiang yun-Xia Sun Dong-Kyu Jung Hyo-Ryoung Kim Jeong-Sook Kim Hideyuki Kobayashi Jee-Won Lee Jeong-Ae Lee Hua Zhang Guang-Hui Li Zhi-Qiang Xu Peng Li Jung-Hwan Oh Se-Jin Oh Chung-Sik Oh Tomoaki Oyama Duk-Gyoo Roh Katsunori-M.Shibata Wen Guo Rong-Bing Zhao Wei-Ye Zhong Jin-Qing Wang Wen-Jun Yang Hao Yan Jae-Hwan Yeom Bin Li Xiao-Fei Li Jian-Ping yuan Jian Dong Zhong Chen Kazunori Akiyama Keiichi Asada Do-Young Byun Yoshiaki Hagiwara Jeffrey Hodgson Tae-Hyun Jung Kee-Tae Kim Sang-Sung Lee Kunwoo Yi Qing-Hui Liu Xiang Liu Ru-Sen Lu Masanori Nakamura Sascha Trippe Na Wang Xue-Zheng Wang Bo Zhang Department of Astronomical Science The Graduate University for Advanced StudiesSOKENDAI2-21-1 OsawaMitakaTokyo 181-8588Japan Mizusawa VLBI Observatory National Astronomical Observatory of Japan2-12 HoshigaokaMizusawaOshuIwate 023-0861Japan Kogakuin University of Technology and Engineering Academic Support Center2665-1 NakanoHachiojiTokyo 192-0015Japan Korea Astronomy and Space Science Institute Yuseong-guDaejeon 34055Korea Department of Astronomy Yonsei University50 Yonsei-roSeodaemun-guSeoul 03722Korea Department of Astronomy and Space Science University of Science and Technology217 Gajeong-roDaejeonKorea Institute of Astronomy and Astrophysics Academia Sinica645 N Aohoku PIHiloHI 96720USA Graduate School of Sciences and Technology for Innovation Yamaguchi UniversityYoshida 1677-1YamaguchiYamaguchi 753-8512Japan Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Key Laboratory of Radio Astronomy Chinese Academy of SciencesNanjing 210008China Institute of Astronomy The University of Tokyo2-21-1 OsawaMitakaTokyo 181-0015Japan Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomia s/nGranada E-18008Spain Department of Physics Faculty of ScienceUniversity of MalayaKuala Lumpur 50603Malaysia Center for Astronomy Ibaraki University2-1-1 BunkyoMitoIbaraki 310-8512Japan Space Light Laboratory 77Yangjaedae-ro 86 roadGangdong-guSeoulKorea Massachusetts Institute of Technology Haystack Observatory 99 Millstone RoadWestfordMA 01886USA National Radio Astronomy Observatory 520 Edgemont RdCharlottesvilleVA 22903USA Toyo University 5-28-20 HakusanBunkyo-kuTokyo 112-8606Japan Department of Physics and Astronomy Seoul National UniversityGwanak-guSeoul 08826Korea Max Planck Institute for Radio Astronomy Auf dem hiigel 69Bonn 53121Germany SNU Astronomy Research Center Seoul National UniversityGwanak-guSeoul 08826Korea

The East Asian Very Long Baseline Interferometry(VLBI) Network(EAVN) is a rapidly evolving international VLBI array that is currently promoted under joint efforts among China,Japan and *** aims at forming a joint VLBI Network by combining a large number of radio telescopes distributed over East Asian *** the combination of the Korean VLBI Network(KVN) and the VLBI Exploration of Radio Astrometry(VERA) into Ka VA,further expansion with the joint array in East Asia is actively *** we report the first imaging results(at 22 and 43 GHz) of bright radio sources obtained with Ka VA connected to Tianma 65-m and Nanshan 26-m Radio Telescopes in *** test the EAVN imaging performance for different sources,we observed four active galactic nuclei(AGN) having different brightness and *** a result,we confirmed that the Tianma 65-m Radio Telescope(TMRT) significantly enhances the overall array sensitivity,a factor of 4 improvement in baseline sensitivity and 2 in image dynamic range compared to the case of Ka VA *** addition of the Nanshan 26-m Radio Telescope(NSRT) further doubled the east-west angular *** the resulting high-dynamic-range,high-resolution images with EAVN(Ka VA+TMRT+NSRT),various fine-scale structures in our targets,such as the counter-jet in M87,a kink-like morphology of the 3 C 273 jet and the weak emission in other sources are successfully *** demonstrates the powerful capability of EAVN to study AGN jets and to achieve other science goals in *** expansion of EAVN will further enhance the angular resolution,detection sensitivity and frequency coverage of the network.

关键词： galaxies:active galaxies:jets instrumentation:interferometers radio continuum:galaxies

不同抗性甘薯品种感染疮痂病后的细胞超微结构

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福建农林大学学报（自然科学版） 2005年第2期34卷 248-251页

作者：余文英潘廷国柯玉琴王湘平艾育芳阮妙鸿福建农林大学生命科学学院福建福州350002 福建农林大学测试中心福建福州350002

在甘薯疮痂病胁迫下,抗病性不同的甘薯品种金山1255(感病)和广薯8870(抗病)染病后,叶片细胞的超微结构都发生了变化,最敏感的部位均是细胞膜;活性氧产生的两个主要部位(叶绿体和线粒体)也受到了不同程度的攻击;感病品种的叶绿体和线粒... 详细信息

在甘薯疮痂病胁迫下,抗病性不同的甘薯品种金山1255(感病)和广薯8870(抗病)染病后,叶片细胞的超微结构都发生了变化,最敏感的部位均是细胞膜;活性氧产生的两个主要部位(叶绿体和线粒体)也受到了不同程度的攻击;感病品种的叶绿体和线粒体外膜外突成致密的小球,产生了大量的吞噬体,抗病品种则产生了大量用于修复细胞膜的高尔基小泡.

关键词：甘薯品种细胞超微结构疮痂病感染抗性金山1255 叶片细胞感病品种抗病品种细胞膜线粒体叶绿体抗病性活性氧吞噬体部位外膜小泡

MR不同脉冲序列成像诊断胆囊腺肌瘤病的价值

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中华放射学杂志 2005年第4期39卷 418-422页

作者：靳二虎马大庆磯田裕義河相吉植村芳子朝倉環赤井幹夫池田耕士谷川昇梁宇婷澤田敏首都医科大学附属北京友谊医院放射科 100050 関西医科大学附属病院放射線科関西医科大学附属病院外科病理室

目的分析35例胆囊腺肌瘤病患者的MRI表现,比较不同脉冲序列显示Rokitansky Aschoff窦(RAS)能力的差异。方法经组织学证实诊断的35例胆囊腺肌瘤病患者(男19例,女16例,年龄32～72岁,平均52岁)均进行了MR常规T1WI、常规T2WI、3mm薄层T2WI... 详细信息

目的分析35例胆囊腺肌瘤病患者的MRI表现,比较不同脉冲序列显示Rokitansky Aschoff窦(RAS)能力的差异。方法经组织学证实诊断的35例胆囊腺肌瘤病患者(男19例,女16例,年龄32～72岁,平均52岁)均进行了MR常规T1WI、常规T2WI、3mm薄层T2WI及MR胰胆管成像(MRCP)。2名高年资放射科医生共同分析MRI,观察胆囊壁增厚情况及RAS信号表现,并与病理所见对照。根据5级评分标准,对RAS可信度达到4和5级的MRI脉冲序列进行统计学分析,比较不同脉冲序列显示RAS能力的差异。结果35例患者的胆囊壁均明显增厚,厚度范围5～12mm,平均7mm。其中包括局限型胆囊腺肌瘤病16例,节段型12例,弥漫型7例。RAS表现为病变胆囊壁内数量不等、大小不一的点状异常信号,其大小2～7mm,平均4mm。在T2WI和MRCP上,RAS呈点状高信号;在T1WI,RAS可呈低、高或等信号。RAS显示率在3mm薄层T2WI、常规T2WI、MRCP、T1WI依次为100%、60%、60%、26%(χ2=40.88,P<0.01)。结论3mm薄层T2WI显示RAS效果最佳。

关键词：胆囊腺肌瘤病脉冲序列成像诊断 MR胰胆管成像 T2WI 价值 T1WI RAS MRCP MRI表现放射科医生胆囊壁增厚统计学分析信号表现评分标准异常信号患者组织学平均薄层可信度局限型节段型弥漫型高信号显示率能力

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山东水稻病虫害系统最优控制研究

生态学报 2001年第2期21卷 271-278页

作者：王玉正朱军生刘汉舒魏靖杨清臣罗守玉任宝珍山东省植物保护总站济南250100 济宁市植物保护工作站济宁272137 东营市植物保护站东营257091

1994～ 1 996年研究了稻田 1 3种可控因素对水稻病虫害、天敌和产量的综合效应以及分期混合施药技术。根据既控制病虫增产又保护生态的原则 ,综合评价了可控因素 ,提出了水稻病虫害系统最优控制为中国 91或辐 4 -2 ,N 1 50 kg/hm2 ,底... 详细信息

1994～ 1 996年研究了稻田 1 3种可控因素对水稻病虫害、天敌和产量的综合效应以及分期混合施药技术。根据既控制病虫增产又保护生态的原则 ,综合评价了可控因素 ,提出了水稻病虫害系统最优控制为中国 91或辐 4 -2 ,N 1 50 kg/hm2 ,底肥 :分蘖肥 :穗肥 N分配比为 80∶ 0∶ 2 0 ,P2 O575kg/ hm2 ,K2 O 2 4 0 kg/ hm2 ,Zn SO4 1 5kg/ hm2 ,插秧期春季稻和夏季稻分别 4月 30日和 6月 1 5日前后 ,种植密度为 36万墩 / hm2 ,水管理为适时标准烤田 ,播种期甲基异柳磷 0 .0 8%与多菌灵 0 .1 5%混合浸种防治地下害虫和恶苗病 ,分蘖初期 ( 7月 2 5日前后 )杀虫双 750 g/ hm2 与井冈霉素 1 50 g/ hm2 × 2混合喷雾防治二代稻纵卷叶螟和纹枯病 ,分蘖后期 ( 8月 2 0日前后 )捕虱灵 75g/ hm2 与三环唑 30 0 g/ hm2 混合喷雾防治稻飞虱和稻瘟病。

关键词：水稻病虫害可控因素综合效应系统最优控制