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Differences in vascular endothelial function and serum proteome between obese people with phlegm-dampness constitution and balanced constitution

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Journal of Traditional Chinese Medicine 2024年第1期44卷 188-196页

作者： ZHU Linghui SUN Ziwei GUAN yuanyuan LIU Meiyi ZHENG Yi yu ruoxi WANG Qi LI Lingru School of Chinese Medicine Beijing University of Chinese MedicineBeijing 102488China National Institute of TCM Constitution and Preventive Medicine Beijing University of Chinese MedicineBeijing 100029China

OBJECTIVE:To evaluate the extent of vascular endothelial dysfunction and preliminary identify serum protein biomarkers associated with obese individuals at risk for cardiovascular disease(CVD).METHODS:Fifteen obese volunteers with the phlegmdampness constitution or balanced constitution were recruited for this study *** clinical baseline data was collected,and the vascular endothelial function was evaluated using the EndoPAT?.Blood samples were collected for the serum proteome *** differences in the serum protein expression levels between the two groups were detected and the protein interaction network analysis,correlation analysis,receiver operating characteristic(ROC)curve analysis,and random forest model investigation were ***:There were no statistical differences found in the baseline *** vascular endothelial function,the reactive hyperemia index(RHI)of the phlegm-dampness constitution obese group was significantly lower than that of the balanced constitution obese group(1.46±0.30 vs 2.82±0.78,P<0.0001),indicating vascular endothelial *** are 66 differentially expressed serum proteins between the two *** A2(Apo A2),angiotensin-converting enzyme 2(ACE-2),interleukin-33(IL-33),and forkhead box P3(FoxP3)showed significant differences and area under curve values of their ROC curves were greater than 0.7 and correlated significantly with ***:Vascular endothelial dysfunction was present in the phlegm-dampness constitution obese ***,alterations in the expression levels of key serum proteins,including Apo A2,ACE-2,IL-33,and Fox P3 could serve as potential biomarkers in the obese population at risk of CVD.

关键词： obesity phlegm-dampness constitution vascular endothelial function proteome reactive hyperemia index

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基于实证分析中国自然保护区地方立法问题检视和优化路径

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生物多样性 2024年第2期32卷 161-167页

作者：所翟俞渃茜李媛辉徐基良北京林业大学人文社会科学学院北京100083 北京林业大学林业和草原法治研究中心北京100083 北京林业大学生态与自然保护学院北京100083

地方立法是中国自然保护区法律体系的重要组成部分。中国自然保护区地方立法从数量上看已不少,但整体上与当前生态文明建设和自然保护区管理提质增效的要求尚有一定差距。本文通过对116部中国自然保护区地方法律规范的实证分析发现,自... 详细信息

地方立法是中国自然保护区法律体系的重要组成部分。中国自然保护区地方立法从数量上看已不少,但整体上与当前生态文明建设和自然保护区管理提质增效的要求尚有一定差距。本文通过对116部中国自然保护区地方法律规范的实证分析发现,自然保护区地方立法主要呈现立法时间跨度较大、立法数量新时期增长较快、立法地域分布广泛、立法模式上综合性与专门性相结合等特征。当前,自然保护区地方立法面临着过时立法、抵触立法、重复立法等诸多问题。为有效破解上述难题,可尝试从立法清理和立法特色两个维度下功夫,加快地方立法清理的工作进程,突出地方立法特色,提升中国自然保护区地方立法质效。

关键词：自然保护区地方立法立法清理立法特色

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基于《黄帝内经》营卫理论探讨老年人少眠机制

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中华中医药杂志 2024年第6期39卷 2809-2812页

作者：李晶刘进娜曹晏齐王媛媛翟盈盈刘兴俞若熙北京中医药大学中医学院北京100029 河北医科大学中西医结合学院石家庄050017 北京中医药大学国家中医体质与治未病研究院北京100029

《黄帝内经》认为营卫是人体寤寐的枢机,卫气“昼行于阳,夜行于阴”的循行规律奠定了营卫主司寤寐的前提,《灵枢·营卫生会》指出气血不足、营衰卫伐是老年人少眠的主要原因。笔者认为老年人营卫失和主要与气血不调、阴液亏损、阳气不... 详细信息

《黄帝内经》认为营卫是人体寤寐的枢机,卫气“昼行于阳,夜行于阴”的循行规律奠定了营卫主司寤寐的前提,《灵枢·营卫生会》指出气血不足、营衰卫伐是老年人少眠的主要原因。笔者认为老年人营卫失和主要与气血不调、阴液亏损、阳气不足、瘀血内阻及脾胃不和这5个方面密切相关。故文章通过讨论这5个方面与营卫失和的关系,以阐释老年人少眠的发生机制,为今后研究老年人睡眠特征及改善其睡眠质量提供思路。

关键词：营卫理论老年人少眠《黄帝内经》睡眠特征

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基于“阳化气”理论的“扶阳调体”诊疗思路与方法

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天津中医药 2024年第4期41卷 440-443页

作者：曹晏齐包雪洁翟盈盈俞若熙北京中医药大学中医学院北京100029 北京中医药大学国家中医体质与治未病研究院北京100029

国医大师王琦提出了体质九分法,平和体质的形成离不开机体阴阳的平衡,8种不同偏颇体质存在不同的阴阳失衡状态。“阳化气,阴成形”构成了人体生命的基本形式,其中“阳化气”推动人体生理功能影响“阴成形”,从而导致不同体质类型的形成... 详细信息

国医大师王琦提出了体质九分法,平和体质的形成离不开机体阴阳的平衡,8种不同偏颇体质存在不同的阴阳失衡状态。“阳化气,阴成形”构成了人体生命的基本形式,其中“阳化气”推动人体生理功能影响“阴成形”,从而导致不同体质类型的形成。因此纠正阴阳偏颇恢复阴阳平衡是体质调理的关键。扶阳法以阳气为人身立命之本,强调通过调理阳气功能使人体达到阴阳平衡。本文将基于“阳化气”理论探讨不同偏颇体质的形成机制,以及运用扶阳法调理体质的思路与方法,为体质调理提供新的临床思路。

关键词：中医体质扶阳法阳化气临床思路

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中医体质学思政教学探索

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中国中医药现代远程教育 2024年第14期22卷 48-51页

作者：包雪洁李英帅王济李玲孺彭桂英俞若熙北京中医药大学国家中医体质与治未病研究院北京100029 北京中医药大学生命科学学院北京100029

思政教学是落实立德树人根本任务的关键课程。从中医体质学的教育现状出发,分析思政教育融入中医体质学课程的重要性与意义,从思政教育与中医体质学说的“四大基本理论”及“三个科学问题”融合两大方面进行论述,充分挖掘符合中医体质... 详细信息

思政教学是落实立德树人根本任务的关键课程。从中医体质学的教育现状出发,分析思政教育融入中医体质学课程的重要性与意义,从思政教育与中医体质学说的“四大基本理论”及“三个科学问题”融合两大方面进行论述,充分挖掘符合中医体质学专业特点的思政资源,体现专业课程教学与思想政治教育的渗透与结合,实现知识传授和思想引领的有机统一。既重视专业课程的教育,也深化思政教育建设,从而更好地培养德才兼备的人才。

关键词：课程思政中医体质学思想政治教育

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Reliability of online near-infrared spectroscopy analysis of the ex-traction process of Huatan Qushi decoction for phlegm-dampness constitution

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Journal of Traditional Chinese Medicine 2017年第6期37卷 804-809页

作者： Zhao Shipeng Zheng Yanfei Li Pin Liang Xue Bao Lei Chen yu yu ruoxi Sun Ranran Li Lingru Wang Qi College of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China

OBJECTIVE: To establish a quantitative model for the online analysis of hesperidin content in the extraction process of Huatan Qushi decoction for individuals with phlegm-dampness constitution by using near-infrared(NIR) spectroscopy and partial least squares(PLS) ***: The reference content of hesperidin, an effective ingredient of Huatan Qushi decoction,was determined using high-performance liquid chromatography(HPLC). The modeling band was selected using synergy interval PLS(Si PLS) algorithms, and a PLS model demonstrating the relationship between NIR predictive values and HPLC reference values was established. The optimal modeling route was selected through global optimization of process trace ***: The root mean square error of cross-validation was 9.8410. The coefficients of determination of the calibration set and prediction set were0.9860(R2 cal) and 0.9458(R_(cal)~2), respectively. The residual predictive deviation was 3.0115. The parameters demonstrated high predictive capability and reliability. The band was selected via the Si PLS method. There were seven latent ***: This study provides a favorable comprehensive evaluation method for variable selection and quality control of the Traditional Chinese Medicine extraction process.

关键词： Spectroscopy, near-infrared Least-squares analysis Hesperidin Phlegm dampness Huatan Qushi decoction

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Method for the extraction of circulating nucleic acids based on MOF reveals cell-free RNA signatures in liver cancer

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National Science Review 2024年第1期11卷 94-106页

作者： yuqing Sun Haixin yu Shaoqing Han ruoxi Ran Ying Yang Yongling Tang yuhao Wang Wenhao Zhang Heng Tang Boqiao Fu Boshi Fu Xiaocheng Weng Song-Mei Liu Hexiang Deng Shuang Peng Xiang Zhou College of Chemistry and Molecular Sciences Key Laboratory of Biomedical Polymers-Ministry of Education Wuhan University Department of Digestive Surgical Oncology Union Hospital Tongji Medical College Huazhong University of Science and Technology Cancer Center Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of Clinical Laboratory Center for Gene Diagnosis and Program of Clinical Laboratory Zhongnan Hospital of Wuhan University College of Chemistry and Materials Science Hubei Engineering University Department of Pharmacology School of Pharmacy China Medical University Taikang Center for Life and Medical Sciences Wuhan University Department of Hematology Zhongnan Hospital of Wuhan University

Cell-free RNA(cf RNA) allows assessment of health, status, and phenotype of a variety of human organs and is a potential biomarker to non-invasively diagnose numerous diseases. Nevertheless, there is a lack of highly efficient and bias-free cf RNA isolation technologies due to the low abundance and instability of cf ***, we developed a reproducible and high-efficiency isolation technology for different types of cell-free nucleic acids(containing cf RNA and viral RNA) in serum/plasma based on the inclusion of nucleic acids by metal-organic framework(MOF) materials, which greatly improved the isolation efficiency and was able to preserve RNA integrity compared with the most widely used research kit method. Importantly, the quality of cf RNA extracted by the MOF method is about 10-fold that of the kit method, and the MOF method isolates more than three times as many different RNA types as the kit method. The whole transcriptome mapping characteristics of cf RNA in serum from patients with liver cancer was described and a cf RNA signature with six cf RNAs was identified to diagnose liver cancer with high diagnostic efficiency(area under curve = 0.905 in the independent validation cohort) using this MOF method. Thus, this new MOF isolation technique will advance the field of liquid biopsy, with the potential to diagnose liver cancer.

关键词： MOF circulating cell-free RNA biomarker liver cancer diagnosis

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Expression profiling-based clustering of healthy subjects recapitulates classifications defined by clinical observation in Chinese medicine

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Journal of Genetics and Genomics 2017年第4期44卷 191-197页

作者： ruoxi yu Dan Liu Yin Yang yuanyuan Han Lingru Li Luyu Zheng Ji wang Yan Zhang Yingshuai Li Qian-Fei Wang Qi wang Health Preservation Institute School of Chinese Medicine BeOing University of Chinese Medicine Beijing 100029 China Key Laboratory of Genomics and Precision Medicine Collaborative Innovation Center of Genetics and Development Beijing Institute of Genomics Chinese Academy of Sciences Beijing 100101 China Center for Studies in Constitution Research of Traditional Chinese Medicine School of Chinese Medicine Beijing University of Chinese Medicine Beijing 100029 China University of Chinese Academy of Sciences Beijing 100049 China

Differences between healthy subjects and associated disease risks are of substantial interest in clinical medicine. Based on clinical presentations, Traditional Chinese Medicine （TCM） classifies healthy people into nine constitutions： Balanced, Qi, Yang or Yin deficiency, Phlegm-dampness, Damp-heat, Blood stasis, Qi stagnation, and Inherited special constitutions. In particular, Yang and Yin deficiency constitutions exhibit cold and heat aversion, respectively. However, the intrinsic molecular characteristics of unbal- anced phenotypes remain unclear. To determine whether gene expression-based clustering can reca- pitulate TCM-based classification, peripheral blood mononudear cells （PBMCs） were collected from Chinese Han individuals with Yang/Yin deficiency （n = 12 each） and Balanced （n = 8） constitutions, and global gene expression profiles were determined using the Affymetrix HC-UI33A Plus 2.0 array. Notably, we found that gene expression-based classifications reflected distinct TCM-based subtypes. Consistent with the clinical observation that subjects with Yang deficiency tend toward obesity, series-clustering analysis detected several key lipid metabolic genes （diacylglycerol acyltransferase （DGAT2）, acyl-CoA synthetase （ACSL1）, and ATP-hinding cassette subfamily A member 1 （ABCAI）） to be down- and up- regulated in Yin and Yang deficiency constitutions, respectively. Our findings suggest that Yin]Yang deficiency and Balanced constitutions are unique entities in their mRNA expression profiles. Moreover, the distinct physical and clinical characteristics of each unbalanced constitution can be explained, in part, by specific gene expression signatures.

关键词： Traditional Chinese Medicine Constitution Classification Gene expression

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后疫情时代大学生自杀现状、影响因素及危机干预的思考

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襄阳职业技术学院学报 2022年第4期21卷 112-115页

作者：余若曦苏州大学文学院江苏苏州215000

文章以2020年网络统计的58起大学生自杀案例为研究对象,研究发现了秋季自杀人数明显多于春季自杀人数、自杀方式仍以跳楼为主、自杀原因以学业压力为主、自杀年级以毕业年级居多等后疫情时代大学生自杀现状,并力图从学业压力、就业压力... 详细信息

文章以2020年网络统计的58起大学生自杀案例为研究对象,研究发现了秋季自杀人数明显多于春季自杀人数、自杀方式仍以跳楼为主、自杀原因以学业压力为主、自杀年级以毕业年级居多等后疫情时代大学生自杀现状,并力图从学业压力、就业压力、媒体不当宣传等方面窥见大学生自杀原因。最后从完善大学生心理危机识别排查机制、预防管理机制、三级预警机制等方面提出降低大学生自杀概率的策略。

关键词：后疫情时代大学生自杀危机干预

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Gene expression signatures for phlegm-dampness constitution of Chinese Medicine

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Science China(Life Sciences) 2017年第1期60卷 105-107页

作者： Lingru Li Juan Feng Haiqiang Yao Lan Xie yu Chen Lingling Yang Shujuan Hou Shipeng Zhao Ranran Sun Yanling Wu Tongtong Bai Yingshuai Li ruoxi yu Ji Wang Qi Wang Center for studies in Constitution Research of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China Medical Systems Biology Research Center School of MedicineTsinghua UniversityBeijing 100084China Nutrition Department China-Japan Friendship HospitalBeijing 100029China Preventive Treatment of Disease Department Zhengzhou Hospital of Traditional Chinese MedicineZhengzhou 450002China

Dear Editor,The term'individualized medicine'was first used in Biochemistry Individuality in 1956 by Williams(Williams et al.,1956).With the emergence of the post-genome era in the21st century,individualized precision medicine has attracted increasing *** traditional Chinese medicine(TCM),there is also concept of individualized medicine,which is known as the Chinese constitutional theory,proposed in the1970s(Wang,2012).According to this theory,the

关键词：中医学体质基因表达特征后基因组时代构成要件不平衡 Bio

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