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Direct in vivo injection of ^(131)I-GMS and its distribution and excretion in rabbit

World Journal of Gastroenterology 2010年第17期16卷 2120-2128页

作者： yu ma,yi wan,li-geng duan,xiao-li chen,the research unit of hepato-bilio-pancreatology and department of hepatic surgery,west china hospital of sichuan university,chengdu 610041,sichuan province,china dong-hui luo,chuan-qin xia,college of chemistry,sichuan university,chengdu 610041,sichuan province,china lin li,department of nuclear medicine and the national key discipline of medical imaging and nuclear medicine,west china hospital of sichuan university,chengdu 610041,sichuan province,china the research unit of hepato-bilio-pancreatology and department of hepatic surgery West China Hospital of Sichuan University Chengdu 610041 Sichuan Province China.

AIM: To explore the distribution and metabolism of 131 I-gelatin microspheres ( 131 I-GMSs) in rabbits after direct injection into rabbits’ ***: Twenty-eight healthy New Zealand rabbits were divided into seven groups,with four rabbits per *** rabbit’s hepatic lobes were directly injected with 41.336 ± 5.106 MBq 131 *** day after 131 I-GMSs administration,4 rabbits were randomly selected,and 250 μL of serum was collected for γ *** and thyroid functions were tested on days 1,4,8,16,24,32,48 and 64 after 131 I-GMSs ***-photon emission computed tomography (SPECT) was taken for each group on days 0,1,4,8,16,24,32,48,64 after 131 I-GMSs administration.A group of rabbits were sacrificed respectively on days 1,4,16,24,32,48,64 after 131 I-GMSs *** livers were taken out for histological ***: After 131 I-GMSs administration,the nuclide was collected in the hepatic area with *** radiation could be detected on day 48 after 131 IGMSs administration,and radiography could be seen in thyroid areas in SPECT on days 4,8,16 and *** day after 131 I-GMSs administration,the liver function was damaged but recovered 4 d *** days after 131 I-GMSs administration,the levels of free triiodothyronine and free thyroxin were reduced,which restored to normal levels on day *** examination showed that the microspheres were degraded to different degrees at 24,32 and 48 d after 131 I-GMSs *** surrounding parts of injection points were in fibrous *** microspheres were detected in histological examination on day 64 after 131 I-GMSs ***: Direct in vivo injection of 131 I-GMSs is safe in *** may be a promising method for treatment of malignant tumors.

关键词： 131 I Label Gelatin microspheres Animal Rabbit hepatic Direct injection

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