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Antibody and T cell responses against wild-type and Omicron SARS-CoV-2 after third-dose BNT162b2 in adolescents

Signal Transduction and Targeted Therapy 2023年第1期8卷 266-275页

作者： Xiaofeng Mu Carolyn A.Cohen Daniel Leung Jaime S.Rosa Duque Samuel M.S.Cheng yuet Chung Howard H.W.Wong Amos M.T.Lee Wing Yan Li Issan Y.S.Tam Jennifer H.Y.Lam Derek H.L.Lee Sau Man Chan Leo C.H.Tsang Karl C.K.Chan John K.C.Li Leo L.H.Luk Sara Chaothai Kelvin K.H.Kwan Nym Coco Chu Masashi Mori Trushar Jeevan Ahmed Kandeil Richard JWebby Wenwei Tu Sophie A.Valkenburg Malik Peiris yu lung lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina HKU-Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Infectious Diseases St Jude Children’s Research HospitalMemphisTNUSA Department of Microbiology and Immunology Peter Doherty Institute for Infection and ImmunityUniversity of MelbourneMelbourneVICAustralia Centre for Immunology&Infection C2i Hong KongChina

The high effectiveness of the third dose of BNT162b2 in healthy adolescents against Omicron BA.1 has been reported in some studies,but immune responses conferring this protection are not yet *** this analysis,our study(NCT04800133)aims to evaluate the humoral and cellular responses against wild-type and Omicron(BA.1,BA.2 and/or BA.5)SARS-CoV-2 before and after a third dose of BNT162b2 in healthy *** 5 months after 2 doses,S IgG,S IgG Fc receptor-binding,and neutralising antibody responses waned significantly,yet neutralising antibodies remained detectable in all tested adolescents and S IgG avidity increased from 1 month after 2 *** antibody responses and S-specific IFN-γ^(+)and IL-2^(+)CD8^(+)T cell responses were significantly boosted in healthy adolescents after a homologous third dose of *** to adults,humoral responses for the third dose were non-inferior or superior in *** S-specific IFN-γ^(+)and IL-2^(+)CD4^(+)and CD8^(+)T cell responses in adolescents and adults were comparable or ***,after 3 doses,adolescents had preserved S IgG,S IgG avidity,S IgG FcγRIIIa-binding,against Omicron BA.2,as well as preserved cellular responses against BA.1 S and moderate neutralisation levels against BA.1,BA.2 and *** from 100 and 96%of adolescents tested at 1 and 5 months after two doses could also neutralise *** study found high antibody and T cell responses,including potent cross-variant reactivity,after three doses of BNT162b2 vaccine in adolescents in its current formulation,suggesting that current vaccines can be protective against symptomatic Omicron disease.

关键词： doses neutral protective

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化脓性无菌性关节炎-坏疽性脓皮病-痤疮综合征一例并文献复习

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中华儿科杂志 2020年第12期58卷 977-981页

作者：梁伟玲李汉广钟共王博深马剑达陈健良毛华伟刘宇隆李珮华香港大学深圳医院儿科 518000 中山大学孙逸仙纪念医院风湿免疫科广州510000 首都医科大学附属北京市儿童医院风湿免疫科 100045

目的:了解化脓性无菌性关节炎-坏疽性脓皮病-痤疮(PAPA)综合征的发病特点及诊治情况。方法:收集2017年香港大学深圳医院诊断的1例6岁男性PAPA综合征患儿的临床资料,监测生物制剂治疗前后血红细胞沉降率(ESR)、C反应蛋白(CRP)及白细胞介... 详细信息

目的:了解化脓性无菌性关节炎-坏疽性脓皮病-痤疮(PAPA)综合征的发病特点及诊治情况。方法:收集2017年香港大学深圳医院诊断的1例6岁男性PAPA综合征患儿的临床资料,监测生物制剂治疗前后血红细胞沉降率(ESR)、C反应蛋白(CRP)及白细胞介素(IL)1、IL-6、肿瘤坏死因子α(TNF-α)等指标改变。以“PAPA综合征”“PSTPIP1基因”为关键词在Pubmeb、万方及知网检索1997年1月至2019年12月的文献资料,对文献资料进行汇总分析。结果:患儿男,6岁,因反复关节肿痛4年余入香港大学深圳医院。治疗前血液CRP(256 mg/L),ESR(105 mm/1 h)均升高,TNF-α,IL-1正常(7.43 ng/L、1000 ng/L)明显增高。磁共振成像示右侧下肢骨质改变,考虑骨髓炎。基因测序示PSTPIP1基因杂合突变(c.748G>A,p.E250K),诊断PAPA综合征,先后选择托珠单抗及英夫利昔单抗治疗,关节肿痛症状曾好转,在有效治疗1年后症状反复。后改IL-1拮抗剂治疗,关节肿痛消退,现定期随访,未再出现关节肿痛反复。末次随访复查血液CRP、ESR、TNF-α、IL-1和IL-6均下降至正常。通过文献检索及复习,共搜索文献29篇,包含本例,共有患者87例。87例患者有关节症状的58例、脓皮病33例、痤疮24例;共发现基因型13种,突变发生在p.E250位置共有47例;治疗以激素、生物制剂为主。结论:对于反复出现非感染化脓性关节炎,炎症指标增高而无明显微生物感染证据患儿,需考虑PAPA综合征,完善基因检查有助于明确诊断,生物制剂可有效控制症状。

关键词：儿童突变基因

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Carbon steel slag as cementitious material for self-consolidating concrete

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第7期11卷 488-494页

作者： yu-Chu PENG Chao-lung HWANG Graduate Institute of Construction Engineering National Taiwan University of Science and Technology Taipei Department of Leisure Management Taiwan Hospitality and Tourism College Taipei

This study deals with the recycling of carbon steel slag (CSS) to produce self-consolidating concrete (SCC). Since the chemical composition of CSS is similar to that of Portland cement or blast furnace slag (BFS), it is expected to behave similarly. In the current study, the pozzolanic activity index of CSS is examined. Furthermore, the use of CSS as a pozzolanic material to partially replace Portland cement in the production of SCC is tested. We designed concrete mixtures with different water-tocementitious material ratios (w/cm) keeping water and superplasticizer (SP) contents constant. Results showed that the design and performance of all the concrete mixtures used in this investigation were comparable to those of SCC and high performance concrete (HPC). However, compared to ordinary plain concrete (OPC), the additional CSS content increases the setting time. In the CSS mixtures set for 90 d, compressive strengths of 86%, 134% and 121% were attained as compared to the control concrete; the corresponding w/cm ratios were 0.28, 0.32 and 0.40, respectively. Verifying the soundness of the SCC for meeting the criteria for HPC, the ultrasonic pulse velocity (UPV) of CSS was found to be comparable to that of ordinary concrete. In conclusion, the recycling of CSS can be advantageously employed in the production of SCC.

关键词： Carbon steel slag (CSS) Self-consolidating concrete (SCC) Pozzolanic Recycling

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Traditional Chinese medicine in the treatment of Helicobacter pylorirelated gastritis:The mechanisms of signalling pathway regulations

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World Journal of Gastroenterology 2025年第3期31卷 11-28页

作者： Pei-Pei Zhang Liang Li Hao-yu Qu Guang-yu Chen Meng-Zhou Xie Yan-Kun Chen School of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina Hunan Engineering Technology Research Center for Medicinal and Functional Food Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina Key Laboratory of Traditional Chinese Medicine Heart and lung Syndrome Differentiation and Medicated Diet and Dietotherapy Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina School of Informatics Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Precision Medicine Research and Development Center Zhuhai Institute of Advanced TechnologyChinese Academy of SciencesZhuhai 519000Guangdong ProvinceChina

Helicobacter pylori-associated gastritis(HPAG)is a common condition of the gastrointestinal ***,extensive and long-term antibiotic use has resulted in numerous adverse effects,including increased resistance,gastrointestinal dysfunction,and increased recurrence *** these concerns develop,traditional Chinese medicine(TCM)may have *** is based on the concept of completeness and aims to eliminate pathogens and strengthen the *** has the potential to prevent this condition while also boosting the rate of Helicobacter pylori *** review elaborates on the mechanism of TCM treatment for HPAG based on cellular signalling pathways,which reflects the flexibility of TCM in treating diseases and the advantages of multi-level,multipathway,and multi-target treatments for HPAG.

关键词： Helicobacter pylori Helicobacter pylori-associated gastritis Traditional Chinese medicine Signalling pathway Eliminate pathogens Strengthen the body

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Development of high performance and high strength heavy concrete for radiation shielding structures

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International Journal of Minerals,Metallurgy and Materials 2011年第1期18卷 89-93页

作者： yu-Chu Peng Chao-lung Hwang Graduate Institute of Construction Engineering Taiwan University of Science and Technology Taipei 11243 China Taipei Department of Resort and Leisure Management Taiwan Hospitality ＆ Tourism College Taipei 11243 China Taipei

Heavy concrete currently used for construction contains special materials that are expensive and difficult to work *** study replaced natural aggregate（stones） in concrete with round steel balls,which are inexpensive and easily *** diameters of the steel balls were 0.5 and 1 cm,and their density was 7.8 kg/*** packing mixture methods were used to produce heavy concrete with densities of 3500 and 5000 kg/*** various properties of this concrete were tested according to the standards of the American Society for Testing and Materials（ASTM）.The results indicated that the construction slump of the concrete could reach 260-280 mm and its slump flow could reach 610-710 *** important,its compressive strength could reach 8848 *** results will significantly alter traditional construction methods that use heavy concrete and enhance innovative ideas for structural design.

关键词： radiation shielding composite structures concretes concrete construction materials properties

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Modular Design Using Sustainable Luminescent Materials in Energy-Saving Reflective Cat’s Eyes for Public Road Safety Planning

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Journal of Renewable Materials 2022年第5期10卷 1415-1437页

作者： lung-Yin Lin yu-Shing Chang Department of Industrial Design National Kaohsiung University of Science and TechnologyKaohsiung82445Taiwan Department of Business Administration National Taichung University of Science and TechnologyTaichung404Taiwan

Recently,there has been a global movement toward environmental protection and energy conservation through the design and development of new products in accordance with sustainable *** this study,rare earth luminescent materials were used owing to their active light emission and ***,solar lightemitting diode lights and car-light reflection were utilised to increase the recognition and reliability of reflective cat *** with carbon reduction,this can save energy and enhance road *** study considered the Theory of Inventive Problem Solving and a literature review to analyse the issues in existing ***,expert interviews were conducted to screen projects and develop product design ***,the ratio of light-storage materials was experimentally determined and the prototypes *** cat’s eye addresses the shortcomings identified in previous analyses of existing *** applied energy storage environmental protection materials,together with material proportioning(which balanced warning efficiency against cost-effectiveness)to develop diversified modular kits;these were flexible in terms of quantity and easily *** study achieved four key objectives:(1)reducing the research and development costs of the manufacturer;(2)offering buyers a diverse suite of products;(3)responding to a need to improve diverse road user safety;and(4)reducing government procurement costs for safety warning *** results provide a reference for the creative modular design of energy-saving products for public road safety planning in various industries.

关键词： Sustainable luminescent materials modular design TRIZ expert interview diverse road safety

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Gut microbiome alters functions of mutant p53 to promote tumorigenesis

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Signal Transduction and Targeted Therapy 2020年第1期5卷 491-492页

作者： Harry Cheuk Hay lau Jun yu Institute of Digestive Disease Department of Medicine and TherapeuticsState Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesCUHK Shenzhen Research InstituteThe Chinese University of Hong KongSha TinN.T.Hong Kong

In a recent study in Nature,Kadosh et al.1 established a landmark relationship between the gut microbiome and host epigenetics in intestinal *** demonstrated the substantial plasticity of mutant p53 in WNT-driven tumo... 详细信息

关键词： tumorigenesis involvement al

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Cosmic microwave background constraints on the tensor-to-scalar ratio

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Research in Astronomy and Astrophysics 2014年第6期14卷 635-647页

作者： King lau Jia-yu Tang Ming-Chung Chu Department of Physics and Institute of Theoretical Physics The Chinese University of Hong Kong

One of the main goals of modern cosmic microwave background （CMB） missions is to measure the tensor-to-scalar ratio r accurately to constrain inflation models. Due to ignorance about the reionization history Xe （z）, this analysis is usu- ally done by assuming an instantaneous reionization Xe （z） which, however, can bias the best-fit value of r. Moreover, due to the strong mixing of B-mode and E-mode polarizations in cut-sky measurements, multiplying the sky coverage fraction fsky by the full-sky likelihood would not give satisfactory results. In this work, we forecast constraints on r for the Planck mission taking into account the general reionization scenario and cut-sky effects. Our results show that by applying an N-point interpo- lation analysis to the reionization history, the bias induced by the assumption of in- stantaneous reionization is removed and the value of r is constrained within 5% error level, if the true value of r is greater than about 0.1.

关键词： cosmology: cosmic microwave background -- cosmology: cosmologicalparameters -- cosmology: early universe -- gravitational waves

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Self-certified multi-proxy signature schemes with message recovery

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第2期10卷 290-300页

作者： Tzong-sun WU Chien-lung HSU Han-yu LIN Department of Computer Science and Engineering National Taiwan Ocean University Keelung 202 Taiwan China Department of Information Management Chang Gung University Taoyuan 333 Taiwan China Department of Computer Science National Chiao Tung University Hsinchu 300 Taiwan. China

Multi-proxy signature schemes allow the original signer to delegate his/her signing power to n proxy signers such that all proxy signers must corporately generate a valid proxy signature on behalf of the original signer. We first propose a multi-proxy signature scheme based on discrete logarithms and then adapt it to the elliptic curve cryptosystem. With the integration of self-certified public-key systems and the message recovery signature schemes,our proposed schemes have the following advan-tages:(1) They do not require the signing message to be transmitted,since the verifier can recover it from the signature;(2) The authentication of the public keys,verification of the signature,and recovery of the message can be simultaneously carried out in a single logical step;(3) No certificate is needed for validating the public keys. Further,the elliptic curve variant with short key lengths especially suits the cryptographic applications with limited computing power and storage space,e.g.,smart cards. As compared with the previous work that was implemented with the certificate-based public-key systems,the proposed schemes give better performance in terms of communication bandwidth and computation efforts.

关键词： Self-certified Multi-proxy signature Message recovery Smart cards Discrete logarithms Elliptic curve

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Bile acids,gut microbiota,and therapeutic insights in hepatocellular carcinoma

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Cancer Biology & Medicine 2024年第2期21卷 144-162页

作者： Yang Song Harry CH lau Xiang Zhang Jun yu Institute of Digestive Disease and Department of Medicine and Therapeutics State Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesCUHK Shenzhen Research InstituteThe Chinese University of Hong KongHong KongChina Department of Gastroenterology Zhongshan Hospital Xiamen UniversityXiamen 361004China

Hepatocellular carcinoma(HCC)is a prevalent and aggressive liver *** interplay between bile acids(BAs)and the gut microbiota has emerged as a critical factor in HCC development and *** normal conditions,BA metabolism is tightly regulated through a bidirectional interplay between gut microorganisms and *** gut microbiota plays a critical role in BA metabolism,and BAs are endogenous signaling molecules that help maintain liver and intestinal *** note,dysbiotic changes in the gut microbiota during pathogenesis and cancer development can disrupt BA homeostasis,thereby leading to liver inflammation and fibrosis,and ultimately contributing to HCC ***,understanding the intricate interplay between BAs and the gut microbiota is crucial for elucidating the mechanisms underlying *** this review,we comprehensively explore the roles and functions of BA metabolism,with a focus on the interactions between BAs and gut microorganisms in ***,therapeutic strategies targeting BA metabolism and the gut microbiota are discussed,including the use of BA agonists/antagonists,probiotic/prebiotic and dietary interventions,fecal microbiota transplantation,and engineered *** summary,understanding the complex BA-microbiota crosstalk can provide valuable insights into HCC development and facilitate the development of innovative therapeutic approaches for liver malignancy.

关键词： Bile acid gut microbiota hepatocellular carcinoma therapeutics microbiota modulation

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