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Development of a diagnostic nomogram for alpha-fetoproteinnegative hepatocellular carcinoma based on serological biomarkers

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2463-2475页

作者： Li He Cui Zhang lan-lan Liu Li-Ping Huang Wen-Jing Lu yuan-yuan Zhang De-Yong Zou yu-Fei Wang Qing Zhang Xiao-Li Yang School of Clinical Medicine Weifang Medical UniversityWeifang 261053Shandong ProvinceChina Department of Organ Transplantation The Third Medical Centre of Chinese PLA General HospitalBeijing 100039China Department of Laboratory Medicine The Third Medical Centre of Chinese PLA General HospitalBeijing 100039China Department of Laboratory Medicine Jingyu County People’s HospitalBaishan 135200Jilin ProvinceChina School of Laboratory Medicine Weifang Medical UniversityWeifang 261053Shandong ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is the third leading cause of cancer-related death *** biomarkers play an important role in the early diagnosis and prognosis of *** a certain percentage of HCC patients are negative for alpha-fetoprotein(AFP),the diagnosis of AFP-negative HCC is essential to improve the detection rate of *** To establish an effective model for diagnosing AFP-negative HCC based on serum tumour *** A total of 180 HCC patients were enrolled in this *** expression levels of GP73,des-γ-carboxyprothrombin(DCP),CK18-M65,and CK18-M30 were detected by a fully automated chemiluminescence *** variables were selected by logistic regression *** models were constructed using stepwise backward logistic *** performance of the models was compared using the C statistic,integrated discrimination improvement,net reclassification improvement,and calibration *** clinical utility of the nomogram was assessed using decision curve analysis(DCA).RESULTS The results showed that the expression levels of GP73,DCP,CK18-M65,and CK18-M30 were significantly greater in AFP-negative HCC patients than in healthy controls(P<0.001).Multivariate logistic regression analysis revealed that GP73,DCP,and CK18-M65 were independent factors for diagnosing AFP-negative *** comparing the diagnostic performance of multiple models,we included GP73 and CK18-M65 as the model variables,and the model had good discrimination ability(area under the curve=0.946)and good goodness of *** DCA curves indicated the good clinical utility of the *** Our study identified GP73 and CK18-M65 as serum biomarkers with certain application value in the diagnosis of AFP-negative *** diagnostic nomogram based on CK18-M65 combined with GP73 demonstrated good performance and effectively identified high-risk groups of patients with HCC.

关键词： Hepatocellular carcinoma Alpha-fetoprotein-negative Diagnostic Nomogram Biomarker

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Bidirectional effects of the tryptophan metabolite indole-3-acetaldehyde on colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2697-2715页

作者： Ze Dai Kai-Li Deng Xiao-Mei Wang Dong-Xue Yang Chun-lan Tang yu-Ping Zhou Department of Gastroenterology The First Affiliated Hospital of Ningbo UniversityNingbo 315020Zhejiang ProvinceChina Health Science Center Ningbo UniversityNingbo 315211Zhejiang ProvinceChina School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Institute of Digestive Disease of Ningbo University Ningbo UniversityNingbo 315020Zhejiang ProvinceChina Ningbo Key Laboratory of Translational Medicine Research on Gastroenterology and Hepatology Ningbo Key LaboratoryNingbo 315020Zhejiang ProvinceChina

BACKGROUND Colorectal cancer(CRC)has a high incidence and *** studies have shown that indole derivatives involved in gut microbiota metabolism can impact the tumorigenesis,progression,and metastasis of *** To investigate the effect of indole-3-acetaldehyde(IAAD)on *** The effect of IAAD was evaluated in a syngeneic mouse model of CRC and CRC cell lines(HCT116 and DLD-1).Cell proliferation was assessed by Ki-67 fluorescence staining and cytotoxicity *** apoptosis was analysed by flow cytometry after staining with Annexin V-fluorescein isothiocyanate and propidium *** was investigated using the transwell *** blotting and real-time fluorescence quantitative polymerase chain reaction were performed to evaluate the expression of epithelial-mesenchymal transition related genes and aryl hydrocarbon receptor(AhR)downstream *** PharmMapper,SEA,and SWISS databases were used to screen for potential target proteins of IAAD,and the core proteins were identified through the String *** IAAD reduced tumorigenesis in a syngeneic mouse *** CRC cell lines HCT116 and DLD1,IAAD exhibited cytotoxicity starting at 24 h of treatment,while it reduced Ki67 expression in the *** results of flow cytometry showed that IAAD induced apoptosis in HCT116 cells but had no effect on DLD1 cells,which may be related to the activation of *** can also increase the invasiveness and epithelial-mesenchymal transition of HCT116 and DLD1 *** low concentrations(<12.5μmol/L),IAAD only exhibited cytotoxic effects without promoting cell *** addition,predictions based on online databases,protein-protein interaction analysis,and molecular docking showed that IAAD can bind to matrix metalloproteinase-9(MMP9),angiotensin converting enzyme(ACE),poly(ADP-ribose)polymerase-1(PARP1),matrix metalloproteinase-2(MMP2),and myeloperoxidase(MPO).CONCLUSION Indole-3-aldehyde can induce cell apoptosis and inhibit cell prol

关键词： Indole-3-acetaldehyde Colorectal cancer Tryptophan metabolism Apoptosis Epithelial-mesenchymal transition

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Achieving High CO_(2)Photoreduction Activity by Conductive Crosslinks of Metal–Organic Framework

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CCS Chemistry 2024年第5期6卷 1211-1221页

作者： Ning Li Gui-Qi Lai Lai-Hon Chung Fei yu Jun He Ya-Qian lan Department School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhouGuangdong 510006 School of Chemistry South China Normal UniversityGuangzhou 510006 School of Chemistry and Materials Science Nanjing Normal UniversityNanjing 210023

Fast photogenerated charge migration is crucial for the improvement of photocatalytic performance,but its deliberate modulation is *** work presents two Zr-based metal–organic framework catalysts,GDUT-8 and GDUT-8-Ox,for photocatalytic CO_(2)***,thiophene pendants in GDUT-8 were coupled covalently via Scholl reaction to give GDUT-8-Ox,a catalyst with at least two orders of magnitude(up to 6.1×10^(−3)S cm^(−1))enhanced conductivity and faster transport of photogenerated carriers during ***,from GDUT-8 to GDUT-8-Ox,stronger ligand-to-cluster charge transfer with pronounced light absorption extension was *** a result,GDUT-8-Ox exhibited the highest photocatalytic CO_(2)-to-HCOO−conversion rate(1725μmol g^(−1)h^(−1))to date,in the absence of photosensitizer,as well as turnover number,turnover frequency,and quantum efficiency much higher than *** work presents an unprecedented strategy to accelerate the photogenerated carrier transport of photocatalysts.

关键词： metal-organic framework Scholl reaction covalent crosslinks high conductivity CO_(2)photoreduction CO_(2)-to-HCOO−conversion

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Benchmark experiment on slab^(238)U with D-T neutrons for validation of evaluated nuclear data

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Nuclear Science and Techniques 2024年第2期35卷 145-159页

作者： Yan-Yan Ding Yang-Bo Nie yue Zhang Zhi-Jie Hu Qi Zhao Huan-yu Zhang Kuo-Zhi Xu Shi-yu Zhang Xin-Yi Pan Chang-Lin lan Jie Ren Xi-Chao Ruan Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China Institute of Fluid Physics China Academy of Engineering PhysicsMianyang 62100China

A benchmark experiment on^(238)U slab samples was conducted using a deuterium-tritium neutron source at the China Institute of Atomic *** leakage neutron spectra within energy levels of 0.8-16 MeV at 60°and 120°were measured using the time-of-flight *** samples were prepared as rectangular slabs with a 30 cm square base and thicknesses of 3,6,and 9 *** leakage neutron spectra were also calculated using the MCNP-4C program based on the latest evaluated files of^(238)U evaluated neutron data from CENDL-3.2,ENDF/B-Ⅷ.0,JENDL-5.0,and *** on the comparison,the deficiencies and improvements in^(238)U evaluated nuclear data were *** results showed the following.(1)The calculated results for CENDL-3.2 significantly overestimated the measurements in the energy interval of elastic scattering at 60°and 120°.(2)The calculated results of CENDL-3.2 overestimated the measurements in the energy interval of inelastic scattering at 120°.(3)The calculated results for CENDL-3.2 significantly overestimated the measurements in the 3-8.5 MeV energy interval at 60°and 120°.(4)The calculated results with JENDL-5.0 were generally consistent with the measurement results.

关键词： Leakage neutron spectra Uranium D-T neutron source Evaluated nuclear data

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luoxetine Rescues Excessive Myelin Formation and Psychological Behaviors in a Murine PTSD Model

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Neuroscience Bulletin 2024年第8期40卷 1037-1052页

作者： Chenrui Yin Kefei Luo Xinyue Zhu Ronghang Zheng yu Wang Guangdan yu Xiaorui Wang Fei She Xiaoying Chen Tao Li Jingfei Chen Baduojie Bian Yixun Su Jianqin niu yuxin Wang Department of Histology and Embryology Third Military Medical UniversityChongqing 400038China Department of Respiratory Diseases Central Medical Branch of PLA General HospitalBeijing 100853China China Astronaut Research and Training Center Beijing 100094China Department of Emergency the Fourth Medical Center of the Chinese PLA General HospitalBeijing 100142China Army 953 Hospital Shigatse Branch of Xinqiao HospitalThird Military Medical University(Army Medical University)Shigatse 857000China Research Centre Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen 518107China

Posttraumatic stress disorder(PTSD)is a complex mental disorder notable for traumatic experience *** current first-line treatments are linked with clinically important symptom reduction,a large proportion of patients retained to experience considerable residual symptoms,indicating pathogenic mechanism should be illustrated *** studies reported that newly formed myelin could shape neural circuit function and be implicated in fear memory ***,its role in PTSD remains to be *** this study,we adopted a restraint stress-induced PTSD mouse model and found that PTSD-related neuropsychiatric symptoms were accompanied by increased myelination in the posterior parietal cortex and ***,but not risperidone or sertraline,has a more profound rescue effect on neuropsychological behaviors and myelin *** mechanistic experiments revealed that fluoxetine could directly interfere with oligodendroglial differentiation by upregulating Wnt *** data demonstrated the correlation between PTSD and abnormal myelination,suggesting that the oligodendroglial lineage could be a target for PTSD treatment.

关键词： PTSD Fear memory Myelination Oligodendroglial differentiation Fluoxetine Wnt signaling

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Huangqin Decoction Delays Progress of Colitis-Associated Carcinogenesis by Regulating Nrf2/HO-1 Antioxidant Signal Pathwayin Mice

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Chinese Journal of Integrative Medicine 2024年第2期30卷 135-142页

作者： GU Li-mei LI He-zhong GAO Lei LI Hui WEI lan-fu PAN Cheng-yu WU Ke-xuan TIAN Yao-zhou Department of Gastrointestinal Endoscopy Affiliated Hospital of Nanjing University of Chinese MedicineNanjing(210029)China Department of Gastroenterology Affiliated Hospital of Integrated Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjing(210028)China School of Integrated Chinese and Western Medicine Nanjing University of Chinese MedicineNanjing(210023)China

Objective:To investigate the effect of Huangqin Decoction(HQD)on nuclear factor erythroid 2 related-factor 2(Nrf2)/heme oxygenase(HO-1)signaling pathway by inducing the colitis-associated carcinogenesis(CAC)model mice with azoxymethane(AOM)/dextran sodium sulfate(DSS).Methods:The chemical components of HQD were analyzed by liquid chromatography-quadrupole-time-of-flight mass spectrometry(LC-Q-TOF-MS/MS)to determine the molecular constituents of *** 48 C57BL/6J mice were randomly divided into 6 groups by a random number table,including control,model(AOM/DSS),mesalazine(MS),low-,medium-,and high-dose HQD(HQD-L,HQD-M,and HQD-H)groups,8 mice in each *** for the control group,the mice in the other groups were intraperitoneally injected with AOM(10 mg/kg)and administrated with 2.5%DSS orally for 1 week every two weeks(totally 3 rounds of DSS)to construct a colitis-associated carcinogenesis mouse *** mice in the HQD-L,HQD-M and HQD-H groups were given HQD by gavage at doses of 2.925,5.85,and 11.7 g/kg,respectively;the mice in the MS group was given a suspension of MS at a dose of 0.043 g/kg(totally 11 weeks).The serum levels of malondialdehyde(MDA)and superoxide dismutase(SOD)were measured by enzyme-linked immunosorbent *** mRNA and protein expression levels of Nrf2,HO-1,and inhibitory KELCH like ECH-related protein 1(Keap1)in colon tissue were detected by quantitative real-time PCR,immunohistochemistry,and Westem blot,***:LC-Q-TOF-MS/MS analysis revealed that the chemical constituents of HQD include baicalin,paeoniflorin,and glycyrrhizic *** to the control group,significantly higher MDA levels and lower SOD levels were observed in the model group(P<0.05),whereas the expressions of Nrf2 and HO-1 were significantly decreased,and the expression of Keap1 increased(P<0.01).Compared with the model group,serum MDA level was decreased and SOD level was increased in the HQD-M,HQD-H and MS groups(P<0.05).Higher expressions of

关键词： Huangqin Decoction colitis-associated carcinogenesis nuclear factor erythroid 2 related-factor 2/heme oxygenase signaling pathway oxidative stress Chinese medicine

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Pleural empyema with endobronchial mass due to Rhodococcus equi infection after renal transplantation: A case report and review of literature

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World Journal of Clinical Cases 2024年第1期12卷 224-231页

作者： Guo-Fu Liang Sheng Chao Zhou Sun Ke-Jing Zhu Qian Chen Lei Jia yu-Lin niu Department of Organ Transplantation School of Clinical MedicineGuizhou Medical UniversityGuiyang 550025Guizhou ProvinceChina Department of Organ Transplantation The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550000Guizhou ProvinceChina

BACKGROUND Kidney transplantation is the best option for patients with end-stage renal ***,the need for lifelong immunosuppression results in renal transplant recipients being susceptible to various *** equi(***)is a rare opportunistic pathogen in humans,and there are limited reports of infection with *** in post-renal transplant recipients and no uniform standard of *** article reports on the diagnosis and treatment of a renal transplant recipient infected with *** 21 mo postoperatively and summarizes the charac-teristics of infection with *** after renal transplantation,along with a detailed review of the ***,we present the case of a 25-year-old man who was infected with *** 21 mo after renal *** the clinical features at the time of presentation were not specific,chest computed tomography(CT)showed a large volume of pus in the right thoracic cavity and right middle lung atelectasis,and fiberoptic bronchoscopy showed an endobronchial mass in the right middle and lower lobe *** culture and metagenomic next-generation sequen-cing sequencing of the pus were suggestive of *** *** immunosup-pressive drugs were immediately suspended and intravenous vancomycin and azithromycin were administered,along with adequate drainage of the *** endobronchial mass was then *** the patient’s clinical symptoms and chest CT presentation resolved,he was switched to intravenous ciprofloxacin and azithromycin,followed by oral ciprofloxacin and *** patient was re-hospitalized 2 wk after discharge for recurrence of *** *** recovered after another round of adequate abscess drainage and intravenous ciprofloxacin and *** Infection with *** in renal transplant recipients is rare and complex,and the clinical presentation lacks *** antibiotic therapy is required,and adequate abscess drainage and s

关键词： Kidney transplantation Rhodococcus equi Pleural empyema Pulmonary atelectasis Immunosuppression Case report

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Immunoglobulin superfamily containing leucine-rich repeat(ISLR)negatively regulates osteogenic differentiation through the BMP-Smad signaling pathway

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Genes & Diseases 2024年第4期11卷 138-140页

作者： Lei Xiong Miaomiao lan Chang Liu Lei Li YingYing yu Tongtong Wang Fan Liu Kun Wang Jin Liu Qingyong Meng State Key Laboratory of Agrobiotechnology College of Biological SciencesChina Agricultural UniversityBeijing 100094China

Osteoporosis(OP)is an aging-associated condition that significantly affects the quality of life in aging humans and has few treatment *** an important marker,recombinant immunoglobulin superfamily containing leucinerich repeat(ISLR)could be used as a gene therapy for *** herein used alkaline phosphatase(ALP)and alizarin red S(ARS)staining to evaluate osteogenic differentiation potential.

关键词： Immunoglobulin alkaline herein

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Use of Evidence-Based Research Approach in RCTs of Acupuncture-Related Therapies for Primary Dysmenorrhea: A Meta-Research

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Chinese Journal of Integrative Medicine 2024年第6期30卷 551-558页

作者： HU Xiao-yi TIAN Zi-yu CHEN Huan HU Xiang-yu MING Tian-yu PENG Hao-xuan JIAO Rui-min SHI lan-jun XIU Wen-cui YANG Ji-wei GANG Wei-juan JING Xiang-hong Institute of Acupuncture and Moxibustion China Academy of Chinese Medical SciencesBeijingChina Department of Traditional Chinese Medicine Beijing Puren HospitalBeijing100062China

Objective To assess the use of evidence-based research(EBR)approach in randomized controlled trials(RCTs)of acupuncture-related therapies for primary dysmenorrhea(PD).Methods PubMed,EMBASE,Cochrane Library,China National Knowledge Infrastructure,Wanfang Database,Chinese Biomedical Database,and China Science and Technology Journal Database were searched from January 2013 to December 2022 for RCTs of acupuncture on *** full text and references of each RCT were read to assess whether systematic reviews(SRs)or other types of studies with similar research questions and end-users’perspectives were cited to justify and design the *** addition,the discussion section were analyzed to evaluate whether trials placed the new result in the existing SRs to draw a *** logistic regression was used to find variables that associated with 3 aspects of EBR approach:(1)citing clinical studies for justification,(2)citing relevant studies that obtain the perspectives of end users,and(3)citing clinical studies for results *** Of 473 RCTs included,45.67%(216)of the trials cited relevant similar studies,21.56%(102)referenced to the studies that collected end-users’perspectives,and 10.99%(52)placed result in the context of the previous *** RCTs appropriately applied EBR *** all the included studies,3.17%(15)of the trials used SRs to inform study questions but none of them used updated SRs with acceptable quality;1.05%(5)of the trials cited SRs of end-user’s perspectives in the justification and design of the study,and only 1 trial added results in existing SR to draw a *** of publication,language,funding,registration,ethical approval and number of sites were significantly associated with 1 of the 3 aspects of EBR *** Few RCTs in acupuncture-related therapies for PD used the EBR approach to minimize research ***,research institutes,funding agencies,ethics committees,journals and peer

关键词： evidence-based research acupuncture therapy primary dysmenorrhea randomized controlled trial systematic review end-usersperspective meta-research

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AIMP2 restricts EV71 replication by recruiting SMURF2 to promote the degradation of 3D polymerase

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Virologica Sinica 2024年第4期39卷 632-644页

作者： Junrui Ren Lei yu Qiuhan Zhang Pengyu Ren yumeng Cai Xueyun Wang Ke lan Shuwen Wu State Key Laboratory of Virology College of Life SciencesWuhan UniversityWuhan430072China Medical Research Institute Wuhan UniversityWuhan430072China Taikang Center for Life and Medical Sciences Wuhan UniversityWuhan430072China

Hand,foot and mouth disease(HFMD),mainly caused by enterovirus 71(EV71),has frequently occurred in the Asia-Pacific region,posing a significant threat to the health of infants and young ***,research on the infection mechanism and pathogenicity of enteroviruses is increasingly becoming *** 3D polymerase,as the most critical RNA-dependent RNA polymerase(RdRp)for EV71 replication,is widely targeted to inhibit EV71 *** this study,we identified a novel host protein,AIMP2,capable of binding to 3D polymerase and inhibiting EV71 *** investigations revealed that AIMP2 recruits the E3 ligase SMURF2,which mediates the polyubiquitination and degradation of 3D ***,the antiviral effect of AIMP2 extended to the CVA16 and CVB1 *** research has uncovered the dynamic regulatory function of AIMP2 during EV71 infection,revealing a novel antiviral mechanism and providing new insights for the development of antienteroviral therapeutic strategies.

关键词： AIMP2 Enterovirus 71(EV71) 3D polymerase E3 ligase SMURF2 Ubiquitination

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