检索结果-南通市图书馆

Neuroprotective effects of bovine colostrum on intracerebral hemorrhage-induced apoptotic neuronal cell death in rats

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2012年第22期7卷 1715-1721页

作者： Sung Eun Kim ll Gyu Ko Mal Soon Shin Chang Ju Kim Young Gwan Ko Hanjin cho Department of Physiology College of Medicine Kyung Hee University Department of Emergency Medicine College of Medicine Kyung Hee University Department of Emergency Medicine Korea University Ansan Hospital

Brain cell death after intracerebral hemorrhage may be mediated in part by an apoptotic mechanism Colostrum is the first milk produced by mammals for their young. It plays an important role in protection and development by providing various antibodies, growth factors and nutrients, and has been used for various diseases in many countries. In the present study, we investigated the anti-apoptotic effects of bovine colostrum using organotypic hippocampal slice cultures and an intracerebral hemorrhage animal model. We performed densitometric measurements of propidium iodide uptake, a step-down avoidance task, Nissl staining, and caspase-3 immunohistochemistry. The present results revealed that colostrum treatment significantly suppressed N-methyI-D-aspartic acid-induced neuronal cell death in the rat hippocampus. Moreover, colostrum treatment improved short-term memory by suppressing hemorrhage-induced apoptotic neuronal cell death and decreasing the volume of the lesion induced by intracerebral hemorrhage in the rat hippocampus. These results suggest that colostrum may have a beneficial role in recovering brain function following hemorrhagic stroke by suppressing apoptotic cell death.

关键词： wintracerebral hemorrhage organotypic hippocampal slice culture bovine colostrum apoptotic celldeath N-methyI-D-aspartic acid caspase-3 hippocampus memory

Surface-engineered binder-free PEDOT shielded nickel magnesium selenide nanosheet arrays electrode for ultralong-life flexible quasi-solid-state hybrid supercapacitors

在线全文

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2023年第5期11卷 1802-1814页

作者： Edugulla Girija Shankar Amit Kumar Das Jae Su yu Department of Electronics and Information Convergence Engineering Institute for Wearable Convergence ElectronicsKyung Hee UniversityGyeonggi-do 17104Republic of Korea

Together with the development of high-performance advanced electronics,flexible supercapacitors(SCs)with tailored nanostructures have great *** deposited nanosheet arrays of nickel magnesium selenide(NixMg3-xSe4,NMgS)with high capacitance provide high potentials as a positive electrode in flexible *** further enhance their electrochemical properties and long-term cycling stability,a promising strategy of surface engineering with conducting polymer poly(3,4-ethylenedioxythiophene)(PEDOT)is *** present work proposes the construction of PEDOT shielded NMgS(P@NMgS-2)on a flexible carbon cloth substrate via a hierarchical electrodeposition *** from the synergistic effect,the P@NMgS-2 exhibits an excellent areal capacitance value of 1440 mF cm^(-2)at 4 mA cm^(-2).A novel shape-adaptable polymer gel electrolyte-assisted flexible quasi-solid-state hybrid SC(FQHSC)device constructed with P@NMgS-2 as a positive electrode and activated carbon as a negative electrode demonstrates the maximum power and energy density values of 14.13 mW cm^(-2)and 0.18 mWh cm^(-2),respectively,followed by outstanding cycling stability(∼100%capacitance retention over 50,000 cycles).Furthermore,the FQHSC device successfully powered electronic devices with no serious degradation upon bending and twisting for wearable electronic applications.

关键词： Hierarchical electrodeposition P@NMgS-2 hybrid Synergistic effect Shape-adaptable electrolyte Flexible quasi-solid-state supercapacitors

SYNCRIP controls miR-137 and striatal learning in animal models of methamphetamine abstinence

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2022年第8期12卷 3281-3297页

作者： Baeksun Kim Sung Hyun Tag Eunjoo Nam Suji Ham Sujin Ahn Juhwan Kim Doo-Wan cho Sangjoon Lee Young-Su Yang Seung Eun Lee Yong Sik Kim Il-Joo cho Kwang Pyo Kim Su-Cheol Han Heh-In Im Convergence Research Center for Diagnosis Treatment and Care System of Dementia(DTC)Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Division of Bio-Medical Science&Technology KIST SchoolKorea University of Science and Technology(UST)Seoul 02792Republic of Korea Center for Neuroscience KISTSeoul 02792Republic of Korea Animal Model Research Center Jeonbuk Department of Inhalation ResearchKorea Institute of Toxicology(KIT)Korea Research Institute of Chemical Technology(KRICT)Jeongeup 56212Republic of Korea Research Animal Resource Center KISTSeoul 02792Republic of Korea Department of Pharmacology Seoul National University College of MedicineSeoul 03080Republic of Korea Center for BioMicrosystems KISTSeoul 02792Republic of Korea Department of Applied Chemistry Kyung Hee UniversityGyeonggi-do 17104Republic of Korea

Abstinence from prolonged psychostimulant use prompts stimulant withdrawal *** adaptations within the dorsal striatum have been considered the main hallmark of stimulant abstinence. Here we explored striatal miRNA-target interaction and its impact on circulating miRNA marker as well as behavioral dysfunctions in methamphetamine(MA) abstinence. We conducted miRNA sequencing and profiling in the nonhuman primate model of MA abstinence, followed by miRNA qPCR,LC-MS/MS proteomics, immunoassays, and behavior tests in mice. In nonhuman primates, MA abstinence triggered a lasting upregulation of miR-137 in the dorsal striatum but a simultaneous downregulation of circulating miR-137. In mice, aberrant increase in striatal miR-137-dependent inhibition of SYNCRIP essentially mediated the MA abstinence-induced reduction of circulating miR-137. Pathway modeling through experimental deduction illustrated that the MA abstinence-mediated downregulation of circulating miR-137 was caused by reduction of SYNCRIP-dependent miRNA sorting into the exosomes in the dorsal striatum. Furthermore, diminished SYNCRIP in the dorsal striatum was necessary for MA abstinence-induced behavioral bias towards egocentric spatial learning. Taken together, our data revealed circulating miR-137 as a potential blood-based marker that could reflect MA abstinence-dependent changes in striatal miR-137/SYNCRIP axis, and striatal SYNCRIP as a potential therapeutic target for striatum-associated cognitive dysfunction by MA withdrawal syndrome.

关键词： Methamphetamine Abstinence Withdrawal Striatum miR-137 SYNCRIP Biomarker Behavior

Handheld endomicroscope using a fiber-optic harmonograph enables real-time and in vivo confocal imaging of living cell morphology and capillary perfusion

在线全文

学校读者我要写书评

暂无评论

Microsystems & Nanoengineering 2020年第1期6卷 449-459页

作者： kyungmin Hwang Yeong-Hyeon Seo Daniel YKim Jinhyo Ahn Soyoung Lee kyung Hee Han Koun-Hee Lee Sangyong Jon Pilhan Kim Kate Eyu Hyungsin Kim Shin-Hyuk Kang Ki-Hun Jeong Department of Bio and Brain Engineering KAIST and KAIST Institute of Health Science and TechnologyDaejeon 34141Republic of Korea Graduate School of Nanoscience and Technology KAIST and KAIST Institute of Health Science and TechnologyDaejeon 34141Republic of Korea Department of Biological Sciences KAIST and KAIST Institute for the BioCenturyDaejeon 34141Republic of Korea Hyunjoo In-Tech Seoul 08390Republic of Korea VPIX Medical IncDeajeon 34141Republic of Korea Graduate School of Medical Science and Engineering Daejeon 34141Republic of Korea Department of Neurosurgery Korea University Anam HospitalKorea University MedicineSeoul 02842Korea

Confocal laser endomicroscopy provides high potential for noninvasive and in vivo optical biopsy at the cellular ***,we report a fully packaged handheld confocal endomicroscopic system for real-time,high-resolution,and in vivo cellular imaging using a Lissajous scanning fiber-optic *** endomicroscopic system features an endomicroscopic probe with a fiber-optic harmonograph,a confocal microscope unit,and an image signal *** fiber-optic harmonograph contains a single mode fiber coupled with a quadrupole piezoelectric tube,which resonantly scans both axes at~1 kHz to obtain a Lissajous *** fiber-optic harmonograph was fully packaged into an endomicroscopic probe with an objective *** endomicroscopic probe was hygienically packaged for waterproofing and disinfection of medical instruments within a 2.6-mm outer diameter stainless tube capable of being inserted through the working channel of a clinical *** probe was further combined with the confocal microscope unit for indocyanine green imaging and the image signal processor for high frame rate and high density Lissajous *** signal processing unit delivers driving signals for probe actuation and reconstructs confocal images using the auto phase matching process of Lissajous fiber *** confocal endomicroscopic system was used to successfully obtain human in vitro fluorescent images and real-time ex vivo and in vivo fluorescent images of the living cell morphology and capillary perfusion inside a single mouse.

关键词： fiber processor confocal

表皮生长因子通过上调环氧酶2促进人食管鳞癌细胞HKESC-1的增殖

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

南方医科大学学报 2011年第8期31卷 1323-1326页

作者：余乐曹之宪刘叔文南方医科大学药学院广东广州510515 香港中文大学生物医学学院

目的研究表皮生长因子(EGF)促进人食管鳞癌细胞增殖的机制。方法氚标记的脱氧胸腺嘧啶核苷掺入法检测细胞增殖。酶免疫法检测前列腺素(PGE2)的释放。免疫印迹法检测环氧酶1(COX-1),环氧酶2(COX-2),PGE2受体亚型EP1和EP2的蛋白表达。结果... 详细信息

目的研究表皮生长因子(EGF)促进人食管鳞癌细胞增殖的机制。方法氚标记的脱氧胸腺嘧啶核苷掺入法检测细胞增殖。酶免疫法检测前列腺素(PGE2)的释放。免疫印迹法检测环氧酶1(COX-1),环氧酶2(COX-2),PGE2受体亚型EP1和EP2的蛋白表达。结果 EGF上调人食管鳞癌HKESC-1细胞COX-2蛋白表达,而不影响COX-1蛋白表达。EGF还能刺激HKESC-1细胞释放PGE2,并上调PGE2受体亚型EP2的蛋白表达。非选择性COX抑制剂吲哚美辛和COX-2选择性抑制剂SC-236均可完全阻断EGF刺激的PGE2释放。这两种COX抑制剂也都能够抑制EGF的促细胞增殖作用。结论 EGF对HKESC-1细胞的促增殖作用,一方面是通过诱导COX-2蛋白的表达从而促进PGE2的释放;另一方面通过上调EP2受体的蛋白表达。

关键词：食管鳞癌 EGF 环氧酶前列腺素环氧酶抑制剂

银杏叶提取物对淡水石斑鱼血清生化指标和肝功能的影响

在线全文

学校读者我要写书评

暂无评论

饲料研究 2024年第1期47卷 44-48页

作者：陆宇杰熊锐孙玉梅冯洪超孙学亮尤宏争毕相东郭永军天津农学院水产学院天津市水产生态及养殖重点实验室天津300392 天津市宝坻区农业发展服务中心天津301899 天津市水产研究所天津301636

试验旨在探究不同水平银杏叶提取物(EGB)对淡水石斑鱼血清抗氧化功能、肝功能、血脂代谢及血清葡萄糖的影响。选取平均体重为(60.30±0.25)g的淡水石斑鱼240尾,随机分为4组,每组3个重复,每个重复20尾,G0组(对照组)、G1组、G2组和G3组分... 详细信息

试验旨在探究不同水平银杏叶提取物(EGB)对淡水石斑鱼血清抗氧化功能、肝功能、血脂代谢及血清葡萄糖的影响。选取平均体重为(60.30±0.25)g的淡水石斑鱼240尾,随机分为4组,每组3个重复,每个重复20尾,G0组(对照组)、G1组、G2组和G3组分别在基础饲料中添加0、50、100、200 mg/kg的EGB。试验期28 d。结果显示,试验21 d时,与对照组相比,G2组试验鱼血清中总超氧化物歧化酶(T-SOD)、谷胱甘肽过氧化物酶(GSH-Px)活性及血清高密度脂蛋白胆固醇(HDL-C)含量提高(Pcho)、甘油三酯(TG)和丙二醛(MDA)的含量及过氧化氢酶(CAT)、谷丙转氨酶(ALT)和谷草转氨酶(AST)活性降低(P<0.05)。研究表明,饲料中添加EGB可以调节淡水石斑鱼血脂代谢,增强淡水石斑鱼的抗氧化能力,可用于预防和治疗高脂血症,EGB添加量为100 mg/kg时投喂14~21 d效果较好。

关键词：淡水石斑鱼银杏叶提取物免疫功能抗氧化功能血清葡萄糖

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

焦油组分重整过程中关键反应的机理研究

可再生能源 2024年第4期42卷 440-447页

作者：杜文亚于震宇郭锐孙超邵正日谢华清重庆赛迪热工环保工程技术有限公司重庆401120 东北大学冶金学院辽宁沈阳110819 营口理工学院辽宁省储能与能源利用技术重点实验室辽宁营口115014

采用密度泛函理论计算方法,对焦油重整过程中主要发生的C-C键裂解反应、CH_(4)重整反应和水煤气转化反应的机理和能量变化进行探究。结果表明:在C-C键裂解反应中,C_(3)H_(8)首先吸附于催化剂表面形成吸附态C_(3)H_(8)*,进一步裂解生成CH... 详细信息

采用密度泛函理论计算方法,对焦油重整过程中主要发生的C-C键裂解反应、CH_(4)重整反应和水煤气转化反应的机理和能量变化进行探究。结果表明:在C-C键裂解反应中,C_(3)H_(8)首先吸附于催化剂表面形成吸附态C_(3)H_(8)*,进一步裂解生成CH_(3)*和CH_(2)CH_(3)*,裂解反应放热,但是反应能垒较大,较难进行;在CH_(4)重整反应中,CH_(4)*发生顺序脱氢反应生成CH_(3)*,CH_(2)*,CH*,相比于继续脱氢,CH*更倾向于与OH*发生重整反应生成cho*,cho*脱氢生成CO*,各步骤产生的H*结合生成H_(2)*,CH_(2)*裂解生成CH*的反应为CH_(4)重整反应的限速步骤;在水煤气转化反应中,H_(2)O*分解后生成的OH*更倾向于与CO*结合生成COOH*,而不是直接与H*生成H_(2)*,COOH*脱去H,生成COO*,该反应为限速步骤。

关键词：焦油重整密度泛函理论基元反应

Demonstration of the approximation of eliminating atomic excited populations in an atom-cavity system

同方期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2012年第2期21卷 272-277页

作者： Zhang yu-Qing Huang Gang Tan Lei Institute of Theoretical Physics Lanzhou UniversityLanzhou 730070China Key Laboratory for Magnetism and Magnetic Materials of the Ministry of Education Lanzhou UniversityLanzhou 730000China

Using the master equation approach to a V-type three-level atom inside a high-finesse single-mode cavity in the strong coupling condition, we demonstrate the approximation of eliminating populations of atomic excited states, which is widely used in the field of the atom cavity systems [Hechenblaikner G, Gangl M, Horak P and Ritsch H 1998 Phys. Rev. A 58 3030]; Liu L W, Tan T and Xu Y 2008 J. Mod. Opt. 56 968; cho J, Angelakis D G and Bose S 2008 Phys. Rev. A 78 062338. This is reflected in the deviation of the population 5, of which the value is 10^-3 - 10^-2. We further find the deviation of the dipole force and demonstrate that the deviation of atomic population will not notably affect the dipole force of the atom in the strong coupling condition. A relevant experimental case is also presented.

关键词： V-type three-level atom high finesse optical cavity dipole force strong coupling condition

Non-rigid registration and KLT filter to improve SNR and CNR in GRE-EPI myocardial perfusion imaging

在线全文

学校读者我要写书评

暂无评论

Journal of Biomedical Science and Engineering 2012年第12期5卷 871-877页

作者： Georgeta Mihai yu Ding Hui Xue Yiu-cho Chung Sanjay Rajagopalan Jens Guehring Orlando P. Simonetti Department of Internal Medicine Cardiovascular Division Dorothy M. Davis Heart and Lung Research Institute Columbus USA Imaging & IT Division Siemens AG Healthcare Sector Erlangen Germany Imaging and Visualization Siemens Corporate Research Princeton USA Shenzhen Institutes of Advanced Technology Shenzhen University Town Shenzhen China

The purpose of the study was to evaluate the effect of motion compensation by non-rigid registration combined with the Karhunen-Loeve Transform (KLT) filter on the signal to noise (SNR) and contrast-to-noise ratio (CNR) of hybrid gradient-echo echoplanar (GRE-EPI) first-pass myocardial perfusion imaging. Twenty one consecutive first-pass adenosine stress perfusion MR data sets interpreted positive for ischemia or infarction were processed by non-rigid Registration followed by KLT filtering. SNR and CNR were measured in abnormal and normal myocardium in unfiltered and KLT filtered images following nonrigid registration to compensate for respiratory and other motions. Image artifacts introduced by filtering in registered and nonregistered images were evaluated by two observers. There was a statistically sig- nificant increase in both SNR and CNR between normal and abnormal myocardium with KLT filtering (mean SNR increased by 62.18% ± 21.05% and mean CNR increased by 58.84% ± 18.06%;p = 0.01). Motion correction prior to KLT filtering reduced significantly the occurrence of filter induced artifacts (KLT only-artifacts in 42 out of 55 image series vs. registered plus KLT-artifacts in 3 out of 55 image series). In conclusion the combination of non-rigid registration and KLT filtering was shown to increase the SNR and CNR of GRE-EPI perfusion images. Subjective evaluation of image artifacts revealed that prior motion compensation significantly reduced the artifacts introduced by the KLT filtering process.

关键词： Cardiac First Pass Perfusion Non-Rigid Registration KLT Filter CNR Dynamic MRI