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The Application of the Korean Dietary Pattern Score;KNHANES (Korean National Health and Nutrition Examination Survey) 2007

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Food and Nutrition Sciences 2012年第12期3卷 1688-1696页

作者： kyung Won Lee Ji Eun Oh Mi Sook cho Department of Nutrition Science and Food Management Ewha Womans University Seoul Korea.

The aim of this study was to apply the Korean Dietary Pattern Score (KDPS) to Korean subjects based on traditional Korean-style meals. The KDPS is based on the 3-Chup Bansang (the traditional Korean daily table setting) and considers the intake of 6 major food groups according to the Korean Dietary Reference Intakes (KDRIs). The KDPS consists of 2 parts: the Korean-Style Meal Score (KSMS) and the Food Group Score (FGS). The KDPS was applied dietary data collected during the Korean National Health and Nutrition Examination Survey (KNHANES) in 2007. Socio-demographic status, gender, age, and body mass index are all factors that have been shown to be meaningful predictors for the KDPS. When the effect of the KDPS on risk of disease was evaluated, a higher total KDPS was associated with a decreased risk of elevated systolic blood pressure (p cholesterolemia (p < 0.05). In addition, as the KSMS increased, the risk of central obesity (p < 0.05) and hypertension (p < 0.01) significantly decreased. A higher total KDPS suggests a greater diversity of food intake, and therefore greater dietary diversity appears to lower the risk of disease. The KDPS is relevant because it integrates scores for Korean-style meal patterns and meal evaluation from a nutritional perspective. In conclusion, the KDPS is appropriate for evaluating the quality of diet, adherence to Korean-style meal patterns, and risk of related diseases. These results will be useful for evaluating the nation’s dietary patterns, nutrition, and health status when planning nutrition policies and programs.

关键词： Korean Dietary Pattern Korean Dietary Index Korean Dietary Pattern Score (KDPS) Korean-Style MealScore (KSMS) Food Group Score (FGS)

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Anti-inflammatory and anti-apoptotic effects of rosuvastatin by regulation of oxidative stress in a dextran sulfate sodium-induced colitis model

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World Journal of Gastroenterology 2017年第25期23卷 4559-4568页

作者： Seung Kak Shin Jae Hee cho Eui Joo Kim Eun-kyung Kim Dong Kyun Park Kwang An Kwon Jun-Won Chung Kyoung Oh Kim Yoon Jae Kim Division of Gastroenterology and Hepatology Department of Internal Medicine Gachon University Gil Medical Center

To evaluate the anti-inflammatory and anti-apoptotic effects of rosuvastatin by regulation of oxidative stress in a dextran sulfate sodium (DSS)-induced colitis model. METHODSAn acute colitis mouse model was induced by oral administration of 5% DSS in the drinking water for 7 d. In the treated group, rosuvastatin (0.3 mg/kg per day) was administered orally before and after DSS administration for 21 d. On day 21, mice were sacrificed and the colons were removed for macroscopic examination, histology, and Western blot analysis. In the in vitro study, IEC-6 cells were stimulated with 50 ng/mL tumor necrosis factor (TNF)-α and then treated with or without rosuvastatin (2 μmol/L). The levels of reactive oxygen species (ROS), inflammatory mediators, and apoptotic markers were measured. RESULTSIn DSS-induced colitis mice, rosuvastatin treatment significantly reduced the disease activity index and histological damage score compared to untreated mice (P < 0.05). Rosuvastatin also attenuated the DSS-induced increase of 8-hydroxy-2’-deoxyguanosine and NADPH oxidase-1 expression in colon tissue. Multiplex ELISA analysis revealed that rosuvastatin treatment reduced the DSS-induced increase of serum IL-2, IL-4, IL-5, IL-6, IL-12 and IL-17, and G-CSF levels. The increased levels of cleaved caspase-3, caspase-7, and poly (ADP-ribose) polymerase in the DSS group were attenuated by rosuvastatin treatment. In vitro, rosuvastatin significantly reduced the production of ROS, inflammatory mediators and apoptotic markers in TNF-α-treated IEC-6 cells (P < 0.05). CONCLUSIONRosuvastatin had the antioxidant, anti-inflammatory and anti-apoptotic effects in DSS-induced colitis model. Therefore, it might be a candidate anti-inflammatory drug in patients with inflammatory bowel disease.

关键词： Oxidative stress Inflammatory bowel disease Rosuvastatin Apoptosis

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Metabolomics investigation on antiobesity effects of Corydalis bungeana on high-fat high-sugar diet-induced obese rats

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Chinese Herbal Medicines 2022年第3期14卷 414-421页

作者： Minghai Fu Terigele Bao Hongzhen yu LiSha A. HuiFang Li Genna Ba Sungbo cho Key Laboratory of Tropical Translational Medicine of Ministry of Education Hainan Key Laboratory for Research and Development of Tropical HerbsSchool of PharmacyHainan Medical UniversityHaikou 571199China NMPA Key Laboratory of Quality Control of Traditional Chinese Medicine(Mongolian Medicine) Inner Mongolia Minzu UniversityTongliao 028000China

Objective:Corydalis bungeana(CB)is a well-used medicinal herb in Mongolian folk medicine and has been traditionally applied as an antiobesity ***,the evidence-based pharmacological effects of CB and its specific metabolic alterations in the obese model are not entirely *** study aimed to utilize untargeted metabolomic techniques to identify biomarkers and gain mechanistic insight into the serum metabolite alterations associated with weight loss and lipid metabolism in obese ***:A high-fat high-sugar(HFHS)diet was used to induce obese models in *** extract was orally gavaged at 0.18,0.9 and 1.8 g/kg doses for six weeks,and feed intake,body weight,fat pad weight,and blood indexes were *** serum metabolites were evaluated by gas chromatography/quadrupole time-of-fight tandem mass spectrometry(GC-TOF/MS).Results:The results showed that compared with the obese group,the administration of CB extract caused significant decreases in body weight(Pcholesterol levels(P<0.05)of obese *** findings showed that nine differential metabolites,including pyruvic acid,D-glucuronic acid,malic acid,dimethylglycine,oxoglutaric acid,pantothenic acid,sorbitol acid,fumaric acid and glucose 6-phosphate were identified under CB treatment and altered metabolic pathways such as TCA cycle,pantothenate and CoA biosynthesis,and glycolysis/***:This study demonstrated weight loss and lipid lowering effects of CB on HFHS diet-induced obese rats and identified nine metabolites as potential biomarkers for evaluating the favorable therapeutic mechanism of CB via regulation of lipid and glucose metabolism.

关键词： Corydalis bungeana Turcz. GC-TOF/MS metabolomics Mongolian medicine obesity

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Splenic Arteriogastric Fistula Resulting from Adrenocortical Carcinoma: A Rare Cause of Massive Upper Gastrointestinal Hemorrhage

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Open Journal of Radiology 2013年第4期3卷 165-168页

作者： Elias J. Dayoub kyung J. cho Department of Radiology Division of Vascular & Interventional Radiology University of Michigan Health System Ann Arbor USA University of Michigan Medical School Ann Arbor USA John F. Kennedy School of Government Harvard University Cambridge USA

Splenic arteriogastric fistula is a rare cause of upper gastrointestinal (GI) hemorrhage, only reported a handful of times in the literature. Herein, we present a case of a 49-year-old woman with metastatic adrenocortical carcincoma who developed a fistula between the splenic artery and gastric lumen as a result of local invasion of her primary tumor. This fistula led to several episodes of massive upper GI bleeding. Selective splenic artery embolization was successful in ceasing the GI bleed;however, the intervention was not timely enough for the patient to survive the hemorrhage. We outline several clinical and imaging findings to assist physicians with earlier detection of splenic arteriogastric fistulas, and advocate prophylactic selective splenic artery embolization when this rare but highly fatal entity is discovered.

关键词： Splenic Artery Fistula Pseudoaneurysm Adrenocortical Carcinoma Embolization

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Serum prostate-specific antigen value adjusted for non-cancerous prostate tissue volume in patients undergoing radical prostatectomy： a new predictor of biochemical recurrence in localized or locally advanced prostate cancer

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Asian Journal of Andrology 2011年第2期13卷 248-253页

作者： Ja Hyeon Ku kyung Chul Moon Sung Yong cho Cheol Kwak Hyeon Hoe Kim Department of Urology Seoul National University College of Medicine Seoul 1 10-744 Korea Department of Pathology Seeul National University College of Medicine Seoul110-744 Korea

The aim of this study was to investigate the significance of serum prostate-specific antigen （PSA） value adjusted for total tumor volume （PSA/tumor volume） and serum PSA value adjusted for non-cancerous prostate tissue volume （NCPV）（PSA/NCPV） as a predictor of pathological findings and clinical outcome after radical prostatectomy. Clinical and pathological data of 407 patients （median age： 66.5 years; range： 41.8--85.7 years） were reviewed retrospectively. The median follow-up period was 18. I months （range： 1.0- 107.8 months）. Biochemical recurrence was defined as detectable PSA levels （greater than 0.2 ng ml-1） and the time of biochemical recurrence was taken to be the first time PSA became detectable. In the multivariate model, PSA/NCPV was an independent predictor of extracapsular extension and positive surgical margin （P〈O.05）, but PSA/tumor volume was not. Kaplan-Meier curves revealed that PSA/NCPV correlated with biochemical recurrence-free survival （P〈O.O01; log-rank test） but PSA/tumor volume did not （P=0.275; log-rank test）. PSA/NCPV was also a significant independent prognostic factor for biochemical recurrence-free survival on multivariate Cox proportional hazard analysis （P=0.004, relative risk=2.42）. Our findings suggest that PSA/NCPV is associated independently with extracapsular extension and surgical margin status and may be an independent prognostic variable of PSA recurrence after radical prostatectomy.

关键词： prostatectomy prostatic neoplasm PSA treatment outcome tumor volume

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Quantum-Dot Spin-Based Secret Sharing in an Optical Microcavity

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Communications in Theoretical Physics 2010年第12期 1049-1053页

作者：张英俏张寿 YEON Kyu-Hwang yu Seong-cho Department of Physics College of ScienceYanbian University BK21 Physics Program and Department of Physics College of Natural SciencesChungbuk National University BK21 Physics Program and Department of Physics College of Natural SciencesChungbuk National UniversityCheongju

Two schemes of quantum secret sharing are proposed via single electron spin confined in charged QDs inside a single-sided microcavity and a double-sided microcavity, respectively. Both schemes rely on coherent photons... 详细信息

关键词： secret sharing quantum-dot spin single-sided microcavity double-sided microcavity

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ROBUST DESIGN MODELS FOR CUSTOMER-SPECIFIED BOUNDS ON PROCESS PARAMETERS

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Journal of Systems Science and Systems Engineering 2006年第1期15卷 2-18页

作者： Sangmun SHIN Byung Rae cho Department of Systems Management&Engineering Inje University GimhaeKyung Nam 621-749South Korea Department of Industrial Engineering Clemson University ClemsonSouth Carolina 29634USA

Robust design (RD) has received much attention from researchers and practitioners for years, and a number of methodologies have been studied in the research community. The majority of existing RD models focus on the minimum variability with a zero bias. However, it is often the case that the customer may specify upper bounds on one of the two process parameters (i.e., the process mean and variance). In this situation, the existing RD models may not work efficiently in incorporating the customer’s needs. To this end, we propose two simple RD models using the ε?constraint feasible region method - one with an upper bound of process bias specified and the other with an upper bound on process variability specified. We then conduct a case study to analyze the effects of upper bounds on each of the process parameters in terms of optimal operating conditions and mean squared error.

关键词： Robust design Process bias process variability response surface methodology ε?constraint method optimization

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Foldable three dimensional neural electrode arrays for simultaneous brain interfacing of cortical surface and intracortical multilayers

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npj Flexible Electronics 2022年第1期6卷 840-853页

作者： Ju Young Lee Sang Hoon Park yujin Kim Young Uk cho Jaejin Park Jung-Hoon Hong Kyubeen Kim Jongwoon Shin Jeong Eun Ju In Sik Min Mingyu Sang Hyogeun Shin Ui-Jin Jeong yuyan Gao Bowen Li Aizhan Zhumbayeva kyung Yeun Kim Eun-Bin Hong Min-Ho Nam Hojeong Jeon Youngmee Jung Huanyu Cheng Il-Joo cho Ki Jun yu School of Electrical and Electronic Engineering Yonsei University50 Yonsei-roSeodaemunguSeoul 03722Republic of Korea Department of Biomedical Sciences College of MedicineKorea UniversitySeoul 02841Republic of Korea Brain Science Institute Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea School of Electrical Engineering Korea UniversitySeoul 02841Republic of Korea Department of Engineering Science and Mechanics The Pennsylvania State UniversityUniversity ParkPA 16802USA Center for Biomaterials Biomedical Research InstituteKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Biomaterials Research Center Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Department of Mechanical Engineering Seoul National UniversitySeoul 08826Republic of Korea Department of Biotechnology College of Life Science and BiotechnologyYonsei UniversitySeoul 03722Republic of Korea Department of KHU-KIST Convergence Science and Technology Kyung Hee UniversitySeoul 02447Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul 02841Republic of Korea School of Electrical and Electronic Engineering YU-KIST InstituteYonsei UniversitySeoul 03722Republic of Korea Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA Materials Research Institute The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Anatomy College of MedicineKorea UniversitySeoul 02841Republic of Korea Department of Electrical and Electronic Engineering YU-Korea Institute of Science and Technology(KIST)InstituteYonsei University50Yonsei-roSeodaemun-guSeoul 03722Korea

Challenges in the understanding of three-dimensional(3D)brain networks by simultaneously recording both surface and intracortical areas of brain signals remain due to the difficulties of constructing mechanical design and spatial limitations of the implanted ***,we present a foldable and flexible 3D neural prosthetic that facilitates the 3D mapping of complex neural circuits with high spatiotemporal dynamics from the intracortical to cortical *** device is the tool to map the 3D neural transmission through sophisticatedly designed four flexible penetrating shanks and surface electrode arrays in one integrated *** demonstrate the potential possibilities of identifying correlations of neural activities from the intracortical area to cortical regions through continuous monitoring of electrophysiological *** also exploited the structural properties of the device to record synchronized signals of single spikes evoked by unidirectional total whisker *** platform offers opportunities to clarify unpredictable 3D neural pathways and provides a next-generation neural interface.

关键词： neural electrode simultaneous

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Association of chronic viral hepatitis B with insulin resistance

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World Journal of Gastroenterology 2012年第42期18卷 6120-6126页

作者： Jeong Gyu Lee Sangyeoup Lee yun Jin Kim Byung Mann cho Joo Sung Park Hyung Hoi Kim JaeHun Cheong Dong Wook Jeong yu Hyun Lee Young Hye cho Mi Jin Bae Eun Jung choi Department of Family Medicine Pusan National University School of MedicineBeomeo-ri Mulgeum-eupYangsan 626-770South Korea Department of Family Medicine Medical Research InstitutePusan National University HospitalBusan 602-739South Korea Medical Education Unit Pusan National University School of MedicineBeomeo-ri Mulgeum-eupYangsan 626-770South Korea Family Medicine Clinic Yangsan Pusan National University HospitalBeomeo-ri Mulgeum-eupYangsan 626-770South Korea Department of Preventive Medicine and Occupational Medicine Pusan National University School of MedicineBeomeo-ri Mulgeum-eupYangsan 626-770South Korea Department of Family Medicine Dong-A University Medical CenterBusan 602-715South Korea Department of Laboratory Medicine Biomedical Informatics UnitPusan National University School of MedicineBeomeo-ri Mulgeum-eupYangsan 626-770South Korea Department of Molecular Biology College of Natural SciencesPusan National UniversityBusan 602-739South Korea

AIM:To investigate the relationship between chronic viral hepatitis B(CVHB) and insulin resistance(IR) in Korean ***:A total of 7880 adults(3851 men,4029 women) who underwent a comprehensive medical examination were enrolled in this *** diagnosed with either diabetes mellitus,or any other disorder that could influence their insulin sensitivity,were ***,metabolic risk factors,hepatitis B surface antigen,hepatitis B surface antibody,hepatitis B core antibody,fasting plasma glucose and insulin were measured for all *** model assessment(HOMA),quantitative insulin check index(QUICKI),and Mf fm index were used for determining insulin *** participant was categorized into a negative,recovery,or CVHB *** compare variables between groups,a t-test and/or one-way analysis of variance were *** correlation coefficients were computed to present the association between insulin resistance and other *** logistic regression analysis was used to assess the independent association between CVHB and ***:The mean age of men and women were 48.9 and 48.6 years,*** in the CVHB group had significantly higher waist circumference [(86.0 ± 7.7 cm vs 87.3 ± 7.8 cm,P = 0.004 in men),(78.3 ± 8.6 cm vs 80.5 ± 8.5 cm,P cholesterol(r = 0.134,P < 0.00

关键词： Hepatitis B Insulin resistance Diabetes mellitus type 2 Metabolic syndrome

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Resveratrol prevents hypoxia-induced retinal ganglion cell death related with ErbB2

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International Journal of Ophthalmology(English edition) 2022年第3期15卷 394-400页

作者： Hyemin Seong Joo Yeon Jeong Jinhyun Ryu Juyeong Park Yong‑Seop Han Hyun-kyung cho Seong Jae Kim Jong Moon Park Sang Soo Kang Seong Wook Seo Department of Ophthalmology Institute of Health SciencesCollege of MedicineGyeongsang National UniversityJinjuGyeongnam 52727Republic of Korea Department of Anatomy and Convergence Medical Science Institute of Health SciencesCollege of MedicineGyeongsang National UniversityJinjuGyeongnam 52727Republic of Korea Department of Ophthalmology Gyeongsang National University Changwon HospitalGyeongsang National UniversityCollege of MedicineChangwon 51472Republic of Korea

AIM: To confirm the changes in proteins related with hypoxia-induced retinal cell death and to assess the effects of resveratrol(Res).METHODS: The therapeutic effect of Res was verified using an ischemic/reperfusion(I/R) model in vivo and a hypoxia modelin retinal ganglion cells(RGCs) in *** of RGCs were confirmed by TUNEL *** expression was confirmed by Western blotting and *** addition, flow cytometric analysis was used to confirm the response in the cell unit to obtain more accurate ***: ErbB2 expression and apoptosis in the ganglion cell layer(GCL) increased after I/R *** of Res rescued I/R-induced ganglion cell death, downregulated apoptosis and ErbB2 protein expression in the *** subsequent in vitro models, Res affects apoptosis by regulating the phosphorylation and expression of mouse double minute 2 homolog(MDM2), along with those of *** results suggest that Res reverses GCL-specific apoptosis via downregulation of ErbB2 in ischemic ***: In light of Res favorable properties, it should be evaluated in the treatment of RGC death and related retinal disease characterized by ErbB2 and MDM2 ***, Res is appropriate therapeutic agent for treating ischemic injury-related eye diseases by targeting the expression of ErbB2 and MDM2.

关键词： ischemia/reperfusion injury hypoxia retinal ganglion cell resveratrol ErbB2

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