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A Review of Formation Mechanism Study on Reservoirs with Tilted Oil-water Contacts

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Acta Geologica Sinica(English Edition) 2017年第1期91卷 320-340页

作者： WANG Sufen ZHANG Tingshan ZHOU Jixian hu yu State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum University Research Institute of Experimental Detection CNPC Xinjiang Petroleum

The distribution characteristics of the oil-water contact are the basis for the reservoir exploration and development and reserves evaluation. The reservoir with a tilted oil-water contact has a unique formation mechanism, and the understanding of its distribution and formation mechanism will directly affect the evaluations for the reservoir type, well deployment, selection of well pattern and type, determination of test section, and reserves evaluation. Based on the analysis of reservoir characteristics, petrophysical properties and geological structure in 40 reservoirs worldwide with tilted oil-water contacts, the progress of the research on the formation mechanisms of titled oil-water contacts is summarized in terms of the hydrodynamic conditions, reservoir heterogeneity, neotectonic movement and oil-gas exploitation. According to the formation mechanism of tilted oil-water contacts and the needs of exploration research, different aspects of research methods are summarized and classified, such as the calculation of equipotential surfaces for oil and water in the formation, analysis of formation pressure and analysis of reservoir physical properties and so on. Based upon statistical analysis, it is suggested that the degree of the inclination of the oil-water contact be divided based on the dip of oil-water contact（DipTOWC）. The tilted oil-water contact is divided into three categories： large dip（DipTOWC≥55 m/km）, medium dip（4 m/km≤DipTOWC55 m/km）, and small dip（DipTOWC4 m/km）. The classification and evaluation method can be combined with structure amplitude and reservoir property. The formation mechanism of domestic and international reservoirs with tilted oil-water contacts are summarized in this paper, which have important significance in guiding the exploration and development of the oilfield with tilted oil-water contacts, reserves evaluation, and well deployment.

关键词： tilted oil-water contact hydrodynamic force reservoir heterogeneity capillary pressure neotectonic movement

Efficient identity-based signature over NTRU lattice

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Frontiers of Information Technology & Electronic Engineering 2016年第2期17卷 135-142页

作者： Jia XIE yu-pu hu Jun-tao GAO Wen GAO School of Telecommunications Engineering Xidian University Xi'an 710071 China The State Key Laboratory of Integrated Services Network Xi 'an 710071 China

Identity-based signature has become an important technique for lightweight authentication as soon as it was proposed in ***,identity-based signature schemes based on the integer factorization problem and discrete logarithm problem were proposed one after ***,the rapid development of quantum computers makes them ***,many efforts have been made to construct identity-based signatures over lattice assumptions against attacks in the quantum ***,their efficiency is not very *** this study,an efficient identity-based signature scheme is presented over the number theory research unit(NTRU) lattice *** new scheme is more efficient than other lattice-and identity-based signature *** new scheme proves to be unforgeable against the adaptively chosen message attack in the random oracle model under the hardness of the γ-shortest vector problem on the NTRU lattice.

关键词： Identity Signature Lattice Number theory research unit (NTRU)

Effects of blade aspect ratio and taper ratio on hovering performance of cycloidal rotor with large blade pitching amplitude

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Chinese Journal of Aeronautics 2019年第5期32卷 1121-1135页

作者： yu hu Xuyang FU Hailang ZHANG Gengqi WANG hussain FARHAT School of Aeronautics Northwestern Polytechnical University

In recent years, a lot of research work has been carried out on the cycloidal rotors. However, it lacks thorough understanding about the effects of the blade platform shape on the hover efficiency of the cycloidal rotor, and the knowledge of how to design the platform shape of the blades. This paper presents a numerical simulation model based on Unsteady ReynoldsAveraged Navier–Stokes equations(URANSs), which is further validated by the experimental results. The effects of blade aspect ratio and taper ratio are analyzed, which shows that the cycloidal rotors with the same chord length have quite similar performance even though the blade aspect ratio varies from a very small value to a large one. By comparing the cycloidal rotors with different taper ratios, it is found that the rotors with large blade taper ratio outperform those with small taper ratio. This is due to the fact that the blade with larger taper ratio has longer chord and hence better efficiency. The analysis results show that the unsteady aerodynamic effects due to blade pitching motion play a more important role in the efficiency than the blade platform shape. Therefore we should pay more attention to the blade airfoil and pitching motion than the blade platform *** main contributions of this paper include: the analysis of the effects of aspect ratio and taper ratio on the hover efficiency of cycloidal rotor based on both the experimental and numerical simulation results; the finding of the main influencing factors on the hover efficiency; the qualitative guidance on how to design the blade platform shape for cycloidal rotors.

关键词： Blade pitching motion Cyclocopter Cyclogyro Cycloidal rotor Dynamic stall

Insights gained from single-cell analysis of chimeric antigen receptor T-cell immunotherapy in cancer

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Military Medical Research 2024年第5期11卷 717-746页

作者： Lu Tang Zhong-Pei huang Heng Mei yu hu Institute of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China hubei Clinical Medical Center of Cell Therapy for Neoplastic Disease Wuhan430022China Key Laboratory of Biological Targeted Therapy The Ministry of EducationWuhan430022China hubei Key Laboratory of Biological Targeted Therapy Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China

Advances in chimeric antigen receptor(CAR)-T cell therapy have significantly improved clinical outcomes of patients with relapsed or refractory hematologic ***,progress is still hindered as clinical benefit is only available for a fraction of patients.A lack of understanding of CAR-T cell behaviors in vivo at the single-cell level impedes their more extensive application in clinical *** evidence suggests that single-cell sequencing techniques can help perfect the receptor design,guide gene-based T cell modification,and optimize the CAR-T manufacturing conditions,and all of them are essential for long-term immunosurveillance and more favorable clinical *** information generated by employing these methods also potentially informs our understanding of the numerous complex factors that dictate therapeutic efficacy and *** this review,we discuss the reasons why CAR-T immunotherapy fails in clinical practice and what this field has learned since the milestone of single-cell sequencing *** further outline recent advances in the application of single-cell analyses in CAR-T ***,we provide an overview of single-cell studies focusing on target antigens,CAR-transgene integration,and preclinical research and clinical applications,and then discuss how it will affect the future of CAR-T cell therapy.

关键词： Single-cell sequencing Cancer immunotherapy CAR-T therapy Cell heterogeneity Trajectory inference Tumor microenvironment

Marketing research in China during the 40-year reform and opening up

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Frontiers of Business Research in China 2020年第1期14卷 1-29页

作者： yu hu Yonggui Wang University of International Business and Economics No.10Huixin DongjieChaoyang DistrictBeijing 100029China Capital University of Economics and Business No.2 JintailiHongmiaoChaoyang DistrictBeijing 100026China

China’s reform and opening up policy initiated by the then leader Deng Xiaoping have undergone a 40-year process since *** period was marked by one of the greatest economic reforms in modern *** this study,we extract literature focused on the Chinese marketization context and marketing practices published in top-tier international marketing journals and Chinese management journals between 1978 and *** study identifies the research questions and research domains investigated in our selected *** authors hope to reveal the general landscape and evolution made in the context of this unique period in Chinese *** thematically focused literature review provides marketing scholars with a snapshot of the academic marketing research in China and gives rise to novel research directions related to the deepening of the economic reform.

关键词： China Reform and opening up Marketing research and practice Chinese consumer Marketing strategy

Instantaneous sediment transport formula for sheet flow beneath asymmetric wave and current

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Journal of Hydrodynamics 2022年第4期34卷 712-724页

作者： Xin-yu hu Zhong-hua Weng Xin Chen Hai-fei Liu The Key Laboratory of Water and Sediment Sciences of Ministry of Education School of EnvironmentBeijing Normal UniversityBeijing100875China Pearl River Water Resources Research Institute Pearl River Water Resources CommissionGuangzhou 510611China College of Water Resources and Civil Engineering China Agricultural UniversityBeijing 100083China

An instantaneous formula is obtained for the sheet flow transport beneath the wave and the current by a product integration of the concentration and velocity profiles over the mobile seabed. The formula involves: (1) The product of the erosion depth and the free stream velocity, which can be reduced to the Shields parameter of power 3/2 in accordance with the classical formulae. (2) The ratio of the wave boundary layer thickness to the erosion depth. The formula incorporates the effects of the acceleration and the phase lag on the erosion depth, the asymmetric wave boundary layer and the wave-current interaction. The validation of the formula is made by the data obtained from the oscillatory tunnels covering a wide range of wave-current and sediment conditions. The instantaneous sediment transport rate is compared with the power function of the velocity with different exponents. The formula consists of a wave force part and a current force part and their relative importance depends on the wave shapes. The present formula gives very good results for the net sediment transport as compared to several existing steady and unsteady formulae. The net sediment transport rates are affected by not only the acceleration, the phase lag and the wave-current interaction, but also the asymmetric boundary layer development.

关键词： Boundary layer thickness erosion depth instantaneous formula sediment transport rate wave and current

Apparent diffusion coefficient-based histogram analysis differentiates histological subtypes of periampullary adenocarcinoma

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World Journal of Gastroenterology 2019年第40期25卷 6116-6128页

作者： Jing-yu Lu Hao yu Xian-Lun Zou Zhen Li Xue-Mei hu Ya-Qi Shen Dao-yu hu Department of Radiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina Department of Radiology the First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina

BACKGROUND For periampullary adenocarcinoma,the histological subtype is a better prognostic predictor than the site of tumor ***-type periampullary adenocarcinoma(IPAC)is reported to have a better prognosis than the pancreatobiliary-type periampullary adenocarcinoma(PPAC).However,the classification of histological subtypes is difficult to determine before *** diffusion coefficient(ADC)histogram analysis is a noninvasive,nonenhanced method with high reproducibility that could help differentiate the two *** To investigate whether volumetric ADC histogram analysis is helpful for distinguishing IPAC from *** Between January 2015 and October 2018,476 consecutive patients who were suspected of having a periampullary tumor and underwent magnetic resonance imaging(MRI)were reviewed in this retrospective *** patients who underwent MRI at 3.0 T with different diffusion-weighted images(b-values=800 and 1000 s/mm^2)and who were confirmed with a periampullary adenocarcinoma were further ***,the mean,5th,10th,25th,50th,75th,90th,and 95th percentiles of ADC values and ADCmin,ADCmax,kurtosis,skewness,and entropy were obtained from the volumetric histogram *** were made by an independent Student's t-test or Mann-Whitney U ***-class receiver operating characteristic curve analysis was performed to determine and compare the diagnostic value of each significant *** In total,40 patients with histopathologically confirmed IPAC(n=17)or PPAC(n=23)were *** mean,5th,25th,50th,75th,90th,and 95th percentiles and ADCmax derived from ADC1000 were significantly lower in the PPAC group than in the IPAC group(P<0.05).However,values derived from ADC800 showed no significant difference between the two *** 75th percentile of ADC1000 values achieved the highest area under the curve(AUC)for differentiating IPAC from PPAC(AUC=0.781;sensitivity,91%;specificity,59%;cut-off value,1.50×10^-3

关键词： Periampullary adenocarcinoma Apparent diffusion coefficient Histogram analysis Histopathology Differential diagnosis

Tests for p-regression Coefficients in Linear Panel Model When p is Divergent

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Acta Mathematicae Applicatae Sinica 2020年第3期36卷 566-580页

作者： Jing ZHAO Mi-xia WU Wei-hu CHENG Yao-hua RONG yu-ping hu China National Institute of Standardization Beijing 100191China College of Applied Sciences Beijing University of TechnologyBeijing100124China School of Mathematics and Statistics Zhengzhou UniversityZhengzhou 450001China

This paper evaluates the performance of the FW-test for testing part of p-regression coefficients in linear panel data model when p is *** asymptotic power of the F_W-statistic is obtained under some regular *** theoretical development are challenging since the number of covariates increases as the sample size *** is worth noting that the inference approach does not require any specification of the error *** simulation comparisons are conducted and show that the simulated power coincide with theoretical power *** method is also illustrated using a renal cancer data example.

关键词： regression coefficient F_W-statistic Panel data

Liquid droplet as efficient master in thin membrane fabrication of poly(dimethylsiloxane) microfluidic devices

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Chinese Science Bulletin 2010年第12期55卷 1120-1126页

作者： LIU DeYe yu hui yu XiaoDong hu yuLin XIA Xinghua Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical Engineering Nanjing University Nanjing 210093China

In this paper,liquid droplet master was for the first time used to fabricate thin membranes integrated polymeric microfluidic *** demonstration,water liquid droplet master was used to make a thin membrane in PDMS microfluidic devices which were prepared by using printed *** PDMS membrane can be controlled down to approximately 10 μm thick with considerable vapour permeation which was adjusted by environmental *** array of the microfluidic devices with thin PDMS membranes was also used for monitoring the crystallization of NaCl.

关键词：微流体装置薄膜制造二甲基硅氧烷微流控液滴有效率硅橡胶膜薄膜制备