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Urinary metabolic profiles during Helicobacter pylori eradication in chronic gastritis

World Journal of Clinical Cases 2024年第5期12卷 951-965页

作者： Wen-Ting An yu-Xia hao hong-Xia Li Xing-Kang Wu Department of Pharmacy Shanxi Provincial People’s HospitalTaiyuan 030012Shanxi ProvinceChina Department of Gastroenterology Shanxi Provincial People's HospitalTaiyuan 030012Shanxi ProvinceChina Department of Oncology Shanxi Provincial People’s HospitalTaiyuan 030012Shanxi ProvinceChina Modern Research Center for Traditional Chinese Medicine Shanxi UniversityTaiyuan 030006Shanxi ProvinceChina

BACKGROUND Helicobacter pylori(***)infection is a major risk factor for chronic gastritis,affecting approximately half of the global *** eradication is a popular treatment method for ***-positive chronic gastritis,but its mecha-nism remains *** metabolomics has been used to elucidate the mechanisms of gastric disease ***,no clinical study has been conducted on urinary metabolomics of chronic *** To elucidate the urinary metabolic profiles during *** eradication in patients with chronic *** We applied LC–MS-based metabolomics and network pharmacology to in-vestigate the relationships between urinary metabolites and ***-positive chronic gastritis via a clinical follow-up *** Our study revealed the different urinary metabolic profiles of ***-positive chronic gastritis before and after *** *** metabolites regulated by *** eradication therapy include cis-aconitic acid,isocitric acid,citric acid,L-tyrosine,L-phenylalanine,L-tryptophan,and hippuric acid,which were involved in four metabolic pathways:(1)Phenylalanine metabolism;(2)phenylalanine,tyrosine,and tryptophan biosynthesis;(3)citrate cycle;and(4)glyoxylate and dicarboxylate *** metabolomics and network pharmacology revealed that MPO,COMT,TPO,TH,EPX,CMA1,DDC,TPH1,and LPO were the key proteins involved in the biological progress of *** eradication in chronic *** Our research provides a new perspective for exploring the significance of urinary metabolites in evaluating the treatment and prognosis of ***-positive chronic gastritis patients.

关键词： LC-MS metabolomics chronic gastritis Helicobacter pylori urinary metabolites

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Clinical efficacy and pathological outcomes of transanal endoscopic intersphincteric resection for low rectal cancer

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 933-944页

作者： Zhi-Wen Xu Jing-Tao Zhu hao-yu Bai Xue-Jun yu Qing-Qi hong Jun You Department of Gastrointestinal Oncology Surgery The First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361000Fujian ProvinceChina

BACKGROUND Transanal endoscopic intersphincteric resection(ISR)surgery currently lacks sufficient clinical research and *** To investigate the clinical effectiveness of transanal endoscopic ISR,in order to promote the clinical application and development of this *** This study utilized a retrospective case series *** and pathological data of patients with lower rectal cancer who underwent transanal endoscopic ISR at the First Affiliated Hospital of Xiamen University between May 2018 and May 2023 were *** patients underwent transanal endoscopic ISR as the surgical *** conducted this study to determine the perioperative recovery status,postoperative complications,and pathological specimen charac-teristics of this group of *** This study included 45 eligible patients,with no perioperative *** overall incidence of early complications was 22.22%,with a rate of 4.44%for Clavien-Dindo grade≥III *** patients(4.4%)developed anastomotic leakage after surgery,including one case of grade A and one case of grade *** pathological examination confirmed negative circumferential resection margins and distal resection margins in all *** mean distance between the tumor lower margin and distal resection margin was found to be 2.30±0.62 *** transanal endoscopic ISR procedure consistently yielded high quality pathological *** Transanal endoscopic ISR is safe,feasible,and provides a clear anatomical *** is associated with a low incidence of postoperative complications and favorable pathological outcomes,making it worth further research and application.

关键词： Intersphincteric resection Transanal Rectal cancer Complications Endoscopic

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Enhancement of mechanical and tribological performance of Ti-6Al-4V alloy by laser surface alloying with Inconel 625 and SiC precursor materials

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Friction 2024年第9期12卷 2089-2107页

作者： hao-Ran CHENG Ki-Hoon SHIN hong Seok KIM Department of Mechanical Engineering Graduate School of Seoul National University of Science and TechnologySeoul 01811Republic of Korea Department of Mechanical and Automotive Engineering Seoul National University of Science and TechnologySeoul 01811Republic of Korea

This study focused on producing metal matrix composite(MMC)coatings on Ti–6Al–4V alloy through laser surface alloying using a novel combination of Inconel 625 and SiC precursor *** ratios of alloying powders were examined to evaluate surface properties such as microhardness,wear resistance,and friction coefficient,along with analyzing the phase composition and microstructure of the *** in situ synthesized MMC coatings exhibited the presence ofα-Ti,NiTi,NiTi_(2),and TiC ***,Ti_(5)Si_(3)andα-Ti/Ti_(5)Si_(3)eutectic structures were observed when the SiC content exceeded 20%.In comparison to the titanium substrate,the MMC coating significantly enhanced microhardness by over threefold and reduced wear by 95%.However,it was crucial to carefully select the appropriate combination of alloying powders to avoid a substantial decrease in friction performance and excessive formation of *** a comparative analysis of experimental results,the optimal precursor material composition was identified as 85%Inconel 625 and 15%*** study demonstrated the effective utilization of Inconel 625 and SiC alloying materials to enhance the surface properties of titanium alloys,thereby expanding their application in challenging environments.

关键词： titanium alloy Inconel 625 SiC ceramic laser surface alloying metal matrix composite(MMC)

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Decomposition of pre-existing Au–P clusters induced in situ a-Fe grains uniformization in Fe–P-based nanocrystalline alloys

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Rare Metals 2024年第10期43卷 5242-5255页

作者： Min-hao Han Cheng Sun Guo-Guo Xi Yang Meng Qiang Luo Xue-Qian yu Wen-Feng Zhang hao Liu hong-Jie Xu Tao Zhang Key Laboratory of Aerospace Materials and Performance(Ministry of Education) School of Materials Science and EngineeringBeihang University Laboratory of Functional Fiber Materials Institute of Bast Fiber CropsChinese Academy of Agricultural Science School of Materials Science and Engineering Jiangsu Key Laboratory for Advanced Metallic MaterialsSoutheast University Institute for Advanced Materials North China Electric Power University Center for Advanced Analysis and Computational Science Zhengzhou University

In Fe-based amorphous-/nanocrystalline ribbons,the uniformization and refinement of a-Fe grains are key aspects for optimizing their soft magnetic and mechanical ***,the Fe–P–C–B nanocrystalline alloy system was selected for *** produced as-spun ribbons with pre-existing nanocrystals through melt-quenching and then obtained a well-distributed a-Fe nanocrystalline structure through annealing below the first crystallization onset temperature （633 K）resulting in excellent magnetic properties (saturation magnetization of 1.65 T and coercivity of 1.6 A·m-1)ultra-wide annealing temperature window （from 613 to 733 K）,and extremely high annealing stability （up to 480 min at 633 K）.Furthermore,we propose a new in situ two-step mechanism for the uniformization of a-Fe nanocrystals,which is separately induced by the decomposition of the Au–P clusters and the pre-existing a-Fe nanocrystals during *** work underscores the crucial significance of micro-alloying via metastable clusters primarily influenced by metal-phosphide interactions in the process of refining a-Fe ***,i introduces a new principle for optimizing the comprehensive properties of Fe-based amorphous/nanocrystalline alloys.

关键词： Fe-based nanocrystalline alloys In-situ nano-crystallization Micro-alloying Soft magnetic property

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Hydrocarbon gas huff-n-puff optimization of multiple horizontal wells with complex fracture networks in the M unconventional reservoir

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Petroleum Science 2024年第2期21卷 1018-1031页

作者： hao-Chuan Zhang Yong Tang You-Wei He Yong Qin Jian-hong Luo yu Sun Ning Wang De-Qiang Wang State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu610500SichuanChina CNPC Research Institute of Petroleum Exploration&Development Beijing100083China Southwest Oil&Gas Field Company PetroChinaChengdu610051SichuanChina State Key Laboratory of Offshore Oil Exploitation CNOOC Research Institute Co.LtdBeijing100027China

The oil production of the multi-fractured horizontal wells(MFHWs) declines quickly in unconventional oil reservoirs due to the fast depletion of natural energy. Gas injection has been acknowledged as an effective method to improve oil recovery factor from unconventional oil reservoirs. Hydrocarbon gas huff-n-puff becomes preferable when the CO_(2) source is limited. However, the impact of complex fracture networks and well interference on the EOR performance of multiple MFHWs is still unclear. The optimal gas huff-n-puff parameters are significant for enhancing oil recovery. This work aims to optimize the hydrocarbon gas injection and production parameters for multiple MFHWs with complex fracture networks in unconventional oil reservoirs. Firstly, the numerical model based on unstructured grids is developed to characterize the complex fracture networks and capture the dynamic fracture ***, the PVT phase behavior simulation was carried out to provide the fluid model for numerical simulation. Thirdly, the optimal parameters for hydrocarbon gas huff-n-puff were obtained. Finally, the dominant factors of hydrocarbon gas huff-n-puff under complex fracture networks are obtained by fuzzy mathematical method. Results reveal that the current pressure of hydrocarbon gas injection can achieve miscible displacement. The optimal injection and production parameters are obtained by single-factor analysis to analyze the effect of individual parameter. Gas injection time is the dominant factor of hydrocarbon gas huff-n-puff in unconventional oil reservoirs with complex fracture networks. This work can offer engineers guidance for hydrocarbon gas huff-n-puff of multiple MFHWs considering the complex fracture networks.

关键词： Unconventional oil reservoir Complex fracture network Hydrocarbon gas huff-n-puff Parameter optimization Numerical simulation

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pH- and near-infrared light-responsive,biomimetic hydrogels from aqueous dispersions of carbon nanotubes

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Nano Research 2024年第4期17卷 3120-3129页

作者： Lulin Hu Xinxin yu Jingcheng hao Lu Xu Shandong Laboratory of Yantai Advanced Materials and Green Manufacturing Yantai 264000China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China Yantai Center for Food and Drug Control Yantai 264000China Key Laboratory of Colloid and Interface Chemistry&Key Laboratory of Special Aggregated Materials Shandong UniversityJinan 250100China

Owing to their low flexibility,poor processability and a lack of responsiveness,inorganic materials are usually non-ideal for constructing a living ***,to date,lifelike materials with structural hierarchies and adaptive properties usually rely on light and soft organic molecules,although few exceptions have been acquired using two-dimensional(2D)inorganic ***,with a systematic study on the gelation behavior of carbon-based 0D quantum dots,1D nanotubes,and 3D fullerenes,we find that acidified 1D carbon nanotubes(CNTs)can serve as an alternative building block for fabricating purely inorganic biomimetic soft *** as-prepared CNT gels exhibit not only a pH-or photothermal-triggered mechanical and tribological adaptivity,which allows them to simulate the behavior of sea cucumbers,peacock mantis shrimps,and mammalian muscles or cortical bones,but also a unique damping property that is similar to spider’s cuticular *** high elasticity,effective lubrication,excellent biocompatibility,and controllable friction and wear also allow them to function as a new type of smart lubricants,whose tribological properties can be regulated either by its internal pH changes or spatiotemporally by near-infrared(NIR)light irradiations,free of any toxic and flammable base oils or additives.

关键词： biomimetic hydrogels carbon nanotubes(CNTs) mechanical and tribological adaptivity pH-and near-infrared(NIR)light responsiveness switchable lubrication

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Event-Triggered Bipartite Consensus Tracking and Vibration Control of Flexible Timoshenko Manipulators Under Time-Varying Actuator Faults

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IEEE/CAA Journal of Automatica Sinica 2024年第5期11卷 1190-1201页

作者： Xiangqian Yao hao Sun Zhijia Zhao yu Liu School of Automation Science and Engineering South China University of TechnologyGuangzhou 510640China Yongjiang Laboratory Ningbo 315202 School of Astronautics Harbin Institute of TechnologyHarbin 150001China School of Mechanical and Electrical Engineering Guangzhou UniversityGuangzhou 510006China

For bipartite angle consensus tracking and vibration suppression of multiple Timoshenko manipulator systems with time-varying actuator faults,parameter and modeling uncertainties,and unknown disturbances,a novel distributed boundary event-triggered control strategy is proposed in this *** contrast to the earlier findings,time-varying consensus tracking and actuator defects are taken into account *** addition,the constructed event-triggered control mechanism can achieve a more flexible design because it is not required to satisfy the input-to-state *** achieve the control objectives,some new integral control variables are given by using back-stepping technique and boundary ***,adaptive neural networks are applied to estimate system *** the proposed event-triggered scheme,control inputs can reduce unnecessary ***,tracking errors and vibration states of the closed-looped network can be exponentially convergent into some small fields,and Zeno behaviors can be *** last,some simulation examples are given to state the effectiveness of the control algorithms.

关键词： Vibration satisfy bipartite

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Nickel Complexes with Non-innocent Ligands as Highly Active Electrocatalysts for Hydrogen Evolution

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Chinese Journal of Chemistry 2018年第12期36卷 1161-1164页

作者： Zhixin Chen Tao Wang Tingting Sun Zhiyong Chen Tian Sheng yu-hao hong Zi-Ang Nan Jun Zhu Zhi-You Zhou Haiping Xia Shi-Gang Sun Collaborative Innovation Center of Chemistry for Energy Materials State Key Laboratory for Physical Chemistry of Solid SurfacesCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamenFujian 361005China

Rational design of a molecular catalyst for a hydrogen evolution reaction (HER) with both high rates and low overpotential remains a challenge. Here we report a series of Ni‐based catalysts incorporating non‐innocent ligands and aimed at reduction of the overpotential by reserving electrons in the ligand, which could decouple the correlation between metal center reduction and metal hydride formation. The third‐order rate constant of our catalysts can be increased by 2 orders of magnitude without increase of overpotential by altering the substituents in the imide since the electronic effect of substituents can change the kinetics of metal hydride formation dramatically. Furthermore, constructing a proton shuttle in the ligand further improves the activity. The catalyst with both of these features can catalyze HER at a turnover frequency of 2572 s-1 with low concentrations of acid and an extremely high third‐order rate constant of 2.7×106 M-2·s-1 at a low overpotential.

关键词： hydrogen evolution molecular electrocatalysis non‐innocent ligand electrochemistry homogeneous catalysis N ligands

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Preparing cyclic polymers at high concentrations via self-folding cyclization technique by adjusting the contents of hydrophilic units in linear precursors

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Chinese Chemical Letters 2024年第2期35卷 283-288页

作者： hao Zha Zuowei Wang Chao Liu Chunyan hong Department of Polymer Science and Engineering University of Science and Technology of ChinaHefei 230026China Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China

Cyclic polymers are a class of polymers that feature endless topology,and the synthesis of cyclic polymers has attracted the attention of many ***,cyclic polymers were efficiently constructed by self-folding cyclization technique at high *** poly((oligo(ethylene glycol)acrylate)-co-(dodecyl acrylate))(P(OEGA-co-DDA))precursors with different ratios of hydrophilic and hydrophobic moieties were synthesized by reversible addition-fragmentation chain transfer(RAFT)polymerization using a bifunctional chain transfer agent with two anthryl end *** amphiphilic linear precursors underwent the self-folding process to generate polymeric nanoparticles in *** irradiating the aqueous solution of the nanoparticles with 365 nm UV light,cyclic polymers were synthesized successfully via coupling of anthryl *** effects of the ratios of hydrophilic and hydrophobic moieties in linear P(OEGA-co-DDA)copolymers and polymer concentration on the purity of the obtained cyclic polymers were explored in detail via ^(1)H nuclear magnetic resonance(^(1)H NMR),dynamic light scattering(DLS),UV‒visible(vis)analysis,three-detection size exclusion chromatography(TD-SEC)and transmission electron microscopy(TEM).It was found that by adjusting the content of the hydrophilic segments in linear precursors,single chain polymeric nanoparticles(SCPNs)can be generated at high polymer ***,cyclic polymers with high purity can be constructed *** method overcomes the limitation of traditional ring-closure method,which is typically conducted in highly dilute conditions,providing an efficient method for the scalable preparation of cyclic polymers.

关键词： Cyclic polymers Self-folding cyclization technique Single chain polymeric nanoparticles RAFT polymerization Direct visualization

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Bioengineered skin organoids:from development to applications

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Military Medical Research 2024年第3期11卷 449-466页

作者： Zi-Xuan hong Shun-Tian Zhu hao Li Jing-Zhi Luo yu Yang Yang An Xi Wang Kai Wang Department of Physiology and Pathophysiology School of Basic Medical SciencesState Key Laboratory of Vascular Homeostasis and RemodelingPeking UniversityBeijing 100191China Department of Hepatopancreatobiliary Surgery the Third Affiliated Hospital of Soochow UniversityChangzhou 213000JiangsuChina Department of Plastic Surgery Peking University Third HospitalBeijing 100191China Clinical Stem Cell Research Center Peking University Third HospitalBeijing 100191China State Key Laboratory of Cardiovascular Disease Fuwai HospitalBeijing 100037China Beijing Key Laboratory of Metabolic Disorder Related Cardiovascular Disease Capital Medical UniversityBeijing 100050China

Signifcant advancements have been made in recent years in the development of highly sophisticated skin *** as three-dimensional(3D)models that mimic human skin,these organoids have evolved into complex structures and are increasingly recognized as efective alternatives to traditional culture models and human skin due to their ability to overcome the limitations of two-dimensional(2D)systems and ethical *** inherent plasticity of skin organoids allows for their construction into physiological and pathological models,enabling the study of skin development and dynamic *** review provides an overview of the pivotal work in the progression from 3D layered epidermis to cyst-like skin organoids with ***,it highlights the latest advancements in organoid construction facilitated by state-of-the-art engineering techniques,such as 3D printing and microfuidic *** review also summarizes and discusses the diverse applications of skin organoids in developmental biology,disease modelling,regenerative medicine,and personalized medicine,while considering their prospects and limitations.

关键词： Skin organoid Organoid generation Skin appendage Tissue engineering Disease modelling Regenerative medicine

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