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Rare Metals 2024年第11期43卷 5835-5847页

作者： Xiao-Jie Hu yu-han sun Ling-yue Liu Dan-Jun Mao Shou-Rong Zheng State Key Laboratory of Pollution Control and Resource Reuse School of the EnvironmentNanjing UniversityNanjing 210023China Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHong Kong 999077Hong KongChina

Monochloroacetic acid(MCAA)is identified as a highly carcinogenic disinfection by-product in chlorinated drinking *** this study,a series of CeO_(2)-supported Pd catalysts(Pd/MCeO_(2))were synthesized through one-step calcination of Pd-loaded Ce-UiO-66-BDC(CeMOF),and the liquid-phase catalytic hydrodechlorination of MCA A was explored using these *** comparison,Pd/CeO_(2)catalysts were additionally synthesized using the conventional impregnation *** characterization results reveal that the catalysts exhibit strong metal-support interaction,leading to high Pd dispersion and Pd^(n+)***,the calcination temperature significantly influences catalytic performance,with the catalyst calcined at 500℃(Pd/MCeO_(2)-500)demonstrating the highest catalytic activity and achieving complete dechlorination of MCA A within 50 ***,it is found that the catalytic MCAA hydrodechlorination using the catalysts adheres to the Langmuir-Hinshelwood ***,low reaction pH is favorable for the catalytic hydrodechlorination of MCAA,enhancing MCAA adsorption on the catalyst surface due to the electrostatic interaction between MCAA and the catalyst *** results suggest that the presence of Pd^(n+)efficiently facilitates MCAA adsorption and C-Cl cleavage,thus significantly enhancing the liquid-phase catalytic hydrodechlorination.

关键词： Ce-UiO-66-BDC One-step calcination Metal-support interaction Liquid-phase catalytic hydrodechlorination Monochloroacetic acid

Expression of p53 in myocardium following coronary microembolization inrats and its significance

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Journal of Geriatric Cardiology 2017年第5期14卷 292-300页

作者： yu-han sun Qiang SU Lang LI Xian-Tao WANG yuan-Xi LU Jia-Bao LIANG Department of Cardiology the First Affiliated Hospital of Guangxi Medical University Nanning China

Background Cardiomyocyte apoptosis is a primary cause for coronary microembolization （CME）-induced cardiac dysfunction, p53induces cell growth retardation and apoptosis through stress pathway. The present study investigated the mechanism of p53-induced myocar-dial apoptosis and cardiac dysfunction by activating the mitochondrion apoptotic pathway following CME. Methods Forty SD rats wereequally divided into microembolization （CME）, sham operation （sham）, CME＋siRNA-p53, and CME＋control-p53 groups. The CME ratmodel was established by injecting microembolization spheres via the left ventricle. Cardiac ultrasound, TUNEL, fluorescence quantitativePCR, and Western blot were used to assess the cardiac function indicators, cardiomyocyte apoptosis, and the expressions of mRNA and pro-tein in myocardial tissues, respectively. Results Echocardiography revealed a significantly reduced cardiac function of the CME group thanthe sham group while the CME-induced cardiac dysfunction was improved in the CME＋siRNA-p53 group. The indicators of myocardialapoptosis in the CME group increased significantly than the sham group; those of the CME＋siRNA-p53 group decreased significantly thanthe CME group. Fluorescence quantitative PCR and Western blot demonstrated that p53, Bbc3 （PUMA）, and cleaved caspase-3 expressionswere significantly increased, and BCL-2 expression was declined in myocardial tissues of the CME group compared to the sham group. Acontrasting result was observed in the CME＋siRNA-p53 group as compared to the CME group. Conclusions P53 is involved in theCME-induced cardiac dysfunction, which may up-regulate Bbc3 to activate BCL-2/caspase3 mitochondrial apoptotic pathway and inducemyocardial apoptosis. Inhibiting the p53 expression can effectively suppress this pathway, thereby reducing myocardial apoptosis and car-diac dysftmction.

关键词： Bbc3 BCL-2 Cardiac dysfunction Coronary microembolization Myocardial apoptosis p53

Nicorandil pretreatment inhibits myocardial apoptosis and improves cardiac function after coronary microembolization in rats

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Journal of Geriatric Cardiology 2018年第9期15卷 591-597页

作者： Wen-Kai HE Qiang SU Jiao-Bao LIANG Xian-Tao WANG yu-han sun Lang LI Department of Cardiology the First Affiliated Hospital of Guangxi Medical University Nanning China

Background Nicorandil （NIC） is a vasodilatory drug used to treat angina. However, its efficacy of cardioprotection in coronary mi- croembolization （CME） is largely unknown. This study was undertaken to determine whether nicorandil pretreatment could attenuate myo- cardial apoptosis and improve cardiac function after CME in rats. Methods Forty-five rats were randomly divided into a Sham group, a CME group and a CME ＋ NIC （NIC） group （n = 15 per group）. CME was established by injecting plastic microspheres （42 pm in diameter） into the left ventricle of the rats in all of the groups except the Sham group. The NIC group received nicorandil at 3 mg/kg per day for seven days before the operation. Cardiac fimction was assessed by echocardiography, the expression levels of cleaved caspase-9/8/3 were detected by Western blot, microinfarction area was measured by haematoxylin-basic fuchsin picric acid staining, and myocardial apoptosis was de- tected by TUNEL staining. Results Compared to that in the Sham group, cardiac fimction in the CME group was significantly decreased （P 〈 0.05）. However, compared to the CME group, the NIC group showed improved cardiac function （P 〈 0.05）. The expression levels of cleaved caspase-9/8/3 protein and myocardial apoptosis were dramatically increased in the CME group compared to those in the Sham group （P 〈 0.05）, while the NIC pretreatment group had significantly decreased expression levels of cleaved caspase-9/8/3 protein as well as a de- creased apoptotic rate （P 〈 0.05）. Conclusions NIC pretreatment inhibited CME-induced myocardial apoptosis and improved cardiac func- tion through blockade of the mitochondrial and death receptor-mediated apoptotic pathways.

关键词： Apoptosis Coronary microembolization Cardiac function Nicorandil

Ischemia/hypoxia inhibits cardiomyocyte autophagy and promotes apoptosis via the Egr-1/Bim/Beclin-1 pathway

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Journal of Geriatric Cardiology 2020年第5期17卷 284-293页

作者： Bo SU Xian-Tao WANG yu-han sun Man-yun LONG Jing ZHENG Wen-Hao WU Lang LI Department of Cardiology the First Affiliated Hospital of Guangxi Medical UniversityNanningChina

Background Myocardial injury caused by microvascular obstruction(MVO)is characterized by persistent ischemia/hypoxia(IH)of cardiomyocytes after *** and Egr-1 were closely associated with various cardiovascular diseases,including *** and Beclin-1 are the important genes for autophagy and *** aimed to explore whether the Egr-1/Bim/Beclin-1 pathway is involved in regulating autophagy and apoptosis in IH-exposed *** Neonatal rat cardiomyocytes exposed to the IH environment in vitro were transfected with lentivirus expressing Egr-1 or Egr-1 sh RNA,or further treated with 3-methyladenine(3-MA).The expressions of autophagy and apoptosis-associated genes were evaluated using RT-q PCR and Western blots *** vacuoles and autophagic flux were detected by transmission electron microscopy(TEM)and confocal microscope,*** injury was assessed by lactate dehydrogenase(LDH)leakage,and apoptosis was determined by flow *** IH exposure elevated Egr-1 and Bim expressions,and decreased Beclin-1 expression in rat ***-1 overexpression in IH-exposed cardiomyocytes significantly up-regulated the levels of Egr-1 and Bim,and down-regulated the level of ***-1 knockdown resulted in down-regulated expressions of Egr-1 and Bim,as well as up-regulated expression of *** addition,Egr-1 knockdown induced autophagy was suppressed by 3-MA *** and autophagic flux experiments also confirmed that Egr-1 inhibited autophagy progression in IH-exposed ***-1 suppression protected cardiomyocytes from IH-induced injury,as evidenced by the positive correlations between Egr-1 expression and LDH leakage or apoptosis index in IH-exposed *** IH-induced cardiomyocyte autophagy and apoptosis are regulated by the Egr-1/Bim/Beclin-1 pathway,which is a potential target for treating cardiomyocyte injury caused by MVO in the IH environment.

关键词： Autophagy Apoptosis Cardiomyocyte Egr-1 Ischemia/hypoxia

Double-Mesopore V-MSU-X Silica and its Pure Siliceous Derivative Prepared by One Synthesis System

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Chinese Chemical Letters 2001年第8期12卷 747-750页

作者： Yan Jun GONG Dong WU yu han sun Zhen Dong ZhanG Hao Guo ZHU Dong yuan ZHAO State Key Laboratory of Coal Conversion Institute of Coal ChemistryChinese Academy of SciencesP.O.BOX165Taiyuan 030001 Department of Chemistry Fudan UniversityShanghai 200032

Non-ionically templated organo-modified MSU-2 mesoporous silicas have been prepared in neutral medium by co-condensation TEOS and vinyltriexoylsiloxane (VTES) and exhibit highly symmetric bimodal mesopore systems. A bromination reaction of V-MSU-2 provides evidence for attachment of most vinyl groups to the accessible surface within the channels. Further, siliceous MSU-2 materials with double pore size have been obtained from calcination of so-produced organo-modified MSU-2 and demonstrate the immense flexibility of the non-ionic templating system.

关键词： Organically modified MSU-X double pore systerm mesoporous materials

Determination of Average Wall Thickness of Mesoporous Silica

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Chinese Chemical Letters 2001年第8期12卷 741-744页

作者： Zhi Hong LI Yan Jun GONG Dong WU yu han sun Jun WANG Yi LIU Bao Zhong DONG State Key Laboratory of Coal Conversion Institute of Coal ChemistryChinese Academy of SciencesP.O.Box 165Taiyuan 030001 Laboratory of Synchrotron Radiation Institute of High Energy PhysicsChinese Academy of SciencesP.O.Box 918Beijing 100039

Small Angle X-ray Scattering (SAXS) experiment using Synchrotron Radiation as X-ray source was used to determine the average wall thickness of mesoporous silica prepared by condensation of tetraethylorthosilicate (TEOS) using non-ionic alkylpolyethyleneoxide (AEO(9)) surfactant as templates. The results agreed with that of high-resolution TEM (HRTEM) measurement.

关键词： Small Angle X-ray Scattering(SAXS) mesoporous silica average wall thickness

Morphology and leaf nutrition of introduced Robinia pseudoacacia clones

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Forestry Studies in China 2013年第1期15卷 24-31页

作者： Guo-Jun ZhanG Jiang-Jie SHEN Li-Mei ZHAO yu-han sun yun LI Zhao-He XU Peng sun National Engineering Laboratory for Tree Breeding Key Laboratory of Genetics and Breeding in Forest Trees and Ornamental Plants of Ministry of Education College of Biological Sciences and Technology Beijing Forestry University College of Horticultural Science and Technology Hebei Normal University of Science & Technology College of Forestry Key Laboratory for Silviculture and Conservation of Ministry of Education Beijing Forestry University

In order to study and popularize clones from the introduced Robinia pseudoacacia, morphological charac- teristics and leaf nutrition of samples of a three-year-old stand were observed and analyzed during its growing season. Combined with data on rooting ability, height and basal diameter, comparisons were made on morphological characteris- tics, growth traits and leaf nutrition of 11 introduced R. pseudoacacia clones （two from Hungary and nine from South Ko- rea） and two domestic clones, The results show that there are significant differences in growth and morphological char- acteristics among the 13 clones, but no significant differences in the contents of crude protein and crude fibers in the leaves （p 〉 0.05）. Height and basal diameter growth of clones B and G were recorded as the fastest, while clone H1 was the slowest. Clone H2 had the largest leaflets, three times as large as other clones, while K4 had the heaviest dry weight per 100 leaflets because of its thick leaves. The 13 clones can be divided into four classes based on the number of leaf- lets per compound leaf, i.e., 1-3, 13-17, 15-23 and 21-25. There were significant differences in thorn size： H2, with the largest leaflets had the smallest thorns. While of course all clones produced roots, there were significant differences; clones 2N, K5 and B had many adventitious roots, while clones K3, K4 and H1 had few. Correlation between content of crude protein and （length x width of leaf） was positive （p 〈 0.05）, while correlations of the content of crude protein, with the number of leaflets per compound leaf, petiole length of compound leaf and thorn length were negative （p 〈 0.01）. Plant height and basal diameter were positively correlated with each other （p 〈 0.01） and negatively correlated with base width of thorns （p 〈 0.05）.

关键词： Robinia pseudoacacia morphological characteristics leaf nutrition growth characteristics rooting ability

A NEW STYRYL-LACTONE COMPOUND FROMGONIOTHALAMUS LEIOCARPUS

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Chinese Chemical Letters 1996年第7期7卷 617-618页

作者： Qing MU Chao Ming LI Hong Jie ZhanG yu WU and han Dong sun(Kunming Institute of Botany, Chinese Academy of Sciences,Kunming 650204) CHINESE ACAD SCI KUNMING INST BOTKUNMING 650204PEOPLES R CHINA

A new styryl-lactone compound, named as leiocarpin A (1), was isolated from Goniothalamus leiocarpus. Its structure and relative configuration were determined by means of spectrum particularly 2D NMR including H-1-H-1...

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Antidiabetic effects of chitooligosaccharides on pancreatic islet cells in streptozotocin-induced diabetic rats

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World Journal of Gastroenterology 2007年第5期13卷 725-731页

作者： Bing Liu Wan-Shun Liu Bao-Qin han yu-Ying sun Department of Marine Life Science Ocean University of ChinaYushan Road No. 5 Qingdao Shandong Province China

AIM: To investigate the effect of chitooligosaccharides on proliferation of pancreatic islet cells, release of insulin and 2 h plasma glucose in streptozotocin-induced diabetic ***: In vitro, the effect of chitooligosaccharides on proliferation of pancreatic islet cells and release of insulin was detected with optical microscopy, colorimetric assay, and radioimmunoassay respectively. In vivo, the general clinical symptoms, 2 h plasma glucose, urine glucose, oral glucose tolerance were examined after sixty days of feeding study to determine the effect of chitooligosaccharides in streptozotocin-induced diabetic rats. RESULTS: Chitooligosaccharides could effectively accelerate the proliferation of pancreatic islet cells. Chitooligosaccharides (100 mg/L) had direct and prominent effect on pancreastic β cells and insulin release from islet cells. All concentrations of chitooligosaccharides could improve the general clinical symptoms of diabetic rats, decrease the 2 h plasma glucose and urine glucose, and normalize the disorders of glucose ***: Chitooligosaccharides possess various biological activities and can be used in the treatment of diabetes mellitus.

关键词： Chitooligosaccharides Diabetes mellitus Two hours plasma glucose Oral glucose Tolerance test Pancreastic islet cells Streptozotocin

Flexible Graphene Field‑Effect Transistors and Their Application in Flexible Biomedical Sensing

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Nano-Micro Letters 2025年第2期17卷 252-313页

作者： Mingyuan sun Shuai Wang Yanbo Liang Chao Wang yunhong Zhang Hong Liu yu Zhang Lin han Institute of Marine Science and Technology Shandong UniversityQingdao 266237ShandongPeople’s Republic of China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100ShandongPeople’s Republic of China School of Integrated Circuits Shandong UniversityJinan 250100ShandongPeople’s Republic of China Shandong Engineering Research Center of Biomarker and Artificial Intelligence Application Jinan250100ShandongPeople’s Republic of China

Flexible electronics are transforming our lives by making daily activities more *** to this innovation are field-effect transistors(FETs),valued for their efficient signal processing,nanoscale fabrication,low-power consumption,fast response times,and ***,known for its exceptional mechanical properties,high electron mobility,and biocompatibility,is an ideal material for FET channels and *** combination of graphene and FETs has given rise to flexible graphene field-effect transistors(FGFETs),driving significant advances in flexible electronics and sparked a strong interest in flexible biomedical ***,we first provide a brief overview of the basic structure,operating mechanism,and evaluation parameters of FGFETs,and delve into their material selection and patterning *** ability of FGFETs to sense strains and biomolecular charges opens up diverse application *** specifically analyze the latest strategies for integrating FGFETs into wearable and implantable flexible biomedical sensors,focusing on the key aspects of constructing high-quality flexible biomedical ***,we discuss the current challenges and prospects of FGFETs and their applications in biomedical *** review will provide valuable insights and inspiration for ongoing research to improve the quality of FGFETs and broaden their application prospects in flexible biomedical sensing.

关键词： Flexible Graphene Field-effect transistor Wearable Implantable Biosensor